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2025-05-12 01:42:51, GGRNA : RefSeq release 60 (20130726)
LOCUS NR_045962 2160 bp RNA linear PRI 16-JUL-2013
DEFINITION Homo sapiens keratin 8 (KRT8), transcript variant 4, non-coding
RNA.
ACCESSION NR_045962
VERSION NR_045962.1 GI:372466574
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2160)
AUTHORS Fortier,A.M., Asselin,E. and Cadrin,M.
TITLE Keratin 8 and 18 loss in epithelial cancer cells increases
collective cell migration and cisplatin sensitivity through
claudin1 up-regulation
JOURNAL J. Biol. Chem. 288 (16), 11555-11571 (2013)
PUBMED 23449973
REMARK GeneRIF: K8/18 expression can influence the phenotype of epithelial
cancer cells at a transcriptional level and supports the hypothesis
that keratins play an active role in cancer progression.
REFERENCE 2 (bases 1 to 2160)
AUTHORS Mathew,J., Loranger,A., Gilbert,S., Faure,R. and Marceau,N.
TITLE Keratin 8/18 regulation of glucose metabolism in normal versus
cancerous hepatic cells through differential modulation of
hexokinase status and insulin signaling
JOURNAL Exp. Cell Res. 319 (4), 474-486 (2013)
PUBMED 23164509
REMARK GeneRIF: A key K8/K18 regulation of glucose metabolism in normal
and cancerous hepatic cells through differential modulations of
mitochondrial hexokinase status and insulin-mediated signaling.
REFERENCE 3 (bases 1 to 2160)
AUTHORS Snider,N.T., Leonard,J.M., Kwan,R., Griggs,N.W., Rui,L. and
Omary,M.B.
TITLE Glucose and SIRT2 reciprocally mediate the regulation of keratin 8
by lysine acetylation
JOURNAL J. Cell Biol. 200 (3), 241-247 (2013)
PUBMED 23358244
REMARK GeneRIF: K8 acetylation at Lys-207, a highly conserved residue
among type II keratins, is up-regulated upon hyperglycemia and
down-regulated by SIRT2.
REFERENCE 4 (bases 1 to 2160)
AUTHORS Iyer,S.V., Dange,P.P., Alam,H., Sawant,S.S., Ingle,A.D.,
Borges,A.M., Shirsat,N.V., Dalal,S.N. and Vaidya,M.M.
TITLE Understanding the role of keratins 8 and 18 in neoplastic potential
of breast cancer derived cell lines
JOURNAL PLoS ONE 8 (1), E53532 (2013)
PUBMED 23341946
REMARK GeneRIF: These results indicate the role of K8/18 in modulating
invasion in breast cancer.
REFERENCE 5 (bases 1 to 2160)
AUTHORS Wang,Y., Zhu,J.F., Liu,Y.Y. and Han,G.P.
TITLE An analysis of cyclin D1, cytokeratin 5/6 and cytokeratin 8/18
expression in breast papillomas and papillary carcinomas
JOURNAL Diagn Pathol 8, 8 (2013)
PUBMED 23327593
REMARK GeneRIF: Report keratin 8 expression in breast papillomas and
papillary carcinoma.
Publication Status: Online-Only
REFERENCE 6 (bases 1 to 2160)
AUTHORS Ljubimov,A.V., Bartek,J., Couchman,J.R., Kapuller,L.L.,
Veselov,V.V., Kovarik,J., Perevoshchikov,A.G. and Krutovskikh,V.A.
TITLE Distribution of individual components of basement membrane in human
colon polyps and adenocarcinomas as revealed by monoclonal
antibodies
JOURNAL Int. J. Cancer 50 (4), 562-566 (1992)
PUBMED 1371500
REFERENCE 7 (bases 1 to 2160)
AUTHORS Waseem,A., Alexander,C.M., Steel,J.B. and Lane,E.B.
TITLE Embryonic simple epithelial keratins 8 and 18: chromosomal location
emphasizes difference from other keratin pairs
JOURNAL New Biol. 2 (5), 464-478 (1990)
PUBMED 1705144
REFERENCE 8 (bases 1 to 2160)
AUTHORS Yamamoto,R., Kao,L.C., McKnight,C.E. and Strauss,J.F. III.
TITLE Cloning and sequence of cDNA for human placental cytokeratin 8.
Regulation of the mRNA in trophoblastic cells by cAMP
JOURNAL Mol. Endocrinol. 4 (3), 370-374 (1990)
PUBMED 1692965
REFERENCE 9 (bases 1 to 2160)
AUTHORS Smedts,F., Ramaekers,F., Robben,H., Pruszczynski,M., van Muijen,G.,
Lane,B., Leigh,I. and Vooijs,P.
