LOCUS       NM_194284               1972 bp    mRNA    linear   PRI 15-JUN-2013
DEFINITION  Homo sapiens claudin 23 (CLDN23), mRNA.
ACCESSION   NM_194284 XM_059895
VERSION     NM_194284.2  GI:124107615
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1972)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS ONE 7 (12), E51954 (2012)
   PUBMED   23251661
REFERENCE   2  (bases 1 to 1972)
  AUTHORS   Lal-Nag,M. and Morin,P.J.
  TITLE     The claudins
  JOURNAL   Genome Biol. 10 (8), 235 (2009)
   PUBMED   19706201
  REMARK    Review article
REFERENCE   3  (bases 1 to 1972)
  AUTHORS   Jovov,B., Orlando,G.S., Tobey,N.A., Brown,K.L., Djukic,Z.,
            Carson,J.L., Brighton,L.E. and Orlando,R.C.
  TITLE     Ion transport and barrier function in a telomerase-immortalized
            human nondysplastic, Barrett's cell line (BAR-T)
  JOURNAL   Dis. Esophagus 22 (5), 386-395 (2009)
   PUBMED   19673046
REFERENCE   4  (bases 1 to 1972)
  AUTHORS   Krause,G., Winkler,L., Mueller,S.L., Haseloff,R.F., Piontek,J. and
            Blasig,I.E.
  TITLE     Structure and function of claudins
  JOURNAL   Biochim. Biophys. Acta 1778 (3), 631-645 (2008)
   PUBMED   18036336
  REMARK    Review article
REFERENCE   5  (bases 1 to 1972)
  AUTHORS   Ballana,E., Mercader,J.M., Fischel-Ghodsian,N. and Estivill,X.
  TITLE     MRPS18CP2 alleles and DEFA3 absence as putative chromosome 8p23.1
            modifiers of hearing loss due to mtDNA mutation A1555G in the 12S
            rRNA gene
  JOURNAL   BMC Med. Genet. 8, 81 (2007)
   PUBMED   18154640
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1972)
  AUTHORS   Katoh,M.
  TITLE     Epithelial-mesenchymal transition in gastric cancer (Review)
  JOURNAL   Int. J. Oncol. 27 (6), 1677-1683 (2005)
   PUBMED   16273224
  REMARK    Review article
REFERENCE   7  (bases 1 to 1972)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     CLDN23 gene, frequently down-regulated in intestinal-type gastric
            cancer, is a novel member of CLAUDIN gene family
  JOURNAL   Int. J. Mol. Med. 11 (6), 683-689 (2003)
   PUBMED   12736707
  REMARK    GeneRIF: characterization of CLDN23 gene, a candidate tumor
            suppressor gene implicated in intestinal-type gastric cancer
            GeneRIF: Human CLDN23, showing 79.5% total-amino-acid identity with
            mouse Cldn23, is a four-transmembrane protein with WWCC motif,
            defined by W-X(17-22)-W-X(2)-C-X(8-10)-C.
