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2025-05-12 01:55:08, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001166425 2143 bp mRNA linear PRI 12-MAY-2013
DEFINITION Homo sapiens guanine nucleotide binding protein (G protein), alpha
inhibiting activity polypeptide 2 (GNAI2), transcript variant 2,
mRNA.
ACCESSION NM_001166425
VERSION NM_001166425.1 GI:261878574
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2143)
AUTHORS Chandrasekaran,P., Buckley,M., Moore,V., Wang,L.Q., Kehrl,J.H. and
Venkatesan,S.
TITLE HIV-1 Nef impairs heterotrimeric G-protein signaling by targeting
Galpha(i2) for degradation through ubiquitination
JOURNAL J. Biol. Chem. 287 (49), 41481-41498 (2012)
PUBMED 23071112
REMARK GeneRIF: HIV-1 Nef impairs heterotrimeric G-protein signaling by
targeting Galpha(i2) for degradation through ubiquitination
REFERENCE 2 (bases 1 to 2143)
AUTHORS Zhong,M., Clarke,S., Vo,B.T. and Khan,S.A.
TITLE The essential role of Gialpha2 in prostate cancer cell migration
JOURNAL Mol. Cancer Res. 10 (10), 1380-1388 (2012)
PUBMED 22936789
REMARK GeneRIF: Gialpha2 plays an essential role in OXT and EGF signaling
to induce prostate cancer cell migration.
REFERENCE 3 (bases 1 to 2143)
AUTHORS Luissint,A.C., Federici,C., Guillonneau,F., Chretien,F., Camoin,L.,
Glacial,F., Ganeshamoorthy,K. and Couraud,P.O.
TITLE Guanine nucleotide-binding protein Galphai2: a new partner of
claudin-5 that regulates tight junction integrity in human brain
endothelial cells
JOURNAL J. Cereb. Blood Flow Metab. 32 (5), 860-873 (2012)
PUBMED 22333621
REMARK GeneRIF: Galphai2 as a novel claudin-5 partner required for TJ
integrity in brain endothelial cells.
REFERENCE 4 (bases 1 to 2143)
AUTHORS Dauphinee,S.M., Voelcker,V., Tebaykina,Z., Wong,F. and Karsan,A.
TITLE Heterotrimeric Gi/Go proteins modulate endothelial TLR signaling
independent of the MyD88-dependent pathway
JOURNAL Am. J. Physiol. Heart Circ. Physiol. 301 (6), H2246-H2253 (2011)
PUBMED 21949112
REMARK GeneRIF: Suggest that Gnia2 is involved in endothelial TLR pathways
along a signaling cascade that is distinct from MyD88.
REFERENCE 5 (bases 1 to 2143)
AUTHORS Kremer,K.N., Kumar,A. and Hedin,K.E.
TITLE G alpha i2 and ZAP-70 mediate RasGRP1 membrane localization and
activation of SDF-1-induced T cell functions
JOURNAL J. Immunol. 187 (6), 3177-3185 (2011)
PUBMED 21856938
REMARK GeneRIF: SDF-1 treatment of T cells induced the formation of a
novel molecular signaling complex containing RasGRP1, Galphai2, and
ZAP-70.
REFERENCE 6 (bases 1 to 2143)
AUTHORS Magovcevic,I., Ang,S.L., Seidman,J.G., Tolman,C.J., Neer,E.J. and
Morton,C.C.
TITLE Regional localization of the human G protein alpha i2 (GNAI2) gene:
assignment to 3p21 and a related sequence (GNAI2L) to 12p12-p13
JOURNAL Genomics 12 (1), 125-129 (1992)
PUBMED 1733849
REFERENCE 7 (bases 1 to 2143)
AUTHORS Cormont,M., Le Marchand-Brustel,Y., Van Obberghen,E., Spiegel,A.M.
and Sharp,G.W.
