2025-05-12 01:36:38, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_013230 2194 bp mRNA linear PRI 07-JUL-2013 DEFINITION Homo sapiens CD24 molecule (CD24), mRNA. ACCESSION NM_013230 XM_001725629 VERSION NM_013230.2 GI:73623396 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2194) AUTHORS de Beca,F.F., Caetano,P., Gerhard,R., Alvarenga,C.A., Gomes,M., Paredes,J. and Schmitt,F. TITLE Cancer stem cells markers CD44, CD24 and ALDH1 in breast cancer special histological types JOURNAL J. Clin. Pathol. 66 (3), 187-191 (2013) PUBMED 23112116 REMARK GeneRIF: Medullary and metaplastic carcinomas are the two types highly associated with high-grade breast carcinomas, basal-like and claudin-low molecular subtypes, and to the breast cancer stem cell phenotype CD44(+)/CD24(-/low)/ALDH1(+). REFERENCE 2 (bases 1 to 2194) AUTHORS Pinato,D.J., Nya,P., Sharma,R. and Mauri,F.A. TITLE CD24: a potential new marker in differentiating malignant mesothelioma from pulmonary adenocarcinoma JOURNAL J. Clin. Pathol. 66 (3), 256-259 (2013) PUBMED 23087328 REMARK GeneRIF: CD24 positivity can accurately discriminate malignant mesothelioma from pulmonary adenocarcinoma. REFERENCE 3 (bases 1 to 2194) AUTHORS Buck,K., Hug,S., Seibold,P., Ferschke,I., Altevogt,P., Sohn,C., Schneeweiss,A., Burwinkel,B., Jager,D., Flesch-Janys,D., Chang-Claude,J. and Marme,F. TITLE CD24 polymorphisms in breast cancer: impact on prognosis and risk JOURNAL Breast Cancer Res. Treat. 137 (3), 927-937 (2013) PUBMED 23314606 REMARK GeneRIF: our current data support an important role of CD24 and its Ala/Val polymorphism in breast cancer with regards to the response to therapy and prognosis. REFERENCE 4 (bases 1 to 2194) AUTHORS Soave,D.F., Oliveira da Costa,J.P., da Silveira,G.G., Ianez,R.C., de Oliveira,L.R., Lourenco,S.V. and Ribeiro-Silva,A. TITLE CD44/CD24 immunophenotypes on clinicopathologic features of salivary glands malignant neoplasms JOURNAL Diagn Pathol 8, 29 (2013) PUBMED 23419168 REMARK GeneRIF: Analysis of CD44/CD24 immunoexpression could give prognostic information associated to clinicopathologic features in salivary glands malignant neoplasms. Publication Status: Online-Only REFERENCE 5 (bases 1 to 2194) AUTHORS Vegfors,J., Petersson,S., Kovacs,A., Polyak,K. and Enerback,C. TITLE The expression of Psoriasin (S100A7) and CD24 is linked and related to the differentiation of mammary epithelial cells JOURNAL PLoS ONE 7 (12), E53119 (2012) PUBMED 23300877 REMARK GeneRIF: expression of psoriasin is linked to the luminal differentiation marker CD24 in mammary epithelial cells. Psoriasin had a role in the shift towards a differentiated CD24(+) phenotype, suggesting a role in the differentiation of mammary epithelial cells. REFERENCE 6 (bases 1 to 2194) AUTHORS Huang,L.R. and Hsu,H.C. TITLE Cloning and expression of CD24 gene in human hepatocellular carcinoma: a potential early tumor marker gene correlates with p53 mutation and tumor differentiation JOURNAL Cancer Res. 55 (20), 4717-4721 (1995) PUBMED 7553654 REFERENCE 7 (bases 1 to 2194) AUTHORS Zarn,J.A., Jackson,D.G., Bell,M.V., Jones,T., Weber,E., Sheer,D., Waibel,R. and Stahel,R.A. TITLE The small cell lung cancer antigen cluster-4 and the leukocyte antigen CD24 are allelic isoforms of the same gene (CD24) on chromosome band 6q21 JOURNAL Cytogenet. Cell Genet. 