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2025-05-12 01:29:19, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_002273 1802 bp mRNA linear PRI 15-JUL-2013
DEFINITION Homo sapiens keratin 8 (KRT8), transcript variant 2, mRNA.
ACCESSION NM_002273
VERSION NM_002273.3 GI:196162709
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1802)
AUTHORS Fortier,A.M., Asselin,E. and Cadrin,M.
TITLE Keratin 8 and 18 loss in epithelial cancer cells increases
collective cell migration and cisplatin sensitivity through
claudin1 up-regulation
JOURNAL J. Biol. Chem. 288 (16), 11555-11571 (2013)
PUBMED 23449973
REMARK GeneRIF: K8/18 expression can influence the phenotype of epithelial
cancer cells at a transcriptional level and supports the hypothesis
that keratins play an active role in cancer progression.
REFERENCE 2 (bases 1 to 1802)
AUTHORS Mathew,J., Loranger,A., Gilbert,S., Faure,R. and Marceau,N.
TITLE Keratin 8/18 regulation of glucose metabolism in normal versus
cancerous hepatic cells through differential modulation of
hexokinase status and insulin signaling
JOURNAL Exp. Cell Res. 319 (4), 474-486 (2013)
PUBMED 23164509
REMARK GeneRIF: A key K8/K18 regulation of glucose metabolism in normal
and cancerous hepatic cells through differential modulations of
mitochondrial hexokinase status and insulin-mediated signaling.
REFERENCE 3 (bases 1 to 1802)
AUTHORS Snider,N.T., Leonard,J.M., Kwan,R., Griggs,N.W., Rui,L. and
Omary,M.B.
TITLE Glucose and SIRT2 reciprocally mediate the regulation of keratin 8
by lysine acetylation
JOURNAL J. Cell Biol. 200 (3), 241-247 (2013)
PUBMED 23358244
REMARK GeneRIF: K8 acetylation at Lys-207, a highly conserved residue
among type II keratins, is up-regulated upon hyperglycemia and
down-regulated by SIRT2.
REFERENCE 4 (bases 1 to 1802)
AUTHORS Iyer,S.V., Dange,P.P., Alam,H., Sawant,S.S., Ingle,A.D.,
Borges,A.M., Shirsat,N.V., Dalal,S.N. and Vaidya,M.M.
TITLE Understanding the role of keratins 8 and 18 in neoplastic potential
of breast cancer derived cell lines
JOURNAL PLoS ONE 8 (1), E53532 (2013)
PUBMED 23341946
REMARK GeneRIF: These results indicate the role of K8/18 in modulating
invasion in breast cancer.
REFERENCE 5 (bases 1 to 1802)
AUTHORS Wang,Y., Zhu,J.F., Liu,Y.Y. and Han,G.P.
TITLE An analysis of cyclin D1, cytokeratin 5/6 and cytokeratin 8/18
expression in breast papillomas and papillary carcinomas
JOURNAL Diagn Pathol 8, 8 (2013)
PUBMED 23327593
REMARK GeneRIF: Report keratin 8 expression in breast papillomas and
papillary carcinoma.
Publication Status: Online-Only
REFERENCE 6 (bases 1 to 1802)
AUTHORS Ljubimov,A.V., Bartek,J., Couchman,J.R., Kapuller,L.L.,
Veselov,V.V., Kovarik,J., Perevoshchikov,A.G. and Krutovskikh,V.A.
TITLE Distribution of individual components of basement membrane in human
colon polyps and adenocarcinomas as revealed by monoclonal
antibodies
JOURNAL Int. J. Cancer 50 (4), 562-566 (1992)
PUBMED 1371500
REFERENCE 7 (bases 1 to 1802)
AUTHORS Waseem,A., Alexander,C.M., Steel,J.B. and Lane,E.B.
TITLE Embryonic simple epithelial keratins 8 and 18: chromosomal location
emphasizes difference from other keratin pairs
JOURNAL New Biol. 2 (5), 464-478 (1990)
PUBMED 1705144
REFERENCE 8 (bases 1 to 1802)
AUTHORS Yamamoto,R., Kao,L.C., McKnight,C.E. and Strauss,J.F. III.
TITLE Cloning and sequence of cDNA for human placental cytokeratin 8.
Regulation of the mRNA in trophoblastic cells by cAMP
JOURNAL Mol. Endocrinol. 4 (3), 370-374 (1990)
PUBMED 1692965
REFERENCE 9 (bases 1 to 1802)
AUTHORS Smedts,F., Ramaekers,F., Robben,H., Pruszczynski,M., van Muijen,G.,
Lane,B., Leigh,I. and Vooijs,P.
