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2025-05-12 01:41:48, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_002070 2200 bp mRNA linear PRI 05-MAY-2013
DEFINITION Homo sapiens guanine nucleotide binding protein (G protein), alpha
inhibiting activity polypeptide 2 (GNAI2), transcript variant 1,
mRNA.
ACCESSION NM_002070
VERSION NM_002070.2 GI:49574535
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2200)
AUTHORS Chandrasekaran,P., Buckley,M., Moore,V., Wang,L.Q., Kehrl,J.H. and
Venkatesan,S.
TITLE HIV-1 Nef impairs heterotrimeric G-protein signaling by targeting
Galpha(i2) for degradation through ubiquitination
JOURNAL J. Biol. Chem. 287 (49), 41481-41498 (2012)
PUBMED 23071112
REMARK GeneRIF: HIV-1 Nef impairs heterotrimeric G-protein signaling by
targeting Galpha(i2) for degradation through ubiquitination
REFERENCE 2 (bases 1 to 2200)
AUTHORS Zhong,M., Clarke,S., Vo,B.T. and Khan,S.A.
TITLE The essential role of Gialpha2 in prostate cancer cell migration
JOURNAL Mol. Cancer Res. 10 (10), 1380-1388 (2012)
PUBMED 22936789
REMARK GeneRIF: Gialpha2 plays an essential role in OXT and EGF signaling
to induce prostate cancer cell migration.
REFERENCE 3 (bases 1 to 2200)
AUTHORS Luissint,A.C., Federici,C., Guillonneau,F., Chretien,F., Camoin,L.,
Glacial,F., Ganeshamoorthy,K. and Couraud,P.O.
TITLE Guanine nucleotide-binding protein Galphai2: a new partner of
claudin-5 that regulates tight junction integrity in human brain
endothelial cells
JOURNAL J. Cereb. Blood Flow Metab. 32 (5), 860-873 (2012)
PUBMED 22333621
REMARK GeneRIF: Galphai2 as a novel claudin-5 partner required for TJ
integrity in brain endothelial cells.
REFERENCE 4 (bases 1 to 2200)
AUTHORS Dauphinee,S.M., Voelcker,V., Tebaykina,Z., Wong,F. and Karsan,A.
TITLE Heterotrimeric Gi/Go proteins modulate endothelial TLR signaling
independent of the MyD88-dependent pathway
JOURNAL Am. J. Physiol. Heart Circ. Physiol. 301 (6), H2246-H2253 (2011)
PUBMED 21949112
REMARK GeneRIF: Suggest that Gnia2 is involved in endothelial TLR pathways
along a signaling cascade that is distinct from MyD88.
REFERENCE 5 (bases 1 to 2200)
AUTHORS Kremer,K.N., Kumar,A. and Hedin,K.E.
TITLE G alpha i2 and ZAP-70 mediate RasGRP1 membrane localization and
activation of SDF-1-induced T cell functions
JOURNAL J. Immunol. 187 (6), 3177-3185 (2011)
PUBMED 21856938
REMARK GeneRIF: SDF-1 treatment of T cells induced the formation of a
novel molecular signaling complex containing RasGRP1, Galphai2, and
ZAP-70.
REFERENCE 6 (bases 1 to 2200)
AUTHORS Magovcevic,I., Ang,S.L., Seidman,J.G., Tolman,C.J., Neer,E.J. and
Morton,C.C.
TITLE Regional localization of the human G protein alpha i2 (GNAI2) gene:
assignment to 3p21 and a related sequence (GNAI2L) to 12p12-p13
JOURNAL Genomics 12 (1), 125-129 (1992)
PUBMED 1733849
REFERENCE 7 (bases 1 to 2200)
AUTHORS Cormont,M., Le Marchand-Brustel,Y., Van Obberghen,E., Spiegel,A.M.
and Sharp,G.W.
