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2025-05-09 19:12:12, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_000435 8089 bp mRNA linear PRI 15-JUL-2013
DEFINITION Homo sapiens notch 3 (NOTCH3), mRNA.
ACCESSION NM_000435
VERSION NM_000435.2 GI:134244284
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 8089)
AUTHORS Yamamoto,Y., Craggs,L.J., Watanabe,A., Booth,T., Attems,J.,
Low,R.W., Oakley,A.E. and Kalaria,R.N.
TITLE Brain microvascular accumulation and distribution of the NOTCH3
ectodomain and granular osmiophilic material in CADASIL
JOURNAL J. Neuropathol. Exp. Neurol. 72 (5), 416-431 (2013)
PUBMED 23584202
REMARK GeneRIF: NOTCH3 fragments are major components of granular
osmiophilic material deposits in brain samples from CADASIL
patients.
REFERENCE 2 (bases 1 to 8089)
AUTHORS Ragno,M., Berbellini,A., Cacchio,G., Manca,A., Di Marzio,F.,
Pianese,L., De Rosa,A., Silvestri,S., Scarcella,M. and De
Michele,G.
TITLE Parkinsonism is a late, not rare, feature of CADASIL: a study on
Italian patients carrying the R1006C mutation
JOURNAL Stroke 44 (4), 1147-1149 (2013)
PUBMED 23412372
REMARK GeneRIF: Parkinsonism is a late, not rare, feature of CADASIL: a
study on Italian patients carrying the R1006C mutation
REFERENCE 3 (bases 1 to 8089)
AUTHORS Viitanen,M., Sundstrom,E., Baumann,M., Poyhonen,M., Tikka,S. and
Behbahani,H.
TITLE Experimental studies of mitochondrial function in CADASIL vascular
smooth muscle cells
JOURNAL Exp. Cell Res. 319 (3), 134-143 (2013)
PUBMED 23036509
REMARK GeneRIF: Cellular and mitochondrial function in vascular smooth
muscle cell lines (VSMCs) established from CADASIL mutation
carriers (R133C) and healthy controls.
REFERENCE 4 (bases 1 to 8089)
AUTHORS Mann,C.D., Bastianpillai,C., Neal,C.P., Masood,M.M., Jones,D.J.,
Teichert,F., Singh,R., Karpova,E., Berry,D.P. and Manson,M.M.
TITLE Notch3 and HEY-1 as prognostic biomarkers in pancreatic
adenocarcinoma
JOURNAL PLoS ONE 7 (12), E51119 (2012)
PUBMED 23226563
REMARK GeneRIF: These data further support a central role for Notch
signalling in pancreatic cancer and suggest that nuclear expression
of Notch3 and its target gene, HEY-1, merit validation in biomarker
panels for diagnosis, prognosis and treatment efficacy.
REFERENCE 5 (bases 1 to 8089)
AUTHORS Meng,H., Zhang,X., Yu,G., Lee,S.J., Chen,Y.E., Prudovsky,I. and
Wang,M.M.
TITLE Biochemical characterization and cellular effects of CADASIL
mutants of NOTCH3
JOURNAL PLoS ONE 7 (9), E44964 (2012)
PUBMED 23028706
REMARK GeneRIF: CADASIL mutants of NOTCH3 complex with NOTCH1, 3, and 4,
slow NOTCH3 clearance, and that overexpressed wild type and mutant
NOTCH3 protein interfere with key NOTCH-mediated functions in
smooth muscle cells
REFERENCE 6 (bases 1 to 8089)
AUTHORS Lewis,J.
TITLE Neurogenic genes and vertebrate neurogenesis
JOURNAL Curr. Opin. Neurobiol. 6 (1), 3-10 (1996)
PUBMED 8794055
REMARK Review article
REFERENCE 7 (bases 1 to 8089)
AUTHORS Larsson,C., Lardelli,M., White,I. and Lendahl,U.
TITLE The human NOTCH1, 2, and 3 genes are located at chromosome
positions 9q34, 1p13-p11, and 19p13.2-p13.1 in regions of
neoplasia-associated translocation
JOURNAL Genomics 24 (2), 253-258 (1994)
PUBMED 7698746
REFERENCE 8 (bases 1 to 8089)
AUTHORS Sugaya,K., Fukagawa,T., Matsumoto,K., Mita,K., Takahashi,E.,
Ando,A., Inoko,H. and Ikemura,T.
TITLE Three genes in the human MHC class III region near the junction
with the class II: gene for receptor of advanced glycosylation end
products, PBX2 homeobox gene and a notch homolog, human counterpart
of mouse mammary tumor gene int-3
JOURNAL Genomics 23 (2), 408-419 (1994)
PUBMED 7835890
REFERENCE 9 (bases 1 to 8089)
AUTHORS Tournier-Lasserve,E., Joutel,A., Melki,J., Weissenbach,J.,
Lathrop,G.M., Chabriat,H., Mas,J.L., Cabanis,E.A., Baudrimont,M.,
Maciazek,J. et al.
