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2025-05-12 01:21:03, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001630 2053 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens annexin A8-like 2 (ANXA8L2), mRNA.
ACCESSION NM_001630 XM_001128973 XR_110466
VERSION NM_001630.2 GI:91807121
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2053)
AUTHORS Karanjawala,Z.E., Illei,P.B., Ashfaq,R., Infante,J.R., Murphy,K.,
Pandey,A., Schulick,R., Winter,J., Sharma,R., Maitra,A., Goggins,M.
and Hruban,R.H.
TITLE New markers of pancreatic cancer identified through differential
gene expression analyses: claudin 18 and annexin A8
JOURNAL Am. J. Surg. Pathol. 32 (2), 188-196 (2008)
PUBMED 18223320
REMARK GeneRIF: Claudin 18 and annexin A8 are frequently highly
overexpressed in infiltrating ductal adenocarcinomas.
REFERENCE 2 (bases 1 to 2053)
AUTHORS Gerke,V., Creutz,C.E. and Moss,S.E.
TITLE Annexins: linking Ca2+ signalling to membrane dynamics
JOURNAL Nat. Rev. Mol. Cell Biol. 6 (6), 449-461 (2005)
PUBMED 15928709
REMARK Review article
REFERENCE 3 (bases 1 to 2053)
AUTHORS Gerke,V. and Moss,S.E.
TITLE Annexins: from structure to function
JOURNAL Physiol. Rev. 82 (2), 331-371 (2002)
PUBMED 11917092
REMARK Review article
REFERENCE 4 (bases 1 to 2053)
AUTHORS Reutelingsperger,C.P., van Heerde,W., Hauptmann,R., Maassen,C., van
Gool,R.G., de Leeuw,P. and Tiebosch,A.
TITLE Differential tissue expression of Annexin VIII in human
JOURNAL FEBS Lett. 349 (1), 120-124 (1994)
PUBMED 8045287
REFERENCE 5 (bases 1 to 2053)
AUTHORS Sarkar,A., Yang,P., Fan,Y.H., Mu,Z.M., Hauptmann,R., Adolf,G.R.,
Stass,S.A. and Chang,K.S.
TITLE Regulation of the expression of annexin VIII in acute promyelocytic
leukemia
JOURNAL Blood 84 (1), 279-286 (1994)
PUBMED 8018923
REFERENCE 6 (bases 1 to 2053)
AUTHORS Chambers,J.A., Gardner,E., Hauptmann,R., Ponder,B.A. and
Mulligan,L.M.
TITLE TaqI polymorphisms at the annexin VIII locus (ANX8)
JOURNAL Hum. Mol. Genet. 1 (7), 550 (1992)
PUBMED 1364010
REFERENCE 7 (bases 1 to 2053)
AUTHORS Hauptmann,R., Maurer-Fogy,I., Krystek,E., Bodo,G., Andree,H. and
Reutelingsperger,C.P.
TITLE Vascular anticoagulant beta: a novel human Ca2+/phospholipid
binding protein that inhibits coagulation and phospholipase A2
activity. Its molecular cloning, expression and comparison with
VAC-alpha
JOURNAL Eur. J. Biochem. 185 (1), 63-71 (1989)
PUBMED 2530088
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DA698972.1, X16662.1,
AL603965.10 and BC008813.2.
On or before Apr 8, 2011 this sequence version replaced
gi:310124568, gi:310124587, gi:4502112.
Summary: This gene encodes a member of the annexin family of
evolutionarily conserved Ca2+ and phospholipid binding proteins.
The encoded protein may function as an an anticoagulant that
indirectly inhibits the thromboplastin-specific complex.
Overexpression of this gene has been associated with acute
myelocytic leukemia. A highly similar duplicated copy of this gene
is found in close proximity on the long arm of chromosome 10.
[provided by RefSeq, Jul 2008].
