LOCUS       NM_000523               2341 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens homeobox D13 (HOXD13), mRNA.
ACCESSION   NM_000523
VERSION     NM_000523.3  GI:116734701
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2341)
  AUTHORS   Puthiyaveetil,A.G., Heid,B., Reilly,C.M., HogenEsch,H. and
            Caudell,D.L.
  TITLE     A NUP98-HOXD13 leukemic fusion gene leads to impaired class switch
            recombination and antibody production
  JOURNAL   Exp. Hematol. 40 (8), 622-633 (2012)
   PUBMED   22613470
  REMARK    GeneRIF: findings show that expression of NUP98-HOXD13 impairs
            class switch recombination and reduces the antibody-mediated immune
            response, in addition to its role in leukemia
REFERENCE   2  (bases 1 to 2341)
  AUTHORS   Wang,B., Xu,B., Cheng,Z., Zhou,X., Wang,J., Yang,G., Cheng,L.,
            Yang,J. and Ma,X.
  TITLE     A novel non-synonymous mutation in the homeodomain of HOXD13 causes
            synpolydactyly in a Chinese family
  JOURNAL   Clin. Chim. Acta 413 (13-14), 1049-1052 (2012)
   PUBMED   22374128
  REMARK    GeneRIF: This finding expands the phenotypic spectrum associated
            with HOXD13 mutations and advances our understanding of human limb
            development.
REFERENCE   3  (bases 1 to 2341)
  AUTHORS   Brison,N., Debeer,P., Fantini,S., Oley,C., Zappavigna,V.,
            Luyten,F.P. and Tylzanowski,P.
  TITLE     An N-terminal G11A mutation in HOXD13 causes synpolydactyly and
            interferes with Gli3R function during limb pre-patterning
  JOURNAL   Hum. Mol. Genet. 21 (11), 2464-2475 (2012)
   PUBMED   22373878
  REMARK    GeneRIF: Misexpression of HOXD13(G11A) in the developing chick limb
            phenocopied the human SPD phenotype
REFERENCE   4  (bases 1 to 2341)
  AUTHORS   Xin,Q., Li,L., Li,J., Qiu,R., Guo,C., Gong,Y. and Liu,Q.
  TITLE     Eight-alanine duplication in homeobox D13 in a Chinese family with
            synpolydactyly
  JOURNAL   Gene 499 (1), 48-51 (2012)
   PUBMED   22406499
  REMARK    GeneRIF: Correlation between Synpolydactyly and alanine expansion
            in HOXD13.
REFERENCE   5  (bases 1 to 2341)
  AUTHORS   Jin,H., Lin,P.F., Wang,Q.M., Mao,F., Cai,Y. and Gong,Y.Q.
  TITLE     [Synpolydactyly in a Chinese kindred: mutation detection, prenatal
            ultrasonographic and molecular diagnosis]
  JOURNAL   Zhonghua Yi Xue Yi Chuan Xue Za Zhi 28 (6), 601-605 (2011)
   PUBMED   22161087
  REMARK    GeneRIF: HOXD13 gene mutation was responsible for the
            synpolydactyly (SPD) phenotype in this family.
REFERENCE   6  (bases 1 to 2341)
  AUTHORS   Goodman,F., Giovannucci-Uzielli,M.L., Hall,C., Reardon,W.,
            Winter,R. and Scambler,P.
  TITLE     Deletions in HOXD13 segregate with an identical, novel foot
            malformation in two unrelated families
  JOURNAL   Am. J. Hum. Genet. 63 (4), 992-1000 (1998)
   PUBMED   9758628
REFERENCE   7  (bases 1 to 2341)
  AUTHORS   Johnson,R.L. and Tabin,C.J.
  TITLE     Molecular models for vertebrate limb development
  JOURNAL   Cell 90 (6), 979-990 (1997)
   PUBMED   9323126
  REMARK    Review article
REFERENCE   8  (bases 1 to 2341)
  AUTHORS   Akarsu,A.N., Stoilov,I., Yilmaz,E., Sayli,B.S. and Sarfarazi,M.
