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2025-05-12 01:24:08, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_019895 2244 bp mRNA linear PRI 17-APR-2013 DEFINITION Homo sapiens claudin domain containing 1 (CLDND1), transcript variant 2, mRNA. ACCESSION NM_019895 VERSION NM_019895.2 GI:93588627 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2244) AUTHORS Liu,Y., Sun,W., Zhang,K., Zheng,H., Ma,Y., Lin,D., Zhang,X., Feng,L., Lei,W., Zhang,Z., Guo,S., Han,N., Tong,W., Feng,X., Gao,Y. and Cheng,S. TITLE Identification of genes differentially expressed in human primary lung squamous cell carcinoma JOURNAL Lung Cancer 56 (3), 307-317 (2007) PUBMED 17316888 REMARK GeneRIF: A cDNA library consisting of 220 upregulated genes in tumour tissue was established and named as LSCC. Differential expression was confirmed in five of these genes, including IGFBP5, SQLE, RAP2B, CLDN1, and TBL1XR1. REFERENCE 2 (bases 1 to 2244) AUTHORS Lamesch,P., Li,N., Milstein,S., Fan,C., Hao,T., Szabo,G., Hu,Z., Venkatesan,K., Bethel,G., Martin,P., Rogers,J., Lawlor,S., McLaren,S., Dricot,A., Borick,H., Cusick,M.E., Vandenhaute,J., Dunham,I., Hill,D.E. and Vidal,M. TITLE hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes JOURNAL Genomics 89 (3), 307-315 (2007) PUBMED 17207965 REFERENCE 3 (bases 1 to 2244) AUTHORS Fayein,N.A., Stankoff,B., Auffray,C. and Devignes,M.D. TITLE Characterization of tissue expression and full-length coding sequence of a novel human gene mapping at 3q12.1 and transcribed in oligodendrocytes JOURNAL Gene 289 (1-2), 119-129 (2002) PUBMED 12036590 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB461184.1, AC021660.16, BC001757.2, EB386420.1 and AA811441.1. On Apr 26, 2006 this sequence version replaced gi:11096339. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 6 encode the same isoform (a). ##Evidence-Data-START## Transcript exon combination :: BC001757.2, BI597093.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025088 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-11 DB461184.1 1-11 12-12 AC021660.16 119164-119164 13-193 DB461184.1 13-193 194-1459 BC001757.2 1-1266 1460-2089 EB386420.1 98-727 2090-2244 AA811441.1 1-155 c FEATURES Location/Qualifiers source 1..2244 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="3" /map="3q12.1" gene 1..2244 /gene="CLDND1" /gene_synonym="C3orf4; GENX-3745" /note="claudin domain containing 1" /db_xref="GeneID:56650" /db_xref="HGNC:1322" /db_xref="HPRD:12822" exon 1..218 /gene="CLDND1" /gene_synonym="C3orf4; GENX-3745" /inference="alignment:Splign:1.39.8" exon 219..269 /gene="CLDND1" /gene_synonym="C3orf4; GENX-3745" /inference="alignment:Splign:1.39.8" variation 257 /gene="CLDND1" /gene_synonym="C3orf4; GENX-3745" /replace="c" /replace="g" /db_xref="dbSNP:11553640" exon 270..579 /gene="CLDND1" /gene_synonym="C3orf4; GENX-3745" /inference="alignment:Splign:1.39.8" variation 273..274 /gene="CLDND1" /gene_synonym="C3orf4; GENX-3745" /replace="a" /replace="c" /db_xref="dbSNP:11553645" variation 284 /gene="CLDND1" /gene_synonym="C3orf4; GENX-3745" /replace="c" /replace="g" /db_xref="dbSNP:11553648" CDS 288..1049 /gene="CLDND1" /gene_synonym="C3orf4; GENX-3745" /note="isoform a is encoded by transcript variant 2; claudin domain containing 1 protein; claudin domain-containing protein 1; membrane protein GENX-3745" /codon_start=1 /product="claudin domain-containing protein 1 isoform a" /protein_id="NP_063948.1" /db_xref="GI:11096340" /db_xref="CCDS:CCDS2930.1" /db_xref="GeneID:56650" /db_xref="HGNC:1322" /db_xref="HPRD:12822" /translation="
MDNRFATAFVIACVLSLISTIYMAASIGTDFWYEYRSPVQENSSDLNKSIWDEFISDEADEKTYNDALFRYNGTVGLWRRCITIPKNMHWYSPPERTESFDVVTKCVSFTLTEQFMEKFVDPGNHNSGIDLLRTYLWRCQFLLPFVSLGLMCFGALIGLCACICRSLYPTIATGILHLLAGLCTLGSVSCYVAGIELLHQKLELPDNVSGEFGWSFCLACVSAPLQFMASALFIWAAHTNRKEYTLMKAYRVA
"
misc_feature 300..362
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9NY35.1);
transmembrane region"
misc_feature 336..989
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/note="PMP-22/EMP/MP20/Claudin tight junction; Region:
Claudin_2; pfam13903"
/db_xref="CDD:206074"
misc_feature 708..770
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9NY35.1);
transmembrane region"
misc_feature 810..872
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9NY35.1);
transmembrane region"
misc_feature 933..995
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9NY35.1);
transmembrane region"
variation 298
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/replace="a"
/replace="g"
/db_xref="dbSNP:11553643"
variation 348
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/replace="a"
/replace="t"
/db_xref="dbSNP:11553647"
variation 364
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/replace="c"
/replace="g"
/db_xref="dbSNP:11553642"
variation 388
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/replace="a"
/replace="g"
/db_xref="dbSNP:11553639"
variation 466
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/replace="a"
/replace="g"
/db_xref="dbSNP:11553646"
variation 533
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/replace="a"
/replace="c"
/db_xref="dbSNP:11553650"
exon 580..690
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/inference="alignment:Splign:1.39.8"
exon 691..828
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/inference="alignment:Splign:1.39.8"
variation 782
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/replace="a"
/replace="t"
/db_xref="dbSNP:11553641"
variation 785
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/replace="c"
/replace="t"
/db_xref="dbSNP:35994971"
exon 829..2235
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/inference="alignment:Splign:1.39.8"
variation 971
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/replace="g"
/replace="t"
/db_xref="dbSNP:11553649"
STS 1031..1121
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/standard_name="D3S2932E"
/db_xref="UniSTS:150916"
variation 1954
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/replace="a"
/replace="g"
/db_xref="dbSNP:11553644"
STS 1998..2200
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/standard_name="D3S3109"
/db_xref="UniSTS:80916"
polyA_signal 2202..2207
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
polyA_signal 2208..2213
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
polyA_site 2225
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
polyA_site 2235
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
ORIGIN
tatcgccgcctcagacagctttcagtctgtccctcctacaactcccacaaggcccctcggccccgggccgcggcccggcccggagtgggggcgggcggaggcgcgggagttatggagggggcgggctctgcagggaagtgcgtcagaggaggcgcggggagagtagggtgctgtggtctgagctagagggtgaagctggcggagcaggaggatgggcgtatgcaggtgatagactagagaacaagacctctgtctccgtagcatcctggagcagtctgaatgccagaatggataaccgttttgctacagcatttgtaattgcttgtgtgcttagcctcatttccaccatctacatggcagcctccattggcacagacttctggtatgaatatcgaagtccagttcaagaaaattccagtgatttgaataaaagcatctgggatgaattcattagtgatgaggcagatgaaaagacttataatgatgcactttttcgatacaatggcacagtgggattgtggagacggtgtatcaccatacccaaaaacatgcattggtatagcccaccagaaaggacagagtcatttgatgtggtcacaaaatgtgtgagtttcacactaactgagcagttcatggagaaatttgttgatcccggaaaccacaatagcgggattgatctccttaggacctatctttggcgttgccagttccttttaccttttgtgagtttaggtttgatgtgctttggggctttgatcggactttgtgcttgcatttgccgaagcttatatcccaccattgccacgggcattctccatctccttgcaggtctgtgtacactgggctcagtaagttgttatgttgctggaattgaactactccaccagaaactagagctccctgacaatgtatccggtgaatttggatggtccttctgcctggcttgtgtctctgctcccttacagttcatggcttctgctctcttcatctgggctgctcacaccaaccggaaagagtacaccttaatgaaggcatatcgtgtggcatgagcaagaaactgcctgctttacaattgccatttttatttttttaaaataatactgatattttccccacctctcaattgtttttaatttttatttgtggatataccattttattatgaaaatctattttatttatacacattcaccactaaatacacacttaataccactaaaatttatgtggtttactttaagcgatgccatctttcaaataaactaatctaggtctagacagaaagaaatggatagagacttgacacaaatttatgaaagaaaattgggagtaggaatgtgaccgaaaacaagttgtgctaatgtctgttagacttttcagtaaaactaaagtaactgtatctgttcaactaaaaactctatattagtttctttgggaaacctctcatcgtcaaaactttatgttcactttgctgttgtagatagccagtcaaccagcagtattagtgctgttttcaaagatttaagctctataaaattgggaaattatctaagatcattttccctaagcattgacacatagcttcatctgaggtgagatatggcagctgtttgtatctgcactgtgtctgtctacaaaaagtgaaaaatacagtgtttacttgaaattttaactttgtaactgcaagaattccagttcagccgggcgaggattagtattatttttaactctccgtaagattttcagtaccaccaaattgttttggattttttttctttcctcttcacataccagggttattaaaagtgtgctttctttttacattatattacagttacaaggtaaaattcctcaactgctatttatttattccagcccagtactataaagaacgtttcaccataatgaccctccagagctgggaaacctaccacaagatctaaagttctggctgtccattaacctccaactatggtctttatttcttgtggtaatatgatgtgcctttccttgcctaaatcccttcctggtgtgtatcaacattatttaatgtcttctaattcagtcatttttttataagtatgtctataaacattgaactttaaaaaacttatttatttattccactactgtagcaattgacagattaaaaaaatgtaacttcataatttcttaccataacctcaatgtcttttttaaaaaataaaattaaaaatgaaaagagactcaattgtaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:56650 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA
by
@meso_cacase at
DBCLS
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