REFERENCE   8  (bases 1 to 1972)
  AUTHORS   Venter,J.C., Adams,M.D., Myers,E.W., Li,P.W., Mural,R.J.,
            Sutton,G.G., Smith,H.O., Yandell,M., Evans,C.A., Holt,R.A.,
            Gocayne,J.D., Amanatides,P., Ballew,R.M., Huson,D.H., Wortman,J.R.,
            Zhang,Q., Kodira,C.D., Zheng,X.H., Chen,L., Skupski,M.,
            Subramanian,G., Thomas,P.D., Zhang,J., Gabor Miklos,G.L.,
            Nelson,C., Broder,S., Clark,A.G., Nadeau,J., McKusick,V.A.,
            Zinder,N., Levine,A.J., Roberts,R.J., Simon,M., Slayman,C.,
            Hunkapiller,M., Bolanos,R., Delcher,A., Dew,I., Fasulo,D.,
            Flanigan,M., Florea,L., Halpern,A., Hannenhalli,S., Kravitz,S.,
            Levy,S., Mobarry,C., Reinert,K., Remington,K., Abu-Threideh,J.,
            Beasley,E., Biddick,K., Bonazzi,V., Brandon,R., Cargill,M.,
            Chandramouliswaran,I., Charlab,R., Chaturvedi,K., Deng,Z., Di
            Francesco,V., Dunn,P., Eilbeck,K., Evangelista,C., Gabrielian,A.E.,
            Gan,W., Ge,W., Gong,F., Gu,Z., Guan,P., Heiman,T.J., Higgins,M.E.,
            Ji,R.R., Ke,Z., Ketchum,K.A., Lai,Z., Lei,Y., Li,Z., Li,J.,
            Liang,Y., Lin,X., Lu,F., Merkulov,G.V., Milshina,N., Moore,H.M.,
            Naik,A.K., Narayan,V.A., Neelam,B., Nusskern,D., Rusch,D.B.,
            Salzberg,S., Shao,W., Shue,B., Sun,J., Wang,Z., Wang,A., Wang,X.,
            Wang,J., Wei,M., Wides,R., Xiao,C., Yan,C., Yao,A., Ye,J., Zhan,M.,
            Zhang,W., Zhang,H., Zhao,Q., Zheng,L., Zhong,F., Zhong,W., Zhu,S.,
            Zhao,S., Gilbert,D., Baumhueter,S., Spier,G., Carter,C.,
            Cravchik,A., Woodage,T., Ali,F., An,H., Awe,A., Baldwin,D.,
            Baden,H., Barnstead,M., Barrow,I., Beeson,K., Busam,D., Carver,A.,
            Center,A., Cheng,M.L., Curry,L., Danaher,S., Davenport,L.,
            Desilets,R., Dietz,S., Dodson,K., Doup,L., Ferriera,S., Garg,N.,
            Gluecksmann,A., Hart,B., Haynes,J., Haynes,C., Heiner,C.,
            Hladun,S., Hostin,D., Houck,J., Howland,T., Ibegwam,C., Johnson,J.,
            Kalush,F., Kline,L., Koduru,S., Love,A., Mann,F., May,D.,
            McCawley,S., McIntosh,T., McMullen,I., Moy,M., Moy,L., Murphy,B.,
            Nelson,K., Pfannkoch,C., Pratts,E., Puri,V., Qureshi,H.,
            Reardon,M., Rodriguez,R., Rogers,Y.H., Romblad,D., Ruhfel,B.,
            Scott,R., Sitter,C., Smallwood,M., Stewart,E., Strong,R., Suh,E.,
            Thomas,R., Tint,N.N., Tse,S., Vech,C., Wang,G., Wetter,J.,
            Williams,S., Williams,M., Windsor,S., Winn-Deen,E., Wolfe,K.,
            Zaveri,J., Zaveri,K., Abril,J.F., Guigo,R., Campbell,M.J.,
            Sjolander,K.V., Karlak,B., Kejariwal,A., Mi,H., Lazareva,B.,
            Hatton,T., Narechania,A., Diemer,K., Muruganujan,A., Guo,N.,
            Sato,S., Bafna,V., Istrail,S., Lippert,R., Schwartz,R., Walenz,B.,
            Yooseph,S., Allen,D., Basu,A., Baxendale,J., Blick,L., Caminha,M.,
            Carnes-Stine,J., Caulk,P., Chiang,Y.H., Coyne,M., Dahlke,C.,
            Mays,A., Dombroski,M., Donnelly,M., Ely,D., Esparham,S., Fosler,C.,
            Gire,H., Glanowski,S., Glasser,K., Glodek,A., Gorokhov,M.,
            Graham,K., Gropman,B., Harris,M., Heil,J., Henderson,S., Hoover,J.,
            Jennings,D., Jordan,C., Jordan,J., Kasha,J., Kagan,L., Kraft,C.,
            Levitsky,A., Lewis,M., Liu,X., Lopez,J., Ma,D., Majoros,W.,
            McDaniel,J., Murphy,S., Newman,M., Nguyen,T., Nguyen,N., Nodell,M.,
            Pan,S., Peck,J., Peterson,M., Rowe,W., Sanders,R., Scott,J.,
            Simpson,M., Smith,T., Sprague,A., Stockwell,T., Turner,R.,
            Venter,E., Wang,M., Wen,M., Wu,D., Wu,M., Xia,A., Zandieh,A. and
            Zhu,X.
