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2025-05-09 19:24:15, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_000458 2842 bp mRNA linear PRI 14-JUL-2013 DEFINITION Homo sapiens HNF1 homeobox B (HNF1B), transcript variant 1, mRNA. ACCESSION NM_000458 VERSION NM_000458.2 GI:156713461 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2842) AUTHORS Pharoah PD, Tsai YY, Ramus SJ, Phelan CM, Goode EL, Lawrenson K, Buckley M, Fridley BL, Tyrer JP, Shen H, Weber R, Karevan R, Larson MC, Song H, Tessier DC, Bacot F, Vincent D, Cunningham JM, Dennis J, Dicks E, Aben KK, Anton-Culver H, Antonenkova N, Armasu SM, Baglietto L, Bandera EV, Beckmann MW, Birrer MJ, Bloom G, Bogdanova N, Brenton JD, Brinton LA, Brooks-Wilson A, Brown R, Butzow R, Campbell I, Carney ME, Carvalho RS, Chang-Claude J, Chen YA, Chen Z, Chow WH, Cicek MS, Coetzee G, Cook LS, Cramer DW, Cybulski C, Dansonka-Mieszkowska A, Despierre E, Doherty JA, Dork T, du Bois A, Durst M, Eccles D, Edwards R, Ekici AB, Fasching PA, Fenstermacher D, Flanagan J, Gao YT, Garcia-Closas M, Gentry-Maharaj A, Giles G, Gjyshi A, Gore M, Gronwald J, Guo Q, Halle MK, Harter P, Hein A, Heitz F, Hillemanns P, Hoatlin M, Hogdall E, Hogdall CK, Hosono S, Jakubowska A, Jensen A, Kalli KR, Karlan BY, Kelemen LE, Kiemeney LA, Kjaer SK, Konecny GE, Krakstad C, Kupryjanczyk J, Lambrechts D, Lambrechts S, Le ND, Lee N, Lee J, Leminen A, Lim BK, Lissowska J, Lubinski J, Lundvall L, Lurie G, Massuger LF, Matsuo K, McGuire V, McLaughlin JR, Menon U, Modugno F, Moysich KB, Nakanishi T, Narod SA, Ness RB, Nevanlinna H, Nickels S, Noushmehr H, Odunsi K, Olson S, Orlow I, Paul J, Pejovic T, Pelttari LM, Permuth-Wey J, Pike MC, Poole EM, Qu X, Risch HA, Rodriguez-Rodriguez L, Rossing MA, Rudolph A, Runnebaum I, Rzepecka IK, Salvesen HB, Schwaab I, Severi G, Shen H, Shridhar V, Shu XO, Sieh W, Southey MC, Spellman P, Tajima K, Teo SH, Terry KL, Thompson PJ, Timorek A, Tworoger SS, van Altena AM, van den Berg D, Vergote I, Vierkant RA, Vitonis AF, Wang-Gohrke S, Wentzensen N, Whittemore AS, Wik E, Winterhoff B, Woo YL, Wu AH, Yang HP, Zheng W, Ziogas A, Zulkifli F, Goodman MT, Hall P, Easton DF, Pearce CL, Berchuck A, Chenevix-Trench G, Iversen E, Monteiro AN, Gayther SA, Schildkraut JM and Sellers TA. CONSRTM Australian Cancer Study; Australian Ovarian Cancer Study Group TITLE GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer JOURNAL Nat. Genet. 45 (4), 362-370 (2013) PUBMED 23535730 REFERENCE 2 (bases 1 to 2842) AUTHORS Li H, Gan W, Lu L, Dong X, Han X, Hu C, Yang Z, Sun L, Bao W, Li P, He M, Sun L, Wang Y, Zhu J, Ning Q, Tang Y, Zhang R, Wen J, Wang D, Zhu X, Guo K, Zuo X, Guo X, Yang H, Zhou X, Zhang X, Qi L, Loos RJ, Hu FB, Wu T, Liu Y, Liu L, Yang Z, Hu R, Jia W, Ji L, Li Y and Lin X. CONSRTM DIAGRAM Consortium; AGEN-T2D Consortium TITLE A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans JOURNAL Diabetes 62 (1), 291-298 (2013) PUBMED 