TITLE Changing patterns of keratin expression during progression of
cervical intraepithelial neoplasia
JOURNAL Am. J. Pathol. 136 (3), 657-668 (1990)
PUBMED 1690513
REFERENCE 10 (bases 1 to 1802)
AUTHORS Krauss,S. and Franke,W.W.
TITLE Organization and sequence of the human gene encoding cytokeratin 8
JOURNAL Gene 86 (2), 241-249 (1990)
PUBMED 1691124
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DA825311.1, BC075839.1 and
BE300986.1.
This sequence is a reference standard in the RefSeqGene project.
On Aug 15, 2008 this sequence version replaced gi:68226427.
Summary: This gene is a member of the type II keratin family
clustered on the long arm of chromosome 12. Type I and type II
keratins heteropolymerize to form intermediate-sized filaments in
the cytoplasm of epithelial cells. The product of this gene
typically dimerizes with keratin 18 to form an intermediate
filament in simple single-layered epithelial cells. This protein
plays a role in maintaining cellular structural integrity and also
functions in signal transduction and cellular differentiation.
Mutations in this gene cause cryptogenic cirrhosis. Alternatively
spliced transcript variants have been found for this gene.
[provided by RefSeq, Jan 2012].
Transcript Variant: This variant (2) differs in the 5' UTR, lacks a
portion of the 5' coding region, and initiates translation in a
downstream start codon, compared to variant 1. The encoded isoform
(2) has a shorter N-terminus, compared to isoform 1. Variants 2 and
3 encode the same isoform 2.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK222941.1, BC063513.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025088 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-55 DA825311.1 2-56
56-1758 BC075839.1 1-1703
1759-1802 BE300986.1 1-44 c
FEATURES Location/Qualifiers
source 1..1802
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="12"
/map="12q13"
gene 1..1802
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/note="keratin 8"
/db_xref="GeneID:3856"
/db_xref="HGNC:6446"
/db_xref="HPRD:01015"
/db_xref="MIM:148060"
exon 1..427
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/inference="alignment:Splign:1.39.8"
misc_feature 14..16
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/note="upstream in-frame stop codon"
variation 34
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/replace="a"
/replace="c"
/db_xref="dbSNP:2070910"
variation 82..83
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/replace="c"
/replace="t"
/db_xref="dbSNP:11554493"
variation 100
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/replace="c"
/replace="t"
/db_xref="dbSNP:1065306"
CDS 104..1555
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/note="isoform 2 is encoded by transcript variant 2;
keratin, type II cytoskeletal 8; cytokeratin 8;
cytokeratin-8; type-II keratin Kb8"
/codon_start=1
/product="keratin, type II cytoskeletal 8 isoform 2"
/protein_id="NP_002264.1"
/db_xref="GI:4504919"
/db_xref="CCDS:CCDS8841.1"
/db_xref="GeneID:3856"
/db_xref="HGNC:6446"
/db_xref="HPRD:01015"
/db_xref="MIM:148060"
/translation="
MSIRVTQKSYKVSTSGPRAFSSRSYTSGPGSRISSSSFSRVGSSNFRGGLGGGYGGASGMGGITAVTVNQSLLSPLVLEVDPNIQAVRTQEKEQIKTLNNKFASFIDKVRFLEQQNKMLETKWSLLQQQKTARSNMDNMFESYINNLRRQLETLGQEKLKLEAELGNMQGLVEDFKNKYEDEINKRTEMENEFVLIKKDVDEAYMNKVELESRLEGLTDEINFLRQLYEEEIRELQSQISDTSVVLSMDNSRSLDMDSIIAEVKAQYEDIANRSRAEAESMYQIKYEELQSLAGKHGDDLRRTKTEISEMNRNISRLQAEIEGLKGQRASLEAAIADAEQRGELAIKDANAKLSELEAALQRAKQDMARQLREYQELMNVKLALDIEIATYRKLLEGEESRLESGMQNMSIHTKTTSGYAGGLSSAYGGLTSPGLSYSLGSSFGSGAGSSSFSRTSSSRAVVVKKIETRDGKLVSESSDVLPK
"
misc_feature 104..373
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P05787.7);
Region: Head"
misc_feature 128..130
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by PKC/PRKCE; propagated from
UniProtKB/Swiss-Prot (P05787.7); phosphorylation site"
misc_feature 164..166
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P05787.7); phosphorylation site"
misc_feature 164..166
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 167..169
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 173..175
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by PKC/PRKCE; propagated from
UniProtKB/Swiss-Prot (P05787.7); phosphorylation site"
misc_feature 173..175
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 176..178
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 182..184
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P05787.7); phosphorylation site"
misc_feature 182..184
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 203..205
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P05787.7); phosphorylation site"
misc_feature 203..205
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 209..211
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P05787.7); phosphorylation site"
misc_feature 212..214
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P05787.7); phosphorylation site"
misc_feature 212..214
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 212..214
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 230..232
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P05787.7); phosphorylation site"