  TITLE     The sequence of the human genome
  JOURNAL   Science 291 (5507), 1304-1351 (2001)
   PUBMED   11181995
  REMARK    Erratum:[Science 2001 Jun 5;292(5523):1838]
REFERENCE   9  (bases 1 to 1972)
  AUTHORS   Gress,T.M., Muller-Pillasch,F., Geng,M., Zimmerhackl,F.,
            Zehetner,G., Friess,H., Buchler,M., Adler,G. and Lehrach,H.
  TITLE     A pancreatic cancer-specific expression profile
  JOURNAL   Oncogene 13 (8), 1819-1830 (1996)
   PUBMED   8895530
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC087269.5, BC125149.1 and
            BC016047.1.
            On Jan 25, 2007 this sequence version replaced gi:34916005.
            
            Summary: This gene encodes a member of the claudin family. Claudins
            are integral membrane proteins and components of tight junction
            strands. Tight junction strands serve as a physical barrier to
            prevent solutes and water from passing freely through the
            paracellular space between epithelial or endothelial cell sheets,
            and also play critical roles in maintaining cell polarity and
            signal transductions. This gene is expressed in germinal center
            B-cells, placenta and stomach as well as in colon tumor. This gene
            is down-regulated in intestinal type gastric cancer. [provided by
            RefSeq, Aug 2010].
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                AC087269.5         80626-80645         c
            21-1153             BC125149.1         1-1133
            1154-1972           BC016047.1         841-1659
FEATURES             Location/Qualifiers
     source          1..1972
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p23.1"
     gene            1..1972
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /note="claudin 23"
                     /db_xref="GeneID:137075"
                     /db_xref="HGNC:17591"
                     /db_xref="MIM:609203"
     exon            1..1952
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /inference="alignment:Splign:1.39.8"
     variation       27
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:186100732"
     variation       47
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141287177"
     variation       52
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:10100895"
     variation       61
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:112989417"
     variation       166
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:75780384"
     variation       167
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:9644774"
     STS             200..1198
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /db_xref="UniSTS:483094"
     variation       204
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:114568694"
     variation       206
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375802466"
     variation       233
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11995449"
     variation       236
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:116706669"
     CDS             244..1122
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /note="2310014B08Rik"
                     /codon_start=1
                     /product="claudin-23"
                     /protein_id="NP_919260.2"
                     /db_xref="GI:124107616"
                     /db_xref="CCDS:CCDS55195.1"
                     /db_xref="GeneID:137075"
                     /db_xref="HGNC:17591"
                     /db_xref="MIM:609203"
                     /translation="

MRTPVVMTLGMVLAPCGLLLNLTGTLAPGWRLVKGFLNQPVDVELYQGLWDMCREQSSRERECGQTDQWGYFEAQPVLVARALMVTSLAATVLGLLLASLGVRCWQDEPNFVLAGLSGVVLFVAGLLGLIPVSWYNHFLGDRDVLPAPASPVTVQVSYSLVLGYLGSCLLLLGGFSLALSFAPWCDERCRRRRKGPSAGPRRSSVSTIQVEWPEPDLAPAIKYYSDGQHRPPPAQHRKPKPKPKVGFPMPRPRPKAYTNSVDVLDGEGWESQDAPSCSTHPCDSSLPCDSDL

"
     misc_feature    253..315
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96B33.2);
                     transmembrane region"
     misc_feature    256..>555
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /note="PMP-22/EMP/MP20/Claudin family; Region:
                     PMP22_Claudin; cl15797"
                     /db_xref="CDD:210197"
     misc_feature    487..549
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96B33.2);
                     transmembrane region"
     misc_feature    574..636
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96B33.2);
                     transmembrane region"
     misc_feature    724..786
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96B33.2);
                     transmembrane region"
     misc_feature    910..912
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    913..915
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     variation       252
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:61754917"
     variation       291
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368361119"
     variation       303
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:190963991"
     variation       315
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:367750166"
     variation       323