22961080 REFERENCE 3 (bases 1 to 2842) AUTHORS Machiela,M.J., Lindstrom,S., Allen,N.E., Haiman,C.A., Albanes,D., Barricarte,A., Berndt,S.I., Bueno-de-Mesquita,H.B., Chanock,S., Gaziano,J.M., Gapstur,S.M., Giovannucci,E., Henderson,B.E., Jacobs,E.J., Kolonel,L.N., Krogh,V., Ma,J., Stampfer,M.J., Stevens,V.L., Stram,D.O., Tjonneland,A., Travis,R., Willett,W.C., Hunter,D.J., Le Marchand,L. and Kraft,P. TITLE Association of type 2 diabetes susceptibility variants with advanced prostate cancer risk in the Breast and Prostate Cancer Cohort Consortium JOURNAL Am. J. Epidemiol. 176 (12), 1121-1129 (2012) PUBMED 23193118 REMARK GeneRIF: No evidence that diabetes mediates the association of the HNF1B locus with prostate cancer risk from a mediation analysis of 9,065 prostate cancer cases and 9,526 controls. REFERENCE 4 (bases 1 to 2842) AUTHORS Zhang,X., Qiao,H., Zhao,Y., Wang,X., Sun,H., Liu,A., Xu,L., Sun,D., Jin,Y., Yu,Y., Meng,X., Bai,J., Chen,F. and Fu,S. TITLE Association of single nucleotide polymorphisms in TCF2 with type 2 diabetes susceptibility in a Han Chinese population JOURNAL PLoS ONE 7 (12), E52938 (2012) PUBMED 23300827 REMARK GeneRIF: Our findings suggested that TCF2 variants may be involved in type 2 diabetes risk in a Han population of northeastern China. REFERENCE 5 (bases 1 to 2842) AUTHORS Maestro,M.A., Cardalda,C., Boj,S.F., Luco,R.F., Servitja,J.M. and Ferrer,J. TITLE Distinct roles of HNF1beta, HNF1alpha, and HNF4alpha in regulating pancreas development, beta-cell function and growth JOURNAL Endocr Dev 12, 33-45 (2007) PUBMED 17923767 REMARK GeneRIF: Findings implicate HNF1beta as a regulator of pancreas organogenesis and differentiation. [REVIEW] Review article REFERENCE 6 (bases 1 to 2842) AUTHORS Senkel,S., Lucas,B., Klein-Hitpass,L. and Ryffel,G.U. TITLE Identification of target genes of the transcription factor HNF1beta and HNF1alpha in a human embryonic kidney cell line JOURNAL Biochim. Biophys. Acta 1731 (3), 179-190 (2005) PUBMED 16297991 REMARK GeneRIF: we propose that HNF1beta overexpression in the ovarian cancer participates in the altered expression pattern REFERENCE 7 (bases 1 to 2842) AUTHORS Horikawa,Y., Iwasaki,N., Hara,M., Furuta,H., Hinokio,Y., Cockburn,B.N., Lindner,T., Yamagata,K., Ogata,M., Tomonaga,O., Kuroki,H., Kasahara,T., Iwamoto,Y. and Bell,G.I. TITLE Mutation in hepatocyte nuclear factor-1 beta gene (TCF2) associated with MODY JOURNAL Nat. Genet. 17 (4), 384-385 (1997) PUBMED 9398836 REFERENCE 8 (bases 1 to 2842) AUTHORS Bach,I., Mattei,M.G., Cereghini,S. and Yaniv,M. TITLE Two members of an HNF1 homeoprotein family are expressed in human liver JOURNAL Nucleic Acids Res. 19 (13), 3553-3559 (1991) PUBMED 1677179 REFERENCE 9 (bases 1 to 2842) AUTHORS Mendel,D.B., Hansen,L.P., Graves,M.K., Conley,P.B. and Crabtree,G.R. TITLE HNF-1 alpha and HNF-1 beta (vHNF-1) share dimerization and homeo domains, but not activation domains, and form heterodimers in