TITLE Identification of G protein alpha-subunits in RINm5F cells and
their selective interaction with galanin receptor
JOURNAL Diabetes 40 (9), 1170-1176 (1991)
PUBMED 1718802
REFERENCE 8 (bases 1 to 2143)
AUTHORS Offermanns,S., Schultz,G. and Rosenthal,W.
TITLE Evidence for opioid receptor-mediated activation of the G-proteins,
Go and Gi2, in membranes of neuroblastoma x glioma (NG108-15)
hybrid cells
JOURNAL J. Biol. Chem. 266 (6), 3365-3368 (1991)
PUBMED 1671672
REFERENCE 9 (bases 1 to 2143)
AUTHORS Lyons,J., Landis,C.A., Harsh,G., Vallar,L., Grunewald,K.,
Feichtinger,H., Duh,Q.Y., Clark,O.H., Kawasaki,E., Bourne,H.R. et
al.
TITLE Two G protein oncogenes in human endocrine tumors
JOURNAL Science 249 (4969), 655-659 (1990)
PUBMED 2116665
REFERENCE 10 (bases 1 to 2143)
AUTHORS Bushfield,M., Murphy,G.J., Lavan,B.E., Parker,P.J., Hruby,V.J.,
Milligan,G. and Houslay,M.D.
TITLE Hormonal regulation of Gi2 alpha-subunit phosphorylation in intact
hepatocytes
JOURNAL Biochem. J. 268 (2), 449-457 (1990)
PUBMED 2114093
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DB044421.1, AK302330.1,
AK126708.1 and AK055574.1.
Summary: The protein encoded by this gene is an alpha subunit of
guanine nucleotide binding proteins (G proteins). The encoded
protein contains the guanine nucleotide binding site and is
involved in the hormonal regulation of adenylate cyclase. Several
transcript variants encoding different isoforms have been detected
for this gene, but the full-length nature of only two are known so
far. [provided by RefSeq, Oct 2009].
Transcript Variant: This variant (2) differs in the 5' UTR and
coding sequence compared to variant 1. The resulting isoform (2)
has a shorter and distinct N-terminus compared to isoform 1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK302330.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084, ERS025085 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-31 DB044421.1 1-31
32-1432 AK302330.1 1-1401
1433-2134 AK126708.1 3185-3886
2135-2143 AK055574.1 2159-2167
FEATURES Location/Qualifiers
source 1..2143
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="3"
/map="3p21.31"
gene 1..2143
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/note="guanine nucleotide binding protein (G protein),
alpha inhibiting activity polypeptide 2"
/db_xref="GeneID:2771"
/db_xref="HGNC:4385"
/db_xref="MIM:139360"
exon 1..182
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/inference="alignment:Splign:1.39.8"
variation 50..51
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace=""
/replace="c"
/db_xref="dbSNP:201995261"
variation 52..53
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace=""
/replace="a"
/db_xref="dbSNP:34181412"
variation 54..55
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace=""
/replace="c"
/db_xref="dbSNP:3831499"
misc_feature 137..139
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/note="upstream in-frame stop codon"
variation 138
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="g"
/db_xref="dbSNP:200422517"
CDS 176..1132
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/note="isoform 2 is encoded by transcript variant 2;
guanine nucleotide-binding protein G(i) subunit alpha-2;
guanine nucleotide-binding protein G(i), alpha-2 subunit;
adenylate cyclase-inhibiting G alpha protein; GTP-binding
regulatory protein Gi alpha-2 chain"
/codon_start=1
/product="guanine nucleotide-binding protein G(i) subunit
alpha-2 isoform 2"
/protein_id="NP_001159897.1"
/db_xref="GI:261878575"
/db_xref="CCDS:CCDS54587.1"
/db_xref="GeneID:2771"
/db_xref="HGNC:4385"
/db_xref="MIM:139360"
/translation="
MRGAGESGKSTIVKQMKIIHEDGYSEEECRQYRAVVYSNTIQSIMAIVKAMGNLQIDFADPSRADDARQLFALSCTAEEQGVLPDDLSGVIRRLWADHGVQACFGRSREYQLNDSAAYYLNDLERIAQSDYIPTQQDVLRTRVKTTGIVETHFTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSAYDLVLAEDEEMNRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKITHSPLTICFPEYTGANKYDEAASYIQSKFEDLNKRKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKDCGLF
"
misc_feature 182..1123
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/note="G protein alpha subunit; Region: G_alpha;
smart00275"
/db_xref="CDD:128571"
misc_feature 182..1111
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/note="Alpha subunit of G proteins (guanine nucleotide