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371447820"
     variation       356
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:202151198"
     variation       413
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376858036"
     variation       418
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369577087"
     variation       419
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373271097"
     variation       425
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372856858"
     variation       426
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376562179"
     variation       442
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:61755871"
     variation       479
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373965839"
     variation       486
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:61754959"
     variation       490
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:370158322"
     variation       496
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372410779"
     variation       511
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201513699"
     variation       534
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370927286"
     variation       547
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373916666"
     variation       572
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368644939"
     variation       602
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376773071"
     variation       644
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:370704598"
     variation       656
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:376115128"
     variation       658
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368422117"
     variation       659
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372707403"
     variation       661
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199648835"
     variation       672
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:187886298"
     variation       683
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:367632118"
     variation       695
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372216782"
     variation       730
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:375160559"
     variation       732
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:369849897"
     variation       736
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:372992848"
     variation       764
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370620610"
     variation       768
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:190408068"
     variation       783
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:182952286"
     variation       792
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:13254610"
     variation       802
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369967730"
     variation       818
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373434191"
     variation       826
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200770293"
     variation       848
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370166073"
     variation       871
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:12548737"
     variation       910
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376340716"
     variation       931
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:371221125"
     variation       937
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2280560"
     variation       954..955
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace=""
                     /replace="caagcc"
                     /db_xref="dbSNP:72264034"
     variation       972
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368268833"
     variation       975..976
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace=""
                     /replace="cccaag"
                     /db_xref="dbSNP:57083604"
     variation       975
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371351490"
     variation       1002
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376054054"
     variation       1023
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200726525"
     variation       1045
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:373783880"
     STS             1111..1243
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /standard_name="RH12660"
                     /db_xref="UniSTS:66739"
     variation       1143
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:371314769"
     variation       1147
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374765263"
     variation       1243
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:73192453"
     variation       1244
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:12153"
     variation       1325
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:77145835"
     variation       1352
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:376922472"
     variation       1416
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:12058"
     variation       1470
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140456217"
