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2025-05-12 01:35:37, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_144632 3588 bp mRNA linear PRI 15-JUN-2013
DEFINITION Homo sapiens transmembrane protein 182 (TMEM182), mRNA.
ACCESSION NM_144632
VERSION NM_144632.3 GI:188528657
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3588)
AUTHORS Lauc,G., Huffman,J.E., Pucic,M., Zgaga,L., Adamczyk,B., Muzinic,A.,
Novokmet,M., Polasek,O., Gornik,O., Kristic,J., Keser,T.,
Vitart,V., Scheijen,B., Uh,H.W., Molokhia,M., Patrick,A.L.,
McKeigue,P., Kolcic,I., Lukic,I.K., Swann,O., van Leeuwen,F.N.,
Ruhaak,L.R., Houwing-Duistermaat,J.J., Slagboom,P.E., Beekman,M.,
de Craen,A.J., Deelder,A.M., Zeng,Q., Wang,W., Hastie,N.D.,
Gyllensten,U., Wilson,J.F., Wuhrer,M., Wright,A.F., Rudd,P.M.,
Hayward,C., Aulchenko,Y., Campbell,H. and Rudan,I.
TITLE Loci associated with N-glycosylation of human immunoglobulin G show
pleiotropy with autoimmune diseases and haematological cancers
JOURNAL PLoS Genet. 9 (1), E1003225 (2013)
PUBMED 23382691
REFERENCE 2 (bases 1 to 3588)
AUTHORS Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
TITLE The secreted protein discovery initiative (SPDI), a large-scale
effort to identify novel human secreted and transmembrane proteins:
a bioinformatics assessment
JOURNAL Genome Res. 13 (10), 2265-2270 (2003)
PUBMED 12975309
REMARK Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AY358262.1 and AC007251.4.
On May 17, 2008 this sequence version replaced gi:40255064.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data because no single transcript was available
for the full length of the gene. The extent of this transcript is
supported by transcript alignments.
##Evidence-Data-START##
Transcript exon combination :: CR936735.1, AK129862.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025083, ERS025084 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-853 AY358262.1 99-951
854-3588 AC007251.4 84870-87604
FEATURES Location/Qualifiers
source 1..3588
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2q12.1"
gene 1..3588
/gene="TMEM182"
/note="transmembrane protein 182"
/db_xref="GeneID:130827"
/db_xref="HGNC:26391"
exon 1..319
/gene="TMEM182"
/inference="alignment:Splign:1.39.8"
variation 10
/gene="TMEM182"
/replace="a"
/replace="g"
/db_xref="dbSNP:118026982"
variation 17
/gene="TMEM182"
/replace="c"
/replace="t"
/db_xref="dbSNP:115087473"
variation 18
/gene="TMEM182"
/replace="c"
/replace="g"
/db_xref="dbSNP:111261034"
STS 53..1165
/gene="TMEM182"
/db_xref="UniSTS:494500"
variation 71
/gene="TMEM182"
/replace="c"
/replace="t"
/db_xref="dbSNP:2732839"
variation 93
/gene="TMEM182"
/replace=""
/replace="t"
/db_xref="dbSNP:5833037"
variation 149
/gene="TMEM182"
/replace="a"
/replace="t"
/db_xref="dbSNP:185595389"
misc_feature 164..166
/gene="TMEM182"
/note="upstream in-frame stop codon"
CDS 188..877
/gene="TMEM182"
/codon_start=1
/product="transmembrane protein 182 precursor"
/protein_id="NP_653233.3"
/db_xref="GI:188528658"
/db_xref="CCDS:CCDS2064.1"
/db_xref="GeneID:130827"
/db_xref="HGNC:26391"
/translation="