vitro JOURNAL Genes Dev. 5 (6), 1042-1056 (1991) PUBMED 2044952 REFERENCE 10 (bases 1 to 2842) AUTHORS Abbott,C., Piaggio,G., Ammendola,R., Solomon,E., Povey,S., Gounari,F., De Simone,V. and Cortese,R. TITLE Mapping of the gene TCF2 coding for the transcription factor LFB3 to human chromosome 17 by polymerase chain reaction JOURNAL Genomics 8 (1), 165-167 (1990) PUBMED 2081590 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC340648.1, BC017714.1, AC091199.6 and AI797324.1. This sequence is a reference standard in the RefSeqGene project. On Sep 1, 2007 this sequence version replaced gi:4507396. Summary: This gene encodes a member of the homeodomain-containing superfamily of transcription factors. The protein binds to DNA as either a homodimer, or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. The gene has been shown to function in nephron development, and regulates development of the embryonic pancreas. Mutations in this gene result in renal cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus, and expression of this gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X58840.1, AK290131.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025084, ERS025085 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-473 DC340648.1 1-473 474-1994 BC017714.1 441-1961 1995-2544 AC091199.6 29528-30077 2545-2842 AI797324.1 1-298 c FEATURES Location/Qualifiers source 1..2842 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="17" /map="17q12" gene 1..2842 /gene="HNF1B" /gene_synonym="FJHN; HNF-1B; HNF1beta; HNF2; HPC11; LF-B3; LFB3; MODY5; TCF-2; TCF2; VHNF1" /note="HNF1 homeobox B" /db_xref="GeneID:6928" /db_xref="HGNC:11630" /db_xref="HPRD:08926" /db_xref="MIM:189907" exon 1..565 /gene="HNF1B" /gene_synonym="FJHN; HNF-1B; HNF1beta; HNF2; HPC11; LF-B3; LFB3; MODY5; TCF-2; TCF2; VHNF1" /inference="alignment:Splign:1.39.8" misc_feature 150..152 /gene="HNF1B" /gene_synonym="FJHN; HNF-1B; HNF1beta; HNF2; HPC11; LF-B3; LFB3; MODY5; TCF-2; TCF2; VHNF1" /note="upstream in-frame stop codon" CDS 222..1895 /gene="HNF1B" /gene_synonym="FJHN; HNF-1B; HNF1beta; HNF2; HPC11; LF-B3; LFB3; MODY5; TCF-2; TCF2; VHNF1" /note="isoform 1 is encoded by transcript variant 1; hepatocyte nuclear factor 1-beta; transcription factor 2, hepatic; HNF1 beta A; HNF-1-beta; homeoprotein LFB3" /codon_start=1 /product="hepatocyte nuclear factor 1-beta isoform 1" /protein_id="NP_000449.1" /db_xref="GI:4507397" /db_xref="CCDS:CCDS11324.1" /db_xref="GeneID:6928" /db_xref="HGNC:11630" /db_xref="HPRD:08926" /db_xref="MIM:189907" /translation="
MVSKLTSLQQELLSALLSSGVTKEVLVQALEELLPSPNFGVKLETLPLSPGSGAEPDTKPVFHTLTNGHAKGRLSGDEGSEDGDDYDTPPILKELQALNTEEAAEQRAEVDRMLSEDPWRAAKMIKGYMQQHNIPQREVVDVTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVRKQREILRQFNQTVQSSGNMTDKSSQDQLLFLFPEFSQQSHGPGQSDDACSEPTNKKMRRNRFKWGPASQQILYQAYDRQKNPSKEEREALVEECNRAECLQRGVSPSKAHGLGSNLVTEVRVYNWFANRRKEEAFRQKLAMDAYSSNQTHSLNPLLSHGSPHHQPSSSPPNKLSGVRYSQQGNNEITSSSTISHHGNSAMVTSQSVLQQVSPASLDPGHNLLSPDGKMISVSGGGLPPVSTLTNIHSLSHHNPQQSQNLIMTPLSGVMAIAQSLNTSQAQSVPVINSVAGSLAALQPVQFSQQLHSPHQQPLMQQSPGSHMAQQPFMAAVTQLQNSHMYAHKQEPPQYSHTSRFPSAMVVTDTSSISTLTNMSSSKQCPLQAW
