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2025-05-12 01:27:16, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_199187 1439 bp mRNA linear PRI 15-JUL-2013
DEFINITION Homo sapiens keratin 18 (KRT18), transcript variant 2, mRNA.
ACCESSION NM_199187
VERSION NM_199187.1 GI:40354194
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1439)
AUTHORS Fortier,A.M., Asselin,E. and Cadrin,M.
TITLE Keratin 8 and 18 loss in epithelial cancer cells increases
collective cell migration and cisplatin sensitivity through
claudin1 up-regulation
JOURNAL J. Biol. Chem. 288 (16), 11555-11571 (2013)
PUBMED 23449973
REMARK GeneRIF: K8/18 expression can influence the phenotype of epithelial
cancer cells at a transcriptional level and supports the hypothesis
that keratins play an active role in cancer progression.
REFERENCE 2 (bases 1 to 1439)
AUTHORS Mathew,J., Loranger,A., Gilbert,S., Faure,R. and Marceau,N.
TITLE Keratin 8/18 regulation of glucose metabolism in normal versus
cancerous hepatic cells through differential modulation of
hexokinase status and insulin signaling
JOURNAL Exp. Cell Res. 319 (4), 474-486 (2013)
PUBMED 23164509
REMARK GeneRIF: A key K8/K18 regulation of glucose metabolism in normal
and cancerous hepatic cells through differential modulations of
mitochondrial hexokinase status and insulin-mediated signaling.
REFERENCE 3 (bases 1 to 1439)
AUTHORS Iyer,S.V., Dange,P.P., Alam,H., Sawant,S.S., Ingle,A.D.,
Borges,A.M., Shirsat,N.V., Dalal,S.N. and Vaidya,M.M.
TITLE Understanding the role of keratins 8 and 18 in neoplastic potential
of breast cancer derived cell lines
JOURNAL PLoS ONE 8 (1), E53532 (2013)
PUBMED 23341946
REMARK GeneRIF: These results indicate the role of K8/18 in modulating
invasion in breast cancer.
REFERENCE 4 (bases 1 to 1439)
AUTHORS Wang,Y., Zhu,J.F., Liu,Y.Y. and Han,G.P.
TITLE An analysis of cyclin D1, cytokeratin 5/6 and cytokeratin 8/18
expression in breast papillomas and papillary carcinomas
JOURNAL Diagn Pathol 8, 8 (2013)
PUBMED 23327593
REMARK GeneRIF: Report keratin 18 expression in breast papillomas and
papillary carcinoma.
Publication Status: Online-Only
REFERENCE 5 (bases 1 to 1439)
AUTHORS Valva,P., Casciato,P., Lezama,C., Galoppo,M., Gadano,A.,
Galdame,O., Galoppo,M.C., Mullen,E., De Matteo,E. and Preciado,M.V.
TITLE Serum apoptosis markers related to liver damage in chronic
hepatitis C: sFas as a marker of advanced fibrosis in children and
adults while M30 of severe steatosis only in children
JOURNAL PLoS ONE 8 (1), E53519 (2013)
PUBMED 23326448
REMARK GeneRIF: Serum sFas could be considered a possible marker of
advanced fibrosis both in pediatric and adult patient with chronic
hepatitis C as well as M30 might be a good predictor of steatosis
severity in children.
REFERENCE 6 (bases 1 to 1439)
AUTHORS Omary,M.B., Baxter,G.T., Chou,C.F., Riopel,C.L., Lin,W.Y. and
Strulovici,B.
TITLE PKC epsilon-related kinase associates with and phosphorylates
cytokeratin 8 and 18
JOURNAL J. Cell Biol. 117 (3), 583-593 (1992)
PUBMED 1374067
REFERENCE 7 (bases 1 to 1439)
AUTHORS Heath,P., Elvin,P., Jenner,D., Gammack,A., Morten,J. and Markham,A.
TITLE Localisation of a cDNA clone for human cytokeratin 18 to chromosome
17p11-p12 by in situ hybridisation
JOURNAL Hum. Genet. 85 (6), 669-670 (1990)
PUBMED 1699878
REFERENCE 8 (bases 1 to 1439)
AUTHORS Waseem,A., Gough,A.C., Spurr,N.K. and Lane,E.B.
TITLE Localization of the gene for human simple epithelial keratin 18 to
chromosome 12 using polymerase chain reaction
JOURNAL Genomics 7 (2), 188-194 (1990)
PUBMED 1693358
REFERENCE 9 (bases 1 to 1439)
AUTHORS Waseem,A., Alexander,C.M., Steel,J.B. and Lane,E.B.