binding); Region: G-alpha; cd00066"
/db_xref="CDD:206639"
misc_feature order(182..184,197..205,608..610,665..667,674..676,
872..877,881..883,1040..1045)
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/note="GTP/Mg2+ binding site [chemical binding]; other
site"
/db_xref="CDD:206639"
misc_feature 182..205
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/note="G1 box; other site"
/db_xref="CDD:206639"
misc_feature order(185..193,275..277,287..289,299..301,308..310,
317..322,374..376,383..385,512..514,599..601,674..676,
698..700,710..712)
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/note="GoLoco binding site; other site"
/db_xref="CDD:206639"
misc_feature 593..619
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/note="Switch I region; other site"
/db_xref="CDD:206639"
misc_feature 608..610
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/note="G2 box; other site"
/db_xref="CDD:206639"
misc_feature order(611..613,617..619,623..625,656..658,662..664,
674..682,686..688,695..700,704..715)
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/note="beta - gamma complex interaction site [polypeptide
binding]; other site"
/db_xref="CDD:206639"
misc_feature order(617..619,692..694,701..706,713..715)
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/note="adenylyl cyclase interaction site [polypeptide
binding]; other site"
/db_xref="CDD:206639"
misc_feature 665..676
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/note="G3 box; other site"
/db_xref="CDD:206639"
misc_feature 668..718
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/note="Switch II region; other site"
/db_xref="CDD:206639"
misc_feature 872..883
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/note="G4 box; other site"
/db_xref="CDD:206639"
misc_feature order(1016..1051,1055..1066)
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/note="putative receptor binding site; other site"
/db_xref="CDD:206639"
misc_feature 1040..1048
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/note="G5 box; other site"
/db_xref="CDD:206639"
exon 183..225
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/inference="alignment:Splign:1.39.8"
variation 189
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="g"
/replace="t"
/db_xref="dbSNP:17851218"
exon 226..367
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/inference="alignment:Splign:1.39.8"
variation 235
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="c"
/replace="t"
/db_xref="dbSNP:138495790"
variation 250
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="g"
/db_xref="dbSNP:762707"
variation 276
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="c"
/db_xref="dbSNP:138213627"
variation 315
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace=""
/replace="t"
/db_xref="dbSNP:67741912"
variation 331
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="c"
/db_xref="dbSNP:1050067"
variation 344
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="g"
/db_xref="dbSNP:183955200"
variation 365
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="g"
/db_xref="dbSNP:149596343"
variation 366
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="c"
/replace="t"
/db_xref="dbSNP:112497464"
exon 368..528
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/inference="alignment:Splign:1.39.8"
variation 400
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="c"
/replace="t"
/db_xref="dbSNP:115287046"
variation 404
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="g"
/db_xref="dbSNP:368004918"
variation 406
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="c"
/replace="t"
/db_xref="dbSNP:146259462"
variation 417
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="g"
/db_xref="dbSNP:371969824"
variation 419
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="g"
/db_xref="dbSNP:150943193"
variation 439
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="c"
/replace="t"
/db_xref="dbSNP:373705209"
variation 441
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="g"
/replace="t"
/db_xref="dbSNP:140764270"
variation 442
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="c"
/replace="t"
/db_xref="dbSNP:142508788"
variation 443
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="g"
/db_xref="dbSNP:200441316"
variation 449
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="c"
/replace="t"
/db_xref="dbSNP:180852414"
variation 502
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="g"
/db_xref="dbSNP:367617983"
variation 511
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="c"
/replace="t"
/db_xref="dbSNP:372356382"
exon 529..657
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/inference="alignment:Splign:1.39.8"
variation 532
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="c"
/replace="t"
/db_xref="dbSNP:367669032"
variation 538
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="c"
/replace="t"
/db_xref="dbSNP:199645073"
variation 599
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:137853226"
variation 600
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="g"
/db_xref="dbSNP:137853227"
variation 601
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="c"
/replace="t"
/db_xref="dbSNP:146768972"
variation 646
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="c"
/replace="t"
/db_xref="dbSNP:149019479"
exon 658..787
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/inference="alignment:Splign:1.39.8"
variation 664
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="t"
/db_xref="dbSNP:137853228"
variation 685
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="c"
/replace="t"
/db_xref="dbSNP:369101180"
variation 688
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="g"
/db_xref="dbSNP:373500446"
variation 718
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="c"
/replace="t"
/db_xref="dbSNP:141848616"
variation 724
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="g"
/db_xref="dbSNP:201958549"
variation 736
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="c"
/replace="t"
/db_xref="dbSNP:143353731"
variation 739
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="c"
/replace="t"
/db_xref="dbSNP:141703681"
variation 740
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="g"
/db_xref="dbSNP:376430681"
variation 778
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="c"
/replace="t"
/db_xref="dbSNP:138946270"
variation 784
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="g"
/db_xref="dbSNP:11557219"
exon 788..941
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/inference="alignment:Splign:1.39.8"
variation 791
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="c"
/replace="t"
/db_xref="dbSNP:12721535"
variation 913
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="c"
/replace="t"
/db_xref="dbSNP:139197363"
variation 914
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="c"
/replace="t"
/db_xref="dbSNP:142945610"
variation 922
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="c"
/db_xref="dbSNP:77643206"
exon 942..1156
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/inference="alignment:Splign:1.39.8"
variation 943
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="g"
/db_xref="dbSNP:143863348"
variation 946
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="c"
/db_xref="dbSNP:375264138"
variation 955
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="c"
/replace="t"
/db_xref="dbSNP:368550765"
variation 1014
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="c"
/replace="g"
/db_xref="dbSNP:372568318"
variation 1030
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="g"
/db_xref="dbSNP:377114196"
variation 1039
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="g"
/replace="t"
/db_xref="dbSNP:147785481"
variation 1046..1047
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace=""
/replace="c"
/db_xref="dbSNP:35326130"
variation 1061
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="g"
/db_xref="dbSNP:139567497"
variation 1087
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="c"
/replace="t"
/db_xref="dbSNP:147937896"
variation 1103..1104
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace=""
/replace="a"
/db_xref="dbSNP:66539739"
variation 1136
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="g"
/replace="t"
/db_xref="dbSNP:200506702"
variation 1150
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="c"
/replace="t"
/db_xref="dbSNP:370947414"
exon 1157..2143