TITLE Changing patterns of keratin expression during progression of
cervical intraepithelial neoplasia
JOURNAL Am. J. Pathol. 136 (3), 657-668 (1990)
PUBMED 1690513
REFERENCE 10 (bases 1 to 2160)
AUTHORS Krauss,S. and Franke,W.W.
TITLE Organization and sequence of the human gene encoding cytokeratin 8
JOURNAL Gene 86 (2), 241-249 (1990)
PUBMED 1691124
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DA051933.1, AK315826.1,
BC011373.1 and CX166336.1.
Summary: This gene is a member of the type II keratin family
clustered on the long arm of chromosome 12. Type I and type II
keratins heteropolymerize to form intermediate-sized filaments in
the cytoplasm of epithelial cells. The product of this gene
typically dimerizes with keratin 18 to form an intermediate
filament in simple single-layered epithelial cells. This protein
plays a role in maintaining cellular structural integrity and also
functions in signal transduction and cellular differentiation.
Mutations in this gene cause cryptogenic cirrhosis. Alternatively
spliced transcript variants have been found for this gene.
[provided by RefSeq, Jan 2012].
Transcript Variant: This variant (4) has an alternate 5' exon,
compared to variant 1, that creates an upstream ORF with a strong
Kozak sequence. The upstream ORF is predicted to inhibit
translation of the downstream ORF and the transcript is a candidate
for nonsense-mediated mRNA decay (NMD).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-24 DA051933.1 1-24
25-1137 AK315826.1 1-1113
1138-2137 BC011373.1 327-1326
2138-2160 CX166336.1 758-780
FEATURES Location/Qualifiers
source 1..2160
/organism="Homo sapiens"
/mol_type="transcribed RNA"
/db_xref="taxon:9606"
/chromosome="12"
/map="12q13"
gene 1..2160
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/note="keratin 8"
/db_xref="GeneID:3856"
/db_xref="HGNC:6446"
/db_xref="MIM:148060"
misc_RNA 1..2160
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/product="keratin 8, transcript variant 4"
/db_xref="GeneID:3856"
/db_xref="HGNC:6446"
/db_xref="MIM:148060"
exon 1..411
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/inference="alignment:Splign:1.39.8"
variation 158
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/replace="c"
/replace="t"
/db_xref="dbSNP:1492241"
misc_feature 310..900
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/inference="COORDINATES: ab initio prediction:ORF Finder"
/note="upstream ORF has strong Kozak sequence and overlaps
primary ORF; nonsense-mediated decay (NMD) candidate"
exon 412..781
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/inference="alignment:Splign:1.39.8"
variation 436..437
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/replace="c"
/replace="t"
/db_xref="dbSNP:11554493"
variation 454
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/replace="c"
/replace="t"
/db_xref="dbSNP:1065306"
misc_feature 458..1909
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/inference="COORDINATES:
alignment:Blast2seq::RefSeq|NM_001256293.1"
/note="primary ORF"
variation 509
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/replace="c"
/replace="t"
/db_xref="dbSNP:11554484"
variation 568
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/replace="c"
/replace="t"
/db_xref="dbSNP:11554498"
variation 577
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/replace="a"
/replace="g"
/db_xref="dbSNP:11554488"
variation 708
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/replace="c"
/replace="t"
/db_xref="dbSNP:11554494"
variation 721
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/replace="c"
/replace="t"
/db_xref="dbSNP:11554492"
variation 724
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/replace="c"
/replace="t"
/db_xref="dbSNP:11554497"
exon 782..990
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/inference="alignment:Splign:1.39.8"
exon 991..1051
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/inference="alignment:Splign:1.39.8"
exon 1052..1147
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/inference="alignment:Splign:1.39.8"
exon 1148..1438
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/inference="alignment:Splign:1.39.8"
variation 1166
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/replace="c"
/replace="t"
/db_xref="dbSNP:11554490"
variation 1262
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/replace="g"
/replace="t"
/db_xref="dbSNP:11554280"
variation 1293
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/replace="a"
/replace="g"
/db_xref="dbSNP:11554499"
variation 1304
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/replace="c"
/replace="t"