  TITLE     Genomic structure of HOXD13 gene: a nine polyalanine duplication
            causes synpolydactyly in two unrelated families
  JOURNAL   Hum. Mol. Genet. 5 (7), 945-952 (1996)
   PUBMED   8817328
  REMARK    GeneRIF: Gene Structure and Report of Nine Polyalanine Duplications
            in Families with Synpolydactyly, Type II
REFERENCE   9  (bases 1 to 2341)
  AUTHORS   D'Esposito,M., Morelli,F., Acampora,D., Migliaccio,E., Simeone,A.
            and Boncinelli,E.
  TITLE     EVX2, a human homeobox gene homologous to the even-skipped
            segmentation gene, is localized at the 5' end of HOX4 locus on
            chromosome 2
  JOURNAL   Genomics 10 (1), 43-50 (1991)
   PUBMED   1675198
REFERENCE   10 (bases 1 to 2341)
  AUTHORS   Acampora,D., D'Esposito,M., Faiella,A., Pannese,M., Migliaccio,E.,
            Morelli,F., Stornaiuolo,A., Nigro,V., Simeone,A. and Boncinelli,E.
  TITLE     The human HOX gene family
  JOURNAL   Nucleic Acids Res. 17 (24), 10385-10402 (1989)
   PUBMED   2574852
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC009336.13 and BX100910.1.
            This sequence is a reference standard in the RefSeqGene project.
            On Oct 26, 2006 this sequence version replaced gi:23510371.
            
            Summary: This gene belongs to the homeobox family of genes. The
            homeobox genes encode a highly conserved family of transcription
            factors that play an important role in morphogenesis in all
            multicellular organisms. Mammals possess four similar homeobox gene
            clusters, HOXA, HOXB, HOXC and HOXD, located on different
            chromosomes, consisting of 9 to 11 genes arranged in tandem. This
            gene is one of several homeobox HOXD genes located in a cluster on
            chromosome 2. Deletions that remove the entire HOXD gene cluster or
            the 5' end of this cluster have been associated with severe limb
            and genital abnormalities. Mutations in this particular gene cause
            synpolydactyly. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AI971733.1, AI858239.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025090, ERS025092 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-868               AC009336.13        76793-77660
            869-2204            AC009336.13        78469-79804
            2205-2341           BX100910.1         1-137               c
FEATURES             Location/Qualifiers
     source          1..2341
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q31.1"
     gene            1..2341
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /note="homeobox D13"
                     /db_xref="GeneID:3239"
                     /db_xref="HGNC:5136"
                     /db_xref="MIM:142989"
     exon            1..868
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /inference="alignment:Splign:1.39.8"
     STS             3..1297
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /db_xref="UniSTS:483796"
     STS             5..509
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /standard_name="PMC23843P1"
                     /db_xref="UniSTS:272211"
     variation       49
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:144577020"
     STS             62..1169
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /db_xref="UniSTS:481600"
     CDS             88..1119
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /note="homeo box D13; homeo box 4I; homeobox protein
                     Hox-4I"
                     /codon_start=1
                     /product="homeobox protein Hox-D13"
                     /protein_id="NP_000514.2"
                     /db_xref="GI:116734702"
                     /db_xref="CCDS:CCDS2264.2"
                     /db_xref="GeneID:3239"
                     /db_xref="HGNC:5136"
                     /db_xref="MIM:142989"
                     /translation="

MSRAGSWDMDGLRADGGGAGGAPASSSSSSVAAAAASGQCRGFLSAPVFAGTHSGRAAAAAAAAAAAAAAASGFAYPGTSERTGSSSSSSSSAVVAARPEAPPAKECPAPTPAAAAAAPPSAPALGYGYHFGNGYYSCRMSHGVGLQQNALKSSPHASLGGFPVEKYMDVSGLASSSVPANEVPARAKEVSFYQGYTSPYQHVPGYIDMVSTFGSGEPRHEAYISMEGYQSWTLANGWNSQVYCTKDQPQGSHFWKSSFPGDVALNQPDMCVYRRGRKKRVPYTKLQLKELENEYAINKFINKDKRRRISAATNLSERQVTIWFQNRRVKDKKIVSKLKDTVS

"
     misc_feature    <469..627
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /note="Hox protein A13 N terminal; Region: HoxA13_N;
                     pfam12284"
                     /db_xref="CDD:152719"
     misc_feature    916..1086
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /note="Homeodomain;  DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:28970"
     misc_feature    order(916..930,934..936,985..987,1003..1005,1042..1044,
                     1048..1053,1060..1065,1069..1077,1081..1086)
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:28970"
     misc_feature    order(922..924,931..933,1051..1053,1060..1065,1072..1074)
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:28970"
     variation       256..267
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /replace="(gcg(15_22))"
                     /db_xref="dbSNP:193922939"
     variation       258..269