70 (1-2), 119-125 (1995) PUBMED 7736776 REFERENCE 8 (bases 1 to 2194) AUTHORS Jackson,D., Waibel,R., Weber,E., Bell,J. and Stahel,R.A. TITLE CD24, a signal-transducing molecule expressed on human B cells, is a major surface antigen on small cell lung carcinomas JOURNAL Cancer Res. 52 (19), 5264-5270 (1992) PUBMED 1327504 REFERENCE 9 (bases 1 to 2194) AUTHORS Kay,R., Rosten,P.M. and Humphries,R.K. TITLE CD24, a signal transducer modulating B cell activation responses, is a very short peptide with a glycosyl phosphatidylinositol membrane anchor JOURNAL J. Immunol. 147 (4), 1412-1416 (1991) PUBMED 1831224 REFERENCE 10 (bases 1 to 2194) AUTHORS Fischer,G.F., Majdic,O., Gadd,S. and Knapp,W. TITLE Signal transduction in lymphocytic and myeloid cells via CD24, a new member of phosphoinositol-anchored membrane molecules JOURNAL J. Immunol. 144 (2), 638-641 (1990) PUBMED 2153173 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK125531.1, AK026603.1, AL535013.3 and BG260536.1. On or before Jul 23, 2008 this sequence version replaced gi:169169824, gi:7019342. Summary: This gene encodes a sialoglycoprotein that is expressed on mature granulocytes and in many B cells. The encoded protein is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK026603.1, AK125531.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-229 AK125531.1 192-420 230-1292 AK026603.1 209-1271 1293-1320 AL535013.3 834-861 c 1321-1650 AK026603.1 1300-1629 1651-1680 AL535013.3 474-503 c 1681-2181 AK026603.1 1660-2160 2182-2194 BG260536.1 638-650 FEATURES Location/Qualifiers source 1..2194 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="6" /map="6q21" gene 1..2194 /gene="CD24" /gene_synonym="CD24A" /note="CD24 molecule" /db_xref="GeneID:100133941" /db_xref="HGNC:1645" /db_xref="HPRD:02510" /db_xref="MIM:600074" STS 67..172 /gene="CD24" /gene_synonym="CD24A" /standard_name="GDB:384220" /db_xref="UniSTS:157080" variation complement(103) /gene="CD24" /gene_synonym="CD24A" /replace="g" /replace="t" /db_xref="dbSNP:79788321" STS 104..316 /gene="CD24" /gene_synonym="CD24A" /standard_name="GDB:384235" /db_xref="UniSTS:157082" variation complement(109) /gene="CD24" /gene_synonym="CD24A" /replace="a" /replace="c" /db_xref="dbSNP:367889696" CDS 111..353 /gene="CD24" /gene_synonym="CD24A" /note="CD24 antigen (small cell lung carcinoma cluster 4 antigen); signal transducer CD24" /codon_start=1 /product="signal transducer CD24 precursor" /protein_id="NP_037362.1" /db_xref="GI:7019343" /db_xref="GeneID:100133941" /db_xref="HGNC:1645" /db_xref="HPRD:02510" /db_xref="MIM:600074" /translation="
MGRAMVARLGLGLLLLALLLPTQIYSSETTTGTSSNSSQSTSNSGLAPNPTNATTKAAGGALQSTASLFVVSLSLLHLYS
" sig_peptide 111..188 /gene="CD24" /gene_synonym="CD24A" /inference="COORDINATES: ab initio prediction:SignalP:4.0" mat_peptide 189..350 /gene="CD24" /gene_synonym="CD24A" /product="signal transducer CD24" variation complement(137) /gene="CD24" /gene_synonym="CD24A" /replace="c" /replace="t" /db_xref="dbSNP:17855271" STS 176..1787 /gene="CD24" /gene_synonym="CD24A" /standard_name="GDB:384236" /db_xref="UniSTS:157083" variation complement(224) /gene="CD24" /gene_synonym="CD24A" /replace="g" /replace="t" /db_xref="dbSNP:11545331" variation complement(240) /gene="CD24" /gene_synonym="CD24A" /replace="a" /replace="t" /db_xref="dbSNP:10465460" STS 245..380 /gene="CD24" /gene_synonym="CD24A" /standard_name="GDB:585571" /db_xref="UniSTS:157891" variation 280 /gene="CD24" /gene_synonym="CD24A" /replace="c" /replace="t" /db_xref="dbSNP:52812045" STS 306..447 /gene="CD24" /gene_synonym="CD24A" /standard_name="RH66795" /db_xref="UniSTS:48497" variation complement(383) /gene="CD24" /gene_synonym="CD24A" /replace="c" /replace="t" /db_xref="dbSNP:10465459" variation complement(490) /gene="CD24" /gene_synonym="CD24A" /replace="g" /replace="t" /db_xref="dbSNP:11545329" variation complement(522) /gene="CD24" /gene_synonym="CD24A" /replace="c" /replace="g" /db_xref="dbSNP:58481495" polyA_signal 691..696 /gene="CD24" /gene_synonym="CD24A" variation complement(702) /gene="CD24" /gene_synonym="CD24A" /replace="a" /replace="c" /db_xref="dbSNP:3950479" polyA_site 718 /gene="CD24" /gene_synonym="CD24A" /experiment="experimental evidence, no additional details recorded" variation complement(840) /gene="CD24" /gene_synonym="CD24A" /replace="c" /replace="t" /db_xref="dbSNP:3810761" variation complement(852) /gene="CD24" /gene_synonym="CD24A" /replace="c" /replace="t" /db_xref="dbSNP:4030413" variation complement(860) /gene="CD24" /gene_synonym="CD24A" /replace="a" /replace="t" /db_xref="dbSNP:4030414" variation complement(899) /gene="CD24" /gene_synonym="CD24A" /replace="a" /replace="t" /db_xref="dbSNP:76484892" STS 939..1332 /gene="CD24" /gene_synonym="CD24A" /standard_name="sY3211" /db_xref="UniSTS:515251" variation complement(966) /gene="CD24" /gene_synonym="CD24A" /replace="c" /replace="t" /db_xref="dbSNP:4030415" STS 1009..1148 /gene="CD24" /gene_synonym="CD24A" /standard_name="RH70313" /db_xref="UniSTS:91262" variation complement(1039) /gene="CD24" /gene_synonym="CD24A" /replace="g" /replace="t" /db_xref="dbSNP:6530603" variation complement(1097) /gene="CD24" /gene_synonym="CD24A" /replace="a" /replace="g" /db_xref="dbSNP:6530602" STS 1109..1957 /gene="CD24" /gene_synonym="CD24A" /standard_name="CD24_1314" /db_xref="UniSTS:277071" STS 1164..1466 /gene="CD24" /gene_synonym="CD24A" /standard_name="PMC95860P1" /db_xref="UniSTS:273624" variation complement(1166) /gene="CD24" /gene_synonym="CD24A" /replace="c" /replace="t" /db_xref="dbSNP:1058818" variation complement(1232) /gene="CD24" /gene_synonym="CD24A" /replace="a" /replace="g" /db_xref="dbSNP:1136210" variation complement(1247) /gene="CD24" /gene_synonym="CD24A" /replace="c" /replace="t" /db_xref="dbSNP:6530600" variation complement(1307) /gene="CD24" /gene_synonym="CD24A" /replace="a" /replace="g" /db_xref="dbSNP:35795274" variation complement(1323) /gene="CD24" /gene_synonym="CD24A" /replace="a" /replace="g" /db_xref="dbSNP:1136221" variation complement(1376) /gene="CD24" /gene_synonym="CD24A" /replace="g" /replace="t" /db_xref="dbSNP:10482601" variation complement(1421) /gene="CD24" /gene_synonym="CD24A" /replace="g" /replace="t" /db_xref="dbSNP:112444617" variation complement(1431) /gene="CD24" /gene_synonym="CD24A" /replace="c" /replace="t" /db_xref="dbSNP:6530599" variation complement(1532) /gene="CD24" /gene_synonym="CD24A" /replace="a" /replace="t" /db_xref="dbSNP:6530598" variation complement(1540) /gene="CD24" /gene_synonym="CD24A" /replace="a" /replace="t" /db_xref="dbSNP:6530597" variation complement(1610) /gene="CD24" /gene_synonym="CD24A" /replace="c" /replace="t" /db_xref="dbSNP:6530596" variation complement(1637..1638) /gene="CD24" /gene_synonym="CD24A" /replace="" /replace="tg" /db_xref="dbSNP:3838646" variation complement(1688..1689) /gene="CD24" /gene_synonym="CD24A" /replace="" /replace="a" /db_xref="dbSNP:139989993" variation complement(1689..1691) /gene="CD24" /gene_synonym="CD24A" /replace="" /replace="t" /db_xref="dbSNP:34905207" variation complement(1691) /gene="CD24" /gene_synonym="CD24A" /replace="a" /replace="t" /db_xref="dbSNP:372202510" variation complement(1692) /gene="CD24" /gene_synonym="CD24A" /replace="a" /replace="t" /db_xref="dbSNP:113599647" variation complement(1699) /gene="CD24" /gene_synonym="CD24A" /replace="c" /replace="t" /db_xref="dbSNP:368996716" variation complement(1700) /gene="CD24" /gene_synonym="CD24A" /replace="c" /replace="t" /db_xref="dbSNP:376691735" variation complement(1736) /gene="CD24" /gene_synonym="CD24A" /replace="c" /replace="t" /db_xref="dbSNP:1058881" variation complement(1740) /gene="CD24" /gene_synonym="CD24A" /replace="c" /replace="t" /db_xref="dbSNP:7892940" variation complement(1839) /gene="CD24" /gene_synonym="CD24A" /replace="a" /replace="c" /db_xref="dbSNP:7893001" variation complement(1845) /gene="CD24" /gene_synonym="CD24A" /replace="g" /replace="t" /db_xref="dbSNP:7893092" STS 1871..2146 /gene="CD24" /gene_synonym="CD24A" /standard_name="DYS415" /db_xref="UniSTS:75737" variation complement(1872) /gene="CD24" /gene_synonym="CD24A" /replace="c" /replace="t" /db_xref="dbSNP:10482600" STS 1887..2005 /gene="CD24" /gene_synonym="CD24A" /standard_name="RH15606" /db_xref="UniSTS:90195" variation complement(1935) /gene="CD24" /gene_synonym="CD24A" /replace="a" /replace="c" /db_xref="dbSNP:11545328" variation complement(1976) /gene="CD24" /gene_synonym="CD24A" /replace="c" /replace="g" /db_xref="dbSNP:7892864" variation complement(1988) /gene="CD24" /gene_synonym="CD24A" /replace="a" /replace="g" /db_xref="dbSNP:7892996" variation complement(2006) /gene="CD24" /gene_synonym="CD24A" /replace="a" /replace="c" /db_xref="dbSNP:7892847" variation complement(2041..2042) /gene="CD24" /gene_synonym="CD24A" /replace="" /replace="tt" /db_xref="dbSNP:3840378" variation complement(2042) /gene="CD24" /gene_synonym="CD24A" /replace="" /replace="tt" /db_xref="dbSNP:111913046" variation complement(2087) /gene="CD24" /gene_synonym="CD24A" /replace="g" /replace="t" /db_xref="dbSNP:78478558" variation complement(2147) /gene="CD24" /gene_synonym="CD24A" /replace="g" /replace="t" /db_xref="dbSNP:1059138" polyA_signal 2157..2162 /gene="CD24" /gene_synonym="CD24A" variation complement(2157) /gene="CD24" /gene_synonym="CD24A" /replace="a" /replace="c" /db_xref="dbSNP:113517437" ORIGIN
gggtctcgccggctcgccgcgctccccaccttgcctgcgcccgcccggagccagcggttctccaagcacccagcatcctgctagacgcgccgcgcaccgacggaggggacatgggcagagcaatggtggccaggctcgggctggggctgctgctgctggcactgctcctacccacgcagatttattccagtgaaacaacaactggaacttcaagtaactcctcccagagtacttccaactctgggttggccccaaatccaactaatgccaccaccaaggcggctggtggtgccctgcagtcaacagccagtctcttcgtggtctcactctctcttctgcatctctactcttaagagactcaggccaagaaacgtcttctaaatttccccatcttctaaacccaatccaaatggcgtctggaagtccaatgtggcaaggaaaaacaggtcttcatcgaatctactaattccacaccttttattgacacagaaaatgttgagaatcccaaatttgattgatttgaagaacatgtgagaggtttgactagatgatggatgccaatattaaatctgctggagtttcatgtacaagatgaaggagaggcaacatccaaaatagttaagacatgatttccttgaatgtggcttgagaaatatggacacttaatactaccttgaaaataagaatagaaataaaggatgggattgtggaatggagattcagttttcatttggttcattaattctataaggccataaaacaggtaatataaaaagcttccatgattctatttatatgtacatgagaaggaacttccaggtgttactgtaattcctcaacgtattgtttcgacagcactaatttaatgccgatatactctagatgaagttttacattgttgagctattgctgttctcttgggaactgaactcactttcctcctgaggctttggatttgacattgcatttgaccttttatgtagtaattgacatgtgccagggcaatgatgaatgagaatctacccccagatccaagcatcctgagcaactcttgattatccatattgagtcaaatggtaggcatttcctatcacctgtttccattcaacaagagcactacattcatttagctaaacggattccaaagagtagaattgcattgaccacgactaatttcaaaatgctttttattattattattttttagacagtctcactttgtcgcccaggccggagtgcagtggtgcgatctcagatcagtgtaccatttgcctcccgggctcaagcgattctcctgcctcagcctcccaagtagctgggattacaggcacctgccaccatgcccggctaatttttgtaattttagtagagacagggtttcaccatgttgcccaggctggtttcgaactcctgacctcaggtgatccacccgcctcggcctcccaaagtgctgggattacaggcttgagcccccgcgcccagccatcaaaatgctttttatttctgcatatgttgaatactttttacaatttaaaaaaatgatctgttttgaaggcaaaattgcaaatcttgaaattaagaaggcaaaaatgtaaaggagtcaaaactataaatcaagtatttgggaagtgaagactggaagctaatttgcattaaattcacaaacttttatactctttctgtatatacattttttttctttaaaaaacaactatggatcagaatagccacatttagaacactttttgttatcagtcaatatttttagatagttagaacctggtcctaagcctaaaagtgggcttgattctgcagtaaatcttttacaactgcctcgacacacataaacctttttaaaaatagacactccccgaagtcttttgttcgcatggtcacacactgatgcttagatgttccagtaatctaatatggccacagtagtcttgatgaccaaagtcctttttttccatctttagaaaactacatgggaacaaacagatcgaacagttttgaagctactgtgtgtgtgaatgaacactcttgctttattccagaatgctgtacatctattttggattgtatattgtgtttgtgtatttacgctttgattcatagtaacttcttatggaattgatttgcattgaacacaaactgtaaataaaaagaaatggctgaaagagcaaaaaaaaaaaaa
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ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:100133941 -> Molecular function: GO:0004871 [signal transducer activity] evidence: NAS GeneID:100133941 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:100133941 -> Molecular function: GO:0019901 [protein kinase binding] evidence: IPI GeneID:100133941 -> Molecular function: GO:0030296 [protein tyrosine kinase activator activity] evidence: IDA GeneID:100133941 -> Biological process: GO:0001666 [response to hypoxia] evidence: IEP GeneID:100133941 -> Biological process: GO:0001775 [cell activation] evidence: IDA GeneID:100133941 -> Biological