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2025-05-12 01:39:44, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001256293 1901 bp mRNA linear PRI 15-JUL-2013
DEFINITION Homo sapiens keratin 8 (KRT8), transcript variant 3, mRNA.
ACCESSION NM_001256293
VERSION NM_001256293.1 GI:372466576
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1901)
AUTHORS Fortier,A.M., Asselin,E. and Cadrin,M.
TITLE Keratin 8 and 18 loss in epithelial cancer cells increases
collective cell migration and cisplatin sensitivity through
claudin1 up-regulation
JOURNAL J. Biol. Chem. 288 (16), 11555-11571 (2013)
PUBMED 23449973
REMARK GeneRIF: K8/18 expression can influence the phenotype of epithelial
cancer cells at a transcriptional level and supports the hypothesis
that keratins play an active role in cancer progression.
REFERENCE 2 (bases 1 to 1901)
AUTHORS Mathew,J., Loranger,A., Gilbert,S., Faure,R. and Marceau,N.
TITLE Keratin 8/18 regulation of glucose metabolism in normal versus
cancerous hepatic cells through differential modulation of
hexokinase status and insulin signaling
JOURNAL Exp. Cell Res. 319 (4), 474-486 (2013)
PUBMED 23164509
REMARK GeneRIF: A key K8/K18 regulation of glucose metabolism in normal
and cancerous hepatic cells through differential modulations of
mitochondrial hexokinase status and insulin-mediated signaling.
REFERENCE 3 (bases 1 to 1901)
AUTHORS Snider,N.T., Leonard,J.M., Kwan,R., Griggs,N.W., Rui,L. and
Omary,M.B.
TITLE Glucose and SIRT2 reciprocally mediate the regulation of keratin 8
by lysine acetylation
JOURNAL J. Cell Biol. 200 (3), 241-247 (2013)
PUBMED 23358244
REMARK GeneRIF: K8 acetylation at Lys-207, a highly conserved residue
among type II keratins, is up-regulated upon hyperglycemia and
down-regulated by SIRT2.
REFERENCE 4 (bases 1 to 1901)
AUTHORS Iyer,S.V., Dange,P.P., Alam,H., Sawant,S.S., Ingle,A.D.,
Borges,A.M., Shirsat,N.V., Dalal,S.N. and Vaidya,M.M.
TITLE Understanding the role of keratins 8 and 18 in neoplastic potential
of breast cancer derived cell lines
JOURNAL PLoS ONE 8 (1), E53532 (2013)
PUBMED 23341946
REMARK GeneRIF: These results indicate the role of K8/18 in modulating
invasion in breast cancer.
REFERENCE 5 (bases 1 to 1901)
AUTHORS Wang,Y., Zhu,J.F., Liu,Y.Y. and Han,G.P.
TITLE An analysis of cyclin D1, cytokeratin 5/6 and cytokeratin 8/18
expression in breast papillomas and papillary carcinomas
JOURNAL Diagn Pathol 8, 8 (2013)
PUBMED 23327593
REMARK GeneRIF: Report keratin 8 expression in breast papillomas and
papillary carcinoma.
Publication Status: Online-Only
REFERENCE 6 (bases 1 to 1901)
AUTHORS Ljubimov,A.V., Bartek,J., Couchman,J.R., Kapuller,L.L.,
Veselov,V.V., Kovarik,J., Perevoshchikov,A.G. and Krutovskikh,V.A.
TITLE Distribution of individual components of basement membrane in human
colon polyps and adenocarcinomas as revealed by monoclonal
antibodies
JOURNAL Int. J. Cancer 50 (4), 562-566 (1992)
PUBMED 1371500
REFERENCE 7 (bases 1 to 1901)
AUTHORS Waseem,A., Alexander,C.M., Steel,J.B. and Lane,E.B.
TITLE Embryonic simple epithelial keratins 8 and 18: chromosomal location
emphasizes difference from other keratin pairs
JOURNAL New Biol. 2 (5), 464-478 (1990)
PUBMED 1705144
REFERENCE 8 (bases 1 to 1901)
AUTHORS Yamamoto,R., Kao,L.C., McKnight,C.E. and Strauss,J.F. III.
TITLE Cloning and sequence of cDNA for human placental cytokeratin 8.
Regulation of the mRNA in trophoblastic cells by cAMP
JOURNAL Mol. Endocrinol. 4 (3), 370-374 (1990)
PUBMED 1692965
REFERENCE 9 (bases 1 to 1901)
AUTHORS Smedts,F., Ramaekers,F., Robben,H., Pruszczynski,M., van Muijen,G.,
Lane,B., Leigh,I. and Vooijs,P.
TITLE Changing patterns of keratin expression during progression of
cervical intraepithelial neoplasia
JOURNAL Am. J. Pathol. 136 (3), 657-668 (1990)
PUBMED 1690513
REFERENCE 10 (bases 1 to 1901)
AUTHORS Krauss,S. and Franke,W.W.
TITLE Organization and sequence of the human gene encoding cytokeratin 8
JOURNAL Gene 86 (2), 241-249 (1990)
PUBMED 1691124
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DA051933.1, AK290938.1,
AK310257.1, BC063513.1 and CX166336.1.
Summary: This gene is a member of the type II keratin family
clustered on the long arm of chromosome 12. Type I and type II
keratins heteropolymerize to form intermediate-sized filaments in
the cytoplasm of epithelial cells. The product of this gene
typically dimerizes with keratin 18 to form an intermediate
filament in simple single-layered epithelial cells. This protein
plays a role in maintaining cellular structural integrity and also
functions in signal transduction and cellular differentiation.
Mutations in this gene cause cryptogenic cirrhosis. Alternatively
spliced transcript variants have been found for this gene.
[provided by RefSeq, Jan 2012].
Transcript Variant: This variant (3) has an alternate 5' exon,
which results in a downstream AUG start codon, compared to variant
1. The encoded isoform (2) has a shorter N-terminus, compared to
isoform 1. Variants 2 and 3 encode the same isoform 2.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK290938.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025088 [ECO:0000350]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-42 DA051933.1 1-42
43-194 AK290938.1 1-152
195-1781 AK310257.1 101-1687
1782-1887 BC063513.1 1652-1757
1888-1901 CX166336.1 767-780
FEATURES Location/Qualifiers
source 1..1901
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="12"
/map="12q13"
gene 1..1901
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/note="keratin 8"
/db_xref="GeneID:3856"
/db_xref="HGNC:6446"
/db_xref="MIM:148060"
exon 1..152
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/inference="alignment:Splign:1.39.8"
misc_feature 130..132
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/note="upstream in-frame stop codon"
exon 153..522
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/inference="alignment:Splign:1.39.8"
variation 177..178
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/replace="c"
/replace="t"
/db_xref="dbSNP:11554493"
variation 195
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/replace="c"
/replace="t"
/db_xref="dbSNP:1065306"
CDS 199..1650
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/note="isoform 2 is encoded by transcript variant 3;
keratin, type II cytoskeletal 8; cytokeratin 8;
cytokeratin-8; type-II keratin Kb8"
/codon_start=1
/product="keratin, type II cytoskeletal 8 isoform 2"
/protein_id="NP_001243222.1"
/db_xref="GI:372466577"
/db_xref="CCDS:CCDS8841.1"
/db_xref="GeneID:3856"
/db_xref="HGNC:6446"
/db_xref="MIM:148060"
/translation="
MSIRVTQKSYKVSTSGPRAFSSRSYTSGPGSRISSSSFSRVGSSNFRGGLGGGYGGASGMGGITAVTVNQSLLSPLVLEVDPNIQAVRTQEKEQIKTLNNKFASFIDKVRFLEQQNKMLETKWSLLQQQKTARSNMDNMFESYINNLRRQLETLGQEKLKLEAELGNMQGLVEDFKNKYEDEINKRTEMENEFVLIKKDVDEAYMNKVELESRLEGLTDEINFLRQLYEEEIRELQSQISDTSVVLSMDNSRSLDMDSIIAEVKAQYEDIANRSRAEAESMYQIKYEELQSLAGKHGDDLRRTKTEISEMNRNISRLQAEIEGLKGQRASLEAAIADAEQRGELAIKDANAKLSELEAALQRAKQDMARQLREYQELMNVKLALDIEIATYRKLLEGEESRLESGMQNMSIHTKTTSGYAGGLSSAYGGLTSPGLSYSLGSSFGSGAGSSSFSRTSSSRAVVVKKIETRDGKLVSESSDVLPK
"
misc_feature 199..468
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P05787.7);
Region: Head"
misc_feature 223..225
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by PKC/PRKCE; propagated from
UniProtKB/Swiss-Prot (P05787.7); phosphorylation site"
misc_feature 259..261
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P05787.7); phosphorylation site"
misc_feature 268..270
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by PKC/PRKCE; propagated from
UniProtKB/Swiss-Prot (P05787.7); phosphorylation site"
misc_feature 277..279
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P05787.7); phosphorylation site"
misc_feature 298..300
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P05787.7); phosphorylation site"
misc_feature 304..306
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P05787.7); phosphorylation site"
misc_feature 307..309
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P05787.7); phosphorylation site"
misc_feature 325..327
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P05787.7); phosphorylation site"
misc_feature 418..420
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by MAPK; propagated from
UniProtKB/Swiss-Prot (P05787.7); phosphorylation site"