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /replace=""
                     /replace="ggcggcggcggc"
                     /db_xref="dbSNP:3832095"
     variation       291
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2518053"
     variation       335
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369711414"
     variation       347
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:139995491"
     variation       383
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143487752"
     variation       384
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:373546423"
     variation       391
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201821228"
     variation       401
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200514497"
     variation       428
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:369717765"
     variation       441
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:372534114"
     variation       480
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:847195"
     variation       492
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201600075"
     variation       513
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140031618"
     variation       556
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:187698441"
     variation       561
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:371806521"
     variation       587
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200067774"
     variation       620
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201904809"
     variation       628
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148979353"
     variation       630
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:13392701"
     variation       676
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:374086950"
     variation       704
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147720746"
     variation       716
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200274374"
     variation       761
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:367674921"
     variation       770
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:121912541"
     variation       777
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:142600246"
     variation       841
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:35290213"
     variation       844
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374920154"
     exon            869..2327
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /inference="alignment:Splign:1.39.8"
     variation       877
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:373737493"
     STS             880..1113
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /standard_name="Hoxd13"
                     /db_xref="UniSTS:265598"
     variation       897
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:185454060"
     variation       900
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199982017"
     variation       901
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:138630870"
     variation       907
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200750564"
     variation       939
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:149097061"
     STS             953..1569
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /standard_name="HOXD13_3043"
                     /db_xref="UniSTS:462256"
     variation       976
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372343718"
     variation       998
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376366804"
     variation       1003
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:28933082"
     variation       1026
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150319624"
     variation       1034
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:28928892"
     variation       1051
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:28928891"
     variation       1061
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:104893635"
     variation       1092
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369216922"
     variation       1138
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:111593893"
     variation       1168
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:199549554"
     variation       1285
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:188371903"
     variation       1292
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138557314"
     variation       1355
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:141649575"
     variation       1359
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:114386082"
     variation       1430
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:72923426"
     variation       1471..1472
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:146564993"
     variation       1479
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:72923428"
     variation       1516
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146173864"
     variation       1627
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370850321"
     variation       1822
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:137896965"