TITLE Cerebral autosomal dominant arteriopathy with subcortical infarcts
and leukoencephalopathy maps to chromosome 19q12
JOURNAL Nat. Genet. 3 (3), 256-259 (1993)
PUBMED 8485581
REFERENCE 10 (bases 1 to 8089)
AUTHORS Beleil,O.M., Mickey,M.R. and Terasaki,P.I.
TITLE Comparison of male and female kidney transplant survival rates
JOURNAL Transplantation 13 (5), 493-500 (1972)
PUBMED 4557798
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from U97669.1 and AC004663.1.
This sequence is a reference standard in the RefSeqGene project.
On Mar 28, 2007 this sequence version replaced gi:4557798.
Summary: This gene encodes the third discovered human homologue of
the Drosophilia melanogaster type I membrane protein notch. In
Drosophilia, notch interaction with its cell-bound ligands (delta,
serrate) establishes an intercellular signalling pathway that plays
a key role in neural development. Homologues of the notch-ligands
have also been identified in human, but precise interactions
between these ligands and the human notch homologues remains to be
determined. Mutations in NOTCH3 have been identified as the
underlying cause of cerebral autosomal dominant arteriopathy with
subcortical infarcts and leukoencephalopathy (CADASIL). [provided
by RefSeq, Jul 2008].
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data because transcript sequence consistent with
the reference genome assembly was not available for all regions of
the RefSeq transcript. The extent of this transcript is supported
by transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: U97669.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: full length.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-681 U97669.1 3-683
682-682 AC004663.1 35190-35190 c
683-999 U97669.1 685-1001
1000-1000 AC004663.1 34693-34693 c
1001-2613 U97669.1 1003-2615
2614-2614 AC004663.1 27480-27480 c
2615-2817 U97669.1 2617-2819
2818-2818 AC004663.1 24783-24783 c
2819-4638 U97669.1 2821-4640
4639-4639 AC004663.1 17398-17398 c
4640-6513 U97669.1 4642-6515
6514-7932 AC004663.1 2929-4347 c
7933-8089 U97669.1 7935-8091
FEATURES Location/Qualifiers
source 1..8089
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="19"
/map="19p13.2-p13.1"
gene 1..8089
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/note="notch 3"
/db_xref="GeneID:4854"
/db_xref="HGNC:7883"
/db_xref="MIM:600276"
exon 1..194
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/inference="alignment:Splign:1.39.8"
CDS 77..7042
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/note="neurogenic locus notch homolog protein 3; Notch
homolog 3"
/codon_start=1
/product="neurogenic locus notch homolog protein 3
precursor"
/protein_id="NP_000426.2"
/db_xref="GI:134244285"
/db_xref="CCDS:CCDS12326.1"
/db_xref="GeneID:4854"
/db_xref="HGNC:7883"
/db_xref="MIM:600276"
/translation="
MGPGARGRRRRRRPMSPPPPPPPVRALPLLLLLAGPGAAAPPCLDGSPCANGGRCTQLPSREAACLCPPGWVGERCQLEDPCHSGPCAGRGVCQSSVVAGTARFSCRCPRGFRGPDCSLPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPMGKTGLLCHLDDACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCSPDPCHHGRCVDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASNPCTFGVCRDGINRYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHGICYDAPGGFRCVCEPGWSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNPCGPGTCTDHVASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPCLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQTGAYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGVPCQQTPRGPRCACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTGPRCEAPAAAPEVSEEPRCPRAACQAKRGDQRCDRECNSPGCGWDGGDCSLSVGDPWRQCEALQCWRLFNNSRCDPACSSPACLYDNFDCHAGGRERTCNPVYEKYCADHFADGRCDQGCNTEECGWDGLDCASEVPALLARGVLVLTVLLPPEELLRSSADFLQRLSAILRTSLRFRLDAHGQAMVFPYHRPSPGSEPRARRELAPEVIGSVVMLEIDNRLCLQSPENDHCFPDAQSAADYLGALSAVERLDFPYPLRDVRGEPLEPPEPSVPLLPLLVAGAVLLLVILVLGVMVARRKREHSTLWFPEGFSLHKDVASGHKGRREPVGQDALGMKNMAKGESLMGEVATDWMDTECPEAKRLKVEEPGMGAEEAVDCRQWTQHHLVAADIRVAPAMALTPPQGDADADGMDVNVRGPDGFTPLMLASFCGGALEPMPTEEDEADDTSASIISDLICQGAQLGARTDRTGETALHLAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAVTADAQGVFQILIRNRSTDLDARMADGSTALILAARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLAAREGSYEAAKLLLDHFANREITDHLDRLPRDVAQERLHQDIVRLLDQPSGPRSPPGPHGLGPLLCPPGAFLPGLKAAQSGSKKSRRPPGKAGLGPQGPRGRGKKLTLACPGPLADSSVTLSPVDSLDSPRPFGGPPASPGGFPLEGPYAAATATAVSLAQLGGPGRAGLGRQPPGGCVLSLGLLNPVAVPLDWARLPPPAPPGPSFLLPLAPGPQLLNPGTPVSPQERPPPYLAVPGHGEEYPAAGAHSSPPKARFLRVPSEHPYLTPSPESPEHWASPSPPSLSDWSESTPSPATATGAMATTTGALPAQPLPLSVPSSLAQAQTQLGPQPEVTPKRQVLA
"
sig_peptide 77..193
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/inference="COORDINATES: ab initio prediction:SignalP:4.0"
misc_feature 548..661
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/note="Calcium-binding EGF-like domain, present in a large
number of membrane-bound and extracellular (mostly animal)
proteins. Many of these proteins require calcium for their