misc_feature 466..1377
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/note="Intermediate filament protein; Region: Filament;
pfam00038"
/db_xref="CDD:200948"
misc_feature 469..1392
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P05787.7);
Region: Rod"
misc_feature 469..576
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P05787.7);
Region: Coil 1A"
misc_feature 499..501
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-malonyllysine; propagated from
UniProtKB/Swiss-Prot (P05787.7); modified site"
misc_feature 547..549
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (P05787.7); acetylation site"
misc_feature 577..627
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P05787.7);
Region: Linker 1"
misc_feature 628..903
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P05787.7);
Region: Coil 1B"
misc_feature 817..819
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (P05787.7); acetylation site"
misc_feature 904..975
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P05787.7);
Region: Linker 12"
misc_feature 955..957
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P05787.7); phosphorylation site"
misc_feature 970..972
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P05787.7); phosphorylation site"
misc_feature 976..1392
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P05787.7);
Region: Coil 2"
misc_feature 979..1344
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P05787.7);
Region: Necessary for interaction with PNN"
misc_feature 1081..1083
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (P05787.7); acetylation site"
misc_feature 1171..1173
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (P05787.7); acetylation site"
misc_feature 1186..1188
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P05787.7); phosphorylation site"
misc_feature 1222..1224
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="Stutter; propagated from UniProtKB/Swiss-Prot
(P05787.7); other site"
misc_feature 1237..1239
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (P05787.7); acetylation site"
misc_feature 1393..1647
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P05787.7);
Region: Tail"
misc_feature 1396..1398
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P05787.7); phosphorylation site"
misc_feature 1426..1428
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P05787.7); phosphorylation site"
misc_feature 1492..1494
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by CaMK2 and MAPK; propagated from
UniProtKB/Swiss-Prot (P05787.7); phosphorylation site"
misc_feature 1621..1623
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P05787.7); phosphorylation site"
misc_feature 1630..1632
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P05787.7); phosphorylation site"
variation 250
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/replace="c"
/replace="t"
/db_xref="dbSNP:11554484"
variation 309
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/replace="c"
/replace="t"
/db_xref="dbSNP:11554498"
variation 318
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/replace="a"
/replace="g"
/db_xref="dbSNP:11554488"
variation 449
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/replace="c"
/replace="t"
/db_xref="dbSNP:11554494"
variation 462
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/replace="c"
/replace="t"
/db_xref="dbSNP:11554492"
variation 465
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/replace="c"
/replace="t"
/db_xref="dbSNP:11554497"
exon 523..731
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/inference="alignment:Splign:1.39.8"
exon 732..792
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/inference="alignment:Splign:1.39.8"
exon 793..888
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/inference="alignment:Splign:1.39.8"
exon 889..1179
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/inference="alignment:Splign:1.39.8"
variation 907
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/replace="c"
/replace="t"
/db_xref="dbSNP:11554490"
variation 1003
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/replace="g"
/replace="t"
/db_xref="dbSNP:11554280"
variation 1034
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/replace="a"
/replace="g"
/db_xref="dbSNP:11554499"
variation 1045
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/replace="c"
/replace="t"
/db_xref="dbSNP:11554487"
variation 1122
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/replace="a"
/replace="t"
/db_xref="dbSNP:1065311"
variation 1154
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/replace="c"
/replace="t"
/db_xref="dbSNP:11554486"
variation 1156