TITLE Identification of G protein alpha-subunits in RINm5F cells and
their selective interaction with galanin receptor
JOURNAL Diabetes 40 (9), 1170-1176 (1991)
PUBMED 1718802
REFERENCE 8 (bases 1 to 2200)
AUTHORS Offermanns,S., Schultz,G. and Rosenthal,W.
TITLE Evidence for opioid receptor-mediated activation of the G-proteins,
Go and Gi2, in membranes of neuroblastoma x glioma (NG108-15)
hybrid cells
JOURNAL J. Biol. Chem. 266 (6), 3365-3368 (1991)
PUBMED 1671672
REFERENCE 9 (bases 1 to 2200)
AUTHORS Lyons,J., Landis,C.A., Harsh,G., Vallar,L., Grunewald,K.,
Feichtinger,H., Duh,Q.Y., Clark,O.H., Kawasaki,E., Bourne,H.R. et
al.
TITLE Two G protein oncogenes in human endocrine tumors
JOURNAL Science 249 (4969), 655-659 (1990)
PUBMED 2116665
REFERENCE 10 (bases 1 to 2200)
AUTHORS Bushfield,M., Murphy,G.J., Lavan,B.E., Parker,P.J., Hruby,V.J.,
Milligan,G. and Houslay,M.D.
TITLE Hormonal regulation of Gi2 alpha-subunit phosphorylation in intact
hepatocytes
JOURNAL Biochem. J. 268 (2), 449-457 (1990)
PUBMED 2114093
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BC012138.1, AK126708.1 and
AK055574.1.
This sequence is a reference standard in the RefSeqGene project.
On Jul 1, 2004 this sequence version replaced gi:4504040.
Summary: The protein encoded by this gene is an alpha subunit of
guanine nucleotide binding proteins (G proteins). The encoded
protein contains the guanine nucleotide binding site and is
involved in the hormonal regulation of adenylate cyclase. Several
transcript variants encoding different isoforms have been detected
for this gene, but the full-length nature of only two are known so
far. [provided by RefSeq, Oct 2009].
Transcript Variant: This variant (1) represents the longer
transcript and encodes the longer isoform (1).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC012138.1, X04828.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025082 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-1351 BC012138.1 40-1390
1352-2191 AK126708.1 3047-3886
2192-2200 AK055574.1 2159-2167
FEATURES Location/Qualifiers
source 1..2200
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="3"
/map="3p21.31"
gene 1..2200
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/note="guanine nucleotide binding protein (G protein),
alpha inhibiting activity polypeptide 2"
/db_xref="GeneID:2771"
/db_xref="HGNC:4385"
/db_xref="HPRD:00764"
/db_xref="MIM:139360"
exon 1..239
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/inference="alignment:Splign:1.39.8"
variation 99
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="c"
/db_xref="dbSNP:34944516"
variation 111
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="c"
/replace="t"
/db_xref="dbSNP:11557220"
CDS 122..1189
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/note="isoform 1 is encoded by transcript variant 1;
guanine nucleotide-binding protein G(i) subunit alpha-2;
guanine nucleotide-binding protein G(i), alpha-2 subunit;
adenylate cyclase-inhibiting G alpha protein; GTP-binding
regulatory protein Gi alpha-2 chain"
/codon_start=1
/product="guanine nucleotide-binding protein G(i) subunit
alpha-2 isoform 1"
/protein_id="NP_002061.1"
/db_xref="GI:4504041"
/db_xref="CCDS:CCDS2813.1"
/db_xref="GeneID:2771"
/db_xref="HGNC:4385"
/db_xref="HPRD:00764"
/db_xref="MIM:139360"
/translation="
MGCTVSAEDKAAAERSKMIDKNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEDGYSEEECRQYRAVVYSNTIQSIMAIVKAMGNLQIDFADPSRADDARQLFALSCTAEEQGVLPDDLSGVIRRLWADHGVQACFGRSREYQLNDSAAYYLNDLERIAQSDYIPTQQDVLRTRVKTTGIVETHFTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSAYDLVLAEDEEMNRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKITHSPLTICFPEYTGANKYDEAASYIQSKFEDLNKRKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKDCGLF
"
misc_feature 158..1180
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/note="G protein alpha subunit; Region: G_alpha;
smart00275"
/db_xref="CDD:128571"
misc_feature 221..1168
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/note="Alpha subunit of G proteins (guanine nucleotide
binding); Region: G-alpha; cd00066"
/db_xref="CDD:206639"
misc_feature order(239..241,254..262,665..667,722..724,731..733,
929..934,938..940,1097..1102)
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/note="GTP/Mg2+ binding site [chemical binding]; other