biological function and calcium-binding sites have been
found to be located at the...; Region: EGF_CA; cd00054"
/db_xref="CDD:28936"
misc_feature order(548..550,557..559,602..604)
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/note="Ca2+ binding site [ion binding]; other site"
/db_xref="CDD:28936"
misc_feature 782..892
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/note="Calcium-binding EGF-like domain, present in a large
number of membrane-bound and extracellular (mostly animal)
proteins. Many of these proteins require calcium for their
biological function and calcium-binding sites have been
found to be located at the...; Region: EGF_CA; cd00054"
/db_xref="CDD:28936"
misc_feature order(782..784,791..793,833..835)
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/note="Ca2+ binding site [ion binding]; other site"
/db_xref="CDD:28936"
misc_feature 896..1009
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/note="Calcium-binding EGF-like domain, present in a large
number of membrane-bound and extracellular (mostly animal)
proteins. Many of these proteins require calcium for their
biological function and calcium-binding sites have been
found to be located at the...; Region: EGF_CA; cd00054"
/db_xref="CDD:28936"
misc_feature order(896..898,905..907,953..955)
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/note="Ca2+ binding site [ion binding]; other site"
/db_xref="CDD:28936"
misc_feature 1016..>1105
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/note="Calcium-binding EGF-like domain, present in a large
number of membrane-bound and extracellular (mostly animal)
proteins. Many of these proteins require calcium for their
biological function and calcium-binding sites have been
found to be located at the...; Region: EGF_CA; cl09941"
/db_xref="CDD:209104"
misc_feature 1247..1363
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/note="Calcium-binding EGF-like domain, present in a large
number of membrane-bound and extracellular (mostly animal)
proteins. Many of these proteins require calcium for their
biological function and calcium-binding sites have been
found to be located at the...; Region: EGF_CA; cd00054"
/db_xref="CDD:28936"
misc_feature order(1247..1249,1256..1258,1304..1306)
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/note="Ca2+ binding site [ion binding]; other site"
/db_xref="CDD:28936"
misc_feature 1367..1477
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/note="Calcium-binding EGF-like domain, present in a large
number of membrane-bound and extracellular (mostly animal)
proteins. Many of these proteins require calcium for their
biological function and calcium-binding sites have been
found to be located at the...; Region: EGF_CA; cd00054"
/db_xref="CDD:28936"
misc_feature order(1367..1369,1376..1378,1418..1420)
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/note="Ca2+ binding site [ion binding]; other site"
/db_xref="CDD:28936"
misc_feature 1481..1591
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/note="Calcium-binding EGF-like domain, present in a large
number of membrane-bound and extracellular (mostly animal)
proteins. Many of these proteins require calcium for their
biological function and calcium-binding sites have been
found to be located at the...; Region: EGF_CA; cd00054"
/db_xref="CDD:28936"
misc_feature order(1481..1483,1490..1492,1532..1534)
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/note="Ca2+ binding site [ion binding]; other site"
/db_xref="CDD:28936"
misc_feature 1595..1705
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/note="Calcium-binding EGF-like domain, present in a large
number of membrane-bound and extracellular (mostly animal)
proteins. Many of these proteins require calcium for their
biological function and calcium-binding sites have been
found to be located at the...; Region: EGF_CA; cd00054"
/db_xref="CDD:28936"
misc_feature order(1595..1597,1604..1606,1646..1648)
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/note="Ca2+ binding site [ion binding]; other site"
/db_xref="CDD:28936"
misc_feature 1709..1816
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/note="Calcium-binding EGF-like domain, present in a large
number of membrane-bound and extracellular (mostly animal)
proteins. Many of these proteins require calcium for their
biological function and calcium-binding sites have been
found to be located at the...; Region: EGF_CA; cd00054"
/db_xref="CDD:28936"
misc_feature order(1709..1711,1718..1720,1757..1759)
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/note="Ca2+ binding site [ion binding]; other site"
/db_xref="CDD:28936"
misc_feature 1823..1930
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/note="Calcium-binding EGF-like domain, present in a large
number of membrane-bound and extracellular (mostly animal)
proteins. Many of these proteins require calcium for their
