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2025-05-12 01:56:09, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001101389 690 bp mRNA linear PRI 27-JAN-2013 DEFINITION Homo sapiens claudin 25 (CLDN25), mRNA. ACCESSION NM_001101389 XM_927777 XM_938396 VERSION NM_001101389.1 GI:157820126 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 690) AUTHORS Lal-Nag,M. and Morin,P.J. TITLE The claudins JOURNAL Genome Biol. 10 (8), 235 (2009) PUBMED 19706201 REMARK Review article REFERENCE 2 (bases 1 to 690) AUTHORS Krause,G., Winkler,L., Mueller,S.L., Haseloff,R.F., Piontek,J. and Blasig,I.E. TITLE Structure and function of claudins JOURNAL Biochim. Biophys. Acta 1778 (3), 631-645 (2008) PUBMED 18036336 REMARK Review article REFERENCE 3 (bases 1 to 690) AUTHORS Katoh,M. and Katoh,M. TITLE CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family JOURNAL Int. J. Mol. Med. 11 (6), 683-689 (2003) PUBMED 12736707 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH471065.1. On or before Oct 4, 2007 this sequence version replaced gi:89034365, gi:89035150. Summary: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. [provided by RefSeq, Jun 2010]. Sequence Note: This RefSeq record was created from genomic sequence data because no transcript was available for the gene. The extent of this transcript is supported by orthologous data. FEATURES Location/Qualifiers source 1..690 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="11" /map="11q23.2" gene 1..690 /gene="CLDN25" /note="claudin 25" /db_xref="GeneID:644672" /db_xref="HGNC:37218" CDS 1..690 /gene="CLDN25" /codon_start=1 /product="putative claudin-25" /protein_id="NP_001094859.1" /db_xref="GI:157820127" /db_xref="CCDS:CCDS44736.1" /db_xref="GeneID:644672" /db_xref="HGNC:37218" /translation="
MAWSFRAKVQLGGLLLSLLGWVCSCVTTILPQWKTLNLELNEMETWIMGIWEVCVDREEVATVCKAFESFLSLPQELQVARILMVASHGLGLLGLLLCSFGSECFQFHRIRWVFKRRLGLLGRTLEASASATTLLPVSWVAHATIQDFWDDSIPDIIPRWEFGGALYLGWAAGIFLALGGLLLIFSACLGKEDVPFPLMAGPTVPLSCAPVEESDGSFHLMLRPRNLVI
"
misc_feature 31..93
/gene="CLDN25"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (C9JDP6.1);
transmembrane region"
misc_feature 244..306
/gene="CLDN25"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (C9JDP6.1);
transmembrane region"
misc_feature 373..435
/gene="CLDN25"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (C9JDP6.1);
transmembrane region"
misc_feature 493..555
/gene="CLDN25"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (C9JDP6.1);
transmembrane region"
exon 1..690
/gene="CLDN25"
/inference="alignment:Splign:1.39.8"
variation 21
/gene="CLDN25"
/replace="a"
/replace="t"
/db_xref="dbSNP:371018780"
variation 22
/gene="CLDN25"
/replace="a"
/replace="g"
/db_xref="dbSNP:375569415"
variation 34
/gene="CLDN25"
/replace="a"
/replace="g"
/db_xref="dbSNP:367566026"
variation 37
/gene="CLDN25"
/replace="a"
/replace="g"
/db_xref="dbSNP:368739845"
variation 51
/gene="CLDN25"
/replace="c"
/replace="t"
/db_xref="dbSNP:370403067"
variation 59
/gene="CLDN25"
/replace="g"
/replace="t"
/db_xref="dbSNP:373997049"
variation 123
/gene="CLDN25"
/replace="c"
/replace="t"
/db_xref="dbSNP:17115958"
variation 124
/gene="CLDN25"
/replace="a"
/replace="g"
/db_xref="dbSNP:371879188"
variation 129
/gene="CLDN25"
/replace="a"
/replace="g"
/db_xref="dbSNP:367712273"
variation 138..139
/gene="CLDN25"
/replace=""
/replace="atcatggggatttgggaggtctgc"
/db_xref="dbSNP:375691427"
variation 170
/gene="CLDN25"
/replace="a"
/replace="g"
/db_xref="dbSNP:371445026"
variation 186
/gene="CLDN25"
/replace="c"
/replace="t"
/db_xref="dbSNP:374737042"
variation 195
/gene="CLDN25"
/replace="a"
/replace="g"
/db_xref="dbSNP:375224880"
variation 202
/gene="CLDN25"
/replace="a"
/replace="g"
/db_xref="dbSNP:190938380"
variation 213
/gene="CLDN25"
/replace="a"
/replace="g"
/db_xref="dbSNP:368118465"
variation 240
/gene="CLDN25"
/replace="c"
/replace="t"
/db_xref="dbSNP:182753809"
variation 241
/gene="CLDN25"
/replace="c"
/replace="g"
/db_xref="dbSNP:200887183"
variation 259
/gene="CLDN25"
/replace="a"
/replace="t"
/db_xref="dbSNP:147182065"
variation 277
/gene="CLDN25"
/replace="c"
/replace="t"
/db_xref="dbSNP:372181019"
variation 289
/gene="CLDN25"
/replace="c"
/replace="t"
/db_xref="dbSNP:201126561"
variation 307
/gene="CLDN25"
/replace="a"
/replace="g"
/db_xref="dbSNP:140547989"
variation 349
/gene="CLDN25"
/replace="c"
/replace="t"
/db_xref="dbSNP:368993117"
variation 350
/gene="CLDN25"
/replace="a"
/replace="g"
/db_xref="dbSNP:202065177"
variation 355
/gene="CLDN25"
/replace="c"
/replace="g"
/db_xref="dbSNP:199984262"
variation 379
/gene="CLDN25"
/replace="a"
/replace="g"
/db_xref="dbSNP:201922794"
variation 385
/gene="CLDN25"
/replace="a"
/replace="g"
/db_xref="dbSNP:201592139"
variation 421
/gene="CLDN25"
/replace="g"
/replace="t"
/db_xref="dbSNP:187854554"
variation 459
/gene="CLDN25"
/replace="a"
/replace="c"
/db_xref="dbSNP:376808395"
variation 467
/gene="CLDN25"
/replace=""
/replace="cat"
/db_xref="dbSNP:113712372"
variation 476
/gene="CLDN25"
/replace="a"
/replace="g"
/db_xref="dbSNP:192382861"
variation 479
/gene="CLDN25"
/replace="a"
/replace="g"
/db_xref="dbSNP:200964173"
variation 500
/gene="CLDN25"
/replace="a"
/replace="c"
/db_xref="dbSNP:373881888"
variation 599
/gene="CLDN25"
/replace="c"
/replace="t"
/db_xref="dbSNP:201639185"
variation 615
/gene="CLDN25"
/replace="c"
/replace="g"
/db_xref="dbSNP:371223196"
variation 622
/gene="CLDN25"
/replace="c"
/replace="t"
/db_xref="dbSNP:199947437"
variation 654
/gene="CLDN25"
/replace="c"
/replace="t"
/db_xref="dbSNP:373289613"
variation 655
/gene="CLDN25"
/replace="c"
/replace="t"
/db_xref="dbSNP:35111413"
variation 671
/gene="CLDN25"
/replace="c"
/replace="t"
/db_xref="dbSNP:201126695"
variation 676
/gene="CLDN25"
/replace="a"
/replace="c"
/db_xref="dbSNP:200276274"
ORIGIN
atggcctggagtttccgtgcaaaagtccagctcggggggctacttctctccctccttggctgggtctgctcctgtgttaccaccatcctgccccagtggaagactcttaatctggaactgaacgagatggagacctggatcatggggatttgggaggtctgcgtggatcgagaggaagtcgccactgtgtgcaaggcctttgaatccttcttgtctctgccccaggagctccaggtagcccgcatcctcatggtagcctcccatgggctgggcctattggggcttttgctctgcagctttgggtctgaatgcttccagtttcacaggatcagatgggtattcaagaggcggcttggtctcctgggaaggactttggaggcatccgcttcagccactaccctccttccagtctcctgggtggcccatgccacaatccaagacttctgggatgacagcatccctgacatcatacctcggtgggagtttggaggtgccctctacttgggctgggctgctggtattttcctggctcttggtgggctactcctcatcttctcggcctgcctgggaaaagaagatgtgccttttcctttgatggctggtcccacagtccccctatcctgtgctccagtggaggagtcagatggctccttccacctcatgctaagacctaggaacctggtcatctag
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:644672 -> Molecular function: GO:0005198 [structural molecule activity] evidence: IEA
GeneID:644672 -> Cellular component: GO:0005886 [plasma membrane] evidence: IEA
GeneID:644672 -> Cellular component: GO:0005923 [tight junction] evidence: IEA
GeneID:644672 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA
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@meso_cacase at
DBCLS
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