misc_feature 230..232
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 323..325
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by MAPK; propagated from
UniProtKB/Swiss-Prot (P05787.7); phosphorylation site"
misc_feature 323..325
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:01496"
misc_feature 323..325
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:02619"
misc_feature 323..325
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:03100"
misc_feature 323..325
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:03479"
misc_feature 371..1282
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/note="Intermediate filament protein; Region: Filament;
pfam00038"
/db_xref="CDD:200948"
misc_feature 374..1297
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P05787.7);
Region: Rod"
misc_feature 374..481
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P05787.7);
Region: Coil 1A"
misc_feature 404..406
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-malonyllysine; propagated from
UniProtKB/Swiss-Prot (P05787.7); modified site"
misc_feature 452..454
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (P05787.7); acetylation site"
misc_feature 482..532
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P05787.7);
Region: Linker 1"
misc_feature 533..808
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P05787.7);
Region: Coil 1B"
misc_feature 713..715
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 722..724
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (P05787.7); acetylation site"
misc_feature 809..880
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P05787.7);
Region: Linker 12"
misc_feature 860..862
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P05787.7); phosphorylation site"
misc_feature 875..877
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P05787.7); phosphorylation site"
misc_feature 881..1297
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P05787.7);
Region: Coil 2"
misc_feature 884..1249
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P05787.7);
Region: Necessary for interaction with PNN"
misc_feature 902..904
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 986..988
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (P05787.7); acetylation site"
misc_feature 1076..1078
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (P05787.7); acetylation site"
misc_feature 1091..1093
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P05787.7); phosphorylation site"
misc_feature 1091..1093
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1127..1129
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="Stutter; propagated from UniProtKB/Swiss-Prot
(P05787.7); other site"
misc_feature 1142..1144
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (P05787.7); acetylation site"
misc_feature 1298..1552
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P05787.7);
Region: Tail"
misc_feature 1301..1303
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P05787.7); phosphorylation site"
misc_feature 1331..1333
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P05787.7); phosphorylation site"
misc_feature 1397..1399
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by CaMK2 and MAPK; propagated from
UniProtKB/Swiss-Prot (P05787.7); phosphorylation site"
misc_feature 1397..1399
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:03479"
misc_feature 1454..1456
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1526..1528
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P05787.7); phosphorylation site"
misc_feature 1526..1528
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1535..1537
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P05787.7); phosphorylation site"
misc_feature 1535..1537
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
variation 155
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/replace="c"
/replace="t"
/db_xref="dbSNP:11554484"
variation 214
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/replace="c"
/replace="t"
/db_xref="dbSNP:11554498"
variation 223
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/replace="a"
/replace="g"
/db_xref="dbSNP:11554488"
variation 354
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/replace="c"
/replace="t"
/db_xref="dbSNP:11554494"
variation 367
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/replace="c"
/replace="t"
/db_xref="dbSNP:11554492"
variation 370
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/replace="c"
/replace="t"
/db_xref="dbSNP:11554497"
exon 428..636
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/inference="alignment:Splign:1.39.8"
exon 637..697
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/inference="alignment:Splign:1.39.8"
exon 698..793
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/inference="alignment:Splign:1.39.8"
exon 794..1084
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/inference="alignment:Splign:1.39.8"
variation 812
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/replace="c"
/replace="t"
/db_xref="dbSNP:11554490"
variation 908
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/replace="g"
/replace="t"
/db_xref="dbSNP:11554280"
variation 939
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/replace="a"
/replace="g"
/db_xref="dbSNP:11554499"
variation 950
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/replace="c"
/replace="t"
/db_xref="dbSNP:11554487"
variation 1027
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/replace="a"
/replace="t"
/db_xref="dbSNP:1065311"
variation 1059
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/replace="c"
/replace="t"
/db_xref="dbSNP:11554486"
variation 1061
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/replace="g"
/replace="t"
/db_xref="dbSNP:11554483"
exon 1085..1305
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/inference="alignment:Splign:1.39.8"
variation 1102
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/replace="c"
/replace="t"
/db_xref="dbSNP:7750"
variation 1178
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/replace="a"
/replace="g"
/db_xref="dbSNP:57626370"
variation 1207
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/replace="c"
/replace="g"
/db_xref="dbSNP:1065362"
exon 1306..1364
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/inference="alignment:Splign:1.39.8"
STS 1310..1716
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/standard_name="GDB:277179"
/db_xref="UniSTS:156366"
exon 1365..1796
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/inference="alignment:Splign:1.39.8"
STS 1368..1785
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/standard_name="KRT8_7288"
/db_xref="UniSTS:466264"
variation 1461
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/replace="g"
/replace="t"
/db_xref="dbSNP:11554491"
STS 1493..1728
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/standard_name="D17S1697"
/db_xref="UniSTS:153850"
STS 1495..1742
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/standard_name="RH79790"
/db_xref="UniSTS:88364"
STS 1509..1634
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/standard_name="RH47175"
/db_xref="UniSTS:57916"
variation 1653
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/replace="a"
/replace="c"
/db_xref="dbSNP:1065710"
polyA_signal 1767..1772
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
polyA_site 1796
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
ORIGIN
aaaaggccattcctgagagctctcctcaccaagaagcagcttctccgctccttctaggatctccgcctggttcggcccgcctgcctccactcctgcctctaccatgtccatcagggtgacccagaagtcctacaaggtgtccacctctggcccccgggccttcagcagccgctcctacacgagtgggcccggttcccgcatcagctcctcgagcttctcccgagtgggcagcagcaactttcgcggtggcctgggcggcggctatggtggggccagcggcatgggaggcatcaccgcagttacggtcaaccagagcctgctgagcccccttgtcctggaggtggaccccaacatccaggccgtgcgcacccaggagaaggagcagatcaagaccctcaacaacaagtttgcctccttcatagacaaggtacggttcctggagcagcagaacaagatgctggagaccaagtggagcctcctgcagcagcagaagacggctcgaagcaacatggacaacatgttcgagagctacatcaacaaccttaggcggcagctggagactctgggccaggagaagctgaagctggaggcggagcttggcaacatgcaggggctggtggaggacttcaagaacaagtatgaggatgagatcaataagcgtacagagatggagaacgaatttgtcctcatcaagaaggatgtggatgaagcttacatgaacaaggtagagctggagtctcgcctggaagggctgaccgacgagatcaacttcctcaggcagctatatgaagaggagatccgggagctgcagtcccagatctcggacacatctgtggtgctgtccatggacaacagccgctccctggacatggacagcatcattgctgaggtcaaggcacagtacgaggatattgccaaccgcagccgggctgaggctgagagcatgtaccagatcaagtatgaggagctgcagagcctggctgggaagcacggggatgacctgcggcgcacaaagactgagatctctgagatgaaccggaacatcagccggctccaggctgagattgagggcctcaaaggccagagggcttccctggaggccgccattgcagatgccgagcagcgtggagagctggccattaaggatgccaacgccaagttgtccgagctggaggccgccctgcagcgggccaagcaggacatggcgcggcagctgcgtgagtaccaggagctgatgaacgtcaagctggccctggacatcgagatcgccacctacaggaagctgctggagggcgaggagagccggctggagtctgggatgcagaacatgagtattcatacgaagaccaccagcggctatgcaggtggtctgagctcggcctatgggggcctcacaagccccggcctcagctacagcctgggctccagctttggctctggcgcgggctccagctccttcagccgcaccagctcctccagggccgtggttgtgaagaagatcgagacacgtgatgggaagctggtgtctgagtcctctgacgtcctgcccaagtgaacagctgcggcagcccctcccagcctacccctcctgcgctgccccagagcctgggaaggaggccgctatgcagggtagcactgggaacaggagacccacctgaggctcagccctagccctcagcccacctggggagtttactacctggggaccccccttgcccatgcctccagctacaaaacaattcaattgctttttttttttggtccaaaataaaacctcagctagctctgccaatgtcaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:3856 -> Molecular function: GO:0005198 [structural molecule activity] evidence: NAS
GeneID:3856 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:3856 -> Molecular function: GO:0097110 [scaffold protein binding] evidence: IPI
GeneID:3856 -> Biological process: GO:0007010 [cytoskeleton organization] evidence: NAS
GeneID:3856 -> Biological process: GO:0019048 [modulation by virus of host morphology or physiology] evidence: IEA
GeneID:3856 -> Cellular component: GO:0005654 [nucleoplasm] evidence: IEA
GeneID:3856 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:3856 -> Cellular component: GO:0005882 [intermediate filament] evidence: IDA
GeneID:3856 -> Cellular component: GO:0005882 [intermediate filament] evidence: NAS
GeneID:3856 -> Cellular component: GO:0016363 [nuclear matrix] evidence: IEA
GeneID:3856 -> Cellular component: GO:0045095 [keratin filament] evidence: IEA
by
@meso_cacase at
DBCLS
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