LOCUS       NM_016369               3359 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens claudin 18 (CLDN18), transcript variant 1, mRNA.
ACCESSION   NM_016369
VERSION     NM_016369.3  GI:60115826
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3359)
  AUTHORS   Tanaka,M., Shibahara,J., Fukushima,N., Shinozaki,A., Umeda,M.,
            Ishikawa,S., Kokudo,N. and Fukayama,M.
  TITLE     Claudin-18 is an early-stage marker of pancreatic carcinogenesis
  JOURNAL   J. Histochem. Cytochem. 59 (10), 942-952 (2011)
   PUBMED   21832145
  REMARK    GeneRIF: Claudin 18 (a marker for early carcinogenesis) is commonly
            expressed in precursor lesions of pancreatic ductal
            adenocarcinomas. Activation of the protein kinase C pathway might
            be involved in claudin 18 expression associated with
            carcinogenesis.
REFERENCE   2  (bases 1 to 3359)
  AUTHORS   Shinozaki,A., Shibahara,J., Noda,N., Tanaka,M., Aoki,T., Kokudo,N.
            and Fukayama,M.
  TITLE     Claudin-18 in biliary neoplasms. Its significance in the
            classification of intrahepatic cholangiocarcinoma
  JOURNAL   Virchows Arch. 459 (1), 73-80 (2011)
   PUBMED   21607649
  REMARK    GeneRIF: These results suggest that CLDN18 may play an important
            role in biliary carcinogenesis.
REFERENCE   3  (bases 1 to 3359)
  AUTHORS   Ito,T., Kojima,T., Yamaguchi,H., Kyuno,D., Kimura,Y., Imamura,M.,
            Takasawa,A., Murata,M., Tanaka,S., Hirata,K. and Sawada,N.
  TITLE     Transcriptional regulation of claudin-18 via specific protein
            kinase C signaling pathways and modification of DNA methylation in
            human pancreatic cancer cells
  JOURNAL   J. Cell. Biochem. 112 (7), 1761-1772 (2011)
   PUBMED   21381080
  REMARK    GeneRIF: Cldn18 is primarily regulated at the transcriptional level
            via specific protein kinase C signaling pathways and modified by
            DNA methylation
REFERENCE   4  (bases 1 to 3359)
  AUTHORS   Lee,J.H., Kim,K.S., Kim,T.J., Hong,S.P., Song,S.Y., Chung,J.B. and
            Park,S.W.
  TITLE     Immunohistochemical analysis of claudin expression in pancreatic
            cystic tumors
  JOURNAL   Oncol. Rep. 25 (4), 971-978 (2011)
   PUBMED   21206985
  REMARK    GeneRIF: High claudin 18 is associated with intraductal papillary
            mucinous neoplasms of the pancreas.
REFERENCE   5  (bases 1 to 3359)
  AUTHORS   Merikallio,H., Paakko,P., Harju,T. and Soini,Y.
  TITLE     Claudins 10 and 18 are predominantly expressed in lung
            adenocarcinomas and in tumors of nonsmokers
  JOURNAL   Int J Clin Exp Pathol 4 (7), 667-673 (2011)
   PUBMED   22076167
  REMARK    GeneRIF: Claudin 10/18 are most commonly expressed in lung
            adenocarcinomas. Female patients and non-smokers express these
            claudins more commonly suggesting that they may play a part in the
            carcinogenesis of tobacco unrelated carcinoma.
REFERENCE   6  (bases 1 to 3359)
  AUTHORS   Tsukita,S. and Furuse,M.
  TITLE     Claudin-based barrier in simple and stratified cellular sheets
  JOURNAL   Curr. Opin. Cell Biol. 14 (5), 531-536 (2002)
   PUBMED   12231346
  REMARK    Review article
REFERENCE   7  (bases 1 to 3359)
  AUTHORS   Niimi,T., Nagashima,K., Ward,J.M., Minoo,P., Zimonjic,D.B.,
            Popescu,N.C. and Kimura,S.
  TITLE     claudin-18, a novel downstream target gene for the T/EBP/NKX2.1
            homeodomain transcription factor, encodes lung- and
            stomach-specific isoforms through alternative splicing
  JOURNAL   Mol. Cell. Biol. 21 (21), 7380-7390 (2001)
   PUBMED   11585919
REFERENCE   8  (bases 1 to 3359)
  AUTHORS   Tsukita,S., Furuse,M. and Itoh,M.
  TITLE     Multifunctional strands in tight junctions
  JOURNAL   Nat. Rev. Mol. Cell Biol. 2 (4), 285-293 (2001)
   PUBMED   11283726
  REMARK    Review article
REFERENCE   9  (bases 1 to 3359)
  AUTHORS   Heiskala,M., Peterson,P.A. and Yang,Y.
  TITLE     The roles of claudin superfamily proteins in paracellular transport
  JOURNAL   Traffic 2 (2), 93-98 (2001)
   PUBMED   11247307
  REMARK    Review article
REFERENCE   10 (bases 1 to 3359)
  AUTHORS   Kniesel,U. and Wolburg,H.
  TITLE     Tight junctions of the blood-brain barrier
  JOURNAL   Cell. Mol. Neurobiol. 20 (1), 57-76 (2000)
   PUBMED   10690502
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY358479.1, AK098474.1, BM785703.1 and AY102073.1.
            On Feb 23, 2005 this sequence version replaced gi:50345280.
            
            Summary: This gene encodes a member of the claudin family. Claudins
            are integral membrane proteins and components of tight junction
            strands. Tight junction strands serve as a physical barrier to
            prevent solutes and water from passing freely through the
            paracellular space between epithelial or endothelial cell sheets,
            and also play critical roles in maintaining cell polarity and
            signal transductions. This gene is upregulated in patients with
            ulcerative colitis and highly overexpressed in infiltrating ductal
            adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated
            protein kinase/activator protein-1) dependent pathway regulates the
            expression of this gene in gastric cells. Alternatively spliced
            transcript variants encoding different isoforms have been
            identified. [provided by RefSeq, Jun 2010].
            
            Transcript Variant: This variant (1) encodes isoform 1, also known
            as isoform A1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC142708.1, AY358479.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025084, ERS025088 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-282               AY358479.1         28-309
            283-1864            AK098474.1         274-1855
            1865-2307           BM785703.1         143-585
            2308-2868           AK098474.1         2297-2857
            2869-3359           AY102073.1         394-884
FEATURES             Location/Qualifiers
     source          1..3359
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q22.3"
     gene            1..3359
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /note="claudin 18"
                     /db_xref="GeneID:51208"
                     /db_xref="HGNC:2039"
                     /db_xref="MIM:609210"
     exon            1..282
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /inference="alignment:Splign:1.39.8"
     variation       29
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373633928"
     variation       46
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:374810800"
     variation       52
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368088796"
     CDS             63..848
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; surfactant associated 5; surfactant associated
                     protein J; surfactant, pulmonary associated protein J;
                     claudin-18"
                     /codon_start=1
                     /product="claudin-18 isoform 1 precursor"
                     /protein_id="NP_057453.1"
                     /db_xref="GI:7705961"
                     /db_xref="CCDS:CCDS3095.1"
                     /db_xref="GeneID:51208"
                     /db_xref="HGNC:2039"
                     /db_xref="MIM:609210"
                     /translation="

MSTTTCQVVAFLLSILGLAGCIAATGMDMWSTQDLYDNPVTSVFQYEGLWRSCVRQSSGFTECRPYFTILGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTLTSGIMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGWVAGGLTLIGGVMMCIACRGLAPEETNYKAVSYHASGHSVAYKPGGFKASTGFGSNTKNKKIYDGGARTEDEVQSYPSKHDYV

"
     sig_peptide     63..131
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
     misc_feature    81..635
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /note="PMP-22/EMP/MP20/Claudin family; Region:
                     PMP22_Claudin; cl15797"
                     /db_xref="CDD:210197"
     misc_feature    81..143
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P56856.1);
                     transmembrane region"
     misc_feature    303..365
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P56856.1);
                     transmembrane region"
     misc_feature    429..491
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P56856.1);
                     transmembrane region"
     misc_feature    585..647
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P56856.1);
                     transmembrane region"
     variation       108
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373852186"
     variation       137
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:144157849"
     variation       170
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201924367"
     variation       178
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376378448"
     variation       189
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201678067"
     variation       194
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:371070256"
     variation       210
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374173675"
     variation       221
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201156499"
     variation       226
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375872728"
     variation       228
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200350564"
     variation       244
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:374110052"
     variation       245
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376611413"
     variation       257
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:145987155"
     variation       279
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372756802"
     exon            283..447
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /inference="alignment:Splign:1.39.8"
     variation       305
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199724224"
     variation       316
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139920646"
     variation       324
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:114998965"
     variation       326
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:144886047"
     variation       341
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377074436"
     variation       375
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369712344"
     variation       376
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200466463"
     variation       401
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:151166278"
     exon            448..565
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /inference="alignment:Splign:1.39.8"
     variation       457
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149872077"
     variation       459
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:113915562"
     variation       507
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:17204075"
     variation       538
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147117084"
     exon            566..676
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /inference="alignment:Splign:1.39.8"
     variation       590
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376466507"
     variation       611
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201712712"
     variation       627
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201345180"
     variation       639
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:370938675"
     variation       645
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138443095"
     variation       647
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:142534874"
     variation       652
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143363724"
     variation       672
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200763024"
     exon            677..3359
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /inference="alignment:Splign:1.39.8"
     variation       687
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:180927693"
     variation       697
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376205087"
     variation       704
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:16847742"
     variation       751
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:375252888"
     variation       786
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141484279"
     variation       790
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376386414"
     variation       809
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370767483"
     variation       818
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150815158"
     variation       830
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374671741"
     variation       832
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138222227"
     variation       852
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200380058"
     variation       873
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199985015"
     variation       874
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372664208"
     variation       884
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201892247"
     variation       887
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374979503"
     variation       921
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:55923693"
     variation       1061
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:75363623"
     STS             1073..1839
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /standard_name="CLDN18_8037"
                     /db_xref="UniSTS:467609"
     variation       1085
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369925737"
     variation       1140..1141
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace=""
                     /replace="tc"
                     /db_xref="dbSNP:368788455"
     variation       1187
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:186179451"
     variation       1267
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:150050712"
     variation       1296
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:191425190"
     variation       1324
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145407892"
     variation       1355
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373078185"
     variation       1415
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:181450586"
     variation       1426
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:116559189"
     variation       1429
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:76261706"
     variation       1451
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:11707127"
     variation       1537
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11707222"
     variation       1605
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:186923182"
     variation       1648
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372249046"
     variation       1703
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374546679"
     variation       1747
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:11707988"
     variation       1772
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:191710814"
     variation       1802
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148762227"
     variation       1865
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:6804932"
     variation       1885
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:143810887"
     variation       1989
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1141890"
     variation       2001
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:6804883"
     variation       2125
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372621582"
     variation       2195..2196
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:200226240"
     variation       2217
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:74535985"
     variation       2234
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376231633"
     variation       2285
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:9858250"
     variation       2313
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:183153196"
     variation       2434
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146812070"
     variation       2496
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140627353"
     variation       2682
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:76613552"
     variation       2761
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:62280604"
     variation       2776
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:9825593"
     variation       2803
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:187828330"
     variation       2804
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:189567724"
     variation       2869
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:2589258"
     variation       3016
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:182214462"
     STS             3073..3192
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /standard_name="RH18207"
                     /db_xref="UniSTS:2978"
     variation       3077
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:151047753"
     variation       3110
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:187774253"
     variation       3122
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:140941500"
     variation       3141
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376101110"
     variation       3190
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150154800"
     variation       3213
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:115125952"
     variation       3283
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:76203754"
     variation       3290
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:59733755"
     variation       3292
                     /gene="CLDN18"
                     /gene_synonym="SFTA5; SFTPJ"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:73867007"
ORIGIN      

