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2025-05-12 01:58:13, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001199185 3531 bp mRNA linear PRI 10-JUN-2013
DEFINITION Homo sapiens ATPase, Ca++ transporting, type 2C, member 1 (ATP2C1),
transcript variant 11, mRNA.
ACCESSION NM_001199185
VERSION NM_001199185.1 GI:312836774
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3531)
AUTHORS Li,X., Zhang,D., Xiao,S. and Peng,Z.
TITLE Four novel mutations of the ATP2C1 gene in Chinese patients are
associated with familial benign chronic pemphigus
JOURNAL Clin. Exp. Dermatol. 37 (7), 797-799 (2012)
PUBMED 22607350
REMARK GeneRIF: we report four novel mutations of the ATP2C1 gene involved
in HHD, expanding the repertoire of ATP2C1 mutations underlying
HHD.
REFERENCE 2 (bases 1 to 3531)
AUTHORS Raiko,L., Siljamaki,E., Mahoney,M.G., Putaala,H., Suominen,E.,
Peltonen,J. and Peltonen,S.
TITLE Hailey-Hailey disease and tight junctions: Claudins 1 and 4 are
regulated by ATP2C1 gene encoding Ca(2+) /Mn(2+) ATPase SPCA1 in
cultured keratinocytes
JOURNAL Exp. Dermatol. 21 (8), 586-591 (2012)
PUBMED 22639968
REMARK GeneRIF: SPCA1 regulates the levels of claudins 1 and 4, but does
not affect desmosomal protein levels in keratinocytes.
REFERENCE 3 (bases 1 to 3531)
AUTHORS Gu,S.Q., Bakthavachalu,B., Han,J., Patil,D.P., Otsuka,Y., Guda,C.
and Schoenberg,D.R.
TITLE Identification of the human PMR1 mRNA endonuclease as an
alternatively processed product of the gene for peroxidasin-like
protein
JOURNAL RNA 18 (6), 1186-1196 (2012)
PUBMED 22543864
REMARK GeneRIF: Human PMR1 bound to c-Src, was tyrosine phosphorylated,
sedimented on polysomes, and catalyzed the selective decay of a
PMR1 substrate mRNA. Human PMR1 expression stimulated cell
motility.
REFERENCE 4 (bases 1 to 3531)
AUTHORS Zhang,D., Li,X., Xiao,S., Huo,J., Wang,S. and Zhou,P.
TITLE Detection and comparison of two types of ATP2C1 gene mutations in
Chinese patients with Hailey-Hailey disease
JOURNAL Arch. Dermatol. Res. 304 (2), 163-170 (2012)
PUBMED 22124882
REMARK GeneRIF: genetic polymorphism is associated with Hailey-Hailey
disease in Chinese patients
REFERENCE 5 (bases 1 to 3531)
AUTHORS Zhang,H.Z., Tian,H.Q., Du,D.H., Wang,G.J., Yan,X.X., Liu,H.,
Zhou,G.Z., Fu,X.A., Yu,Y.X., Yu,G.Q., Liu,H.X. and Zhang,F.R.
TITLE Analysis of ATP2C1 gene mutations in Chinese patients with
Hailey-Hailey disease
JOURNAL Clin. Exp. Dermatol. 37 (2), 190-193 (2012)
PUBMED 21883398
REMARK GeneRIF: we report five novel mutations and four recurrent
mutations of the ATP2C1 gene in Chinese patients. This further
expands the mutation spectrum in Hailey-Hailey Disease.
REFERENCE 6 (bases 1 to 3531)
AUTHORS Ton,V.K., Mandal,D., Vahadji,C. and Rao,R.
TITLE Functional expression in yeast of the human secretory pathway
Ca(2+), Mn(2+)-ATPase defective in Hailey-Hailey disease
JOURNAL J. Biol. Chem. 277 (8), 6422-6427 (2002)
PUBMED 11741891
REFERENCE 7 (bases 1 to 3531)
AUTHORS Dobson-Stone,C., Fairclough,R., Dunne,E., Brown,J., Dissanayake,M.,
Munro,C.S., Strachan,T., Burge,S., Sudbrak,R., Monaco,A.P. and
Hovnanian,A.
TITLE Hailey-Hailey disease: molecular and clinical characterization of
novel mutations in the ATP2C1 gene
JOURNAL J. Invest. Dermatol. 118 (2), 338-343 (2002)
PUBMED 11841554
REMARK GeneRIF: failed to yield any clear correlation between the nature
of the mutation and clinical features of Hailey-Hailey disease.
REFERENCE 8 (bases 1 to 3531)
AUTHORS Sudbrak,R., Brown,J., Dobson-Stone,C., Carter,S., Ramser,J.,
White,J., Healy,E., Dissanayake,M., Larregue,M., Perrussel,M.,
Lehrach,H., Munro,C.S., Strachan,T., Burge,S., Hovnanian,A. and
Monaco,A.P.
TITLE Hailey-Hailey disease is caused by mutations in ATP2C1 encoding a
novel Ca(2+) pump
JOURNAL Hum. Mol. Genet. 9 (7), 1131-1140 (2000)
PUBMED 10767338
REFERENCE 9 (bases 1 to 3531)
AUTHORS Hu,Z., Bonifas,J.M., Beech,J., Bench,G., Shigihara,T., Ogawa,H.,
Ikeda,S., Mauro,T. and Epstein,E.H. Jr.
TITLE Mutations in ATP2C1, encoding a calcium pump, cause Hailey-Hailey
disease
JOURNAL Nat. Genet. 24 (1), 61-65 (2000)
PUBMED 10615129
REFERENCE 10 (bases 1 to 3531)
AUTHORS Ikeda,S., Welsh,E.A., Peluso,A.M., Leyden,W., Duvic,M.,
Woodley,D.T. and Epstein,E.H. Jr.
TITLE Localization of the gene whose mutations underlie Hailey-Hailey
disease to chromosome 3q
JOURNAL Hum. Mol. Genet. 3 (7), 1147-1150 (1994)
PUBMED 7981684
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DC343471.1, AF181121.1,
BC028139.1 and AF225981.1.
Summary: The protein encoded by this gene belongs to the family of
P-type cation transport ATPases. This magnesium-dependent enzyme
catalyzes the hydrolysis of ATP coupled with the transport of
calcium ions. Defects in this gene cause Hailey-Hailey disease, an
autosomal dominant disorder. Alternatively spliced transcript
variants encoding different isoforms have been identified.
[provided by RefSeq, Aug 2011].
Transcript Variant: This variant (11) has an alternate 5' exon and
lacks an internal exon in the 3' region, as compared to variant 6.
The resulting isoform (1c) has shorter and distinct N- and
C-termini, as compared to isoform 2a. Variants 3 and 11 encode the
same isoform 1c.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AF181121.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025082, ERS025083 [ECO:0000348]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-87 DC343471.1 1-87
88-505 AF181121.1 1-418
506-3484 BC028139.1 376-3354
3485-3531 AF225981.1 3412-3458
FEATURES Location/Qualifiers
source 1..3531
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="3"
/map="3q22.1"
gene 1..3531
/gene="ATP2C1"
/gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
/note="ATPase, Ca++ transporting, type 2C, member 1"
/db_xref="GeneID:27032"
/db_xref="HGNC:13211"
/db_xref="MIM:604384"
exon 1..328
/gene="ATP2C1"
/gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
/inference="alignment:Splign:1.39.8"
misc_feature 290..292
/gene="ATP2C1"
/gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
/note="upstream in-frame stop codon"
CDS 323..2989
/gene="ATP2C1"
/gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
/EC_number="3.6.3.8"
/note="isoform 1c is encoded by transcript variant 11;
secretory pathway Ca2+/Mn2+ ATPase 1; ATPase,
Ca(2+)-sequestering; ATPase 2C1; HUSSY-28;
calcium-transporting ATPase type 2C member 1;
ATP-dependent Ca(2+) pump PMR1"
/codon_start=1
/product="calcium-transporting ATPase type 2C member 1
isoform 1c"
/protein_id="NP_001186114.1"
/db_xref="GI:312836775"
/db_xref="CCDS:CCDS46913.1"
/db_xref="GeneID:27032"
/db_xref="HGNC:13211"
/db_xref="MIM:604384"
/translation="
MKVARFQKIPNGENETMIPVLTSKKASELPVSEVASILQADLQNGLNKCEVSHRRAFHGWNEFDISEDEPLWKKYISQFKNPLIMLLLASAVISVLMHQFDDAVSITVAILIVVTVAFVQEYRSEKSLEELSKLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDLSIDESSLTGETTPCSKVTAPQPAATNGDLASRSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGIIGIIMLVGWLLGKDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTSDGLHAEVTGVGYNQFGEVIVDGDVVHGFYNPAVSRIVEAGCVCNDAVIRNNTLMGKPTEGALIALAMKMGLDGLQQDYIRKAEYPFSSEQKWMAVKCVHRTQQDRPEICFMKGAYEQVIKYCTTYQSKGQTLTLTQQQRDVYQQEKARMGSAGLRVLALASGPELGQLTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSKTSQSVSGEEIDAMDVQQLSQIVPKVAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLISLATLMNFPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRKPPRNWKDSILTKNLILKILVSSIIIVCGTLFVFWRELRDNVITPRDTTMTFTCFVFFDMFNALSSRSQTKSVFEIGLCSNRMFCYAVLGSIMGQLLVIYFPPLQKVFQTESLSILGLALGEEWTAAG
"
misc_feature 389..2956
/gene="ATP2C1"
/gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
/note="golgi membrane calcium-translocating P-type ATPase;
Region: ATPase-IIA2_Ca; TIGR01522"
/db_xref="CDD:130585"
misc_feature 398..604
/gene="ATP2C1"
/gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
/note="Cation transporter/ATPase, N-terminus; Region:
Cation_ATPase_N; pfam00690"
/db_xref="CDD:201397"
misc_feature 533..595
/gene="ATP2C1"
/gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P98194.3);
transmembrane region"
misc_feature 635..691
/gene="ATP2C1"
/gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P98194.3);
transmembrane region"
misc_feature 680..1342
/gene="ATP2C1"
/gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
/note="E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122"
/db_xref="CDD:201018"
misc_feature 1109..1168
/gene="ATP2C1"
/gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P98194.3);
transmembrane region"
misc_feature 1205..1258
/gene="ATP2C1"
/gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P98194.3);
transmembrane region"
misc_feature 1547..1801
/gene="ATP2C1"
/gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
/note="Putative hydrolase of sodium-potassium ATPase alpha
subunit; Region: Hydrolase_like2; pfam13246"
/db_xref="CDD:205426"
misc_feature 1973..2305
/gene="ATP2C1"
/gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
/note="Haloacid dehalogenase-like hydrolases. The haloacid
dehalogenase-like (HAD) superfamily includes L-2-haloacid
dehalogenase, epoxide hydrolase, phosphoserine
phosphatase, phosphomannomutase, phosphoglycolate
phosphatase, P-type ATPase, and many others; Region:
HAD_like; cd01427"
/db_xref="CDD:119389"
misc_feature 2030..2032
/gene="ATP2C1"
/gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
/note="motif II; other site"
/db_xref="CDD:119389"
misc_feature 2420..2479
/gene="ATP2C1"
/gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P98194.3);
transmembrane region"
misc_feature 2498..2962
/gene="ATP2C1"
/gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
/note="Cation transporting ATPase, C-terminus; Region:
Cation_ATPase_C; pfam00689"
/db_xref="CDD:201396"
misc_feature 2510..2572
/gene="ATP2C1"
/gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P98194.3);
transmembrane region"
misc_feature 2633..2701
/gene="ATP2C1"
/gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P98194.3);
transmembrane region"
misc_feature 2747..2806
/gene="ATP2C1"
/gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P98194.3);
transmembrane region"
misc_feature 2846..2902
/gene="ATP2C1"
/gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P98194.3);
transmembrane region"
exon 329..439
/gene="ATP2C1"
/gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
/inference="alignment:Splign:1.39.8"
exon 440..556
/gene="ATP2C1"
/gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
/inference="alignment:Splign:1.39.8"
exon 557..646
/gene="ATP2C1"
/gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
/inference="alignment:Splign:1.39.8"
exon 647..682
/gene="ATP2C1"
/gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
/inference="alignment:Splign:1.39.8"
exon 683..744
/gene="ATP2C1"
/gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
/inference="alignment:Splign:1.39.8"
exon 745..853
/gene="ATP2C1"
/gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
/inference="alignment:Splign:1.39.8"
exon 854..1009
/gene="ATP2C1"
/gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
/inference="alignment:Splign:1.39.8"
exon 1010..1078
/gene="ATP2C1"
/gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
/inference="alignment:Splign:1.39.8"
exon 1079..1154
/gene="ATP2C1"
/gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
/inference="alignment:Splign:1.39.8"
exon 1155..1221
/gene="ATP2C1"
/gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
/inference="alignment:Splign:1.39.8"
exon 1222..1346
/gene="ATP2C1"
/gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
/inference="alignment:Splign:1.39.8"
exon 1347..1444
/gene="ATP2C1"
/gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
/inference="alignment:Splign:1.39.8"
exon 1445..1540
/gene="ATP2C1"
/gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
/inference="alignment:Splign:1.39.8"
exon 1541..1630
/gene="ATP2C1"
/gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
/inference="alignment:Splign:1.39.8"
exon 1631..1735
/gene="ATP2C1"
/gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
/inference="alignment:Splign:1.39.8"
exon 1736..1892
/gene="ATP2C1"
/gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
/inference="alignment:Splign:1.39.8"
exon 1893..2063
/gene="ATP2C1"
/gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
/inference="alignment:Splign:1.39.8"
exon 2064..2161
/gene="ATP2C1"
/gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
/inference="alignment:Splign:1.39.8"
exon 2162..2212
/gene="ATP2C1"
/gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
/inference="alignment:Splign:1.39.8"
exon 2213..2379
/gene="ATP2C1"
/gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
/inference="alignment:Splign:1.39.8"
exon 2380..2448
/gene="ATP2C1"
/gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
/inference="alignment:Splign:1.39.8"
exon 2449..2565
/gene="ATP2C1"
/gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
/inference="alignment:Splign:1.39.8"
exon 2566..2713
/gene="ATP2C1"
/gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
/inference="alignment:Splign:1.39.8"
exon 2714..2809
/gene="ATP2C1"
/gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
/inference="alignment:Splign:1.39.8"
exon 2810..2951
/gene="ATP2C1"
/gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
/inference="alignment:Splign:1.39.8"
exon 2952..3512
/gene="ATP2C1"
/gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
/inference="alignment:Splign:1.39.8"
STS 2986..3135
/gene="ATP2C1"
/gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
/standard_name="RH11935"
/db_xref="UniSTS:51335"
variation complement(3096)
/gene="ATP2C1"
/gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
/replace="g"
/replace="t"
/db_xref="dbSNP:34786162"
polyA_signal 3474..3479
/gene="ATP2C1"
/gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
polyA_site 3512
/gene="ATP2C1"
/gene_synonym="ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1"
ORIGIN
gctggcgtgagctggggacgttgcgggcacacgacggggcgggtgcgggatcttggggaggggggctcccgagatagtggctgggcggggaactccttcctcagcctctcgtcagcgccgcttctcctggtttctcttgcagatgctgctgctaggggtggtgggagcagccgtgggacgcgtggccgggagcgggggtgacagcctgggattccgggggcttctcttccttgtcctcctcctctcctctctattcccagtgtggccgtggctgacactaaagactttgtagccatcaacccgagtgcagtttcgatggaaaatgaaggttgcacgttttcaaaaaatacctaatggtgaaaatgagacaatgattcctgtattgacatcaaaaaaagcaagtgaattaccagtcagtgaagttgcaagcattctccaagctgatcttcagaatggtctaaacaaatgtgaagttagtcataggcgagcctttcatggctggaatgagtttgatattagtgaagatgagccactgtggaagaagtatatttctcagtttaaaaatccccttattatgctgcttctggcttctgcagtcatcagtgttttaatgcatcagtttgatgatgccgtcagtatcactgtggcaatacttatcgttgttacagttgcctttgttcaggaatatcgttcagaaaaatctcttgaagaattgagtaaacttgtgccaccagaatgccattgtgtgcgtgaaggaaaattggagcatacacttgcccgagacttggttccaggtgatacagtttgcctttctgttggggatagagttcctgctgacttacgcttgtttgaggctgtggatctttccattgatgagtccagcttgacaggtgagacaacgccttgttctaaggtgacagctcctcagccagctgcaactaatggagatcttgcatcgagaagtaacattgcctttatgggaacactggtcagatgtggcaaagcaaagggtgttgtcattggaacaggagaaaattctgaatttggggaggtttttaaaatgatgcaagcagaagaggcaccaaaaacccctctgcagaagagcatggacctcttaggaaaacaactttccttttactcctttggtataataggaatcatcatgttggttggctggttactgggaaaagatatcctggaaatgtttactattagtgtaagtttggctgtagcagcaattcctgaaggtctccccattgtggtcacagtgacgctagctcttggtgttatgagaatggtgaagaaaagggccattgtgaaaaagctgcctattgttgaaactctgggctgctgtaatgtgatttgttcagataaaactggaacactgacgaagaatgaaatgactgttactcacatatttacttcagatggtctgcatgctgaggttactggagttggctataatcaatttggggaagtgattgttgatggtgatgttgttcatggattctataacccagctgttagcagaattgttgaggcgggctgtgtgtgcaatgatgctgtaattagaaacaatactctaatggggaagccaacagaaggggccttaattgctcttgcaatgaagatgggtcttgatggacttcaacaagactacatcagaaaagctgaatacccttttagctctgagcaaaagtggatggctgttaagtgtgtacaccgaacacagcaggacagaccagagatttgttttatgaaaggtgcttacgaacaagtaattaagtactgtactacataccagagcaaagggcagaccttgacacttactcagcagcagagagatgtgtaccaacaagagaaggcacgcatgggctcagcgggactcagagttcttgctttggcttctggtcctgaactgggacagctgacatttcttggcttggtgggaatcattgatccacctagaactggtgtgaaagaagctgttacaacactcattgcctcaggagtatcaataaaaatgattactggagattcacaggagactgcagttgcaatcgccagtcgtctgggattgtattccaaaacttcccagtcagtctcaggagaagaaatagatgcaatggatgttcagcagctttcacaaatagtaccaaaggttgcagtattttacagagctagcccaaggcacaagatgaaaattattaagtcgctacagaagaacggttcagttgtagccatgacaggagatggagtaaatgatgcagttgctctgaaggctgcagacattggagttgcgatgggccagactggtacagatgtttgcaaagaggcagcagacatgatcctagtggatgatgattttcaaaccataatgtctgcaatcgaagagggtaaagggatttataataacattaaaaatttcgttagattccagctgagcacgagtatagcagcattaactttaatctcattggctacattaatgaactttcctaatcctctcaatgccatgcagattttgtggatcaatattattatggatggacccccagctcagagccttggagtagaaccagtggataaagatgtcattcgtaaacctcctcgcaactggaaagacagcattttgactaaaaacttgatacttaaaatacttgtttcatcaataatcattgtttgtgggactttgtttgtcttctggcgtgagctacgagacaatgtgattacacctcgagacacaacaatgaccttcacatgctttgtgttttttgacatgttcaatgcactaagttccagatcccagaccaagtctgtgtttgagattggactctgcagtaatagaatgttttgctatgcagttcttggatccatcatgggacaattactagttatttactttcctccgcttcagaaggtttttcagactgagagcctaagcatactgggtctggctctgggagaggagtggacagcagctggttgagatacatccccatctggagacaggactgccactgacagaagatgtgagctgtgtctaagtccagtcttgtgcccagccgtgtctgcgccttcactctttggaactctgcatacaacatcttagcaccatcttcctgcagctcttccttacctaaataaagaaacagcccaagggcagtatttctaaaagcactgtaacagcttttcattttctccacatatactacaaattctataaagaaagaaattaatttaaaaaaactaagatgtttttctcttctggcttcataaatgccttgctgtataaattgaaatattgatactgaactgtctttttaatgatgacctaactttattcaacccatcggaatttactttttccctgaaataagatcttttccactggtctactacctgaccataaacatgtctgcatttgaattctctaaaccctaaatctgtgtctatgaaaaatacaaatgactattaaatattattctctttactgttctctttcaccgaaaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:27032 -> Molecular function: GO:0004871 [signal transducer activity] evidence: IMP
GeneID:27032 -> Molecular function: GO:0005388 [calcium-transporting ATPase activity] evidence: IDA
GeneID:27032 -> Molecular function: GO:0005388 [calcium-transporting ATPase activity] evidence: IMP
GeneID:27032 -> Molecular function: GO:0005509 [calcium ion binding] evidence: IDA
GeneID:27032 -> Molecular function: GO:0005524 [ATP binding] evidence: IDA
GeneID:27032 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:27032 -> Molecular function: GO:0015410 [manganese-transporting ATPase activity] evidence: IDA
GeneID:27032 -> Molecular function: GO:0030145 [manganese ion binding] evidence: IDA
GeneID:27032 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
GeneID:27032 -> Biological process: GO:0006816 [calcium ion transport] evidence: IDA
GeneID:27032 -> Biological process: GO:0006816 [calcium ion transport] evidence: IMP
GeneID:27032 -> Biological process: GO:0006828 [manganese ion transport] evidence: IDA
GeneID:27032 -> Biological process: GO:0006874 [cellular calcium ion homeostasis] evidence: IDA
GeneID:27032 -> Biological process: GO:0006874 [cellular calcium ion homeostasis] evidence: IMP
GeneID:27032 -> Biological process: GO:0007165 [signal transduction] evidence: IMP
GeneID:27032 -> Biological process: GO:0008544 [epidermis development] evidence: IMP
GeneID:27032 -> Biological process: GO:0016339 [calcium-dependent cell-cell adhesion] evidence: IMP
GeneID:27032 -> Biological process: GO:0030026 [cellular manganese ion homeostasis] evidence: IDA
GeneID:27032 -> Biological process: GO:0031532 [actin cytoskeleton reorganization] evidence: IMP
GeneID:27032 -> Biological process: GO:0032468 [Golgi calcium ion homeostasis] evidence: IMP
GeneID:27032 -> Biological process: GO:0032472 [Golgi calcium ion transport] evidence: IMP
GeneID:27032 -> Biological process: GO:0034220 [ion transmembrane transport] evidence: TAS
GeneID:27032 -> Biological process: GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB cascade] evidence: IMP
GeneID:27032 -> Biological process: GO:0055085 [transmembrane transport] evidence: TAS
GeneID:27032 -> Cellular component: GO:0000139 [Golgi membrane] evidence: IDA
GeneID:27032 -> Cellular component: GO:0000139 [Golgi membrane] evidence: TAS
GeneID:27032 -> Cellular component: GO:0005794 [Golgi apparatus] evidence: IDA
GeneID:27032 -> Cellular component: GO:0005802 [trans-Golgi network] evidence: IDA
GeneID:27032 -> Cellular component: GO:0016021 [integral to membrane] evidence: NAS
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_001186114 -> EC 3.6.3.8
by
@meso_cacase at
DBCLS
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