##Evidence-Data-START##
RNAseq introns :: single sample supports all introns ERS025084,
ERS025088 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-87 DA698972.1 54-140
88-467 X16662.1 2-381
468-513 AL603965.10 66241-66286
514-604 AL603965.10 67050-67140
605-684 AL603965.10 67800-67879
685-744 AL603965.10 68368-68427
745-838 AL603965.10 68974-69067
839-934 AL603965.10 69307-69402
935-993 AL603965.10 71181-71239
994-1116 AL603965.10 71985-72107
1117-1989 AL603965.10 74463-75335
1990-2053 BC008813.2 1821-1884
FEATURES Location/Qualifiers
source 1..2053
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="10"
/map="10q11.22"
gene 1..2053
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/note="annexin A8-like 2"
/db_xref="GeneID:244"
/db_xref="HGNC:23335"
exon 1..213
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/inference="alignment:Splign:1.39.8"
variation 59
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/replace="a"
/replace="c"
/db_xref="dbSNP:138970875"
variation 125
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/replace="a"
/replace="g"
/db_xref="dbSNP:373237589"
variation 164
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/replace="a"
/replace="g"
/db_xref="dbSNP:200231986"
variation 173
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/replace="a"
/replace="g"
/db_xref="dbSNP:202192438"
variation 180
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/replace="c"
/replace="t"
/db_xref="dbSNP:374033985"
variation 181
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/replace="a"
/replace="g"
/db_xref="dbSNP:377110649"
variation 183
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/replace="a"
/replace="g"
/db_xref="dbSNP:370212312"
CDS 193..1176
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/note="annexin A8L2"
/codon_start=1
/product="annexin A8-like protein 2"
/protein_id="NP_001621.2"
/db_xref="GI:91807122"
/db_xref="CCDS:CCDS7216.1"
/db_xref="GeneID:244"
/db_xref="HGNC:23335"
/translation="
MAWWKAWIEQEGVTVKSSSHFNPDPDAETLYKAMKGIGTNEQAIIDVLTKRSNTQRQQIAKSFKAQFGKDLTETLKSELSGKFERLIVALMYPPYRYEAKELHDAMKGLGTKEGVIIEILASRTKNQLREIMKAYEEDYGSSLEEDIQADTSGYLERILVCLLQGSRDDVSSFVDPALALQDAQDLYAAGENIRGTDEMKFITILCTRSATHLLRVFEEYEKIANKSIEDSIKSETHGSLEEAMLTVVKCTQNLHSYFAERLYYAMKGAGTRDGTLIRNIVSRSEIDLNLIKCHFKKMYGKTLSSMIMEDTSGDYKNALLSLVGSDP
"
misc_feature 265..462
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q5VT79.1);
Region: Annexin 1"
misc_feature 268..462
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/note="Annexin; Region: Annexin; pfam00191"
/db_xref="CDD:201070"
misc_feature 481..678
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/note="Annexin; Region: Annexin; pfam00191"
/db_xref="CDD:201070"
misc_feature 481..678
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q5VT79.1);
Region: Annexin 2"
misc_feature 733..933
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q5VT79.1);
Region: Annexin 3"
misc_feature 775..933
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/note="Annexin repeats; Region: ANX; smart00335"
/db_xref="CDD:197661"
misc_feature 961..1158
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/note="Annexin; Region: Annexin; pfam00191"
/db_xref="CDD:201070"
misc_feature 961..1158
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q5VT79.1);
Region: Annexin 4"
exon 214..304
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/inference="alignment:Splign:1.39.8"
variation 286
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/replace="a"
/replace="c"
/db_xref="dbSNP:2670516"
exon 305..399
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/inference="alignment:Splign:1.39.8"
variation 339
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/replace="c"
/replace="g"
/db_xref="dbSNP:2271516"
exon 400..513
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/inference="alignment:Splign:1.39.8"
variation 468
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/replace="c"
/replace="t"
/db_xref="dbSNP:2271517"
exon 514..604
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/inference="alignment:Splign:1.39.8"
variation 542
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/replace="c"
/replace="t"
/db_xref="dbSNP:75086646"
variation 570
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/replace="c"
/replace="t"
/db_xref="dbSNP:149943195"
variation 593
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/replace="c"
/replace="t"
/db_xref="dbSNP:2271519"
variation 593
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/replace="c"
/replace="t"
/db_xref="dbSNP:200976247"
exon 605..684
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/inference="alignment:Splign:1.39.8"
exon 685..744
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/inference="alignment:Splign:1.39.8"
variation 688
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/replace="a"
/replace="g"
/db_xref="dbSNP:144726888"
variation 690
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/replace="a"
/replace="c"
/db_xref="dbSNP:139931538"
variation 692
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/replace="a"
/replace="g"
/db_xref="dbSNP:145448356"
variation 706
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/replace="a"
/replace="c"
/db_xref="dbSNP:147659536"
variation 717
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/replace="c"
/replace="t"
/db_xref="dbSNP:77623921"
variation 718
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/replace="c"
/replace="g"
/db_xref="dbSNP:142447427"
variation 719
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/replace="c"
/replace="t"
/db_xref="dbSNP:151338701"
variation 720
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/replace="a"
/replace="g"