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/inference="alignment:Splign:1.39.8"
STS 1166..1370
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/standard_name="SGC31568"
/db_xref="UniSTS:34294"
variation 1169
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="c"
/replace="t"
/db_xref="dbSNP:76737154"
variation 1215
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="g"
/db_xref="dbSNP:374572856"
variation 1294
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="c"
/db_xref="dbSNP:116369548"
variation 1304
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="g"
/db_xref="dbSNP:137909745"
STS 1309..1500
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/standard_name="GDB:181210"
/db_xref="UniSTS:155178"
variation 1428
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="g"
/replace="t"
/db_xref="dbSNP:113343486"
variation 1429
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="g"
/replace="t"
/db_xref="dbSNP:12813"
variation 1507
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="c"
/replace="t"
/db_xref="dbSNP:115699651"
STS 1522..1648
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/standard_name="G07074"
/db_xref="UniSTS:30223"
variation 1577
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="c"
/replace="t"
/db_xref="dbSNP:183872438"
STS 1588..1664
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/standard_name="M13963"
/db_xref="UniSTS:124916"
variation 1591
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="c"
/db_xref="dbSNP:188823486"
variation 1612
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="g"
/db_xref="dbSNP:192924654"
STS 1644..1824
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/standard_name="BI273769"
/db_xref="UniSTS:248822"
variation 1681
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="g"
/db_xref="dbSNP:3209953"
variation 1682
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="t"
/db_xref="dbSNP:3209954"
variation 1686
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="g"
/db_xref="dbSNP:199935816"
variation 1686
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace=""
/replace="g"
/db_xref="dbSNP:146158517"
variation 1687
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="g"
/db_xref="dbSNP:76340684"
variation 1697
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace=""
/replace="a"
/db_xref="dbSNP:71688940"
variation 1699..1700
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace=""
/replace="a"
/db_xref="dbSNP:71728346"
variation 1745
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="c"
/replace="t"
/db_xref="dbSNP:368304611"
variation 1831
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="g"
/db_xref="dbSNP:12895"
variation 2070..2071
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace=""
/replace="c"
/db_xref="dbSNP:34342188"
variation 2083
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
/replace="a"
/replace="g"
/db_xref="dbSNP:15488"
polyA_signal 2119..2124
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
polyA_site 2143
/gene="GNAI2"
/gene_synonym="GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1"
ORIGIN
agtagctctgactcctgtcccaggttatgctgagtcccagcagggaaccaccacagctctgaatcagcctgttagccgctgtccattgctcttcatctgctctttatctgaaaatcttcagaagctttccttcaaatgagatgaccacagcagtcttctctgcaggttgcaggaaatgagaggtgctggggagtcagggaagagcaccatcgtcaagcagatgaagatcatccacgaggatggctactccgaggaggaatgccggcagtaccgggcggttgtctacagcaacaccatccagtccatcatggccattgtcaaagccatgggcaacctgcagatcgactttgccgacccctccagagcggacgacgccaggcagctatttgcactgtcctgcaccgccgaggagcaaggcgtgctccctgatgacctgtccggcgtcatccggaggctctgggctgaccatggtgtgcaggcctgctttggccgctcaagggaataccagctcaacgactcagctgcctactacctgaacgacctggagcgtattgcacagagtgactacatccccacacagcaagatgtgctacggacccgcgtaaagaccacggggatcgtggagacacacttcaccttcaaggacctacacttcaagatgtttgatgtgggtggtcagcggtctgagcggaagaagtggatccactgctttgagggcgtcacagccatcatcttctgcgtagccttgagcgcctatgacttggtgctagctgaggacgaggagatgaaccgcatgcatgagagcatgaagctattcgatagcatctgcaacaacaagtggttcacagacacgtccatcatcctcttcctcaacaagaaggacctgtttgaggagaagatcacacacagtcccctgaccatctgcttccctgagtacacaggggccaacaaatatgatgaggcagccagctacatccagagtaagtttgaggacctgaataagcgcaaagacaccaaggagatctacacgcacttcacgtgcgccaccgacaccaagaacgtgcagttcgtgtttgacgccgtcaccgatgtcatcatcaagaacaacctgaaggactgcggcctcttctgaggggcagcggggcctggcgggatgggccaccgccgactttgtaccccccaacccctgaggaagatgggggcaagaagatcacgctccccgcctgttcccccgccgcttttctcctctttcctctctttgttctcagctccccctgtcccctcagctccagacgtaggggaggggttgccacaggcctccctgtttgaagcctgcccttgtctgagatgctggtaatggccatggtacccccttctgggcatctgttctggtttttaaccattgtcttgttctgtgatgaggggaggggggcacatgctgagtctcccaaggctgcgtctggaggggcccctgcttctccagcctggacccccagctttgcccaacaccagcccctgccccagcccaagtccaaatgtttacagggagcctcctgcccagtcccccaaccccagccgctcggaggccccaaaggaaaaagcacaagaagcgtgagacgccaccattcctggaaaccacagtccacctgctcattctcgtagctttttaaaaaaatgaaagtaaaggaaaaaaaaaaaactgcaaatctagaaaactttttagagaaaaactatttaaaactgtcagatcctgaccagcaagcccccccccagccccccttccaagtgactccgtgccttgagtgtgtctgcgtgtttacacccgtccctctgctggccgcccccgtgcgagcggcacccctgccctgccctccacagaattgggttccaagggctgttccagacaactgccaacgtcactgagggccctgccccagcggccctggccccaggctctattaacctaaaatgtagctccctagcgctaacctaggaaccgccgctgcctgctggggggccacgcccctcatgcccttgtcccaggcccggggccttcagcgttgaacacttccttgcttttttcacatgttttatggaattgttcacctggtttgaaataataaaatgtagaaagaaaaaaaat
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:2771 -> Molecular function: GO:0001664 [G-protein coupled receptor binding] evidence: IBA
GeneID:2771 -> Molecular function: GO:0003924 [GTPase activity] evidence: IBA
GeneID:2771 -> Molecular function: GO:0004871 [signal transducer activity] evidence: IBA
GeneID:2771 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:2771 -> Molecular function: GO:0005525 [GTP binding] evidence: IEA
GeneID:2771 -> Molecular function: GO:0031683 [G-protein beta/gamma-subunit complex binding] evidence: IBA
GeneID:2771 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
GeneID:2771 -> Biological process: GO:0000186 [activation of MAPKK activity] evidence: IEA
GeneID:2771 -> Biological process: GO:0001973 [adenosine receptor signaling pathway] evidence: IBA
GeneID:2771 -> Biological process: GO:0007049 [cell cycle] evidence: IEA
GeneID:2771 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
GeneID:2771 -> Biological process: GO:0007186 [G-protein coupled receptor signaling pathway] evidence: TAS
GeneID:2771 -> Biological process: GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway] evidence: TAS
GeneID:2771 -> Biological process: GO:0007194 [negative regulation of adenylate cyclase activity] evidence: TAS
GeneID:2771 -> Biological process: GO:0007213 [G-protein coupled acetylcholine receptor signaling pathway] evidence: IEA
GeneID:2771 -> Biological process: GO:0007214 [gamma-aminobutyric acid signaling pathway] evidence: IBA
GeneID:2771 -> Biological process: GO:0007243 [intracellular protein kinase cascade] evidence: IEA
GeneID:2771 -> Biological process: GO:0007268 [synaptic transmission] evidence: TAS
GeneID:2771 -> Biological process: GO:0007584 [response to nutrient] evidence: TAS
GeneID:2771 -> Biological process: GO:0007596 [blood coagulation] evidence: TAS
GeneID:2771 -> Biological process: GO:0008283 [cell proliferation] evidence: IEA
GeneID:2771 -> Biological process: GO:0008284 [positive regulation of cell proliferation] evidence: IEA
GeneID:2771 -> Biological process: GO:0030168 [platelet activation] evidence: TAS
GeneID:2771 -> Biological process: GO:0050805 [negative regulation of synaptic transmission] evidence: IEA
GeneID:2771 -> Biological process: GO:0051301 [cell division] evidence: IMP
GeneID:2771 -> Biological process: GO:0051924 [regulation of calcium ion transport] evidence: IEA
GeneID:2771 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
GeneID:2771 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:2771 -> Cellular component: GO:0005813 [centrosome] evidence: IDA
GeneID:2771 -> Cellular component: GO:0005829 [cytosol] evidence: IEA
GeneID:2771 -> Cellular component: GO:0005834 [heterotrimeric G-protein complex] evidence: IBA
GeneID:2771 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA
GeneID:2771 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
GeneID:2771 -> Cellular component: GO:0030496 [midbody] evidence: IDA
GeneID:2771 -> Cellular component: GO:0031234 [extrinsic to internal side of plasma membrane] evidence: IBA
GeneID:2771 -> Cellular component: GO:0045121 [membrane raft] evidence: IEA
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@meso_cacase at
DBCLS
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