     variation       1473
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:75700848"
     variation       1517
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:114865749"
     variation       1518
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:78843073"
     STS             1615..1821
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /standard_name="RH67977"
                     /db_xref="UniSTS:65777"
     variation       1646
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:10105591"
     variation       1705
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:187839059"
     variation       1726..1727
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:11403457"
     variation       1728
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:192926090"
     variation       1732..1734
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="agca"
                     /replace="cgc"
                     /db_xref="dbSNP:71286005"
     variation       1734
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1060107"
     variation       1777
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:4840350"
     variation       1787
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1060106"
     variation       1802
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:184100360"
     variation       1837
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:187841496"
     variation       1871..1872
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="ca"
                     /replace="tg"
                     /db_xref="dbSNP:372332994"
     variation       1871
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="ca"
                     /replace="tg"
                     /db_xref="dbSNP:71537848"
     variation       1871
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11249882"
     variation       1872
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11249883"
     variation       1887
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11249884"
     polyA_signal    1922..1927
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
     variation       1940
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143580227"
     polyA_site      1952
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
ORIGIN      

aggagggcggagcggccgggacgccaggagggaactagcctaagtggggacggtccccgtgcaggagacaaagagcgtccctggagcgatcagggctcaggagcccgacccggagcccggggcgtccgcgctgacttcgggtccccggagcctggggcacggcagggagaagacgacggcggagaaggcgacagcggagaaggaaggcaggctgcaggggcgccgtcggcgcggcgggccgggatgcggacgccggtggtgatgacgctgggcatggtgttggcgccctgcgggctcctgctcaacctgaccggcaccctggcgcccggctggcggctggtgaagggcttcctgaaccagccagtggacgtggagttgtaccagggcctgtgggacatgtgtcgcgagcagagcagccgcgagcgcgagtgcggccagacggaccagtggggctacttcgaggcccagcccgtgctggtggcgcgggcactcatggtcacctcgctggccgccacggtcctggggcttctgctggcgtcgctgggcgtgcgctgctggcaggacgagcccaacttcgtgctggcagggctctcgggcgtcgtgctcttcgtcgctggcctcctcggcctcatcccggtgtcctggtacaaccacttcttgggggaccgcgacgtgctgcccgccccggccagcccggtcacggtgcaggtcagctacagcctggtcctgggctacctgggcagctgcctcctgctgctgggcggcttctcgctggcgctcagcttcgcgccctggtgcgacgagcgttgtcgccgccgccgcaagggaccctccgccgggcctcgccgcagcagcgtcagcaccatccaagtggagtggcccgagcccgacctggcgcccgccatcaagtactacagcgacggccagcaccgaccgccgcctgcccagcaccgcaagcccaagcccaagcccaaggtcggcttccccatgccgcggccgcggcccaaggcctacaccaactcggtggacgtcctcgacggggaggggtgggagtcccaggacgctccctcgtgcagcacccacccctgcgacagctcgctgccctgcgactccgacctctagacgcttgtagagcctggggggcgccgggtggcaaaggactcacccccgcacaggcccgcctggcttcgagttggaacccggacacttgcccctcactggtgtggatggaaatctgcctttcgtgggaccaaacaggactccttggacgattagttcaggttgggtttggttttcttcttaaagagtttagttttcctctccagagggatcagggtcctcttagggagtgacgggcttttcatatatttttgctgaagaatatatggaaagggtggcatttgcgtcacgtggaccagggacagtgctgaaatcagcagtgctcagaaacaatttaacatgttgaaacgacaatattctaaaatactgatgaatcttgcatcaatataattattgggttttttttctttttcctgctgtataactccttgccatgcaaactctcaagaggccaatatattcctggccatgtttgaatgagcctcttaaaataaacttagagccatgcaaatgccagcagcttaatggatttcatggaatgaaataccgtgattaactcatagctacatatcattgcataaatgggatttatcttttttctcacttatttttgcggtgaaagtcgagggcatgcaagagtttctcttccagaagccaagaggagaacaaaggtcctaatgctgtactattccaccctttggacgcctcatccaggacgcagaggactctaggtttaacattttgtacaaaatggaacctgttaatcatattaaagcacatatgtatatatcttttatttataaataaaattttaaaacaatagtttcagtataaaaaaaaaaaaaaaaaaaaa

//

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:137075 -> Molecular function: GO:0005198 [structural molecule activity] evidence: IEA
            GeneID:137075 -> Molecular function: GO:0042802 [identical protein binding] evidence: ISS
            GeneID:137075 -> Biological process: GO:0016338 [calcium-independent cell-cell adhesion] evidence: ISS
            GeneID:137075 -> Biological process: GO:0034329 [cell junction assembly] evidence: TAS
            GeneID:137075 -> Biological process: GO:0045216 [cell-cell junction organization] evidence: TAS
            GeneID:137075 -> Biological process: GO:0070830 [tight junction assembly] evidence: TAS
            GeneID:137075 -> Cellular component: GO:0005886 [plasma membrane] evidence: IEA
            GeneID:137075 -> Cellular component: GO:0005923 [tight junction] evidence: ISS
            GeneID:137075 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA