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2025-05-12 01:28:18, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001306 1318 bp mRNA linear PRI 14-APR-2013 DEFINITION Homo sapiens claudin 3 (CLDN3), mRNA. ACCESSION NM_001306 VERSION NM_001306.3 GI:171541813 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1318) AUTHORS Shang,X., Lin,X., Manorek,G. and Howell,S.B. TITLE Claudin-3 and claudin-4 regulate sensitivity to cisplatin by controlling expression of the copper and cisplatin influx transporter CTR1 JOURNAL Mol. Pharmacol. 83 (1), 85-94 (2013) PUBMED 23053666 REMARK GeneRIF: Claudin-3(CLDN3) and claudin-4 (CLDN4) affect sensitivity of the ovarian cancer cells to the cytotoxic effect of cisplatin by regulating expression of the Cu transporter CTR1. REFERENCE 2 (bases 1 to 1318) AUTHORS Shang,X., Lin,X., Alvarez,E., Manorek,G. and Howell,S.B. TITLE Tight junction proteins claudin-3 and claudin-4 control tumor growth and metastases JOURNAL Neoplasia 14 (10), 974-985 (2012) PUBMED 23097631 REMARK GeneRIF: High CLDN3 expression is associated with tumor growth and metastases. REFERENCE 3 (bases 1 to 1318) AUTHORS Okugawa,T., Oshima,T., Chen,X., Hori,K., Tomita,T., Fukui,H., Watari,J., Matsumoto,T. and Miwa,H. TITLE Down-regulation of claudin-3 is associated with proliferative potential in early gastric cancers JOURNAL Dig. Dis. Sci. 57 (6), 1562-1567 (2012) PUBMED 22290341 REMARK GeneRIF: Dow-regulation of Claudin-3 is associated with the progression of early gastric adenocarcinomas. REFERENCE 4 (bases 1 to 1318) AUTHORS Veshnyakova,A., Piontek,J., Protze,J., Waziri,N., Heise,I. and Krause,G. TITLE Mechanism of Clostridium perfringens enterotoxin interaction with claudin-3/-4 protein suggests structural modifications of the toxin to target specific claudins JOURNAL J. Biol. Chem. 287 (3), 1698-1708 (2012) PUBMED 22128179 REMARK GeneRIF: Mechanism of Clostridium perfringens enterotoxin interaction with claudin-3/-4 protein suggests structural modifications of the toxin to target specific claudins REFERENCE 5 (bases 1 to 1318) AUTHORS Sun,C., Yi,T., Song,X., Li,S., Qi,X., Chen,X., Lin,H., He,X., Li,Z., Wei,Y. and Zhao,X. TITLE Efficient inhibition of ovarian cancer by short hairpin RNA targeting claudin-3 JOURNAL Oncol. Rep. 26 (1), 193-200 (2011) PUBMED 21519794 REMARK GeneRIF: CLDN3 may have a role in ovarian cancer, and its inhibition by short hairpin RNA could be a treatment strategy. REFERENCE 6 (bases 1 to 1318) AUTHORS Itoh,M., Furuse,M., Morita,K., Kubota,K., Saitou,M. and Tsukita,S. TITLE Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins JOURNAL J. Cell Biol. 147 (6), 1351-1363 (1999) PUBMED 10601346 REFERENCE 7 (bases 1 to 1318) AUTHORS Furuse,M., Sasaki,H. and Tsukita,S. TITLE Manner of interaction of heterogeneous claudin species within and between tight junction strands JOURNAL J. Cell Biol. 147 (4), 891-903 (1999) PUBMED 10562289 REFERENCE 8 (bases 1 to 1318) AUTHORS Morita,K., Furuse,M., Fujimoto,K. and Tsukita,S. TITLE Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands JOURNAL Proc. Natl. Acad. Sci. U.S.A. 96 (2), 511-516 (1999) PUBMED 9892664 REFERENCE 9 (bases 1 to 1318) AUTHORS Peacock,R.E., Keen,T.J. and Inglehearn,C.F. TITLE Analysis of a human gene homologous to rat ventral prostate.1 protein JOURNAL Genomics 46 (3), 443-449 (1997) PUBMED 9441748 REFERENCE 10 (bases 1 to 1318) AUTHORS Katahira,J., Sugiyama,H., Inoue,N., Horiguchi,Y., Matsuda,M. and Sugimoto,N. TITLE Clostridium perfringens enterotoxin utilizes two structurally related membrane proteins as functional receptors in vivo JOURNAL J. Biol. Chem. 272 (42), 26652-26658 (1997) PUBMED 9334247 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM764277.1 and BC016056.1. This sequence is a reference standard in the RefSeqGene project. On Apr 1, 2008 this sequence version replaced gi:21536298. Summary: Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intronless gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares aa sequence similarity with a putative apoptosis-related protein found in rat. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-24 BM764277.1 1-24 25-1318 BC016056.1 1-1294 FEATURES Location/Qualifiers source 1..1318 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="7" /map="7q11.23" gene 1..1318 /gene="CLDN3" /gene_synonym="C7orf1; CPE-R2; CPETR2; HRVP1; RVP1" /note="claudin 3" /db_xref="GeneID:1365" /db_xref="HGNC:2045" /db_xref="HPRD:04219" /db_xref="MIM:602910" exon 1..1274 /gene="CLDN3" /gene_synonym="C7orf1; CPE-R2; CPETR2; HRVP1; RVP1" /inference="alignment:Splign:1.39.8" variation 166 /gene="CLDN3" /gene_synonym="C7orf1; CPE-R2; CPETR2; HRVP1; RVP1" /replace="c" /replace="g" /db_xref="dbSNP:7084" CDS 222..884 /gene="CLDN3" /gene_synonym="C7orf1; CPE-R2; CPETR2; HRVP1; RVP1" /note="Clostridium perfringens enterotoxin receptor 2; CPE-receptor 2; ventral prostate.1-like protein; CPE-R 2; ventral prostate.1 protein homolog" /codon_start=1 /product="claudin-3" /protein_id="NP_001297.1" /db_xref="GI:4502875" /db_xref="CCDS:CCDS5559.1" /db_xref="GeneID:1365" /db_xref="HGNC:2045" /db_xref="HPRD:04219" /db_xref="MIM:602910" /translation="
MSMGLEITGTALAVLGWLGTIVCCALPMWRVSAFIGSNIITSQNIWEGLWMNCVVQSTGQMQCKVYDSLLALPQDLQAARALIVVAILLAAFGLLVALVGAQCTNCVQDDTAKAKITIVAGVLFLLAALLTLVPVSWSANTIIRDFYNPVVPEAQKREMGAGLYVGWAAAALQLLGGALLCCSCPPREKKYTATKVVYSAPRSTGPGASLGTGYDRKDYV
"
misc_feature 228..722
/gene="CLDN3"
/gene_synonym="C7orf1; CPE-R2; CPETR2; HRVP1; RVP1"
/note="PMP-22/EMP/MP20/Claudin family; Region:
PMP22_Claudin; cl15797"
/db_xref="CDD:210197"
misc_feature 246..308
/gene="CLDN3"
/gene_synonym="C7orf1; CPE-R2; CPETR2; HRVP1; RVP1"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (O15551.1);
transmembrane region"
misc_feature 462..524
/gene="CLDN3"
/gene_synonym="C7orf1; CPE-R2; CPETR2; HRVP1; RVP1"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (O15551.1);
transmembrane region"
misc_feature 567..629
/gene="CLDN3"
/gene_synonym="C7orf1; CPE-R2; CPETR2; HRVP1; RVP1"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (O15551.1);
transmembrane region"
misc_feature 699..761
/gene="CLDN3"
/gene_synonym="C7orf1; CPE-R2; CPETR2; HRVP1; RVP1"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (O15551.1);
transmembrane region"
misc_feature 795..797
/gene="CLDN3"
/gene_synonym="C7orf1; CPE-R2; CPETR2; HRVP1; RVP1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:03382"
misc_feature 861..863
/gene="CLDN3"
/gene_synonym="C7orf1; CPE-R2; CPETR2; HRVP1; RVP1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 876..881