biological function and calcium-binding sites have been
found to be located at the...; Region: EGF_CA; cd00054"
/db_xref="CDD:28936"
misc_feature order(1829..1831,1871..1873)
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/note="Ca2+ binding site [ion binding]; other site"
/db_xref="CDD:28936"
misc_feature 2504..2617
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/note="Calcium-binding EGF-like domain, present in a large
number of membrane-bound and extracellular (mostly animal)
proteins. Many of these proteins require calcium for their
biological function and calcium-binding sites have been
found to be located at the...; Region: EGF_CA; cd00054"
/db_xref="CDD:28936"
misc_feature order(2504..2506,2513..2515,2558..2560)
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/note="Ca2+ binding site [ion binding]; other site"
/db_xref="CDD:28936"
misc_feature 2621..2728
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/note="Calcium-binding EGF-like domain, present in a large
number of membrane-bound and extracellular (mostly animal)
proteins. Many of these proteins require calcium for their
biological function and calcium-binding sites have been
found to be located at the...; Region: EGF_CA; cd00054"
/db_xref="CDD:28936"
misc_feature order(2621..2623,2630..2632,2672..2674)
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/note="Ca2+ binding site [ion binding]; other site"
/db_xref="CDD:28936"
misc_feature 2735..2842
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/note="Calcium-binding EGF-like domain, present in a large
number of membrane-bound and extracellular (mostly animal)
proteins. Many of these proteins require calcium for their
biological function and calcium-binding sites have been
found to be located at the...; Region: EGF_CA; cd00054"
/db_xref="CDD:28936"
misc_feature order(2735..2737,2744..2746,2783..2785)
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/note="Ca2+ binding site [ion binding]; other site"
/db_xref="CDD:28936"
misc_feature 2861..2956
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/note="Calcium-binding EGF-like domain, present in a large
number of membrane-bound and extracellular (mostly animal)
proteins. Many of these proteins require calcium for their
biological function and calcium-binding sites have been
found to be located at the...; Region: EGF_CA; cd00054"
/db_xref="CDD:28936"
misc_feature 3326..3436
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/note="Calcium-binding EGF-like domain, present in a large
number of membrane-bound and extracellular (mostly animal)
proteins. Many of these proteins require calcium for their
biological function and calcium-binding sites have been
found to be located at the...; Region: EGF_CA; cd00054"
/db_xref="CDD:28936"
misc_feature order(3326..3328,3335..3337,3377..3379)
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/note="Ca2+ binding site [ion binding]; other site"
/db_xref="CDD:28936"
misc_feature 3440..3550
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/note="Calcium-binding EGF-like domain, present in a large
number of membrane-bound and extracellular (mostly animal)
proteins. Many of these proteins require calcium for their
biological function and calcium-binding sites have been
found to be located at the...; Region: EGF_CA; cd00054"
/db_xref="CDD:28936"
misc_feature order(3440..3442,3449..3451,3491..3493)
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/note="Ca2+ binding site [ion binding]; other site"
/db_xref="CDD:28936"
misc_feature 3587..3685
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/note="Calcium-binding EGF-like domain, present in a large
number of membrane-bound and extracellular (mostly animal)
proteins. Many of these proteins require calcium for their
biological function and calcium-binding sites have been
found to be located at the...; Region: EGF_CA; cd00054"
/db_xref="CDD:28936"
misc_feature 4232..4327
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/note="Domain found in Notch and Lin-12; Region: NL;
smart00004"
/db_xref="CDD:197463"
misc_feature 4235..4357
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UM47.2);
Region: LNR 1"
misc_feature 4337..4450
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/note="Domain found in Notch and Lin-12; Region: NL;
smart00004"
/db_xref="CDD:197463"
misc_feature 4358..4450
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UM47.2);
Region: LNR 2"
misc_feature 4475..4591
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UM47.2);
Region: LNR 3"
misc_feature 4487..4576
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/note="LNR domain; Region: Notch; pfam00066"
/db_xref="CDD:200970"
misc_feature 4589..4756
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/note="NOTCH protein; Region: NOD; pfam06816"
/db_xref="CDD:191614"
misc_feature 4787..4792
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/inference="non-experimental evidence, no additional
