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2025-05-12 01:56:09, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001204210 2509 bp mRNA linear PRI 28-JAN-2013
DEFINITION Homo sapiens transmembrane protein 235 (TMEM235), transcript
variant 1, mRNA.
ACCESSION NM_001204210
VERSION NM_001204210.1 GI:323633424
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2509)
AUTHORS Maher,G.J., Hilton,E.N., Urquhart,J.E., Davidson,A.E.,
Spencer,H.L., Black,G.C. and Manson,F.D.
TITLE The cataract-associated protein TMEM114, and TMEM235, are
glycosylated transmembrane proteins that are distinct from claudin
family members
JOURNAL FEBS Lett. 585 (14), 2187-2192 (2011)
PUBMED 21689651
REMARK GeneRIF: Data demonstrate that TMEM114, and the closely related
TMEM235, are closely related to members of the voltage dependent
calcium channel gamma subunit family.
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BC042066.1, AC087645.19, BI757060.1 and BI757981.1.
Transcript Variant: This variant (1) represents the longest
transcript and encodes the longest isoform (1).
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-607 BC042066.1 1-607
608-608 AC087645.19 110118-110118 c
609-662 BC042066.1 609-662
663-950 BI757060.1 1-288
951-1322 BI757981.1 221-592
1323-2376 BC042066.1 1104-2157
2377-2377 AC087645.19 101252-101252 c
2378-2509 BC042066.1 2159-2290
FEATURES Location/Qualifiers
source 1..2509
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="17"
/map="17q25.3"
gene 1..2509
/gene="TMEM235"
/gene_synonym="ARGM1"
/note="transmembrane protein 235"
/db_xref="GeneID:283999"
/db_xref="HGNC:27563"
exon 1..32
/gene="TMEM235"
/gene_synonym="ARGM1"
/inference="alignment:Splign:1.39.8"
exon 33..814
/gene="TMEM235"
/gene_synonym="ARGM1"
/inference="alignment:Splign:1.39.8"
variation 102
/gene="TMEM235"
/gene_synonym="ARGM1"
/replace="a"
/replace="t"
/db_xref="dbSNP:373457945"
variation 208
/gene="TMEM235"
/gene_synonym="ARGM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:8068282"
misc_feature 277..279
/gene="TMEM235"
/gene_synonym="ARGM1"
/note="upstream in-frame stop codon"
variation 310
/gene="TMEM235"
/gene_synonym="ARGM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:190468765"
variation 454
/gene="TMEM235"
/gene_synonym="ARGM1"
/replace="a"
/replace="c"
/db_xref="dbSNP:182291436"
variation 566
/gene="TMEM235"
/gene_synonym="ARGM1"
/replace="c"
/replace="g"
/db_xref="dbSNP:28758682"
variation 568
/gene="TMEM235"
/gene_synonym="ARGM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:186093980"
variation 608
/gene="TMEM235"
/gene_synonym="ARGM1"
/replace="a"
/replace="t"
/db_xref="dbSNP:8068943"
CDS 625..1296
/gene="TMEM235"
/gene_synonym="ARGM1"
/note="isoform 1 precursor is encoded by transcript
variant 1; transmembrane protein ENSP00000364084"
/codon_start=1
/product="transmembrane protein 235 isoform 1 precursor"
/protein_id="NP_001191139.1"
/db_xref="GI:323633425"
/db_xref="CCDS:CCDS56046.1"
/db_xref="GeneID:283999"
/db_xref="HGNC:27563"
/translation="
MARLGALLLAAALGALLSFALLAAAVASDYWYILEVADAGNGSAWPGRAELLSSHSGLWRICEGQNGCIPLVDPFASESLDVSTSVQHLILLHRAVIVVLPLSLVLLVCGWICGLLSSLAQSVSLLLFTGCYFLLGSVLTLAGVSIYISYSHLAFAETVQQYGPQHMQGVRVSFGWSMALAWGSCALEAFSGTLLLSAAWTLSLSPPICGHLSPQQVGGRGGD
"
sig_peptide 625..708
/gene="TMEM235"
/gene_synonym="ARGM1"
/inference="non-experimental evidence, no additional
details recorded"
/note="Potential; propagated from UniProtKB/Swiss-Prot
(A6NFC5.3)"
misc_feature 706..1185
/gene="TMEM235"
/gene_synonym="ARGM1"
/note="PMP-22/EMP/MP20/Claudin tight junction; Region:
Claudin_2; pfam13903"
/db_xref="CDD:206074"
mat_peptide 709..1293
/gene="TMEM235"
/gene_synonym="ARGM1"
/product="Transmembrane protein 235"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (A6NFC5.3)"
misc_feature 910..972
/gene="TMEM235"
/gene_synonym="ARGM1"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (A6NFC5.3);
transmembrane region"
misc_feature 1000..1062
/gene="TMEM235"
/gene_synonym="ARGM1"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (A6NFC5.3);
transmembrane region"
misc_feature 1150..1212
/gene="TMEM235"
/gene_synonym="ARGM1"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (A6NFC5.3);
transmembrane region"
exon 815..895
/gene="TMEM235"
/gene_synonym="ARGM1"
/inference="alignment:Splign:1.39.8"
variation 822
/gene="TMEM235"
/gene_synonym="ARGM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:61730389"
variation 831
/gene="TMEM235"
/gene_synonym="ARGM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:375739797"
variation 864
/gene="TMEM235"
/gene_synonym="ARGM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:9894186"
variation 867
/gene="TMEM235"
/gene_synonym="ARGM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:372588474"
variation 869..870
/gene="TMEM235"
/gene_synonym="ARGM1"
/replace=""
/replace="c"
/db_xref="dbSNP:35761771"
exon 896..1033
/gene="TMEM235"
/gene_synonym="ARGM1"
/inference="alignment:Splign:1.39.8"
variation 915
/gene="TMEM235"
/gene_synonym="ARGM1"
/replace="g"
/replace="t"
/db_xref="dbSNP:79885699"
variation 945
/gene="TMEM235"
/gene_synonym="ARGM1"
/replace="a"
/replace="c"
/db_xref="dbSNP:187765975"
variation 951
/gene="TMEM235"
/gene_synonym="ARGM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:11077350"
variation 1011
/gene="TMEM235"
/gene_synonym="ARGM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:75864177"
exon 1034..1283
/gene="TMEM235"
/gene_synonym="ARGM1"
/inference="alignment:Splign:1.39.8"
variation 1076
/gene="TMEM235"
/gene_synonym="ARGM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:373064807"
variation 1077
/gene="TMEM235"
/gene_synonym="ARGM1"
/replace="g"
/replace="t"
/db_xref="dbSNP:375022647"
variation 1091
/gene="TMEM235"
/gene_synonym="ARGM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:200061211"
variation 1092
/gene="TMEM235"
/gene_synonym="ARGM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:61742450"
variation 1098
/gene="TMEM235"
/gene_synonym="ARGM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:377630810"
variation 1132
/gene="TMEM235"
/gene_synonym="ARGM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:200805574"
variation 1146
/gene="TMEM235"
/gene_synonym="ARGM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:61742094"
variation 1176
/gene="TMEM235"
/gene_synonym="ARGM1"
/replace="c"
/replace="g"
/db_xref="dbSNP:370152360"
variation 1192
/gene="TMEM235"
/gene_synonym="ARGM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:370270314"
variation 1197
/gene="TMEM235"
/gene_synonym="ARGM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:373537642"
variation 1227
/gene="TMEM235"
/gene_synonym="ARGM1"
/replace="c"
/replace="g"
/db_xref="dbSNP:373500178"
variation 1246
/gene="TMEM235"
/gene_synonym="ARGM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:201651781"
variation 1259
/gene="TMEM235"
/gene_synonym="ARGM1"
/replace="a"
/replace="t"
/db_xref="dbSNP:56319950"
variation 1265
/gene="TMEM235"
/gene_synonym="ARGM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:201037898"
exon 1284..2491
/gene="TMEM235"
/gene_synonym="ARGM1"
/inference="alignment:Splign:1.39.8"
variation 1307
/gene="TMEM235"
/gene_synonym="ARGM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:370508383"
variation 1335
/gene="TMEM235"
/gene_synonym="ARGM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:374568034"
variation 1378
/gene="TMEM235"
/gene_synonym="ARGM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:367858964"
variation 1385
/gene="TMEM235"
/gene_synonym="ARGM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:140627927"
variation 1411..1412
/gene="TMEM235"
/gene_synonym="ARGM1"
/replace=""
/replace="g"
/db_xref="dbSNP:35192751"
variation 1437
/gene="TMEM235"
/gene_synonym="ARGM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:370495709"
variation 1608
/gene="TMEM235"
/gene_synonym="ARGM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:142931529"
variation 1609
/gene="TMEM235"
/gene_synonym="ARGM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:147426172"
variation 1690
/gene="TMEM235"
/gene_synonym="ARGM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:74880921"
variation 1704
/gene="TMEM235"
/gene_synonym="ARGM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:376042034"
variation 1759
/gene="TMEM235"
/gene_synonym="ARGM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:117797315"
variation 1817
/gene="TMEM235"
/gene_synonym="ARGM1"
/replace="g"
/replace="t"
/db_xref="dbSNP:370651751"
variation 1881..1882
/gene="TMEM235"
/gene_synonym="ARGM1"
/replace=""
/replace="c"
/db_xref="dbSNP:35326777"
variation 1900
/gene="TMEM235"
/gene_synonym="ARGM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:7211670"
variation 1915
/gene="TMEM235"
/gene_synonym="ARGM1"
/replace="c"
/replace="g"
/db_xref="dbSNP:139709610"
variation 1946
/gene="TMEM235"
/gene_synonym="ARGM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:111622843"
variation 1989
/gene="TMEM235"
/gene_synonym="ARGM1"
/replace="c"
/replace="g"
/db_xref="dbSNP:375124947"
variation 2076
/gene="TMEM235"
/gene_synonym="ARGM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:368312826"
variation 2119
/gene="TMEM235"
/gene_synonym="ARGM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:149927936"
variation 2170
/gene="TMEM235"
/gene_synonym="ARGM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:74963848"
variation 2206
/gene="TMEM235"
/gene_synonym="ARGM1"
/replace=""
/replace="g"
/db_xref="dbSNP:35317789"
variation 2318
/gene="TMEM235"
/gene_synonym="ARGM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:182459585"
variation 2377
/gene="TMEM235"
/gene_synonym="ARGM1"
/replace="a"
/replace="c"
/db_xref="dbSNP:7211218"
variation 2486
/gene="TMEM235"
/gene_synonym="ARGM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:368970365"
ORIGIN
gtcctagaaggttctttctgcctgttttctccccccccgcccggctgtggggcccagccactgcacttcaccggatgccgtctggttggtcctcaggactgatacagaccaggaccccagggccagcccgtgccaggctcctatgcttccaggagcacgggtgggtggtcctgctgcctggccggccatcctcctggggtcggtctctggccgatcctccctcctcctctcaagccctgcacagcccggccaggcaggtgcatcttgtttggctgctgaggagccgggggttcagggaaattaaggaacgtgcccagggacccggggccagcccgtggggacgctgggattggagcccaagccccaggttcgccgcgcggctctcgacttcctctcctttcccccaggggcgagctcagcgaccgcagagaggtggggtcgatctccctgcgaccccagggggcccgcgaggccagtgcgcgggcaggagcggggacgtgctcagaagagccgggcgccgccgcgcccgcccgccccccgtcccccggctcccggctccgcgcgccccccgccgcccccggggccctgctacccccgacccgtcccctcccgccggccgcccccatggcccggctgggcgcgctgctcctggccgccgccctgggtgcactgctcagcttcgcgctcctggccgccgcggtcgccagcgactactggtacatcctggaggtggcggacgccggcaatggcagcgcctggcccgggcgcgcagagctgctctcctcgcactcggggctctggcgcatctgcgaagggcagaacggctgcatcccgctggtcgacccttttgccagtgagagcctggacgtctccacctcggtgcagcacctcatcttgctgcaccgtgcagtcattgtggtcctgcccctgagcctggtccttctcgtgtgtggctggatctgcggcctgctcagctccctggcccagagcgtgtctctgctgcttttcaccggctgctacttcctgctggggagtgtcctgacactggcgggggtcagcatctacatcagctactcgcacctggcctttgcggagacggtgcagcagtatggcccgcagcacatgcagggcgtccgcgtcagcttcggctggtccatggccctggcctggggctcctgtgccttggaggcattcagcggaaccctcctgctctcagctgcctggaccctcagcctgagccccccaatctgtggtcatctgagtccccagcaggtgggagggagagggggagactgaggcccagagcggcagagggacccacccagatcgcctggcgccagagagatgccgtctcaggccaaggcctccctggcctctgttctgtccactctccccgaagggcaggcttggtggagaagaggctgatgagagggcccgagagcccctccgatttgcaggggtggggggcaaggagctgagcgatccagatgtacccctctgccccctcccttgttctcaagcctgctaggtacttttcactgagcacttccgggaagagcaggcacccagatctctgtccttgtcctggcacaggctgctgctgcttccggcccccgacccttcctctctgcagcaacccgggggaggtatgccactgtgagtgccctggtgggcacactgagctggcagagatggaagtcccagaagggtggggtgggggtgtcatgccatggtggaggagtttggggccactccttgcctgcctcaaagggggcctggctgagggtgcttcttgaccacaggggccagggctgcctagggtggcgcagggctgggcctggagtttgggatgcaggcttgttaaacacagggcagaaccccaggttgggaggggctcagtttgcaggcccaggcccgcaggcccactgctggtcccagggtgagacaggtgagaagagggatggccagcacacacttgagtccccttgggccacaaaggctggggcacgcccaccgttatgcagatggacagttgaggtggctgcaggagaagggttcccagggcctgtacaacacgtggaagcactaaacggccccgtttggggtttgggggcccttcccgagtcttgagaggtcttgagaggtgtgctggggaaggtggcagcctcttgtagcttgatcttcctccaccctgccccacccctaggtctctttattgattcaaaggttaaggaagctcctgggggcttgagggggtggcacagttttggtggggcccagtgaggacaaatctggggggtgagcagggcctcctcttcctcctggtgtttgaacgtttaccattccatgtgggaccattgtgccaatttgtccttaagtaaatcacttgtgctgtgtgcagtataagccttttatttttcttagaacttttcaaaataggtaacacatgcctgtctgtcataaacagtacaaacgtgagcaaacactgtcaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:283999 -> Molecular function: GO:0005198 [structural molecule activity] evidence: IEA
GeneID:283999 -> Cellular component: GO:0005783 [endoplasmic reticulum] evidence: IEA
GeneID:283999 -> Cellular component: GO:0005923 [tight junction] evidence: IEA
GeneID:283999 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA
GeneID:283999 -> Cellular component: GO:0016324 [apical plasma membrane] evidence: IEA
by
@meso_cacase at
DBCLS
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