/gene="CLDN3"
/gene_synonym="C7orf1; CPE-R2; CPETR2; HRVP1; RVP1"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (O15551.1);
Region: Interactions with TJP1, TJP2 and TJP3 (By
similarity)"
misc_feature 876..878
/gene="CLDN3"
/gene_synonym="C7orf1; CPE-R2; CPETR2; HRVP1; RVP1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
STS 222..884
/gene="CLDN3"
/gene_synonym="C7orf1; CPE-R2; CPETR2; HRVP1; RVP1"
/standard_name="Cldn3"
/db_xref="UniSTS:465377"
STS 338..652
/gene="CLDN3"
/gene_synonym="C7orf1; CPE-R2; CPETR2; HRVP1; RVP1"
/standard_name="D7S3297"
/db_xref="UniSTS:254196"
variation 555
/gene="CLDN3"
/gene_synonym="C7orf1; CPE-R2; CPETR2; HRVP1; RVP1"
/replace="g"
/replace="t"
/db_xref="dbSNP:9133"
STS 644..1269
/gene="CLDN3"
/gene_synonym="C7orf1; CPE-R2; CPETR2; HRVP1; RVP1"
/standard_name="CLDN3_194"
/db_xref="UniSTS:277103"
STS 1111..1248
/gene="CLDN3"
/gene_synonym="C7orf1; CPE-R2; CPETR2; HRVP1; RVP1"
/standard_name="RH93920"
/db_xref="UniSTS:84235"
variation 1129
/gene="CLDN3"
/gene_synonym="C7orf1; CPE-R2; CPETR2; HRVP1; RVP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:1129965"
ORIGIN
agcccagtcgccgccgcccgcccacaaagccacaggcaggtgcaggcgcagccgcggcgagagcgtatggagccgagccgttagcgcgcgccgtcggtgagtcagtccgtccgtccgtccgtccgtcggggcgccgcagctcccgccaggcccagcggccccggcccctcgtctccccgcacccggagccacccggtggagcgggccttgccgcggcagccatgtccatgggcctggagatcacgggcaccgcgctggccgtgctgggctggctgggcaccatcgtgtgctgcgcgttgcccatgtggcgcgtgtcggccttcatcggcagcaacatcatcacgtcgcagaacatctgggagggcctgtggatgaactgcgtggtgcagagcaccggccagatgcagtgcaaggtgtacgactcgctgctggcactgccacaggaccttcaggcggcccgcgccctcatcgtggtggccatcctgctggccgccttcgggctgctagtggcgctggtgggcgcccagtgcaccaactgcgtgcaggacgacacggccaaggccaagatcaccatcgtggcaggcgtgctgttccttctcgccgccctgctcaccctcgtgccggtgtcctggtcggccaacaccattatccgggacttctacaaccccgtggtgcccgaggcgcagaagcgcgagatgggcgcgggcctgtacgtgggctgggcggccgcggcgctgcagctgctggggggcgcgctgctctgctgctcgtgtcccccacgcgagaagaagtacacggccaccaaggtcgtctactccgcgccgcgctccaccggcccgggagccagcctgggcacaggctacgaccgcaaggactacgtctaagggacagacgcagggagaccccaccaccaccaccaccaccaacaccaccaccaccaccgcgagctggagcgcgcaccaggccatccagcgtgcagccttgcctcggaggccagcccacccccagaagccaggaagcccccgcgctggactggggcagcttccccagcagccacggctttgcgggccgggcagtcgacttcggggcccagggaccaacctgcatggactgtgaaacctcacccttctggagcacggggcctgggtgaccgccaatacttgaccaccccgtcgagccccatcgggccgctgcccccatgctcgcgctgggcagggaccggcagccctggaaggggcacttgatatttttcaataaaagcctttcgttttgcaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:1365 -> Molecular function: GO:0004888 [transmembrane signaling receptor activity] evidence: TAS
GeneID:1365 -> Molecular function: GO:0005198 [structural molecule activity] evidence: IEA
GeneID:1365 -> Molecular function: GO:0042802 [identical protein binding] evidence: IEA
GeneID:1365 -> Biological process: GO:0001666 [response to hypoxia] evidence: IEP
GeneID:1365 -> Biological process: GO:0016338 [calcium-independent cell-cell adhesion] evidence: IEA
GeneID:1365 -> Cellular component: GO:0005887 [integral to plasma membrane] evidence: TAS
GeneID:1365 -> Cellular component: GO:0005923 [tight junction] evidence: IEA
GeneID:1365 -> Cellular component: GO:0016021 [integral to membrane] evidence: TAS
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