/db_xref="dbSNP:11554487"
variation 1381
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/replace="a"
/replace="t"
/db_xref="dbSNP:1065311"
variation 1413
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/replace="c"
/replace="t"
/db_xref="dbSNP:11554486"
variation 1415
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/replace="g"
/replace="t"
/db_xref="dbSNP:11554483"
exon 1439..1659
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/inference="alignment:Splign:1.39.8"
variation 1456
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/replace="c"
/replace="t"
/db_xref="dbSNP:7750"
variation 1532
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/replace="a"
/replace="g"
/db_xref="dbSNP:57626370"
variation 1561
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/replace="c"
/replace="g"
/db_xref="dbSNP:1065362"
exon 1660..1718
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/inference="alignment:Splign:1.39.8"
exon 1719..2150
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/inference="alignment:Splign:1.39.8"
variation 1815
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/replace="g"
/replace="t"
/db_xref="dbSNP:11554491"
variation 2007
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/replace="a"
/replace="c"
/db_xref="dbSNP:1065710"
polyA_signal 2121..2126
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
polyA_site 2150
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
ORIGIN
acaggcctttccttacctccctccatgctgtccacttcctctgtaaagctctcaaccctgtccccttccccctctctcctgggaaagagccctcccatgcctagctgctgctcttagggaccctgtggctaggtgcgcggatggaaatccaggtatgcccaaccccctcccggtggagtaggggttgggtggttatggaatgacggaaagaggcaaaggagtgtataattggagggtcagacaaggctgggagttgaggtccctcctaccccttacctgagccctcaggtcctcgatgatcttgaagtaatggctccagtctctgacctggggtcccttcttctccaagtgctcccggattttgctctccagcctccggttctcggtctccaggctcctcactctgtccaggatctccgcctggttcggcccgcctgcctccactcctgcctctaccatgtccatcagggtgacccagaagtcctacaaggtgtccacctctggcccccgggccttcagcagccgctcctacacgagtgggcccggttcccgcatcagctcctcgagcttctcccgagtgggcagcagcaactttcgcggtggcctgggcggcggctatggtggggccagcggcatgggaggcatcaccgcagttacggtcaaccagagcctgctgagcccccttgtcctggaggtggaccccaacatccaggccgtgcgcacccaggagaaggagcagatcaagaccctcaacaacaagtttgcctccttcatagacaaggtacggttcctggagcagcagaacaagatgctggagaccaagtggagcctcctgcagcagcagaagacggctcgaagcaacatggacaacatgttcgagagctacatcaacaaccttaggcggcagctggagactctgggccaggagaagctgaagctggaggcggagcttggcaacatgcaggggctggtggaggacttcaagaacaagtatgaggatgagatcaataagcgtacagagatggagaacgaatttgtcctcatcaagaaggatgtggatgaagcttacatgaacaaggtagagctggagtctcgcctggaagggctgaccgacgagatcaacttcctcaggcagctatatgaagaggagatccgggagctgcagtcccagatctcggacacatctgtggtgctgtccatggacaacagccgctccctggacatggacagcatcattgctgaggtcaaggcacagtacgaggatattgccaaccgcagccgggctgaggctgagagcatgtaccagatcaagtatgaggagctgcagagcctggctgggaagcacggggatgacctgcggcgcacaaagactgagatctctgagatgaaccggaacatcagccggctccaggctgagattgagggcctcaaaggccagagggcttccctggaggccgccattgcagatgccgagcagcgtggagagctggccattaaggatgccaacgccaagttgtccgagctggaggccgccctgcagcgggccaagcaggacatggcgcggcagctgcgtgagtaccaggagctgatgaacgtcaagctggccctggacatcgagatcgccacctacaggaagctgctggagggcgaggagagccggctggagtctgggatgcagaacatgagtattcatacgaagaccaccagcggctatgcaggtggtctgagctcggcctatgggggcctcacaagccccggcctcagctacagcctgggctccagctttggctctggcgcgggctccagctccttcagccgcaccagctcctccagggccgtggttgtgaagaagatcgagacacgtgatgggaagctggtgtctgagtcctctgacgtcctgcccaagtgaacagctgcggcagcccctcccagcctacccctcctgcgctgccccagagcctgggaaggaggccgctatgcagggtagcactgggaacaggagacccacctgaggctcagccctagccctcagcccacctggggagtttactacctggggaccccccttgcccatgcctccagctacaaaacaattcaattgctttttttttttggtccaaaataaaacctcagctagctctgccaatgtcaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:3856 -> Molecular function: GO:0005198 [structural molecule activity] evidence: NAS
GeneID:3856 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:3856 -> Molecular function: GO:0097110 [scaffold protein binding] evidence: IPI
GeneID:3856 -> Biological process: GO:0007010 [cytoskeleton organization] evidence: NAS
GeneID:3856 -> Biological process: GO:0019048 [modulation by virus of host morphology or physiology] evidence: IEA
GeneID:3856 -> Cellular component: GO:0005654 [nucleoplasm] evidence: IEA
GeneID:3856 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:3856 -> Cellular component: GO:0005882 [intermediate filament] evidence: IDA
GeneID:3856 -> Cellular component: GO:0005882 [intermediate filament] evidence: NAS
GeneID:3856 -> Cellular component: GO:0016363 [nuclear matrix] evidence: IEA
GeneID:3856 -> Cellular component: GO:0045095 [keratin filament] evidence: IEA
by
@meso_cacase at
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