details recorded"
/note="Cleavage, by furin-like protease (By similarity);
propagated from UniProtKB/Swiss-Prot (Q9UM47.2); cleavage
site"
misc_feature 4802..4966
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/note="NOTCH protein; Region: NODP; pfam07684"
/db_xref="CDD:191811"
misc_feature 4958..4960
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/experiment="experimental evidence, no additional details
recorded"
/note="proteolytic cleavage site; modified site"
misc_feature 5006..5068
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UM47.2);
transmembrane region"
misc_feature 5057..5059
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/experiment="experimental evidence, no additional details
recorded"
/note="proteolytic cleavage site; modified site"
misc_feature <5411..5854
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/note="ankyrin repeats; ankyrin repeats mediate
protein-protein interactions in very diverse families of
proteins. The number of ANK repeats in a protein can range
from 2 to over 20 (ankyrins, for example). ANK repeats may
occur in combinations with other...; Region: ANK; cd00204"
/db_xref="CDD:29261"
misc_feature 5588..5677
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UM47.2);
Region: ANK 1"
misc_feature 5672..6052
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/note="ankyrin repeats; ankyrin repeats mediate
protein-protein interactions in very diverse families of
proteins. The number of ANK repeats in a protein can range
from 2 to over 20 (ankyrins, for example). ANK repeats may
occur in combinations with other...; Region: ANK; cd00204"
/db_xref="CDD:29261"
misc_feature 5672..5815
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/note="Ankyrin repeats (many copies); Region: Ank_5;
pfam13857"
/db_xref="CDD:206028"
misc_feature 5687..5779
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UM47.2);
Region: ANK 2"
misc_feature 5789..5878
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UM47.2);
Region: ANK 3"
misc_feature 5804..6082
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/note="Ankyrin repeats (3 copies); Region: Ank_2;
pfam12796"
/db_xref="CDD:205076"
misc_feature 5888..5977
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UM47.2);
Region: ANK 4"
misc_feature 5987..6076
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UM47.2);
Region: ANK 5"
misc_feature 6707..6880
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/note="Domain of unknown function (DUF3454); Region:
DUF3454; pfam11936"
/db_xref="CDD:152371"
exon 195..273
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/inference="alignment:Splign:1.39.8"
exon 274..416
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/inference="alignment:Splign:1.39.8"
exon 417..755
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/inference="alignment:Splign:1.39.8"
variation 682
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/replace="a"
/replace="g"
/db_xref="dbSNP:1043994"
exon 756..878
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/inference="alignment:Splign:1.39.8"
exon 879..1112
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/inference="alignment:Splign:1.39.8"
variation 1000
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/replace="c"
/replace="t"
/db_xref="dbSNP:1043995"
exon 1113..1268
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/inference="alignment:Splign:1.39.8"
exon 1269..1454
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/inference="alignment:Splign:1.39.8"
exon 1455..1568
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/inference="alignment:Splign:1.39.8"
exon 1569..1682
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/inference="alignment:Splign:1.39.8"
variation 1570
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/replace="c"
/replace="t"
/db_xref="dbSNP:142762020"
variation 1576
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/replace="c"
/replace="t"
/db_xref="dbSNP:146055867"
exon 1683..1916
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/inference="alignment:Splign:1.39.8"
variation 1748
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/replace="a"
/replace="g"
/db_xref="dbSNP:75068032"
variation 1801
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/replace="a"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:79926127"
exon 1917..2027
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/inference="alignment:Splign:1.39.8"
exon 2028..2220
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/inference="alignment:Splign:1.39.8"
exon 2221..2372
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/inference="alignment:Splign:1.39.8"
exon 2373..2486
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/inference="alignment:Splign:1.39.8"
exon 2487..2642
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/inference="alignment:Splign:1.39.8"
variation 2614