process: GO:0001959 [regulation of cytokine-mediated signaling pathway] evidence: ISS GeneID:100133941 -> Biological process: GO:0002237 [response to molecule of bacterial origin] evidence: ISS GeneID:100133941 -> Biological process: GO:0002768 [immune response-regulating cell surface receptor signaling pathway] evidence: IC GeneID:100133941 -> Biological process: GO:0007204 [elevation of cytosolic calcium ion concentration] evidence: IDA GeneID:100133941 -> Biological process: GO:0007411 [axon guidance] evidence: TAS GeneID:100133941 -> Biological process: GO:0016055 [Wnt receptor signaling pathway] evidence: NAS GeneID:100133941 -> Biological process: GO:0016337 [cell-cell adhesion] evidence: NAS GeneID:100133941 -> Biological process: GO:0016477 [cell migration] evidence: ISS GeneID:100133941 -> Biological process: GO:0030856 [regulation of epithelial cell differentiation] evidence: NAS GeneID:100133941 -> Biological process: GO:0031295 [T cell costimulation] evidence: IDA GeneID:100133941 -> Biological process: GO:0032597 [B cell receptor transport into membrane raft] evidence: IDA GeneID:100133941 -> Biological process: GO:0032600 [chemokine receptor transport out of membrane raft] evidence: ISS GeneID:100133941 -> Biological process: GO:0032913 [negative regulation of transforming growth factor beta3 production] evidence: IMP GeneID:100133941 -> Biological process: GO:0042104 [positive regulation of activated T cell proliferation] evidence: IDA GeneID:100133941 -> Biological process: GO:0042325 [regulation of phosphorylation] evidence: IDA GeneID:100133941 -> Biological process: GO:0042632 [cholesterol homeostasis] evidence: ISS GeneID:100133941 -> Biological process: GO:0043406 [positive regulation of MAP kinase activity] evidence: IDA GeneID:100133941 -> Biological process: GO:0043408 [regulation of MAPK cascade] evidence: IDA GeneID:100133941 -> Biological process: GO:0043627 [response to estrogen stimulus] evidence: IEP GeneID:100133941 -> Biological process: GO:0045730 [respiratory burst] evidence: IDA GeneID:100133941 -> Biological process: GO:0061098 [positive regulation of protein tyrosine kinase activity] evidence: IDA GeneID:100133941 -> Biological process: GO:0072112 [glomerular visceral epithelial cell differentiation] evidence: IMP GeneID:100133941 -> Biological process: GO:0072139 [glomerular parietal epithelial cell differentiation] evidence: IMP GeneID:100133941 -> Biological process: GO:0097193 [intrinsic apoptotic signaling pathway] evidence: NAS GeneID:100133941 -> Biological process: GO:2000768 [positive regulation of nephron tubule epithelial cell differentiation] evidence: IMP GeneID:100133941 -> Cellular component: GO:0005886 [plasma membrane] evidence: IEA GeneID:100133941 -> Cellular component: GO:0009986 [cell surface] evidence: IDA GeneID:100133941 -> Cellular component: GO:0016020 [membrane] evidence: IDA GeneID:100133941 -> Cellular component: GO:0031225 [anchored to membrane] evidence: IEA GeneID:100133941 -> Cellular component: GO:0045121 [membrane raft] evidence: IDA
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