TITLE Embryonic simple epithelial keratins 8 and 18: chromosomal location
emphasizes difference from other keratin pairs
JOURNAL New Biol. 2 (5), 464-478 (1990)
PUBMED 1705144
REFERENCE 10 (bases 1 to 1439)
AUTHORS Romano,V., Hatzfeld,M., Magin,T.M., Zimbelmann,R., Franke,W.W.,
Maier,G. and Ponstingl,H.
TITLE Cytokeratin expression in simple epithelia. I. Identification of
mRNA coding for human cytokeratin no. 18 by a cDNA clone
JOURNAL Differentiation 30 (3), 244-253 (1986)
PUBMED 2422083
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BG753529.1, CD106591.1,
X12881.1 and BC000180.2.
Summary: KRT18 encodes the type I intermediate filament chain
keratin 18. Keratin 18, together with its filament partner keratin
8, are perhaps the most commonly found members of the intermediate
filament gene family. They are expressed in single layer epithelial
tissues of the body. Mutations in this gene have been linked to
cryptogenic cirrhosis. Two transcript variants encoding the same
protein have been found for this gene. [provided by RefSeq, Jul
2008].
Transcript Variant: This variant (2) differs in the 5' UTR compared
to variant 1. Variants 1 and 2 both encode the same protein.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
CDS exon combination :: BC000180.2, BC072017.1 [ECO:0000331]
RNAseq introns :: single sample supports all introns
ERS025083, ERS025084 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-99 BG753529.1 1-99
100-726 CD106591.1 146-772
727-1421 X12881.1 704-1398
1422-1439 BC000180.2 1394-1411
FEATURES Location/Qualifiers
source 1..1439
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="12"
/map="12q13"
gene 1..1439
/gene="KRT18"
/gene_synonym="CYK18; K18"
/note="keratin 18"
/db_xref="GeneID:3875"
/db_xref="HGNC:6430"
/db_xref="HPRD:01020"
/db_xref="MIM:148070"
exon 1..68
/gene="KRT18"
/gene_synonym="CYK18; K18"
/inference="alignment:Splign:1.39.8"
variation 26
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="g"
/replace="t"
/db_xref="dbSNP:115941399"
variation 64
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="g"
/db_xref="dbSNP:79477652"
exon 69..486
/gene="KRT18"
/gene_synonym="CYK18; K18"
/inference="alignment:Splign:1.39.8"
CDS 70..1362
/gene="KRT18"
/gene_synonym="CYK18; K18"
/note="cytokeratin 18; cell proliferation-inducing protein
46; CK-18; keratin-18; cytokeratin-18; cell
proliferation-inducing gene 46 protein"
/codon_start=1
/product="keratin, type I cytoskeletal 18"
/protein_id="NP_954657.1"
/db_xref="GI:40354195"
/db_xref="CCDS:CCDS31809.1"
/db_xref="GeneID:3875"
/db_xref="HGNC:6430"
/db_xref="HPRD:01020"
/db_xref="MIM:148070"
/translation="
MSFTTRSTFSTNYRSLGSVQAPSYGARPVSSAASVYAGAGGSGSRISVSRSTSFRGGMGSGGLATGIAGGLAGMGGIQNEKETMQSLNDRLASYLDRVRSLETENRRLESKIREHLEKKGPQVRDWSHYFKIIEDLRAQIFANTVDNARIVLQIDNARLAADDFRVKYETELAMRQSVENDIHGLRKVIDDTNITRLQLETEIEALKEELLFMKKNHEEEVKGLQAQIASSGLTVEVDAPKSQDLAKIMADIRAQYDELARKNREELDKYWSQQIEESTTVVTTQSAEVGAAETTLTELRRTVQSLEIDLDSMRNLKASLENSLREVEARYALQMEQLNGILLHLESELAQTRAEGQRQAQEYEALLNIKVKLEAEIATYRRLLEDGEDFNLGDALDSSNSMQTIQKTTTRRIVDGKVVSETNDTKVLRH
"
misc_feature 73..306
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P05783.2);
Region: Head"
misc_feature 73..75
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="N-acetylserine; propagated from
UniProtKB/Swiss-Prot (P05783.2); acetylation site"
misc_feature 88..90
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P05783.2); phosphorylation site"
misc_feature 97..99
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P05783.2); phosphorylation site"
misc_feature 106..108
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 112..114
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P05783.2); phosphorylation site"
misc_feature 121..123
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P05783.2); phosphorylation site"
misc_feature 157..159
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="glycosylation site"
misc_feature 160..162
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="glycosylation site"
misc_feature 160..162
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, alternate; propagated from
UniProtKB/Swiss-Prot (P05783.2); phosphorylation site"
misc_feature 169..171
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by CDK1; propagated from
UniProtKB/Swiss-Prot (P05783.2); phosphorylation site"
misc_feature 169..171
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:00302"
misc_feature 175..177
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphotyrosine; propagated from
UniProtKB/Swiss-Prot (P05783.2); phosphorylation site"
misc_feature 193..195
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P05783.2); phosphorylation site"
misc_feature 214..216
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="glycosylation site"
misc_feature 226..228
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by CAMK, PKC/PRKCE and AURKA;
propagated from UniProtKB/Swiss-Prot (P05783.2);
phosphorylation site"
misc_feature 226..228
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/citation=[6]
/db_xref="HPRD:01498"
misc_feature 226..228
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/citation=[6]
/db_xref="HPRD:02092"
misc_feature 226..228
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/citation=[6]
/db_xref="HPRD:01500"
misc_feature 226..228
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/citation=[6]
/db_xref="HPRD:06532"
misc_feature 247..249
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P05783.2); phosphorylation site"