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/replace="c"
/replace="t"
/db_xref="dbSNP:1043996"
exon 2643..2868
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/inference="alignment:Splign:1.39.8"
variation 2818
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/replace="a"
/replace="g"
/db_xref="dbSNP:1043997"
exon 2869..3070
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/inference="alignment:Splign:1.39.8"
variation 3017
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/replace="c"
/replace="t"
/db_xref="dbSNP:143695196"
exon 3071..3218
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/inference="alignment:Splign:1.39.8"
variation 3159
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/replace="g"
/replace="t"
/db_xref="dbSNP:146829488"
exon 3219..3403
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/inference="alignment:Splign:1.39.8"
exon 3404..3536
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/inference="alignment:Splign:1.39.8"
variation 3448
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/replace="c"
/replace="t"
/db_xref="dbSNP:140642726"
exon 3537..3794
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/inference="alignment:Splign:1.39.8"
STS 3786..3910
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/standard_name="SHGC-57293"
/db_xref="UniSTS:52587"
exon 3795..3913
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/inference="alignment:Splign:1.39.8"
exon 3914..4479
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/inference="alignment:Splign:1.39.8"
variation 4120
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/replace="a"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:78926093"
variation 4393
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/replace="a"
/replace="g"
/db_xref="dbSNP:76555145"
exon 4480..4812
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/inference="alignment:Splign:1.39.8"
variation 4639
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/replace="a"
/replace="g"
/db_xref="dbSNP:1044006"
exon 4813..4967
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/inference="alignment:Splign:1.39.8"
exon 4968..5190
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/inference="alignment:Splign:1.39.8"
variation 4990
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/replace="a"
/replace="g"
/db_xref="dbSNP:149222385"
exon 5191..5275
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/inference="alignment:Splign:1.39.8"
variation 5205
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/replace="a"
/replace="g"
/db_xref="dbSNP:143411026"
exon 5276..5438
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/inference="alignment:Splign:1.39.8"
exon 5439..5743
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/inference="alignment:Splign:1.39.8"
exon 5744..5891
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/inference="alignment:Splign:1.39.8"
exon 5892..5989
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/inference="alignment:Splign:1.39.8"
exon 5990..8071
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/inference="alignment:Splign:1.39.8"
variation 6107
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/replace="a"
/replace="g"
/db_xref="dbSNP:142007575"
variation 6174
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/replace="c"
/replace="t"
/db_xref="dbSNP:145859816"
variation 6318
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/replace="g"
/replace="t"
/db_xref="dbSNP:141231747"
variation 6514
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/replace="a"
/replace="g"
/db_xref="dbSNP:1044008"
variation 6744
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/replace="c"
/replace="t"
/db_xref="dbSNP:1044009"
STS 7055..7292
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/standard_name="PMC122602P1"
/db_xref="UniSTS:270400"
variation 7651
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/replace="g"
/replace="t"
/db_xref="dbSNP:1804976"
variation 7710
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/replace="g"
/replace="t"
/db_xref="dbSNP:1044055"
STS 7783..7943
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/standard_name="G62127"
/db_xref="UniSTS:139187"
STS 7828..7942
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/standard_name="D19S1009"
/db_xref="UniSTS:20959"
variation 7850
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/replace="a"
/replace="g"
/db_xref="dbSNP:1044116"
variation 7879
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/replace="a"
/replace="g"
/db_xref="dbSNP:12082"
variation 7932
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
/replace="c"
/replace="t"
/db_xref="dbSNP:1044123"
polyA_signal 8049..8054
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
polyA_site 8071
/gene="NOTCH3"
/gene_synonym="CADASIL; CASIL; IMF2"
ORIGIN