MRLNIAIFFGALFGALGVLLFLVAFGSDYWLLATEVGRCSGEKNIENVTFHHEGFFWRCWFNGIVEENDSNIWKFWYTNQPPSKNCTHAYLSPYPFMRGEHNSTSYDSAVIYRGFWAVLMLLGVVAVVIASFLIICAAPFASHFLYKAGGGSYIAAGILFSLVVMLYVIWVQAVADMESYRNMKMKDCLDFTPSVLYGWSFFLAPAGIFFSLLAGLLFLVVGWHIQIHH
"
sig_peptide 188..265
/gene="TMEM182"
/inference="non-experimental evidence, no additional
details recorded"
/note="Potential; propagated from UniProtKB/Swiss-Prot
(Q6ZP80.2)"
mat_peptide 266..874
/gene="TMEM182"
/product="Transmembrane protein 182"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q6ZP80.2)"
misc_feature 266..847
/gene="TMEM182"
/note="PMP-22/EMP/MP20/Claudin tight junction; Region:
Claudin_2; pfam13903"
/db_xref="CDD:206074"
misc_feature 530..592
/gene="TMEM182"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q6ZP80.2);
transmembrane region"
misc_feature 647..709
/gene="TMEM182"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q6ZP80.2);
transmembrane region"
misc_feature 788..850
/gene="TMEM182"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q6ZP80.2);
transmembrane region"
variation 203
/gene="TMEM182"
/replace="g"
/replace="t"
/db_xref="dbSNP:145943993"
variation 208
/gene="TMEM182"
/replace="a"
/replace="c"
/db_xref="dbSNP:141575902"
variation 241
/gene="TMEM182"
/replace="a"
/replace="g"
/db_xref="dbSNP:139384397"
variation 256
/gene="TMEM182"
/replace="a"
/replace="g"
/db_xref="dbSNP:368685589"
variation 268
/gene="TMEM182"
/replace="a"
/replace="g"
/db_xref="dbSNP:147702904"
variation 278
/gene="TMEM182"
/replace="c"
/replace="t"
/db_xref="dbSNP:200405126"
exon 320..419
/gene="TMEM182"
/inference="alignment:Splign:1.39.8"
variation 329
/gene="TMEM182"
/replace="a"
/replace="g"
/db_xref="dbSNP:370445639"
variation 332
/gene="TMEM182"
/replace="a"
/replace="g"
/db_xref="dbSNP:200283037"
variation 363
/gene="TMEM182"
/replace="c"
/replace="g"
/db_xref="dbSNP:201534618"
variation 368
/gene="TMEM182"
/replace="c"
/replace="t"
/db_xref="dbSNP:144693740"
variation 418
/gene="TMEM182"
/replace="c"
/replace="t"
/db_xref="dbSNP:148918467"
exon 420..518
/gene="TMEM182"
/inference="alignment:Splign:1.39.8"
variation 432
/gene="TMEM182"
/replace="c"
/replace="t"
/db_xref="dbSNP:376506997"
variation 433
/gene="TMEM182"
/replace="g"
/replace="t"
/db_xref="dbSNP:369237390"
variation 466
/gene="TMEM182"
/replace="a"
/replace="g"
/db_xref="dbSNP:79354230"
variation 485
/gene="TMEM182"
/replace="a"
/replace="g"
/db_xref="dbSNP:137985902"
variation 495
/gene="TMEM182"
/replace="c"
/replace="t"
/db_xref="dbSNP:377199521"
exon 519..656
/gene="TMEM182"
/inference="alignment:Splign:1.39.8"
variation 524
/gene="TMEM182"
/replace="c"
/replace="t"
/db_xref="dbSNP:199691513"
variation 525
/gene="TMEM182"
/replace="a"
/replace="g"
/db_xref="dbSNP:376008407"
variation 532
/gene="TMEM182"
/replace="c"
/replace="t"
/db_xref="dbSNP:369312176"
variation 556
/gene="TMEM182"
/replace="c"
/replace="g"
/db_xref="dbSNP:373489178"
variation 575
/gene="TMEM182"
/replace="a"
/replace="g"
/db_xref="dbSNP:114571302"
variation 607
/gene="TMEM182"
/replace="c"
/replace="t"
/db_xref="dbSNP:140175654"
variation 651
/gene="TMEM182"
/replace="c"