cacaccttcggcagcaggagggcggcagcttctcgcaggcggcagggcgggcggccaggatcatgtccaccaccacatgccaagtggtggcgttcctcctgtccatcctggggctggccggctgcatcgcggccaccgggatggacatgtggagcacccaggacctgtacgacaaccccgtcacctccgtgttccagtacgaagggctctggaggagctgcgtgaggcagagttcaggcttcaccgaatgcaggccctatttcaccatcctgggacttccagccatgctgcaggcagtgcgagccctgatgatcgtaggcatcgtcctgggtgccattggcctcctggtatccatctttgccctgaaatgcatccgcattggcagcatggaggactctgccaaagccaacatgacactgacctccgggatcatgttcattgtctcaggtctttgtgcaattgctggagtgtctgtgtttgccaacatgctggtgactaacttctggatgtccacagctaacatgtacaccggcatgggtgggatggtgcagactgttcagaccaggtacacatttggtgcggctctgttcgtgggctgggtcgctggaggcctcacactaattgggggtgtgatgatgtgcatcgcctgccggggcctggcaccagaagaaaccaactacaaagccgtttcttatcatgcctcaggccacagtgttgcctacaagcctggaggcttcaaggccagcactggctttgggtccaacaccaaaaacaagaagatatacgatggaggtgcccgcacagaggacgaggtacaatcttatccttccaagcacgactatgtgtaatgctctaagacctctcagcacgggcggaagaaactcccggagagctcacccaaaaaacaaggagatcccatctagatttcttcttgcttttgactcacagctggaagttagaaaagcctcgatttcatctttggagaggccaaatggtcttagcctcagtctctgtctctaaatattccaccataaaacagctgagttatttatgaattagaggctatagctcacattttcaatcctctatttctttttttaaatataactttctactctgatgagagaatgtggttttaatctctctctcacattttgatgatttagacagactccccctcttcctcctagtcaataaacccattgatgatctatttcccagcttatccccaagaaaacttttgaaaggaaagagtagacccaaagatgttattttctgctgtttgaattttgtctccccacccccaacttggctagtaataaacacttactgaagaagaagcaataagagaaagatatttgtaatctctccagcccatgatctcggttttcttacactgtgatcttaaaagttaccaaaccaaagtcattttcagtttgaggcaaccaaacctttctactgctgttgacatcttcttattacagcaacaccattctaggagtttcctgagctctccactggagtcctctttctgtcgcgggtcagaaattgtccctagatgaatgagaaaattattttttttaatttaagtcctaaatatagttaaaataaataatgttttagtaaaatgatacactatctctgtgaaatagcctcacccctacatgtggatagaaggaaatgaaaaaataattgctttgacattgtctatatggtactttgtaaagtcatgcttaagtacaaattccatgaaaagctcactgatcctaattctttccctttgaggtctctatggctctgattgtacatgatagtaagtgtaagccatgtaaaaagtaaataatgtctgggcacagtggctcacgcctgtaatcctagcactttgggaggctgaggaggaaggatcacttgagcccagaagttcgagactagcctgggcaacatggagaagccctgtctctacaaaatacagagagaaaaaatcagccagtcatggtggcctacacctgtagtcccagcattccgggaggctgaggtgggaggatcacttgagcccagggaggttggggctgcagtgagccatgatcacaccactgcactccagccaggtgacatagcgagatcctgtctaaaaaaataaaaaataaataatggaacacagcaagtcctaggaagtaggttaaaactaattctttaaaaaaaaaaaaaagttgagcctgaattaaatgtaatgtttccaagtgacaggtatccacatttgcatggttacaagccactgccagttagcagtagcactttcctggcactgtggtcggttttgttttgttttgctttgtttagagacggggtctcactttccaggctggcctcaaactcctgcactcaagcaattcttctaccctggcctcccaagtagctggaattacaggtgtgcgccatcacaactagctggtggtcagttttgttactctgagagctgttcacttctctgaattcacctagagtggttggaccatcagatgtttgggcaaaactgaaagctctttgcaaccacacaccttccctgagcttacatcactgcccttttgagcagaaagtctaaattccttccaagacagtagaattccatcccagtaccaaagccagataggccccctaggaaactgaggtaagagcagtctctaaaaactacccacagcagcattggtgcaggggaacttggccattaggttattatttgagaggaaagtcctcacatcaatagtacatatgaaagtgacctccaaggggattggtgaatactcataaggatcttcaggctgaacagactatgtctggggaaagaacggattatgccccattaaataacaagttgtgttcaagagtcagagcagtgagctcagaggcccttctcactgagacagcaacatttaaaccaaaccagaggaagtatttgtggaactcactgcctcagtttgggtaaaggatgagcagacaagtcaactaaagaaaaaagaaaagcaaggaggagggttgagcaatctagagcatggagtttgttaagtgctctctggatttgagttgaagagcatccatttgagttgaaggccacagggcacaatgagctctcccttctaccaccagaaagtccctggtcaggtctcaggtagtgcggtgtggctcagctgggtttttaattagcgcattctctatccaacatttaattgtttgaaagcctccatatagttagattgtgctttgtaattttgttgttgttgctctatcttattgtatatgcattgagtattaacctgaatgttttgttacttaaatattaaaaacactgttatcctacagtt

//

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:51208 -> Molecular function: GO:0005198 [structural molecule activity] evidence: IEA
            GeneID:51208 -> Molecular function: GO:0042802 [identical protein binding] evidence: ISS
            GeneID:51208 -> Biological process: GO:0016338 [calcium-independent cell-cell adhesion] evidence: ISS
            GeneID:51208 -> Biological process: GO:0034329 [cell junction assembly] evidence: TAS
            GeneID:51208 -> Biological process: GO:0045216 [cell-cell junction organization] evidence: TAS
            GeneID:51208 -> Biological process: GO:0070830 [tight junction assembly] evidence: TAS
            GeneID:51208 -> Cellular component: GO:0005886 [plasma membrane] evidence: IEA
            GeneID:51208 -> Cellular component: GO:0005923 [tight junction] evidence: ISS
            GeneID:51208 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA