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2025-05-12 01:55:08, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001109763 4922 bp mRNA linear PRI 15-JUN-2013
DEFINITION Homo sapiens GSG1-like (GSG1L), transcript variant 1, mRNA.
ACCESSION NM_001109763
VERSION NM_001109763.1 GI:157951717
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4922)
AUTHORS Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
Gibbs,R.A. and Butte,N.F.
TITLE Novel genetic loci identified for the pathophysiology of childhood
obesity in the Hispanic population
JOURNAL PLoS ONE 7 (12), E51954 (2012)
PUBMED 23251661
REFERENCE 2 (bases 1 to 4922)
AUTHORS Rual,J.F., Hirozane-Kishikawa,T., Hao,T., Bertin,N., Li,S.,
Dricot,A., Li,N., Rosenberg,J., Lamesch,P., Vidalain,P.O.,
Clingingsmith,T.R., Hartley,J.L., Esposito,D., Cheo,D., Moore,T.,
Simmons,B., Sequerra,R., Bosak,S., Doucette-Stamm,L., Le Peuch,C.,
Vandenhaute,J., Cusick,M.E., Albala,J.S., Hill,D.E. and Vidal,M.
TITLE Human ORFeome version 1.1: a platform for reverse proteomics
JOURNAL Genome Res. 14 (10B), 2128-2135 (2004)
PUBMED 15489335
REFERENCE 3 (bases 1 to 4922)
AUTHORS Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
TITLE The secreted protein discovery initiative (SPDI), a large-scale
effort to identify novel human secreted and transmembrane proteins:
a bioinformatics assessment
JOURNAL Genome Res. 13 (10), 2265-2270 (2003)
PUBMED 12975309
REMARK Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AI418246.1, AK128775.1, CV024949.1, AC008732.9 and DB306756.1.
Transcript Variant: This variant (2) lacks several 5' coding exons
and has an alternate 5' UTR, compared to variant 1. This results in
a shorter protein (isoform 2) that lacks the GSG-1 conserved
domain.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data because no single transcript was available
for the full length of the gene. The extent of this transcript is
supported by transcript alignments.
##Evidence-Data-START##
Transcript exon combination :: AK128775.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025082, ERS025083 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-461 AI418246.1 1-461
462-776 AK128775.1 83-397
777-921 CV024949.1 227-371
922-1346 AK128775.1 543-967
1347-4798 AC008732.9 166868-170319
4799-4922 DB306756.1 1-124 c
FEATURES Location/Qualifiers
source 1..4922
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="16"
/map="16p12.1"
gene 1..4922
/gene="GSG1L"
/gene_synonym="PRO19651"
/note="GSG1-like"
/db_xref="GeneID:146395"
/db_xref="HGNC:28283"
exon 1..434
/gene="GSG1L"
/gene_synonym="PRO19651"
/inference="alignment:Splign:1.39.8"
CDS 86..1081
/gene="GSG1L"
/gene_synonym="PRO19651"
/note="isoform 1 precursor is encoded by transcript
variant 1; germ cell-specific gene 1-like protein;
KTSR5831; GSG1-like protein"
/codon_start=1
/product="germ cell-specific gene 1-like protein isoform 1
precursor"
/protein_id="NP_001103233.1"
/db_xref="GI:157951718"
/db_xref="CCDS:CCDS45450.1"
/db_xref="GeneID:146395"
/db_xref="HGNC:28283"
/translation="
MKTSRRGRALLAVALNLLALLFATTAFLTTHWCQGTQRVPKPGCGQGGRANCPNSGANATANGTAAPAAAAAAATASGNGPPGGALYSWETGDDRFLFRNFHTGIWYSCEEELSGLGEKCRSFIDLAPASEKGVLWLSVVSEVLYILLLVVGFSLMCLELFHSSNVIDGLKLNAFAAVFTVLSGLLGMVAHMMYTQVFQVTVSLGPEDWRPHSWDYGWSFCLAWGSFTCCMAASVTTLNSYTKTVIEFRHKRKVFEQGYREEPTFIDPEAIKYFRERMEKRDGSEEDFHLDCRHERYPARHQPHMADSWPRSSAQEAPELNRQCWVLGHWV
"
sig_peptide 86..163
/gene="GSG1L"
/gene_synonym="PRO19651"
/inference="COORDINATES: ab initio prediction:SignalP:4.0"
misc_feature 89..484
/gene="GSG1L"
/gene_synonym="PRO19651"
/note="GSG1-like protein; Region: GSG-1; pfam07803"
/db_xref="CDD:149072"
misc_feature 110..172
/gene="GSG1L"
/gene_synonym="PRO19651"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q6UXU4.2);
transmembrane region"
misc_feature 380..790
/gene="GSG1L"
/gene_synonym="PRO19651"
/note="PMP-22/EMP/MP20/Claudin tight junction; Region:
Claudin_2; pfam13903"
/db_xref="CDD:206074"
misc_feature 482..544
/gene="GSG1L"
/gene_synonym="PRO19651"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q6UXU4.2);
transmembrane region"
misc_feature 605..667
/gene="GSG1L"
/gene_synonym="PRO19651"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q6UXU4.2);
transmembrane region"
misc_feature 737..799
/gene="GSG1L"
/gene_synonym="PRO19651"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q6UXU4.2);
transmembrane region"
exon 435..482
/gene="GSG1L"
/gene_synonym="PRO19651"
/inference="alignment:Splign:1.39.8"
exon 483..635
/gene="GSG1L"
/gene_synonym="PRO19651"
/inference="alignment:Splign:1.39.8"
exon 636..747
/gene="GSG1L"
/gene_synonym="PRO19651"
/inference="alignment:Splign:1.39.8"
exon 748..915
/gene="GSG1L"
/gene_synonym="PRO19651"
/inference="alignment:Splign:1.39.8"
exon 916..983
/gene="GSG1L"
/gene_synonym="PRO19651"
/inference="alignment:Splign:1.39.8"
exon 984..4922
/gene="GSG1L"
/gene_synonym="PRO19651"
/inference="alignment:Splign:1.39.8"
STS 1289..1436
/gene="GSG1L"
/gene_synonym="PRO19651"
/standard_name="RH91752"
/db_xref="UniSTS:87375"
STS 1408..1550
/gene="GSG1L"
/gene_synonym="PRO19651"
/standard_name="D16S2573E"
/db_xref="UniSTS:151654"
variation 1435
/gene="GSG1L"
/gene_synonym="PRO19651"
/replace="a"
/replace="g"
/db_xref="dbSNP:2292646"
variation 1462
/gene="GSG1L"
/gene_synonym="PRO19651"
/replace="a"
/replace="g"
/db_xref="dbSNP:2292647"
STS 3778..4049
/gene="GSG1L"
/gene_synonym="PRO19651"
/standard_name="SHGC-147786"
/db_xref="UniSTS:176011"
ORIGIN
gcggccgctgacgcggggcgccagctgccaacttcgcgcgcggagctccccggcggtgcagtcccgtcccggcggcgcgggcggcatgaagactagccgccgcggccgagcgctcctggccgtggccctgaacctgctggcgctgctgttcgccaccaccgctttcctcaccacgcactggtgccagggcacgcagcgggtccccaagccgggctgcggccagggcgggcgcgccaactgccccaactcgggcgccaacgccacggccaacggcaccgccgcccccgccgccgccgccgccgccgccaccgcctcggggaacggcccccctggcggcgcgctctacagctgggagaccggcgacgaccgcttcctcttcaggaatttccacaccggcatctggtactcgtgcgaggaggagctcagcgggcttggtgaaaaatgtcgcagcttcattgacctggccccggcatcggagaaaggggtcctgtggctgtctgtggtctccgaggtgctgtacattctgctgctggtggttggcttcagcctcatgtgtctcgagctcttccactccagcaatgtcatcgacgggctcaagctcaatgccttcgcggctgtcttcacggtgctctcaggcctcctgggaatggtcgcccacatgatgtacacgcaggtgttccaggtcaccgtgagcctcggtcctgaggactggagaccccattcctgggactacgggtggtccttctgcctggcgtggggctcctttacctgctgcatggcagcctctgtcaccacgctcaactcctacaccaagacggtcattgagttccggcacaagcgcaaggtctttgagcagggctaccgggaagagccgaccttcatagaccctgaggccatcaagtacttccgggagaggatggagaagagggacgggagcgaggaggactttcacttagactgccgccacgagagataccctgcccgacaccagccacacatggcggattcctggccccggagctccgcacaggaagcaccagagctgaaccgacagtgctgggtcttggggcactgggtgtgaccaagacctcaacctggcccgcggacctcaggccatcgctggcaccagcccctgctgcaagaccaccagagtggtgcccccagaaccctggcctgtgtgccgtgaactcagtcagcctgcgtgggagatgccaggcctgtcctgcccatcgctgcctgggtcccatggccttggaaatggggccagggcaggcccaagggaatgcacagggctgcacagagtgactttgggacagcagccccggactcttgccatcatcacatgagccctgctgggcacagctgcgatgccaggagacacatggccactggccactgaatggctggcacccacaagccagtcaggtgcccagaggggcagagccctttggggggcagagagtggcttcctgaaggagggggcagtggcgcaggcactgcaggggtgtcacacagcaggcacacagcaggggctcaataaatgcttgttgaacttgttttcttgcggtgtatggaggccagttgctctgtgggctgtggctgccctgtcattgccccaccccattactcctcaaggaggctgaaggtgacagcagagactgtgcagaggccagggccagacactgcagggtggcagggagggagcacagagcccaggctggacacaggctggcagggctgccttgtattccagagagtgggcaaggcaggggccaggcaagcaagagatgtggggcgagcaagaagtgggcccccaaacccaagccctaagcagggagggtgaagaagccacatttctcttcagagctcagcaacatcacaccaccctgaccctgaggaggctttaccctgtgcctagcaccacctttacagaaaatcccagggcttagatgcctggagaaacagattcttattataaagaggaggaaaattagggtcacagagatgaatgaagtaacttgcctgtgattacagagctagcaaatggcagagatggggtttgaatcaggactcctgactccaagttcagtcatttcccaagaggccttattccttcccagaagaatttctagagcttttccccacgtagaatatattcttctcctttatccttccatccttccatccatcatccatcactcatccagccattatccattatccatccatccattcatcattcgtccatctattatccacccattcatcatctattatccatccatcattcatcatccatccatcattcataattcatctttccactcatccatccatcattcattcattcatccatccttccatccatccatcatctatccattcatccatccatttgccatccatccactcattcatcagctatccatcatctatccatccatccatccatccagcatctatcactcatccagctattgtccattgtccattcatccatttttcattcatccctccatcatcattaatccattatccacccactcatcatctattatccatctatagtccatcaaccatccatccttcatcatccatccatccatccttcatccatccatccacccatccatccatccatcatctgtccatccattatctatccattcatccatccattcatcatccacccacctattcatcagctatctatccatcatccatccatccatcatccatccatccatccatccatccatcatctatccattcattgtctatgctttcatccatccattcatcatccatccacccattcgttagctatttatccattatccattcctccatctatccatcatccattcatcccttatccattcaaccattatgcatttcttcatttatccattatttatccttccatccatcatccatcatctttccatccactatctatccattcatccatctatccatcatccatccatcctttatccatcattcatcagccatcatccctccatctatccattatccatcatccactcatccattcatccctccatctgcccattatccatcaaccatccatccatccattatccgtcatccacacatccattcatccctccatctgcccattatccatcaaccatccatccatccattatccatttctgcattatccatttattctttatccatttcttcatctattcatcatctatccatccattatccttacacctatctatcatccatccattccttcatctatccatcatccatcaattatccatccattcatccatccatctatccatcttctattgattgcttgtcatccttccttgtatcagacttccatccatcctccttccatgtgtcacacatcctcattactcaaccatccagctgtgcatccatctattcactgatatagttcactgtgcccctactatgtgccaagcactgtggtaggcacttgaggtgggatgctggagcatccagagagggcatctattgtcgtgagcctgggttcagattccaccttctccacttgtgaccttgggcgagttacttgacctttctgtgcctgtttcctcatccattaaatccggataatcattatacctacctcttcaagctgttgtgcaaattaaatgagctaacatatttgaagtgtctagaacagagcctggcacaagtaaacactttgtgggtgtttactaacaggacaacaaggggaaatcggggctgtgggagctgtagtctagggaggctcctttgagaaaatgatgtctaagccaagacatgaagattgtctgggcatcagccaggcaagagtatagcagggaaagaaagtacattagaggactttaaaatagtcccaatggcaggtgtggagagcagggaggtcaggaggcagttgtgggaaattaggcatcagagggcagtggagccaggccaggaggaactggaaaccttcttagggagcttagagtttaccctggggcaatggggagtgggcagtgagatgcttttagcagactgggatgcgcctgggtgtacatttgaggaagatcaccgcaactatgggcacagaatagttgtgggagatgcttctcccttcctcatccctcttacactcaagaaagagaagaaagtgggctggcttaggaaagttgccctggggaggggaccatgcgggcagattcaggaaccaattaggagggaatagactgagtgggagaagaggaaagttggtgacgactctcaggttacagggtcagcttgggggatagggaagacggagacttcgtggttcagatgtcttgagtctcaggggctcaggggacagccagctggaggtttgtgctcattcattcacgcattgattcatcaagcgaacaatttgttaattcactttccattcattcagtaaatattaatgacctactaggtggggcttaaggcggggctggaaatgggcctgggagagcaattatggtccagctctactgaggccttgaatgtcagaacaaggaatttgggctttggcctcatgcaagagagggcggctgccatatatgggcctgggcagggacagatctgacagggatctagccctggccaccaggcatctaggagctcttgttctcacccagggtccttctgaagttggcgagtggaccgcaggaggtccaggagatgattgtagttgacacatggggaaaattttaatctattttaatagttgtgtttatgtaaatgtgtattagaaaaaaatgtacagtgggcacatcagtgctatgacttcacagacgttactgcttaggatgaaaccaaaataggcatttaagtaaaagaaaaaaagagttggcttaaagaaaaatattaaataaataatcgtgcaagtg
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:146395 -> Cellular component: GO:0005886 [plasma membrane] evidence: IEA
GeneID:146395 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA
GeneID:146395 -> Cellular component: GO:0030054 [cell junction] evidence: IEA
GeneID:146395 -> Cellular component: GO:0032279 [asymmetric synapse] evidence: IEA
by
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