/replace="g"
/db_xref="dbSNP:147305207"
exon 657..3588
/gene="TMEM182"
/inference="alignment:Splign:1.39.8"
variation 671
/gene="TMEM182"
/replace="c"
/replace="t"
/db_xref="dbSNP:115991670"
variation 683
/gene="TMEM182"
/replace="c"
/replace="g"
/db_xref="dbSNP:200341477"
variation 703
/gene="TMEM182"
/replace="c"
/replace="g"
/db_xref="dbSNP:189839305"
variation 716
/gene="TMEM182"
/replace="a"
/replace="g"
/db_xref="dbSNP:374072656"
variation 729
/gene="TMEM182"
/replace="a"
/replace="g"
/db_xref="dbSNP:199665908"
variation 754
/gene="TMEM182"
/replace="a"
/replace="g"
/db_xref="dbSNP:369032228"
variation 811
/gene="TMEM182"
/replace="a"
/replace="g"
/db_xref="dbSNP:144729903"
variation 844
/gene="TMEM182"
/replace="g"
/replace="t"
/db_xref="dbSNP:114369090"
variation 854
/gene="TMEM182"
/replace="a"
/replace="g"
/db_xref="dbSNP:887987"
variation 925
/gene="TMEM182"
/replace="a"
/replace="g"
/db_xref="dbSNP:368028024"
variation 964
/gene="TMEM182"
/replace="a"
/replace="t"
/db_xref="dbSNP:112070535"
variation 1033
/gene="TMEM182"
/replace="a"
/replace="g"
/db_xref="dbSNP:113860378"
variation 1055
/gene="TMEM182"
/replace="c"
/replace="t"
/db_xref="dbSNP:146311996"
variation 1158
/gene="TMEM182"
/replace="c"
/replace="t"
/db_xref="dbSNP:112432276"
variation 1160
/gene="TMEM182"
/replace="a"
/replace="c"
/db_xref="dbSNP:148527685"
variation 1249..1250
/gene="TMEM182"
/replace=""
/replace="a"
/db_xref="dbSNP:377063389"
variation 1377
/gene="TMEM182"
/replace="a"
/replace="g"
/db_xref="dbSNP:79127541"
variation 1453
/gene="TMEM182"
/replace="a"
/replace="c"
/db_xref="dbSNP:142881486"
variation 1516
/gene="TMEM182"
/replace="a"
/replace="g"
/db_xref="dbSNP:151186061"
variation 1582
/gene="TMEM182"
/replace="a"
/replace="g"
/db_xref="dbSNP:140305419"
variation 1616
/gene="TMEM182"
/replace="a"
/replace="g"
/db_xref="dbSNP:370851484"
variation 1663
/gene="TMEM182"
/replace="c"
/replace="t"
/db_xref="dbSNP:187080616"
variation 1664
/gene="TMEM182"
/replace="a"
/replace="g"
/db_xref="dbSNP:370654099"
variation 1718
/gene="TMEM182"
/replace="g"
/replace="t"
/db_xref="dbSNP:368850580"
variation 1768
/gene="TMEM182"
/replace="a"
/replace="g"
/db_xref="dbSNP:878802"
variation 1787
/gene="TMEM182"
/replace="a"
/replace="g"
/db_xref="dbSNP:2732822"
variation 1804
/gene="TMEM182"
/replace="a"
/replace="g"
/db_xref="dbSNP:145270982"
variation 1813
/gene="TMEM182"
/replace="a"
/replace="t"
/db_xref="dbSNP:189530221"
variation 1859
/gene="TMEM182"
/replace="a"
/replace="g"
/db_xref="dbSNP:111896953"
variation 1882
/gene="TMEM182"
/replace="a"
/replace="t"
/db_xref="dbSNP:112687821"
variation 1948
/gene="TMEM182"
/replace="c"
/replace="g"
/db_xref="dbSNP:180810596"
variation 2076
/gene="TMEM182"
/replace="a"
/replace="t"
/db_xref="dbSNP:185418708"
variation 2100
/gene="TMEM182"
/replace="a"
/replace="g"
/db_xref="dbSNP:367806688"
variation 2175
/gene="TMEM182"
/replace="c"
/replace="t"
/db_xref="dbSNP:10201334"
variation 2237
/gene="TMEM182"
/replace="a"
/replace="g"
/db_xref="dbSNP:4476374"
variation 2259
/gene="TMEM182"
/replace="a"
/replace="g"
/db_xref="dbSNP:371556407"