     variation       1856
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:73029937"
     variation       1883
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:12615946"
     variation       1921
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:112259280"
     variation       1942
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150914949"
     variation       2108
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:184749616"
     variation       2162
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:28661358"
     variation       2181
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:189204555"
     polyA_signal    2305..2310
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
     polyA_site      2327
                     /gene="HOXD13"
                     /gene_synonym="BDE; BDSD; HOX4I; SPD"
ORIGIN      

gagaaaggagaggagggaggaggcgcgccgcgccatggtgtcctgcgcggggccagggccagggccggggccgggccaggccgggccatgagccgcgccgggagctgggacatggacgggctgcgggcagacggcgggggcgccggtggcgccccggcctcttcctcctcctcatcggtggcggcggcggcggcgtcaggccagtgccgcggctttctctccgcgcctgtgttcgccgggacgcattcggggcgggcggcggcggcggcagcggcggctgcggcggcggcggcggcagcctccggctttgcgtaccccgggacctctgagcgcacgggctcttcctcgtcgtcgtcctcttctgccgttgtagcggcgcgcccggaggctcccccagccaaagagtgcccagcacccacgcctgcagcggccgctgcagcgcccccgagcgctccagcgctgggctacggctaccacttcggcaacggctactacagctgccgtatgtcgcacggcgtgggcttacagcagaatgcgctcaagtcatcgccgcacgcctcgctgggaggctttcccgtggagaagtacatggacgtgtcaggcctggcgagcagcagcgtaccggccaacgaggtgccagcgcgagccaaggaggtatccttctaccagggctatacgagcccttaccagcacgtgcccggctatatcgacatggtgtccactttcggctccggggagcctcggcacgaggcctacatctccatggaggggtaccagtcctggacgctggctaacgggtggaacagccaggtgtactgcaccaaggaccagccacaggggtcccacttttggaaatcttcctttccaggggatgtggctctaaatcagccggacatgtgcgtctaccgaagagggaggaagaagagagtgccttacaccaaactgcagcttaaagaactggagaacgagtatgccattaacaaattcattaacaaggacaagcggcggcgtatctcggctgctacgaacctatctgagagacaagtgaccatttggtttcagaaccgaagagtgaaggacaagaaaattgtctccaagctcaaagatactgtctcctgatgtggtccaggttggccacagacagcttagaagccattcggttgtctccaaaaggcctttggaaagacttgaatatgtatttaattccccccaccccctgccaatggtggcaaattttgtgaattgtttttctctcttccccttatctggctctaaaaccttctgctgcccaacctgactttgtagttctgatttttacttgtttattattggttttgttcttgcctagggtttttaaaatatctgtttttaatgttttgtttctccctccaggccagtataaagggacttgaagtattttttaataatccgccccccaatgaacttcagaagtgccattctgatttaagggtttttttaaaaaattactttatttgttcattcccagcactgattatcttcataatccattaggacagaatggttttcagtcgttcatatcctgtaattaggtaattgaatcattagctctcagcagttgccctgaggcaagtggaaaggcaggcagtgctctggggtcaccgagaaagtctaaaaacaggaggctgaaggtactgtgatggctttaaaaatggccaccttattaaatagggattgtatcaatattgaaatgaagacaatctttccaactttgggtgtttcacttgctgttttaattgtttgtttttaacactttgtaggtttgtgttttcataatctttaatttgaaactcatgtgtcctcatggatcgtggatgccttcatttcttgagctctcaatgcagacatttaaatggctgcaatcagtagagtgacccgcggatggcataaatgcacctccttttcttggccttggatctatgggtctgggattgtggtcatctcctcaatcctcaaaaagaggctgaatcaatgtggccgtgggtgggaacttacatacagaacccaatgaagaacttgactgtctaaacaagggggcctcgcatggagctgtaaagcatctaacaaatatgaaaaatgtgaagttccaaggtccaagaagaaaaataatgatgtttctgaaagtgatgataaataattacttttaaagtgctgcatatttatacaattgagagattatttttgtaaatgcaatgtctgtgagctgggatacatgggcagtgcttcagacatttaaaaatcactttttactcctagggagatgccaataaacagaactcttttgtttcaaaaaaaaaaaaaa

//

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:3239 -> Molecular function: GO:0003677 [DNA binding] evidence: TAS
            GeneID:3239 -> Molecular function: GO:0003682 [chromatin binding] evidence: IEA
            GeneID:3239 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IEA
            GeneID:3239 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IEA
            GeneID:3239 -> Biological process: GO:0001501 [skeletal system development] evidence: IEA
            GeneID:3239 -> Biological process: GO:0006355 [regulation of transcription, DNA-dependent] evidence: TAS
            GeneID:3239 -> Biological process: GO:0006366 [transcription from RNA polymerase II promoter] evidence: TAS
            GeneID:3239 -> Biological process: GO:0007275 [multicellular organismal development] evidence: TAS
            GeneID:3239 -> Biological process: GO:0009952 [anterior/posterior pattern specification] evidence: IEA
            GeneID:3239 -> Biological process: GO:0030539 [male genitalia development] evidence: IEA
            GeneID:3239 -> Biological process: GO:0042127 [regulation of cell proliferation] evidence: IEA
            GeneID:3239 -> Biological process: GO:0042733 [embryonic digit morphogenesis] evidence: IEA
            GeneID:3239 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IEA
            GeneID:3239 -> Biological process: GO:0048619 [embryonic hindgut morphogenesis] evidence: IEA
            GeneID:3239 -> Biological process: GO:0060527 [prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis] evidence: IEA
            GeneID:3239 -> Biological process: GO:0060571 [morphogenesis of an epithelial fold] evidence: IEA
            GeneID:3239 -> Biological process: GO:0060602 [branch elongation of an epithelium] evidence: IEA
            GeneID:3239 -> Biological process: GO:0060687 [regulation of branching involved in prostate gland morphogenesis] evidence: IEA
            GeneID:3239 -> Cellular component: GO:0005634 [nucleus] evidence: IEA