"
misc_feature 222..767
/gene="HNF1B"
/gene_synonym="FJHN; HNF-1B; HNF1beta; HNF2; HPC11; LF-B3;
LFB3; MODY5; TCF-2; TCF2; VHNF1"
/note="Hepatocyte nuclear factor 1 (HNF-1), N terminus;
Region: HNF-1_N; pfam04814"
/db_xref="CDD:147128"
misc_feature 222..314
/gene="HNF1B"
/gene_synonym="FJHN; HNF-1B; HNF1beta; HNF2; HPC11; LF-B3;
LFB3; MODY5; TCF-2; TCF2; VHNF1"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P35680.1);
Region: Dimerization (By similarity)"
misc_feature 915..1142
/gene="HNF1B"
/gene_synonym="FJHN; HNF-1B; HNF1beta; HNF2; HPC11; LF-B3;
LFB3; MODY5; TCF-2; TCF2; VHNF1"
/note="Homeodomain; DNA binding domains involved in the
transcriptional regulation of key eukaryotic developmental
processes; may bind to DNA as monomers or as homo- and/or
heterodimers, in a sequence-specific manner; Region:
homeodomain; cd00086"
/db_xref="CDD:28970"
misc_feature order(915..929,933..935,984..986,1002..1004,1104..1106,
1110..1115,1122..1127,1131..1139)
/gene="HNF1B"
/gene_synonym="FJHN; HNF-1B; HNF1beta; HNF2; HPC11; LF-B3;
LFB3; MODY5; TCF-2; TCF2; VHNF1"
/note="DNA binding site [nucleotide binding]"
/db_xref="CDD:28970"
misc_feature order(921..923,930..932,1113..1115,1122..1127,1134..1136)
/gene="HNF1B"
/gene_synonym="FJHN; HNF-1B; HNF1beta; HNF2; HPC11; LF-B3;
LFB3; MODY5; TCF-2; TCF2; VHNF1"
/note="specific DNA base contacts [nucleotide binding];
other site"
/db_xref="CDD:28970"
misc_feature 1161..1829
/gene="HNF1B"
/gene_synonym="FJHN; HNF-1B; HNF1beta; HNF2; HPC11; LF-B3;
LFB3; MODY5; TCF-2; TCF2; VHNF1"
/note="Hepatocyte nuclear factor 1 (HNF-1), beta isoform C
terminus; Region: HNF-1B_C; pfam04812"
/db_xref="CDD:191099"
STS 481..1278
/gene="HNF1B"
/gene_synonym="FJHN; HNF-1B; HNF1beta; HNF2; HPC11; LF-B3;
LFB3; MODY5; TCF-2; TCF2; VHNF1"
/standard_name="Hnf1b"
/db_xref="UniSTS:506980"
exon 566..765
/gene="HNF1B"
/gene_synonym="FJHN; HNF-1B; HNF1beta; HNF2; HPC11; LF-B3;
LFB3; MODY5; TCF-2; TCF2; VHNF1"
/inference="alignment:Splign:1.39.8"
STS 742..1020
/gene="HNF1B"
/gene_synonym="FJHN; HNF-1B; HNF1beta; HNF2; HPC11; LF-B3;
LFB3; MODY5; TCF-2; TCF2; VHNF1"
/standard_name="Hnf1b"
/db_xref="UniSTS:545949"
exon 766..1030
/gene="HNF1B"
/gene_synonym="FJHN; HNF-1B; HNF1beta; HNF2; HPC11; LF-B3;
LFB3; MODY5; TCF-2; TCF2; VHNF1"
/inference="alignment:Splign:1.39.8"
STS 807..999
/gene="HNF1B"
/gene_synonym="FJHN; HNF-1B; HNF1beta; HNF2; HPC11; LF-B3;
LFB3; MODY5; TCF-2; TCF2; VHNF1"
/standard_name="Tcf2"
/db_xref="UniSTS:233983"
exon 1031..1266
/gene="HNF1B"
/gene_synonym="FJHN; HNF-1B; HNF1beta; HNF2; HPC11; LF-B3;
LFB3; MODY5; TCF-2; TCF2; VHNF1"
/inference="alignment:Splign:1.39.8"
exon 1267..1427
/gene="HNF1B"
/gene_synonym="FJHN; HNF-1B; HNF1beta; HNF2; HPC11; LF-B3;
LFB3; MODY5; TCF-2; TCF2; VHNF1"