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/replace="g"
/replace="t"
/db_xref="dbSNP:11554483"
exon 1180..1400
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/inference="alignment:Splign:1.39.8"
variation 1197
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/replace="c"
/replace="t"
/db_xref="dbSNP:7750"
variation 1273
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/replace="a"
/replace="g"
/db_xref="dbSNP:57626370"
variation 1302
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/replace="c"
/replace="g"
/db_xref="dbSNP:1065362"
exon 1401..1459
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/inference="alignment:Splign:1.39.8"
STS 1405..1811
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/standard_name="GDB:277179"
/db_xref="UniSTS:156366"
exon 1460..1891
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/inference="alignment:Splign:1.39.8"
STS 1463..1880
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/standard_name="KRT8_7288"
/db_xref="UniSTS:466264"
variation 1556
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/replace="g"
/replace="t"
/db_xref="dbSNP:11554491"
STS 1588..1823
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/standard_name="D17S1697"
/db_xref="UniSTS:153850"
STS 1590..1837
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/standard_name="RH79790"
/db_xref="UniSTS:88364"
STS 1604..1729
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/standard_name="RH47175"
/db_xref="UniSTS:57916"
variation 1748
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
/replace="a"
/replace="c"
/db_xref="dbSNP:1065710"
polyA_signal 1862..1867
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
polyA_site 1891
/gene="KRT8"
/gene_synonym="CARD2; CK-8; CK8; CYK8; K2C8; K8; KO"
ORIGIN
acaggcctttccttacctccctccatgctgtccacttcctctgtaaagctctcaaccctgtccccttccccctctctcctgggaaagagccctcccatgcctagctgctgctcttagggaccctgtggctaggtgcgcggatggaaatccaggatctccgcctggttcggcccgcctgcctccactcctgcctctaccatgtccatcagggtgacccagaagtcctacaaggtgtccacctctggcccccgggccttcagcagccgctcctacacgagtgggcccggttcccgcatcagctcctcgagcttctcccgagtgggcagcagcaactttcgcggtggcctgggcggcggctatggtggggccagcggcatgggaggcatcaccgcagttacggtcaaccagagcctgctgagcccccttgtcctggaggtggaccccaacatccaggccgtgcgcacccaggagaaggagcagatcaagaccctcaacaacaagtttgcctccttcatagacaaggtacggttcctggagcagcagaacaagatgctggagaccaagtggagcctcctgcagcagcagaagacggctcgaagcaacatggacaacatgttcgagagctacatcaacaaccttaggcggcagctggagactctgggccaggagaagctgaagctggaggcggagcttggcaacatgcaggggctggtggaggacttcaagaacaagtatgaggatgagatcaataagcgtacagagatggagaacgaatttgtcctcatcaagaaggatgtggatgaagcttacatgaacaaggtagagctggagtctcgcctggaagggctgaccgacgagatcaacttcctcaggcagctatatgaagaggagatccgggagctgcagtcccagatctcggacacatctgtggtgctgtccatggacaacagccgctccctggacatggacagcatcattgctgaggtcaaggcacagtacgaggatattgccaaccgcagccgggctgaggctgagagcatgtaccagatcaagtatgaggagctgcagagcctggctgggaagcacggggatgacctgcggcgcacaaagactgagatctctgagatgaaccggaacatcagccggctccaggctgagattgagggcctcaaaggccagagggcttccctggaggccgccattgcagatgccgagcagcgtggagagctggccattaaggatgccaacgccaagttgtccgagctggaggccgccctgcagcgggccaagcaggacatggcgcggcagctgcgtgagtaccaggagctgatgaacgtcaagctggccctggacatcgagatcgccacctacaggaagctgctggagggcgaggagagccggctggagtctgggatgcagaacatgagtattcatacgaagaccaccagcggctatgcaggtggtctgagctcggcctatgggggcctcacaagccccggcctcagctacagcctgggctccagctttggctctggcgcgggctccagctccttcagccgcaccagctcctccagggccgtggttgtgaagaagatcgagacacgtgatgggaagctggtgtctgagtcctctgacgtcctgcccaagtgaacagctgcggcagcccctcccagcctacccctcctgcgctgccccagagcctgggaaggaggccgctatgcagggtagcactgggaacaggagacccacctgaggctcagccctagccctcagcccacctggggagtttactacctggggaccccccttgcccatgcctccagctacaaaacaattcaattgctttttttttttggtccaaaataaaacctcagctagctctgccaatgtcaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:3856 -> Molecular function: GO:0005198 [structural molecule activity] evidence: NAS
GeneID:3856 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:3856 -> Molecular function: GO:0097110 [scaffold protein binding] evidence: IPI
GeneID:3856 -> Biological process: GO:0007010 [cytoskeleton organization] evidence: NAS
GeneID:3856 -> Biological process: GO:0019048 [modulation by virus of host morphology or physiology] evidence: IEA
GeneID:3856 -> Cellular component: GO:0005654 [nucleoplasm] evidence: IEA
GeneID:3856 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:3856 -> Cellular component: GO:0005882 [intermediate filament] evidence: IDA
GeneID:3856 -> Cellular component: GO:0005882 [intermediate filament] evidence: NAS
GeneID:3856 -> Cellular component: GO:0016363 [nuclear matrix] evidence: IEA
GeneID:3856 -> Cellular component: GO:0045095 [keratin filament] evidence: IEA
by
@meso_cacase at
DBCLS
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