/db_xref="dbSNP:2942949"
variation 722
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/replace="c"
/replace="g"
/db_xref="dbSNP:75345346"
variation 722
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:3013886"
variation 729
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/replace="c"
/replace="t"
/db_xref="dbSNP:375281576"
variation 738
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/replace="c"
/replace="t"
/db_xref="dbSNP:150445437"
variation 739
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/replace="a"
/replace="g"
/db_xref="dbSNP:138417320"
exon 745..838
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/inference="alignment:Splign:1.39.8"
variation 754
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/replace="a"
/replace="g"
/db_xref="dbSNP:374712956"
variation 759
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/replace="a"
/replace="c"
/db_xref="dbSNP:369933973"
variation 768
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/replace="g"
/replace="t"
/db_xref="dbSNP:977788"
variation 768
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/replace="g"
/replace="t"
/db_xref="dbSNP:202221168"
variation 773
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/replace="a"
/replace="g"
/db_xref="dbSNP:373508737"
variation 812
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/replace="c"
/replace="t"
/db_xref="dbSNP:376366484"
variation 813
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/replace="a"
/replace="g"
/db_xref="dbSNP:369623324"
exon 839..934
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/inference="alignment:Splign:1.39.8"
exon 935..993
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/inference="alignment:Splign:1.39.8"
variation 978
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/replace="c"
/replace="g"
/db_xref="dbSNP:4922529"
variation 978
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/replace="c"
/replace="g"
/db_xref="dbSNP:200846894"
exon 994..1116
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/inference="alignment:Splign:1.39.8"
exon 1117..2030
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/inference="alignment:Splign:1.39.8"
variation 1131
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/replace="c"
/replace="t"
/db_xref="dbSNP:2801067"
STS 1189..1531
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/standard_name="SHGC-12720"
/db_xref="UniSTS:23001"
variation 1277
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/replace="g"
/replace="t"
/db_xref="dbSNP:112174058"
variation 1283
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/replace="a"
/replace="g"
/db_xref="dbSNP:2670521"
variation 1694
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/replace="c"
/replace="t"
/db_xref="dbSNP:6776"
variation 1880
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/replace="a"
/replace="g"
/db_xref="dbSNP:8979"
variation 1979..1980
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/replace="c"
/replace="t"
/db_xref="dbSNP:11559194"
variation 1980
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
/replace="a"
/replace="g"
/db_xref="dbSNP:10663"
polyA_signal 2006..2011
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
polyA_site 2024
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
polyA_site 2030
/gene="ANXA8L2"
/gene_synonym="ANXA8; bA145E20.2"
ORIGIN
aaagccaggcagagcccgggggcgagggggcggcaggcaggtgtagcgctgccctgggcgggcttgcacccccacacccaagtgagcggcctgctcactcctcagctgcaggagccagacgtgtggagtcccagcagaggccaacctgtgtctcttcatctccgtgagaaaggtgcccccgaagtgaaagagatggcctggtggaaagcctggattgaacaggagggtgtcacagtgaagagcagctcccacttcaacccagaccctgatgcagagaccctctacaaagccatgaaggggatcgggaccaacgagcaggctatcatcgatgtgctcaccaagagaagcaacacgcagcggcagcagatcgccaagtccttcaaggctcagttcggcaaggacctcactgagaccttgaagtctgagctcagtggcaagtttgagaggctcattgtggcccttatgtacccgccatacagatacgaagccaaggagctgcatgacgccatgaagggcttaggaaccaaggagggtgtcatcattgagatcctggcctctcggaccaagaaccagctgcgggagataatgaaggcgtatgaggaagactatgggtccagcctggaggaggacatccaagcagacacaagtggctacctggagaggatcctggtgtgcctcctgcagggcagcagggatgatgtgagcagctttgtggacccggcactggccctccaagacgcacaggatctgtatgcggcaggcgagaatattcgtgggactgatgagatgaaattcatcaccatcctgtgcacgcgcagtgccactcacctgctgagagtgtttgaagagtatgagaaaattgccaacaagagcattgaggacagcatcaagagtgagacccatggctcactggaggaggccatgctcactgtggtgaaatgcacccaaaacctccacagctactttgcagagagactctactatgccatgaagggagcagggacgcgtgatgggaccctgataagaaacatcgtttcaaggagcgagattgacttaaatcttatcaaatgtcacttcaagaagatgtacggcaagaccctcagcagcatgatcatggaagacaccagcggtgactacaagaacgccctgctgagcctggtgggcagcgacccctgaggcacagaagaacaagagcaaagaccatgaagccagagtctccaggactcctcactcaacctcggccatggacgcaggttgggtgtgaggggggtcccagcctttcggtcttctatttccctatttccagtgctttccagccgggtttctgacccagagggtggaaccggcctggactcctcttcccaacttcctccaggtcatttcccagtgtgagcacaatgccaaccttagtgtttctccagccagacagatgcctcagcatgaagggcttggggacttgtggatcattccttcctccctgcaggagcttcccaagctggtcacagagtctcctgggcacaggttatacagaccccagccccattcccatctactgaaacagggtctccacaagaggggccagggaatatgggtttttaacaagcgtcttacaaaacacttctctatcatgcagccggagagctggctgggagcccttttgttttagaacacacatccttcagcagctgagaaacgaacacgaatccatcccaaccgagatgccattaacattcatctaaaaatgttaggctctaaatggacgaaaaattctctcgccatcttaataacaaaataaactacaaattcctgacccaaggacactgtgttataagaggcgtgggctcccctggtggctgaccaggtcagctgccctggccttgcacccctctgcatgcagcacagaagggtgtgaccatgccctcagcaccactcttgtccccactgaacggcaactgagactgggtacctggagattctgaagtgcctttgctgtggttttcaaaataataaagatttgtattcaactcaaaaaaaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:244 -> Molecular function: GO:0005509 [calcium ion binding] evidence: IEA
GeneID:244 -> Molecular function: GO:0005544 [calcium-dependent phospholipid binding] evidence: IEA
by
@meso_cacase at
DBCLS
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