STS 2261..2372
/gene="TMEM182"
/standard_name="D2S1551E"
/db_xref="UniSTS:150636"
variation 2367
/gene="TMEM182"
/replace="a"
/replace="g"
/db_xref="dbSNP:190229516"
variation 2381
/gene="TMEM182"
/replace="c"
/replace="g"
/db_xref="dbSNP:147640501"
variation 2390
/gene="TMEM182"
/replace="c"
/replace="t"
/db_xref="dbSNP:181432006"
variation 2393
/gene="TMEM182"
/replace="c"
/replace="t"
/db_xref="dbSNP:186594943"
variation 2419..2420
/gene="TMEM182"
/replace=""
/replace="aat"
/db_xref="dbSNP:367982014"
variation 2420..2421
/gene="TMEM182"
/replace=""
/replace="aat"
/db_xref="dbSNP:72378965"
variation 2422..2423
/gene="TMEM182"
/replace=""
/replace="taa"
/replace="taataa"
/db_xref="dbSNP:72301570"
variation 2429..2430
/gene="TMEM182"
/replace=""
/replace="aataat"
/replace="ataata"
/db_xref="dbSNP:10661746"
variation 2430..2431
/gene="TMEM182"
/replace=""
/replace="ataata"
/db_xref="dbSNP:34075213"
variation 2449..2450
/gene="TMEM182"
/replace=""
/replace="taataa"
/db_xref="dbSNP:71989508"
variation 2485
/gene="TMEM182"
/replace="a"
/replace="g"
/db_xref="dbSNP:191382079"
variation 2515
/gene="TMEM182"
/replace="c"
/replace="t"
/db_xref="dbSNP:183748203"
variation 2634
/gene="TMEM182"
/replace="a"
/replace="g"
/db_xref="dbSNP:142310271"
variation 2652
/gene="TMEM182"
/replace="c"
/replace="g"
/db_xref="dbSNP:113531244"
variation 2742
/gene="TMEM182"
/replace="c"
/replace="g"
/db_xref="dbSNP:6752950"
variation 2783
/gene="TMEM182"
/replace="a"
/replace="g"
/db_xref="dbSNP:79663120"
variation 2793
/gene="TMEM182"
/replace="c"
/replace="t"
/db_xref="dbSNP:111739828"
variation 2847
/gene="TMEM182"
/replace="c"
/replace="t"
/db_xref="dbSNP:188630784"
variation 2965
/gene="TMEM182"
/replace="a"
/replace="g"
/db_xref="dbSNP:191017848"
variation 2968
/gene="TMEM182"
/replace="c"
/replace="t"
/db_xref="dbSNP:10204500"
variation 2984
/gene="TMEM182"
/replace="a"
/replace="c"
/db_xref="dbSNP:111540340"
STS 2986..3137
/gene="TMEM182"
/standard_name="RH94134"
/db_xref="UniSTS:91767"
variation 3037
/gene="TMEM182"
/replace="c"
/replace="t"
/db_xref="dbSNP:367658201"
variation 3074
/gene="TMEM182"
/replace="a"
/replace="t"
/db_xref="dbSNP:2540321"
variation 3329
/gene="TMEM182"
/replace="a"
/replace="g"
/db_xref="dbSNP:116709911"
variation 3436
/gene="TMEM182"
/replace="a"
/replace="g"
/db_xref="dbSNP:369173661"
variation 3459
/gene="TMEM182"
/replace=""
/replace="t"
/db_xref="dbSNP:370136386"
ORIGIN
gaatctgccggtggggcgtgagcgagaagccaccaaaacatgagctaggacagccttctcaagaagattctgccaactcaaaaatattattcttttttttttttttttgctgttgtttctgagaaactaggtgtcttaccattttaaaatttcatattttatttaaaaggaaaccagtgaattgaaaatgagactaaatatcgctatcttctttggagctctctttggtgctttgggggtgttactctttttggtggcttttggatcggattattggcttcttgcaactgaagtggggagatgttcaggtgaaaagaatatagagaacgtcacttttcaccatgaagggttcttctggaggtgttggtttaatgggattgtggaagagaatgactccaatatttggaagttctggtacaccaatcagccaccgtccaagaactgcacacatgcttacctgtctccgtaccccttcatgagaggcgagcacaactcgacctcctatgactctgcagttatttaccgtggtttctgggcagtcctgatgctcctgggggtagttgctgtagtcatcgcaagctttttgatcatctgtgcagcccccttcgccagccattttctctacaaagctgggggaggctcatatattgctgcaggcatcctattttcattggtggtgatgctgtatgtcatctgggtccaggcagtggctgacatggaaagctaccgaaacatgaaaatgaaggactgcctggatttcaccccttctgttctgtatggctggtcatttttcctggccccagctgggatatttttttctttgctagctggattactatttctggttgttggatggcatattcagatacatcactaaatcaactgttgccacaagtattttcttgagagattttaaaacaaggaatactttttttccattttgtttcattgatcccagcataaagttagtagatataactttttagttgctattcaaattaatcattttactaaaattttcttcagtaagaaggtcctagaatctctccagacaccagcaagcctctatcttgtctaagtgctgtcaaggacctagttctttagggaataggtaaacaggtctccctttcattgaacatgttagagttcatgcaggtcgcaaaggcctgataatagcttaataccatgacatggggaaaatctcgatagatttggcttaaagtctccttggcattcacttctgctaattaaaaaaaatccttgaagaataattaagaatgggcaaggttgtcagagaatttattttgtttcttgcccacacagataatatccacatacacattcactggctcttgtgagcaaatgaatttaaaaatagacagcagttgttctaattagtgggagccatgtactcaccagttaaaatgggccacaacaaacaagactgagagcatgtacttatcttgctttttcaccaacagtggtttggttacctagttttattcacttaattgtgcatgcttacataaactttaaactacatttaaaactagcaaatctgcataccaaattatgtataacgtagattgaatttttatgaacttaaagtgagttaattgtataatgtaatattgtttaaaatatgtaaaaaccaagcatttccgcttggtccataattctatttgatattttaaaattctcatttaaaaattatattgctatcattcagcatgtgaaaatttattgataaaatgtgattttaatattttttagatataaactttcaacgtacttccatatgaggattataatagccctgctttattaaagaccataaaatattaactttccccaagatgttatgggttccagttcttctgatcatttgattcctttaattactgtccctcaatttcttcatctttacaatagatatattaacatttacagatcgactatttcctttaacctcctagaagaaagtttttgtggggaaagatgattctgtattattcagtagcatagacattttgcatatcaaagatgttcatttggcactaatgttgattgaaatcaaatccatctgagatgcctagctcgtatttgcattctggaagcctccatcgcaggggagctcggcagggtatgtgagctttgttggaggtgcggtgtttcattctgcagctgttgtgaggacagagaggcatggcccacaggcaaaaaaagtcaccacccagaagatgctctgggatagaggaactgctccttttcatcagctcttccaatgccgtgggagaggtgatcccagtcttctctgtacatcttgtgcttttccattaagacttgttccagtgggaaggagctttggaaaaattgcaaaggtctgaatcttcagggcattttcatgacaggacttgccaataataataataataataataataataataataataaagctccagaggcctaactggtttctcaagtcatttcagtgatatcattgaaacgtttttgtggtacttccctttgtctttcactgtttcatttttatattgcttcatttacttctttgcttttggctttgttattagaaaaaataattatgaggtctgttgtgcatgttgactgtgatattaagttatggcatgccattaagttttccagacgatgttggatgtatctgattagttcatgtcatctgtaaatacaattcttttttgtagtactttggaatggagcctttttctggtgtactgtatgccatttaagtttcacatacaagctgctttcggcaaaggcttgaatatttataaatttcagatggttatcctcactttatagtacacttaagtggctaccatatattttttatatgacaattggctgaatagctgatgtgtatgacacttttacacagatttgcactttggaactattttatagttgtaatgcatcaatcaaatacatttcaagcacatttcttgatcaatttaccagcaaccctctgaaggaatgaaggagagttgtgattgctatgtcaatgagtgaaatatacttaaaaatggcagagttatatagtacattattgtagcaaccttatatctgatttgagatactgtgttgccaaatgtccatgttatgtttatttctctattggttgtatttattaatttttagaagcctttaaactgtgttagaatctttttgaaaaatgttgattttgcatcataaagtttcaatttatcaaggatatcttttcagttacacttttagaaagagtgaataaaaagggcagtgagttatgctcttggacttggtgaaagctatcatctctccatattgtatttgttcagctggtttaattcactcaggtggatgattgcacatacattggaattggctggagagactacacagagaagtttaatgatcgtgtacaatttgagggttgatggtagggctttctaaaaaaagtaatatcaagtgtgttgttagtattcatttagtcatttttattactaatctataaatatatttattaaatttgaagattaaatggaattataaaggaatatattggaggaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:130827 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA
by
@meso_cacase at
DBCLS
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