misc_feature 262..264
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine; propagated from
UniProtKB/Swiss-Prot (P05783.2); phosphorylation site"
misc_feature 262..264
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 277..1188
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P05783.2);
Region: Necessary for interaction with PNN"
misc_feature 298..453
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P05783.2);
Region: Interaction with TRADD"
misc_feature 304..1236
/gene="KRT18"
/gene_synonym="CYK18; K18"
/note="Intermediate filament protein; Region: Filament;
pfam00038"
/db_xref="CDD:200948"
misc_feature 307..1230
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P05783.2);
Region: Rod"
misc_feature 307..414
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P05783.2);
Region: Coil 1A"
misc_feature 367..369
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P05783.2); phosphorylation site"
misc_feature 415..465
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P05783.2);
Region: Linker 1"
misc_feature 460..462
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (P05783.2); acetylation site"
misc_feature 466..741
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P05783.2);
Region: Coil 1B"
misc_feature 598..600
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P05783.2); phosphorylation site"
misc_feature 742..813
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P05783.2);
Region: Linker 12"
misc_feature 781..786
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="Cleavage, by caspase-3, caspase-6 or caspase-7;
propagated from UniProtKB/Swiss-Prot (P05783.2); cleavage
site"
misc_feature 781..783
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="proteolytic cleavage site; modified site"
/db_xref="HPRD:02799"
misc_feature 781..783
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="proteolytic cleavage site; modified site"
/db_xref="HPRD:03321"
misc_feature 781..783
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="proteolytic cleavage site; modified site"
/db_xref="HPRD:03457"
misc_feature 796..1242
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P05783.2);
Region: Interaction with DNAJB6"
misc_feature 814..1230
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P05783.2);
Region: Coil 2"
misc_feature 880..882
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="Stutter; propagated from UniProtKB/Swiss-Prot
(P05783.2); other site"
misc_feature 973..975
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine; propagated from
UniProtKB/Swiss-Prot (P05783.2); phosphorylation site"
misc_feature 1024..1026
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P05783.2); phosphorylation site"
misc_feature 1060..1062
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="Stutter; propagated from UniProtKB/Swiss-Prot
(P05783.2); other site"
misc_feature 1231..1359
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P05783.2);
Region: Tail"
misc_feature 1258..1260
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="proteolytic cleavage site; modified site"
/db_xref="HPRD:02799"
misc_feature 1264..1266
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P05783.2); phosphorylation site"
misc_feature 1264..1266
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1279..1281
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine; propagated from
UniProtKB/Swiss-Prot (P05783.2); phosphorylation site"
misc_feature 1345..1347
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (P05783.2); acetylation site"
variation 74
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="g"
/db_xref="dbSNP:369198778"
variation 75
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:141170056"
variation 80
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:76301931"
variation 117
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:80354424"
variation 119
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:79476176"
variation 122
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="g"
/db_xref="dbSNP:147350452"
variation 138
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:141066547"
variation 145
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:78514003"
variation 146
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:11551634"
variation 148
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:77825282"
variation 152
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="c"
/db_xref="dbSNP:74379840"
variation 161
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="g"
/replace="t"
/db_xref="dbSNP:374064321"
variation 163
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="g"
/replace="t"
/db_xref="dbSNP:74953757"
variation 171
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:78343594"
variation 181
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="g"
/replace="t"
/db_xref="dbSNP:77999286"
variation 183
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:75380684"
variation 186
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:75174163"
variation 196
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="g"
/db_xref="dbSNP:75441140"
variation 203
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="g"
/db_xref="dbSNP:200221269"
variation 210
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:80004568"
variation 217
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:78479490"
variation 218
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="g"
/replace="t"
/db_xref="dbSNP:11551633"
variation 232
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="c"
/db_xref="dbSNP:78718957"
variation 236
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:76183244"
variation 246
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="g"
/replace="t"
/db_xref="dbSNP:76187914"
variation 249
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:186267053"
variation 262..285
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace=""
/replace="accgggatagccgggggtctggca"
/db_xref="dbSNP:267607417"
variation 264
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="g"
/db_xref="dbSNP:79913669"
variation 270
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:77364359"
variation 274
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:11551624"
variation 307
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:199572098"
variation 321
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:79346135"
variation 338
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:11551641"
variation 344
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:11551623"
variation 351
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:386834224"
variation 374
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="t"
/db_xref="dbSNP:144926827"
variation 376
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:61136606"
variation 378
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="g"
/db_xref="dbSNP:373362435"
variation 385
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:11551638"
variation 399
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:11551621"
variation 411
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="g"
/db_xref="dbSNP:11551637"
variation 425
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:147945345"
variation 436
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="g"
/replace="t"
/db_xref="dbSNP:11551629"
variation 439
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:11551632"
variation 447
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="g"
/replace="t"
/db_xref="dbSNP:140324943"
variation 452
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="t"
/db_xref="dbSNP:57758506"
exon 487..569
/gene="KRT18"
/gene_synonym="CYK18; K18"
/inference="alignment:Splign:1.39.8"
variation 507
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:370728079"
variation 515
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:200694483"
variation 517
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:59979366"
variation 542
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:369948432"
variation 543
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:78791501"
variation 550
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:11551626"
variation 558
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:77832070"
exon 570..726
/gene="KRT18"
/gene_synonym="CYK18; K18"
/inference="alignment:Splign:1.39.8"
variation 571..572
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:17856017"
variation 581
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="t"
/db_xref="dbSNP:11551625"
variation 594
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:369743947"
variation 645
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:11551628"
variation 646
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:11170343"
variation 654
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:115544685"
variation 668
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:146788536"
variation 672
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="c"
/db_xref="dbSNP:11551622"
variation 720
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:372594060"
variation 721
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:375823747"
exon 727..891
/gene="KRT18"
/gene_synonym="CYK18; K18"
/inference="alignment:Splign:1.39.8"
variation 758
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="g"
/db_xref="dbSNP:58472472"
variation 789
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="c"
/db_xref="dbSNP:1049159"
variation 810
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:17174405"
STS 811..988
/gene="KRT18"
/gene_synonym="CYK18; K18"
/standard_name="G66248"
/db_xref="UniSTS:230089"
variation 816
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:191325805"
variation 830
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="g"
/db_xref="dbSNP:11551642"
variation 831
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:145578755"
variation 851
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:57354642"
variation 858
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:11551643"
exon 892..1017
/gene="KRT18"
/gene_synonym="CYK18; K18"
/inference="alignment:Splign:1.39.8"
variation 896
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:61696408"
variation 923
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:59112368"
variation 945
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="g"
/replace="t"
/db_xref="dbSNP:141750671"
variation 951
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:150137089"
variation 953
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:267607418"
variation 959
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:115810585"
variation 969
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="t"
/db_xref="dbSNP:11551636"
variation 993
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:149270992"
variation 994
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:199930351"
exon 1018..1241
/gene="KRT18"
/gene_synonym="CYK18; K18"
/inference="alignment:Splign:1.39.8"
variation 1056
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:371513958"
variation 1057
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:147365823"
variation 1062
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:58138700"
STS 1064..1252
/gene="KRT18"
/gene_synonym="CYK18; K18"
/standard_name="SHGC-11808"
/db_xref="UniSTS:27701"
variation 1071
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="g"
/db_xref="dbSNP:11542066"
variation 1081
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:11551635"
variation 1086
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:372449912"
variation 1087
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:57370769"
STS 1096..1174
/gene="KRT18"
/gene_synonym="CYK18; K18"
/standard_name="G66074"
/db_xref="UniSTS:230065"
variation 1105
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:143380812"
STS 1139..1308
/gene="KRT18"
/gene_synonym="CYK18; K18"
/standard_name="PMC17321P1"
/db_xref="UniSTS:271636"
variation 1155
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:144702029"
variation 1186
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="g"
/db_xref="dbSNP:17467"
variation 1211
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:147541172"
variation 1213
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="c"
/db_xref="dbSNP:11551627"
STS 1227..1407
/gene="KRT18"
/gene_synonym="CYK18; K18"
/standard_name="STS-N95819"
/db_xref="UniSTS:81461"
exon 1242..1421
/gene="KRT18"
/gene_synonym="CYK18; K18"
/inference="alignment:Splign:1.39.8"
variation 1297
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="c"
/db_xref="dbSNP:1063607"
variation 1299
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="g"
/db_xref="dbSNP:386834225"
variation 1301
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:148580152"
variation 1304
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:146080391"
variation 1305
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:142940942"
variation 1337
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:200552337"
variation 1351
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:709170"
variation 1389
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:377238570"
polyA_signal 1402..1407
/gene="KRT18"
/gene_synonym="CYK18; K18"
polyA_site 1421
/gene="KRT18"
/gene_synonym="CYK18; K18"
ORIGIN
gcagcctcgagggccaacaacacctgctgtccgtgtccatgcccggttggccaccccgtttctgggggcatgagcttcaccactcgctccaccttctccaccaactaccggtccctgggctctgtccaggcgcccagctacggcgcccggccggtcagcagcgcggccagcgtctatgcaggcgctgggggctctggttcccggatctccgtgtcccgctccaccagcttcaggggcggcatggggtccgggggcctggccaccgggatagccgggggtctggcaggaatgggaggcatccagaacgagaaggagaccatgcaaagcctgaacgaccgcctggcctcttacctggacagagtgaggagcctggagaccgagaaccggaggctggagagcaaaatccgggagcacttggagaagaagggaccccaggtcagagactggagccattacttcaagatcatcgaggacctgagggctcagatcttcgcaaatactgtggacaatgcccgcatcgttctgcagattgacaatgcccgtcttgctgctgatgactttagagtcaagtatgagacagagctggccatgcgccagtctgtggagaacgacatccatgggctccgcaaggtcattgatgacaccaatatcacacgactgcagctggagacagagatcgaggctctcaaggaggagctgctcttcatgaagaagaaccacgaagaggaagtaaaaggcctacaagcccagattgccagctctgggttgaccgtggaggtagatgcccccaaatctcaggacctcgccaagatcatggcagacatccgggcccaatatgacgagctggctcggaagaaccgagaggagctagacaagtactggtctcagcagattgaggagagcaccacagtggtcaccacacagtctgctgaggttggagctgctgagacgacgctcacagagctgagacgtacagtccagtccttggagatcgacctggactccatgagaaatctgaaggccagcttggagaacagcctgagggaggtggaggcccgctacgccctacagatggagcagctcaacgggatcctgctgcaccttgagtcagagctggcacagacccgggcagagggacagcgccaggcccaggagtatgaggccctgctgaacatcaaggtcaagctggaggctgagatcgccacctaccgccgcctgctggaagatggcgaggactttaatcttggtgatgccttggacagcagcaactccatgcaaaccatccaaaagaccaccacccgccggatagtggatggcaaagtggtgtctgagaccaatgacaccaaagttctgaggcattaagccagcagaagcagggtaccctttggggagcaggaggccaataaaaagttcagagttcaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:3875 -> Molecular function: GO:0005198 [structural molecule activity] evidence: IEA
GeneID:3875 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:3875 -> Molecular function: GO:0097110 [scaffold protein binding] evidence: IPI
GeneID:3875 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:3875 -> Biological process: GO:0007049 [cell cycle] evidence: IEA
GeneID:3875 -> Biological process: GO:0009653 [anatomical structure morphogenesis] evidence: TAS
GeneID:3875 -> Biological process: GO:0019048 [modulation by virus of host morphology or physiology] evidence: IEA
GeneID:3875 -> Biological process: GO:0033209 [tumor necrosis factor-mediated signaling pathway] evidence: IEA
GeneID:3875 -> Biological process: GO:0043000 [Golgi to plasma membrane CFTR protein transport] evidence: IDA
GeneID:3875 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: IDA
GeneID:3875 -> Cellular component: GO:0005730 [nucleolus] evidence: IEA
GeneID:3875 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:3875 -> Cellular component: GO:0005815 [microtubule organizing center] evidence: IDA
GeneID:3875 -> Cellular component: GO:0005882 [intermediate filament] evidence: IDA
GeneID:3875 -> Cellular component: GO:0034451 [centriolar satellite] evidence: IDA
GeneID:3875 -> Cellular component: GO:0045095 [keratin filament] evidence: IDA
GeneID:3875 -> Cellular component: GO:0048471 [perinuclear region of cytoplasm] evidence: IEA
by
@meso_cacase at
DBCLS
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