/inference="alignment:Splign:1.39.8"
exon 1428..1560
/gene="HNF1B"
/gene_synonym="FJHN; HNF-1B; HNF1beta; HNF2; HPC11; LF-B3;
LFB3; MODY5; TCF-2; TCF2; VHNF1"
/inference="alignment:Splign:1.39.8"
exon 1561..1755
/gene="HNF1B"
/gene_synonym="FJHN; HNF-1B; HNF1beta; HNF2; HPC11; LF-B3;
LFB3; MODY5; TCF-2; TCF2; VHNF1"
/inference="alignment:Splign:1.39.8"
exon 1756..1874
/gene="HNF1B"
/gene_synonym="FJHN; HNF-1B; HNF1beta; HNF2; HPC11; LF-B3;
LFB3; MODY5; TCF-2; TCF2; VHNF1"
/inference="alignment:Splign:1.39.8"
exon 1875..2836
/gene="HNF1B"
/gene_synonym="FJHN; HNF-1B; HNF1beta; HNF2; HPC11; LF-B3;
LFB3; MODY5; TCF-2; TCF2; VHNF1"
/inference="alignment:Splign:1.39.8"
variation 1994
/gene="HNF1B"
/gene_synonym="FJHN; HNF-1B; HNF1beta; HNF2; HPC11; LF-B3;
LFB3; MODY5; TCF-2; TCF2; VHNF1"
/replace="a"
/replace="c"
/db_xref="dbSNP:2229295"
variation 1995
/gene="HNF1B"
/gene_synonym="FJHN; HNF-1B; HNF1beta; HNF2; HPC11; LF-B3;
LFB3; MODY5; TCF-2; TCF2; VHNF1"
/replace="a"
/replace="g"
/db_xref="dbSNP:1800929"
STS 2105..2429
/gene="HNF1B"
/gene_synonym="FJHN; HNF-1B; HNF1beta; HNF2; HPC11; LF-B3;
LFB3; MODY5; TCF-2; TCF2; VHNF1"
/standard_name="WI-7310"
/db_xref="UniSTS:29648"
STS 2124..2428
/gene="HNF1B"
/gene_synonym="FJHN; HNF-1B; HNF1beta; HNF2; HPC11; LF-B3;
LFB3; MODY5; TCF-2; TCF2; VHNF1"
/standard_name="G60393"
/db_xref="UniSTS:137499"
STS 2158..2351
/gene="HNF1B"
/gene_synonym="FJHN; HNF-1B; HNF1beta; HNF2; HPC11; LF-B3;
LFB3; MODY5; TCF-2; TCF2; VHNF1"
/standard_name="TCF2"
/db_xref="UniSTS:480211"
variation 2169
/gene="HNF1B"
/gene_synonym="FJHN; HNF-1B; HNF1beta; HNF2; HPC11; LF-B3;
LFB3; MODY5; TCF-2; TCF2; VHNF1"
/replace="a"
/replace="t"
/db_xref="dbSNP:2689"
variation 2279
/gene="HNF1B"
/gene_synonym="FJHN; HNF-1B; HNF1beta; HNF2; HPC11; LF-B3;
LFB3; MODY5; TCF-2; TCF2; VHNF1"
/replace="a"
/replace="g"
/db_xref="dbSNP:1058166"
variation 2339
/gene="HNF1B"
/gene_synonym="FJHN; HNF-1B; HNF1beta; HNF2; HPC11; LF-B3;
LFB3; MODY5; TCF-2; TCF2; VHNF1"
/replace="a"
/replace="c"
/db_xref="dbSNP:2688"
variation 2819
/gene="HNF1B"
/gene_synonym="FJHN; HNF-1B; HNF1beta; HNF2; HPC11; LF-B3;
LFB3; MODY5; TCF-2; TCF2; VHNF1"
/replace="c"
/replace="g"
/db_xref="dbSNP:10962"
ORIGIN
aatttgcatatcttatatggcctaatggtggcgatcatggcaagttagaagttttctgactcctttcggaggagcctccgggaccccggggagtaacaggtgtctggaggctgaagggtggaggggttcctggatttggggtttgcttgtgaaactcccctccaccctcctctctcgcacccacccaccccctcacccccttctttttccgtccttggaaaatggtgtccaagctcacgtcgctccagcaagaactcctgagcgccctgctgagctccggggtcaccaaggaggtgctggttcaggccttggaggagttgctgccatccccgaacttcggggtgaagctggagacgctgcccctgtcccctggcagcggggccgagcccgacaccaagccggtcttccatactctcaccaacggccacgccaagggccgcttgtccggcgacgagggctccgaggacggcgacgactatgacacacctcccatcctcaaggagctgcaggcgctcaacaccgaggaggcggcggagcagcgggcggaggtggaccggatgctcagtgaggacccttggagggctgctaaaatgatcaagggttacatgcagcaacacaacatcccccagagggaggtggtcgatgtcaccggcctgaaccagtcgcacctctcccagcatctcaacaagggcacccctatgaagacccagaagcgtgccgctctgtacacctggtacgtcagaaagcaacgagagatcctccgacaattcaaccagacagtccagagttctggaaatatgacagacaaaagcagtcaggatcagctgctgtttctctttccagagttcagtcaacagagccatgggcctgggcagtccgatgatgcctgctctgagcccaccaacaagaagatgcgccgcaaccggttcaaatgggggcccgcgtcccagcaaatcttgtaccaggcctacgatcggcaaaagaaccccagcaaggaagagagagaggccttagtggaggaatgcaacagggcagaatgtttgcagcgaggggtgtccccctccaaagcccacggcctgggctccaacttggtcactgaggtccgtgtctacaactggtttgcaaaccgcaggaaggaggaggcattccggcaaaagctggccatggacgcctatagctccaaccagactcacagcctgaaccctctgctctcccacggctccccccaccaccagcccagctcctctcctccaaacaagctgtcaggagtgcgctacagccagcagggaaacaatgagatcacttcctcctcaacaatcagtcaccatggcaacagcgccatggtgaccagccagtcggttttacagcaagtctccccagccagcctggacccaggccacaatctcctctcacctgatggtaaaatgatctcagtctcaggaggaggtttgcccccagtcagcaccttgacgaatatccacagcctctcccaccataatccccagcaatctcaaaacctcatcatgacacccctctctggagtcatggcaattgcacaaagcctcaacacctcccaagcacagagtgtccctgtcatcaacagtgtggccggcagcctggcagccctgcagcccgtccagttctcccagcagctgcacagccctcaccagcagcccctcatgcagcagagcccaggcagccacatggcccagcagcccttcatggcagctgtgactcagctgcagaactcacacatgtacgcacacaagcaggaacccccccagtattcccacacctcccggtttccatctgcaatggtggtcacagataccagcagcatcagtacactcaccaacatgtcttcaagtaaacagtgtcctctacaagcctggtgatgcccacacaccacttacttcgtgcgcaacaacaaggaccctgttttccacaccatcaccctctgggcagctgtcatggaaaagcccagtgacctgaccggcacctgcgagaggtccctgcttacctgacggacgtcctgctggcacctcagacaatccactctcaggaggcgcagcccgaagcccagtttcccttctatgcagtattgccacaatgcctctcccacgatgtcaaggactcctgtctgtcctggaggtgggagacaaggaaccaccgaagaggaagcaagaaagccgtactgtctatgttgtgatccttcatcgaacaaactgatgcgaaaacttgaatctgttactgaaatgaggagagaaggacatgtgctattgaactgagccaaacacactgtaaatatccacagactccctcccctgcccccatcccacatgatcttgagatttcttttaaagaagtaaatttgtccaatggctgtaaactataaactactgtaattaagtgcaatttcccctctgtgtcctctcccctctgccctgtatataatactaaagtgtctattagttttctttgtaaaggtcagagtcaaaatttcaaaagtgatctgtcccctctcccctcatggagaaacatcctaagtgggaagtgaagccccttgtcctctcccgcgggcctggacacttatggggacagcataccttggactgactaccagctaactccagtctcctgacattaagacacacctctggatccctggaggggctgaatgtagtgtgtcagagtaacatgccagcttcctgtgggccaggagctcagccgtgcactccctaagaaaccccagggcagggaaactggctgtttgatagcagaagaaaaagttgcagtctcagaaagccttccattaaaacaatttattttatcactaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:6928 -> Molecular function: GO:0003677 [DNA binding] evidence: IDA
GeneID:6928 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IDA
GeneID:6928 -> Molecular function: GO:0003705 [RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity] evidence: IEA
GeneID:6928 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:6928 -> Molecular function: GO:0042803 [protein homodimerization activity] evidence: IEA
GeneID:6928 -> Molecular function: GO:0042803 [protein homodimerization activity] evidence: IPI
GeneID:6928 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IEA
GeneID:6928 -> Molecular function: GO:0044212 [transcription regulatory region DNA binding] evidence: IEA
GeneID:6928 -> Molecular function: GO:0046982 [protein heterodimerization activity] evidence: IEA
GeneID:6928 -> Biological process: GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] evidence: IEA
GeneID:6928 -> Biological process: GO:0001714 [endodermal cell fate specification] evidence: IEA
GeneID:6928 -> Biological process: GO:0001822 [kidney development] evidence: IDA
GeneID:6928 -> Biological process: GO:0001822 [kidney development] evidence: IMP
GeneID:6928 -> Biological process: GO:0001826 [inner cell mass cell differentiation] evidence: IEA
GeneID:6928 -> Biological process: GO:0009749 [response to glucose stimulus] evidence: IEA
GeneID:6928 -> Biological process: GO:0009952 [anterior/posterior pattern specification] evidence: IEA
GeneID:6928 -> Biological process: GO:0030073 [insulin secretion] evidence: IEA
GeneID:6928 -> Biological process: GO:0030111 [regulation of Wnt receptor signaling pathway] evidence: IEA
GeneID:6928 -> Biological process: GO:0030902 [hindbrain development] evidence: IEA
GeneID:6928 -> Biological process: GO:0031018 [endocrine pancreas development] evidence: IMP
GeneID:6928 -> Biological process: GO:0031018 [endocrine pancreas development] evidence: TAS
GeneID:6928 -> Biological process: GO:0035565 [regulation of pronephros size] evidence: IMP
GeneID:6928 -> Biological process: GO:0039020 [pronephric nephron tubule development] evidence: IGI
GeneID:6928 -> Biological process: GO:0042663 [regulation of endodermal cell fate specification] evidence: IEA
GeneID:6928 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: IEA
GeneID:6928 -> Biological process: GO:0045893 [positive regulation of transcription, DNA-dependent] evidence: IDA
GeneID:6928 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IEA
GeneID:6928 -> Biological process: GO:0048557 [embryonic digestive tract morphogenesis] evidence: IEA
GeneID:6928 -> Biological process: GO:0048754 [branching morphogenesis of an epithelial tube] evidence: IEA
GeneID:6928 -> Biological process: GO:0048793 [pronephros development] evidence: IMP
GeneID:6928 -> Biological process: GO:0048806 [genitalia development] evidence: IMP
GeneID:6928 -> Biological process: GO:0050673 [epithelial cell proliferation] evidence: IEA
GeneID:6928 -> Biological process: GO:0060261 [positive regulation of transcription initiation from RNA polymerase II promoter] evidence: IDA
GeneID:6928 -> Biological process: GO:0060677 [ureteric bud elongation] evidence: IEA
GeneID:6928 -> Biological process: GO:0061017 [hepatoblast differentiation] evidence: IEA
GeneID:6928 -> Biological process: GO:0072095 [regulation of branch elongation involved in ureteric bud branching] evidence: IEA
GeneID:6928 -> Biological process: GO:0072181 [mesonephric duct formation] evidence: IEA
GeneID:6928 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:6928 -> Cellular component: GO:0005667 [transcription factor complex] evidence: IEA
GeneID:6928 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
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