site"
/db_xref="CDD:206639"
misc_feature 239..262
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/note="G1 box; other site"
/db_xref="CDD:206639"
misc_feature order(242..250,332..334,344..346,356..358,365..367,
374..379,431..433,440..442,569..571,656..658,731..733,
755..757,767..769)
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/note="GoLoco binding site; other site"
/db_xref="CDD:206639"
misc_feature 326..328
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 650..676
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/note="Switch I region; other site"
/db_xref="CDD:206639"
misc_feature 665..667
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/note="G2 box; other site"
/db_xref="CDD:206639"
misc_feature order(668..670,674..676,680..682,713..715,719..721,
731..739,743..745,752..757,761..772)
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/note="beta - gamma complex interaction site [polypeptide
binding]; other site"
/db_xref="CDD:206639"
misc_feature order(674..676,749..751,758..763,770..772)
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/note="adenylyl cyclase interaction site [polypeptide
binding]; other site"
/db_xref="CDD:206639"
misc_feature 722..733
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/note="G3 box; other site"
/db_xref="CDD:206639"
misc_feature 725..775
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/note="Switch II region; other site"
/db_xref="CDD:206639"
misc_feature 929..940
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/note="G4 box; other site"
/db_xref="CDD:206639"
misc_feature order(1073..1108,1112..1123)
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/note="putative receptor binding site; other site"
/db_xref="CDD:206639"
misc_feature 1097..1105
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/note="G5 box; other site"
/db_xref="CDD:206639"
variation 134
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="g"
/replace="t"
/db_xref="dbSNP:143760938"
STS 219..693
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/standard_name="Gnai2"
/db_xref="UniSTS:506940"
exon 240..282
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/inference="alignment:Splign:1.39.8"
variation 246
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="g"
/replace="t"
/db_xref="dbSNP:17851218"
exon 283..424
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/inference="alignment:Splign:1.39.8"
variation 292
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="c"
/replace="t"
/db_xref="dbSNP:138495790"
variation 307
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="g"
/db_xref="dbSNP:762707"
variation 333
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="c"
/db_xref="dbSNP:138213627"
variation 372
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace=""
/replace="t"
/db_xref="dbSNP:67741912"
variation 388
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="c"
/db_xref="dbSNP:1050067"
variation 401
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="g"
/db_xref="dbSNP:183955200"
variation 422
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="g"
/db_xref="dbSNP:149596343"
variation 423
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="c"
/replace="t"
/db_xref="dbSNP:112497464"
exon 425..585
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/inference="alignment:Splign:1.39.8"
variation 457
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="c"
/replace="t"
/db_xref="dbSNP:115287046"
variation 461
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="g"
/db_xref="dbSNP:368004918"
variation 463
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="c"
/replace="t"
/db_xref="dbSNP:146259462"
variation 474
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="g"
/db_xref="dbSNP:371969824"
variation 476
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="g"
/db_xref="dbSNP:150943193"
variation 496
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="c"
/replace="t"
/db_xref="dbSNP:373705209"
variation 498
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="g"
/replace="t"
/db_xref="dbSNP:140764270"
variation 499
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="c"
/replace="t"
/db_xref="dbSNP:142508788"
variation 500