gcggcgcggaggctggcccgggacgcgcccggagcccagggaaggagggaggaggggagggtcgcggccggccgccatggggccgggggcccgtggccgccgccgccgccgtcgcccgatgtcgccgccaccgccaccgccacccgtgcgggcgctgcccctgctgctgctgctagcggggccgggggctgcagcccccccttgcctggacggaagcccgtgtgcaaatggaggtcgttgcacccagctgccctcccgggaggctgcctgcctgtgcccgcctggctgggtgggtgagcggtgtcagctggaggacccctgtcactcaggcccctgtgctggccgtggtgtctgccagagttcagtggtggctggcaccgcccgattctcatgccggtgcccccgtggcttccgaggccctgactgctccctgccagatccctgcctcagcagcccttgtgcccacggtgcccgctgctcagtggggcccgatggacgcttcctctgctcctgcccacctggctaccagggccgcagctgccgaagcgacgtggatgagtgccgggtgggtgagccctgccgccatggtggcacctgcctcaacacacctggctccttccgctgccagtgtccagctggctacacagggccactatgtgagaaccccgcggtgccctgtgcaccctcaccatgccgtaacgggggcacctgcaggcagagtggcgacctcacttacgactgtgcctgtcttcctgggtttgagggtcagaattgtgaagtgaacgtggacgactgtccaggacaccgatgtctcaatggggggacatgcgtggatggcgtcaacacctataactgccagtgccctcctgagtggacaggccagttctgcacggaggacgtggatgagtgtcagctgcagcccaacgcctgccacaatgggggtacctgcttcaacacgctgggtggccacagctgcgtgtgtgtcaatggctggacaggcgagagctgcagtcagaatatcgatgactgtgccacagccgtgtgcttccatggggccacctgccatgaccgcgtggcttctttctactgtgcctgccccatgggcaagactggcctcctgtgtcacctggatgacgcctgtgtcagcaacccctgccacgaggatgctatctgtgacacaaatccggtgaacggccgggccatttgcacctgtcctcccggcttcacgggtggggcatgtgaccaggatgtggacgagtgctctatcggcgccaacccctgcgagcacttgggcaggtgcgtgaacacgcagggctccttcctgtgccagtgcggtcgtggctacactggacctcgctgtgagaccgatgtcaacgagtgtctgtcggggccctgccgaaaccaggccacgtgcctcgaccgcataggccagttcacctgtatctgtatggcaggcttcacaggaacctattgcgaggtggacattgacgagtgtcagagtagcccctgtgtcaacggtggggtctgcaaggaccgagtcaatggcttcagctgcacctgcccctcgggcttcagcggctccacgtgtcagctggacgtggacgaatgcgccagcacgccctgcaggaatggcgccaaatgcgtggaccagcccgatggctacgagtgccgctgtgccgagggctttgagggcacgctgtgtgatcgcaacgtggacgactgctcccctgacccatgccaccatggtcgctgcgtggatggcatcgccagcttctcatgtgcctgtgctcctggctacacgggcacacgctgcgagagccaggtggacgaatgccgcagccagccctgccgccatggcggcaaatgcctagacctggtggacaagtacctctgccgctgcccttctgggaccacaggtgtgaactgcgaagtgaacattgacgactgtgccagcaacccctgcacctttggagtctgccgtgatggcatcaaccgctacgactgtgtctgccaacctggcttcacagggcccctttgtaacgtggagatcaatgagtgtgcttccagcccatgcggcgagggaggttcctgtgtggatggggaaaatggcttccgctgcctctgcccgcctggctccttgcccccactctgcctccccccgagccatccctgtgcccatgagccctgcagtcacggcatctgctatgatgcacctggcgggttccgctgtgtgtgtgagcctggctggagtggcccccgctgcagccagagcctggcccgagacgcctgtgagtcccagccgtgcagggccggtgggacatgcagcagcgatggaatgggtttccactgcacctgcccgcctggtgtccagggacgtcagtgtgaactcctctccccctgcaccccgaacccctgtgagcatgggggccgctgcgagtctgcccctggccagctgcctgtctgctcctgcccccagggctggcaaggcccacgatgccagcaggatgtggacgagtgtgctggccccgcaccctgtggccctcatggtatctgcaccaacctggcagggagtttcagctgcacctgccatggagggtacactggcccttcctgcgatcaggacatcaatgactgtgaccccaacccatgcctgaacggtggctcgtgccaagacggcgtgggctccttttcctgctcctgcctccctggtttcgccggcccacgatgcgcccgcgatgtggatgagtgcctgagcaacccctgcggcccgggcacctgtaccgaccacgtggcctccttcacctgcacctgcccgccaggctacggaggcttccactgcgaacaggacctgcccgactgcagccccagctcctgcttcaatggcgggacctgtgtggacggcgtgaactcgttcagctgcctgtgccgtcccggctacacaggagcccactgccaacatgaggcagacccctgcctctcgcggccctgcctacacgggggcgtctgcagcgccgcccaccctggcttccgctgcacctgcctcgagagcttcacgggcccgcagtgccagacgctggtggattggtgcagccgccagccttgtcaaaacgggggtcgctgcgtccagactggggcctattgcctttgtccccctggatggagcggacgcctctgtgacatccgaagcttgccctgcagggaggccgcagcccagatcggggtgcggctggagcagctgtgtcaggcgggtgggcagtgtgtggatgaagacagctcccactactgcgtgtgcccagagggccgtactggtagccactgtgagcaggaggtggacccctgcttggcccagccctgccagcatggggggacctgccgtggctatatggggggctacatgtgtgagtgtcttcctggctacaatggtgataactgtgaggacgacgtggacgagtgtgcctcccagccctgccagcacgggggttcatgcattgacctcgtggcccgctatctctgctcctgtcccccaggaacgctgggggtgctctgcgagattaatgaggatgactgcggcccaggcccaccgctggactcagggccccggtgcctacacaatggcacctgcgtggacctggtgggtggtttccgctgcacctgtcccccaggatacactggtttgcgctgcgaggcagacatcaatgagtgtcgctcaggtgcctgccacgcggcacacacccgggactgcctgcaggacccaggcggaggtttccgttgcctttgtcatgctggcttctcaggtcctcgctgtcagactgtcctgtctccctgcgagtcccagccatgccagcatggaggccagtgccgtcctagcccgggtcctgggggtgggctgaccttcacctgtcactgtgcccagccgttctggggtccgcgttgcgagcgggtggcgcgctcctgccgggagctgcagtgcccggtgggcgtcccatgccagcagacgccccgcgggccgcgctgcgcctgccccccagggttgtcgggaccctcctgccgcagcttcccggggtcgccgccgggggccagcaacgccagctgcgcggccgccccctgtctccacgggggctcctgccgccccgcgccgctcgcgcccttcttccgctgcgcttgcgcgcagggctggaccgggccgcgctgcgaggcgcccgccgcggcacccgaggtctcggaggagccgcggtgcccgcgcgccgcctgccaggccaagcgcggggaccagcgctgcgaccgcgagtgcaacagcccaggctgcggctgggacggcggcgactgctcgctgagcgtgggcgacccctggcggcaatgcgaggcgctgcagtgctggcgcctcttcaacaacagccgctgcgaccccgcctgcagctcgcccgcctgcctctacgacaacttcgactgccacgccggtggccgcgagcgcacttgcaacccggtgtacgagaagtactgcgccgaccactttgccgacggccgctgcgaccagggctgcaacacggaggagtgcggctgggatgggctggattgtgccagcgaggtgccggccctgctggcccgcggcgtgctggtgctcacagtgctgctgccgccagaggagctactgcgttccagcgccgactttctgcagcggctcagcgccatcctgcgcacctcgctgcgcttccgcctggacgcgcacggccaggccatggtcttcccttaccaccggcctagtcctggctccgaaccccgggcccgtcgggagctggcccccgaggtgatcggctcggtagtaatgctggagattgacaaccggctctgcctgcagtcgcctgagaatgatcactgcttccccgatgcccagagcgccgctgactacctgggagcgttgtcagcggtggagcgcctggacttcccgtacccactgcgggacgtgcggggggagccgctggagcctccagaacccagcgtcccgctgctgccactgctagtggcgggcgctgtcttgctgctggtcattctcgtcctgggtgtcatggtggcccggcgcaagcgcgagcacagcaccctctggttccctgagggcttctcactgcacaaggacgtggcctctggtcacaagggccggcgggaacccgtgggccaggacgcgctgggcatgaagaacatggccaagggtgagagcctgatgggggaggtggccacagactggatggacacagagtgcccagaggccaagcggctaaaggtagaggagccaggcatgggggctgaggaggctgtggattgccgtcagtggactcaacaccatctggttgctgctgacatccgcgtggcaccagccatggcactgacaccaccacagggcgacgcagatgctgatggcatggatgtcaatgtgcgtggcccagatggcttcaccccgctaatgctggcttccttctgtgggggggctctggagccaatgccaactgaagaggatgaggcagatgacacatcagctagcatcatctccgacctgatctgccagggggctcagcttggggcacggactgaccgtactggcgagactgctttgcacctggctgcccgttatgcccgtgctgatgcagccaagcggctgctggatgctggggcagacaccaatgcccaggaccactcaggccgcactcccctgcacacagctgtcacagccgatgcccagggtgtcttccagattctcatccgaaaccgctctacagacttggatgcccgcatggcagatggctcaacggcactgatcctggcggcccgcctggcagtagagggcatggtggaagagctcatcgccagccatgctgatgtcaatgctgtggatgagcttgggaaatcagccttacactgggctgcggctgtgaacaacgtggaagccactttggccctgctcaaaaatggagccaataaggacatgcaggatagcaaggaggagacccccctattcctggccgcccgcgagggcagctatgaggctgccaagctgctgttggaccactttgccaaccgtgagatcaccgaccacctggacaggctgccgcgggacgtagcccaggagagactgcaccaggacatcgtgcgcttgctggatcaacccagtgggccccgcagcccccccggtccccacggcctggggcctctgctctgtcctccaggggccttcctccctggcctcaaagcggcacagtcggggtccaagaagagcaggaggccccccgggaaggcggggctggggccgcaggggccccgggggcggggcaagaagctgacgctggcctgcccgggccccctggctgacagctcggtcacgctgtcgcccgtggactcgctggactccccgcggcctttcggtgggccccctgcttcccctggtggcttcccccttgaggggccctatgcagctgccactgccactgcagtgtctctggcacagcttggtggcccaggccgggcgggtctagggcgccagccccctggaggatgtgtactcagcctgggcctgctgaaccctgtggctgtgcccctcgattgggcccggctgcccccacctgcccctccaggcccctcgttcctgctgccactggcgccgggaccccagctgctcaacccagggacccccgtctccccgcaggagcggcccccgccttacctggcagtcccaggacatggcgaggagtacccggcggctggggcacacagcagccccccaaaggcccgcttcctgcgggttcccagtgagcacccttacctgaccccatcccccgaatcccctgagcactgggccagcccctcacctccctccctctcagactggtccgaatccacgcctagcccagccactgccactggggccatggccaccaccactggggcactgcctgcccagccacttcccttgtctgttcccagctcccttgctcaggcccagacccagctggggccccagccggaagttacccccaagaggcaagtgttggcctgagacgctcgtcagttcttagatcttgggggcctaaagagacccccgtcctgcctcctttctttctctgtctcttccttccttttagtctttttcatcctcttctctttccaccaaccctcctgcatccttgccttgcagcgtgaccgagataggtcatcagcccagggcttcagtcttcctttatttataatgggtgggggctaccacccaccctctcagtcttgtgaagagtctgggacctccttcttccccacttctctcttccctcattcctttctctctccttctggcctctcatttccttacactctgacatgaatgaattattattatttttatttttctttttttttttacattttgtatagaaacaaattcatttaaacaaacttattattattattttttacaaaatatatatatggagatgctccctccccctgtgaaccccccagtgcccccgtggggctgagtctgtgggcccattcggccaagctggattctgtgtacctagtacacaggcatgactgggatcccgtgtaccgagtacacgacccaggtatgtaccaagtaggcacccttgggcgcacccactggggccaggggtcgggggagtgttgggagcctcctccccaccccacctccctcacttcactgcattccagatgggacatgttccatagccttgctggggaagggcccactgccaactccctctgccccagccccacccttggccatctccctttgggaactagggggctgctggtgggaaatgggagccagggcagatgtatgcattcctttgtgtccctgtaaatgtgggactacaagaagaggagctgcctgagtggtactttctcttcctggtaatcctctggcccagcctcatggcagaatagaggtatttttaggctatttttgtaatatggcttctggtcaaaatccctgtgtagctgaattcccaagccctgcattgtacagccccccactcccctcaccacctaataaaggaatagttaacactcaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:4854 -> Molecular function: GO:0005509 [calcium ion binding] evidence: IEA
GeneID:4854 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:4854 -> Molecular function: GO:0019899 [enzyme binding] evidence: IEA
GeneID:4854 -> Biological process: GO:0006355 [regulation of transcription, DNA-dependent] evidence: IEA
GeneID:4854 -> Biological process: GO:0006367 [transcription initiation from RNA polymerase II promoter] evidence: TAS
GeneID:4854 -> Biological process: GO:0007219 [Notch signaling pathway] evidence: TAS
GeneID:4854 -> Biological process: GO:0007220 [Notch receptor processing] evidence: TAS
GeneID:4854 -> Biological process: GO:0010467 [gene expression] evidence: TAS
GeneID:4854 -> Biological process: GO:0030900 [forebrain development] evidence: IEA
GeneID:4854 -> Biological process: GO:0045665 [negative regulation of neuron differentiation] evidence: IEA
GeneID:4854 -> Biological process: GO:0048661 [positive regulation of smooth muscle cell proliferation] evidence: IEA
GeneID:4854 -> Biological process: GO:0048663 [neuron fate commitment] evidence: IEA
GeneID:4854 -> Biological process: GO:0072104 [glomerular capillary formation] evidence: IEA
GeneID:4854 -> Cellular component: GO:0000139 [Golgi membrane] evidence: TAS
GeneID:4854 -> Cellular component: GO:0005576 [extracellular region] evidence: TAS
GeneID:4854 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
GeneID:4854 -> Cellular component: GO:0005789 [endoplasmic reticulum membrane] evidence: TAS
GeneID:4854 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:4854 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
GeneID:4854 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA
by
@meso_cacase at
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