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="g"
/db_xref="dbSNP:200441316"
variation 506
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="c"
/replace="t"
/db_xref="dbSNP:180852414"
variation 559
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="g"
/db_xref="dbSNP:367617983"
variation 568
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="c"
/replace="t"
/db_xref="dbSNP:372356382"
exon 586..714
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/inference="alignment:Splign:1.39.8"
variation 589
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="c"
/replace="t"
/db_xref="dbSNP:367669032"
variation 595
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="c"
/replace="t"
/db_xref="dbSNP:199645073"
variation 656
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:137853226"
variation 657
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="g"
/db_xref="dbSNP:137853227"
variation 658
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="c"
/replace="t"
/db_xref="dbSNP:146768972"
variation 703
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="c"
/replace="t"
/db_xref="dbSNP:149019479"
exon 715..844
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/inference="alignment:Splign:1.39.8"
variation 721
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="t"
/db_xref="dbSNP:137853228"
variation 742
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="c"
/replace="t"
/db_xref="dbSNP:369101180"
variation 745
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="g"
/db_xref="dbSNP:373500446"
variation 775
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="c"
/replace="t"
/db_xref="dbSNP:141848616"
variation 781
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="g"
/db_xref="dbSNP:201958549"
variation 793
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="c"
/replace="t"
/db_xref="dbSNP:143353731"
variation 796
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="c"
/replace="t"
/db_xref="dbSNP:141703681"
variation 797
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="g"
/db_xref="dbSNP:376430681"
variation 835
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="c"
/replace="t"
/db_xref="dbSNP:138946270"
variation 841
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="g"
/db_xref="dbSNP:11557219"
exon 845..998
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/inference="alignment:Splign:1.39.8"
variation 848
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="c"
/replace="t"
/db_xref="dbSNP:12721535"
variation 970
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="c"
/replace="t"
/db_xref="dbSNP:139197363"
variation 971
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="c"
/replace="t"
/db_xref="dbSNP:142945610"
variation 979
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="c"
/db_xref="dbSNP:77643206"
exon 999..1213
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/inference="alignment:Splign:1.39.8"
variation 1000
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="g"
/db_xref="dbSNP:143863348"
variation 1003
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="c"
/db_xref="dbSNP:375264138"
variation 1012
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="c"
/replace="t"
/db_xref="dbSNP:368550765"
variation 1071
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="c"
/replace="g"
/db_xref="dbSNP:372568318"
variation 1087
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="g"
/db_xref="dbSNP:377114196"
variation 1096
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="g"
/replace="t"
/db_xref="dbSNP:147785481"
variation 1103..1104
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace=""
/replace="c"
/db_xref="dbSNP:35326130"
variation 1118
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="g"
/db_xref="dbSNP:139567497"
variation 1144
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="c"
/replace="t"
/db_xref="dbSNP:147937896"
variation 1160..1161
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace=""
/replace="a"
/db_xref="dbSNP:66539739"
variation 1193
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="g"
/replace="t"
/db_xref="dbSNP:200506702"
variation 1207
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="c"
/replace="t"
/db_xref="dbSNP:370947414"
exon 1214..2200
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/inference="alignment:Splign:1.39.8"
STS 1223..1427
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/standard_name="SGC31568"
/db_xref="UniSTS:34294"
variation 1226
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="c"
/replace="t"
/db_xref="dbSNP:76737154"
variation 1272
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="g"
/db_xref="dbSNP:374572856"
variation 1351
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="c"
/db_xref="dbSNP:116369548"
variation 1361
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="g"
/db_xref="dbSNP:137909745"
STS 1366..1557
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/standard_name="GDB:181210"
/db_xref="UniSTS:155178"
variation 1485
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="g"
/replace="t"
/db_xref="dbSNP:113343486"
variation 1486
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="g"
/replace="t"
/db_xref="dbSNP:12813"
variation 1564
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="c"
/replace="t"
/db_xref="dbSNP:115699651"
STS 1579..1705
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/standard_name="G07074"
/db_xref="UniSTS:30223"
variation 1634
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="c"
/replace="t"
/db_xref="dbSNP:183872438"
STS 1645..1721
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/standard_name="M13963"
/db_xref="UniSTS:124916"
variation 1648
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="c"
/db_xref="dbSNP:188823486"
variation 1669
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="g"
/db_xref="dbSNP:192924654"
STS 1701..1881
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/standard_name="BI273769"
/db_xref="UniSTS:248822"
variation 1738
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="g"
/db_xref="dbSNP:3209953"
variation 1739
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="t"
/db_xref="dbSNP:3209954"
variation 1743
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="g"
/db_xref="dbSNP:199935816"
variation 1743
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace=""
/replace="g"
/db_xref="dbSNP:146158517"
variation 1744
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="g"
/db_xref="dbSNP:76340684"
variation 1754
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace=""
/replace="a"
/db_xref="dbSNP:71688940"
variation 1756..1757
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace=""
/replace="a"
/db_xref="dbSNP:71728346"
variation 1802
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="c"
/replace="t"
/db_xref="dbSNP:368304611"
variation 1888
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="g"
/db_xref="dbSNP:12895"
variation 2127..2128
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace=""
/replace="c"
/db_xref="dbSNP:34342188"
variation 2140
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="g"
/db_xref="dbSNP:15488"
polyA_signal 2176..2181
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
polyA_site 2200
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
ORIGIN
actgccgacccgagtgcttcccgcagagggctggtggtgggagcggagtgggtcgggcggggccgagccgggccgtgggccgtgtgggggccgggcggcggccgggccggcggacggcgggatgggctgcaccgtgagcgccgaggacaaggcggcggccgagcgctctaagatgatcgacaagaacctgcgggaggacggagagaaggcggcgcgggaggtgaagttgctgctgttgggtgctggggagtcagggaagagcaccatcgtcaagcagatgaagatcatccacgaggatggctactccgaggaggaatgccggcagtaccgggcggttgtctacagcaacaccatccagtccatcatggccattgtcaaagccatgggcaacctgcagatcgactttgccgacccctccagagcggacgacgccaggcagctatttgcactgtcctgcaccgccgaggagcaaggcgtgctccctgatgacctgtccggcgtcatccggaggctctgggctgaccatggtgtgcaggcctgctttggccgctcaagggaataccagctcaacgactcagctgcctactacctgaacgacctggagcgtattgcacagagtgactacatccccacacagcaagatgtgctacggacccgcgtaaagaccacggggatcgtggagacacacttcaccttcaaggacctacacttcaagatgtttgatgtgggtggtcagcggtctgagcggaagaagtggatccactgctttgagggcgtcacagccatcatcttctgcgtagccttgagcgcctatgacttggtgctagctgaggacgaggagatgaaccgcatgcatgagagcatgaagctattcgatagcatctgcaacaacaagtggttcacagacacgtccatcatcctcttcctcaacaagaaggacctgtttgaggagaagatcacacacagtcccctgaccatctgcttccctgagtacacaggggccaacaaatatgatgaggcagccagctacatccagagtaagtttgaggacctgaataagcgcaaagacaccaaggagatctacacgcacttcacgtgcgccaccgacaccaagaacgtgcagttcgtgtttgacgccgtcaccgatgtcatcatcaagaacaacctgaaggactgcggcctcttctgaggggcagcggggcctggcgggatgggccaccgccgactttgtaccccccaacccctgaggaagatgggggcaagaagatcacgctccccgcctgttcccccgccgcttttctcctctttcctctctttgttctcagctccccctgtcccctcagctccagacgtaggggaggggttgccacaggcctccctgtttgaagcctgcccttgtctgagatgctggtaatggccatggtacccccttctgggcatctgttctggtttttaaccattgtcttgttctgtgatgaggggaggggggcacatgctgagtctcccaaggctgcgtctggaggggcccctgcttctccagcctggacccccagctttgcccaacaccagcccctgccccagcccaagtccaaatgtttacagggagcctcctgcccagtcccccaaccccagccgctcggaggccccaaaggaaaaagcacaagaagcgtgagacgccaccattcctggaaaccacagtccacctgctcattctcgtagctttttaaaaaaatgaaagtaaaggaaaaaaaaaaaactgcaaatctagaaaactttttagagaaaaactatttaaaactgtcagatcctgaccagcaagcccccccccagccccccttccaagtgactccgtgccttgagtgtgtctgcgtgtttacacccgtccctctgctggccgcccccgtgcgagcggcacccctgccctgccctccacagaattgggttccaagggctgttccagacaactgccaacgtcactgagggccctgccccagcggccctggccccaggctctattaacctaaaatgtagctccctagcgctaacctaggaaccgccgctgcctgctggggggccacgcccctcatgcccttgtcccaggcccggggccttcagcgttgaacacttccttgcttttttcacatgttttatggaattgttcacctggtttgaaataataaaatgtagaaagaaaaaaaat
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:2771 -> Molecular function: GO:0001664 [G-protein coupled receptor binding] evidence: IBA
GeneID:2771 -> Molecular function: GO:0003924 [GTPase activity] evidence: IBA
GeneID:2771 -> Molecular function: GO:0004871 [signal transducer activity] evidence: IBA
GeneID:2771 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:2771 -> Molecular function: GO:0005525 [GTP binding] evidence: IEA
GeneID:2771 -> Molecular function: GO:0031683 [G-protein beta/gamma-subunit complex binding] evidence: IBA
GeneID:2771 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
GeneID:2771 -> Biological process: GO:0000186 [activation of MAPKK activity] evidence: IEA
GeneID:2771 -> Biological process: GO:0001973 [adenosine receptor signaling pathway] evidence: IBA
GeneID:2771 -> Biological process: GO:0007049 [cell cycle] evidence: IEA
GeneID:2771 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
GeneID:2771 -> Biological process: GO:0007186 [G-protein coupled receptor signaling pathway] evidence: TAS
GeneID:2771 -> Biological process: GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway] evidence: TAS
GeneID:2771 -> Biological process: GO:0007194 [negative regulation of adenylate cyclase activity] evidence: TAS
GeneID:2771 -> Biological process: GO:0007213 [G-protein coupled acetylcholine receptor signaling pathway] evidence: IEA
GeneID:2771 -> Biological process: GO:0007214 [gamma-aminobutyric acid signaling pathway] evidence: IBA
GeneID:2771 -> Biological process: GO:0007243 [intracellular protein kinase cascade] evidence: IEA
GeneID:2771 -> Biological process: GO:0007268 [synaptic transmission] evidence: TAS
GeneID:2771 -> Biological process: GO:0007584 [response to nutrient] evidence: TAS
GeneID:2771 -> Biological process: GO:0007596 [blood coagulation] evidence: TAS
GeneID:2771 -> Biological process: GO:0008283 [cell proliferation] evidence: IEA
GeneID:2771 -> Biological process: GO:0008284 [positive regulation of cell proliferation] evidence: IEA
GeneID:2771 -> Biological process: GO:0030168 [platelet activation] evidence: TAS
GeneID:2771 -> Biological process: GO:0050805 [negative regulation of synaptic transmission] evidence: IEA
GeneID:2771 -> Biological process: GO:0051301 [cell division] evidence: IMP
GeneID:2771 -> Biological process: GO:0051924 [regulation of calcium ion transport] evidence: IEA
GeneID:2771 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
GeneID:2771 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:2771 -> Cellular component: GO:0005813 [centrosome] evidence: IDA
GeneID:2771 -> Cellular component: GO:0005829 [cytosol] evidence: IEA
GeneID:2771 -> Cellular component: GO:0005834 [heterotrimeric G-protein complex] evidence: IBA
GeneID:2771 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA
GeneID:2771 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
GeneID:2771 -> Cellular component: GO:0030496 [midbody] evidence: IDA
GeneID:2771 -> Cellular component: GO:0031234 [extrinsic to internal side of plasma membrane] evidence: IBA
GeneID:2771 -> Cellular component: GO:0045121 [membrane raft] evidence: IEA
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@meso_cacase at
DBCLS
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