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2025-05-12 01:49:59, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001040199 2500 bp mRNA linear PRI 17-APR-2013 DEFINITION Homo sapiens claudin domain containing 1 (CLDND1), transcript variant 6, mRNA. ACCESSION NM_001040199 VERSION NM_001040199.1 GI:93588649 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2500) AUTHORS Liu,Y., Sun,W., Zhang,K., Zheng,H., Ma,Y., Lin,D., Zhang,X., Feng,L., Lei,W., Zhang,Z., Guo,S., Han,N., Tong,W., Feng,X., Gao,Y. and Cheng,S. TITLE Identification of genes differentially expressed in human primary lung squamous cell carcinoma JOURNAL Lung Cancer 56 (3), 307-317 (2007) PUBMED 17316888 REMARK GeneRIF: A cDNA library consisting of 220 upregulated genes in tumour tissue was established and named as LSCC. Differential expression was confirmed in five of these genes, including IGFBP5, SQLE, RAP2B, CLDN1, and TBL1XR1. REFERENCE 2 (bases 1 to 2500) AUTHORS Lamesch,P., Li,N., Milstein,S., Fan,C., Hao,T., Szabo,G., Hu,Z., Venkatesan,K., Bethel,G., Martin,P., Rogers,J., Lawlor,S., McLaren,S., Dricot,A., Borick,H., Cusick,M.E., Vandenhaute,J., Dunham,I., Hill,D.E. and Vidal,M. TITLE hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes JOURNAL Genomics 89 (3), 307-315 (2007) PUBMED 17207965 REFERENCE 3 (bases 1 to 2500) AUTHORS Fayein,N.A., Stankoff,B., Auffray,C. and Devignes,M.D. TITLE Characterization of tissue expression and full-length coding sequence of a novel human gene mapping at 3q12.1 and transcribed in oligodendrocytes JOURNAL Gene 289 (1-2), 119-129 (2002) PUBMED 12036590 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB461184.1, AC021660.16, BF967477.1, BI552824.1, BC013610.1, EB386420.1 and AA811441.1. Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 6 encode the same isoform (a). ##Evidence-Data-START## Transcript exon combination :: BI551055.1, BI667707.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025082, ERS025083 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-11 DB461184.1 1-11 12-243 AC021660.16 119164-119395 244-460 BF967477.1 14-230 461-852 BI552824.1 4-395 853-1896 BC013610.1 391-1434 1897-2345 EB386420.1 279-727 2346-2500 AA811441.1 1-155 c FEATURES Location/Qualifiers source 1..2500 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="3" /map="3q12.1" gene 1..2500 /gene="CLDND1" /gene_synonym="C3orf4; GENX-3745" /note="claudin domain containing 1" /db_xref="GeneID:56650" /db_xref="HGNC:1322" exon 1..525 /gene="CLDND1" /gene_synonym="C3orf4; GENX-3745" /inference="alignment:Splign:1.39.8" misc_feature 361..363 /gene="CLDND1" /gene_synonym="C3orf4; GENX-3745" /note="upstream in-frame stop codon" exon 526..835 /gene="CLDND1" /gene_synonym="C3orf4; GENX-3745" /inference="alignment:Splign:1.39.8" variation 529..530 /gene="CLDND1" /gene_synonym="C3orf4; GENX-3745" /replace="a" /replace="c" /db_xref="dbSNP:11553645" variation 540 /gene="CLDND1" /gene_synonym="C3orf4; GENX-3745" /replace="c" /replace="g" /db_xref="dbSNP:11553648" CDS 544..1305 /gene="CLDND1" /gene_synonym="C3orf4; GENX-3745" /note="isoform a is encoded by transcript variant 6; claudin domain containing 1 protein; claudin domain-containing protein 1; membrane protein GENX-3745" /codon_start=1 /product="claudin domain-containing protein 1 isoform a" /protein_id="NP_001035289.1" /db_xref="GI:93588650" /db_xref="CCDS:CCDS2930.1" /db_xref="GeneID:56650" /db_xref="HGNC:1322" /translation="
MDNRFATAFVIACVLSLISTIYMAASIGTDFWYEYRSPVQENSSDLNKSIWDEFISDEADEKTYNDALFRYNGTVGLWRRCITIPKNMHWYSPPERTESFDVVTKCVSFTLTEQFMEKFVDPGNHNSGIDLLRTYLWRCQFLLPFVSLGLMCFGALIGLCACICRSLYPTIATGILHLLAGLCTLGSVSCYVAGIELLHQKLELPDNVSGEFGWSFCLACVSAPLQFMASALFIWAAHTNRKEYTLMKAYRVA
"
misc_feature 556..618
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9NY35.1);
transmembrane region"
misc_feature 592..1245
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/note="PMP-22/EMP/MP20/Claudin tight junction; Region:
Claudin_2; pfam13903"
/db_xref="CDD:206074"
misc_feature 964..1026
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9NY35.1);
transmembrane region"
misc_feature 1066..1128
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9NY35.1);
transmembrane region"
misc_feature 1189..1251
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9NY35.1);
transmembrane region"
variation 554
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/replace="a"
/replace="g"
/db_xref="dbSNP:11553643"
variation 604
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/replace="a"
/replace="t"
/db_xref="dbSNP:11553647"
variation 620
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/replace="c"
/replace="g"
/db_xref="dbSNP:11553642"
variation 644
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/replace="a"
/replace="g"
/db_xref="dbSNP:11553639"
variation 722
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/replace="a"
/replace="g"
/db_xref="dbSNP:11553646"
variation 789
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/replace="a"
/replace="c"
/db_xref="dbSNP:11553650"
exon 836..946
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/inference="alignment:Splign:1.39.8"
exon 947..1084
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/inference="alignment:Splign:1.39.8"
variation 1038
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/replace="a"
/replace="t"
/db_xref="dbSNP:11553641"
variation 1041
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/replace="c"
/replace="t"
/db_xref="dbSNP:35994971"
exon 1085..2491
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/inference="alignment:Splign:1.39.8"
variation 1227
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/replace="g"
/replace="t"
/db_xref="dbSNP:11553649"
STS 1287..1377
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/standard_name="D3S2932E"
/db_xref="UniSTS:150916"
variation 2210
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/replace="a"
/replace="g"
/db_xref="dbSNP:11553644"
STS 2254..2456
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/standard_name="D3S3109"
/db_xref="UniSTS:80916"
polyA_signal 2458..2463
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
polyA_signal 2464..2469
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
polyA_site 2481
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
polyA_site 2491
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
ORIGIN
tatcgccgcctcagacagctttcagtctgtccctcctacaactcccacaaggcccctcggccccgggccgcggcccggcccggagtgggggcgggcggaggcgcgggagttatggagggggcgggctctgcagggaagtgcgtcagaggaggcgcggggagagtagggtgctgtggtctgagctagagggtgaagctggcggagcaggaggatgggcggtgagtgagcgggacctgcgtcgccgggcaggggtcgcgtcgcggttccatgttcccggcggtttgaagaggggcccccttcccgggcgtggtcgggctgggcgggttccgagcggcggatttgtcccagggccgagccctctagggcggggcctggtcgggtaccgggggaccctggcccggggccgagcacggctgccccgccccagccctggccttctccggccccgccgtgaggcccaggaggtggctgctgcaggcgtccggcttggacgaaccgccgttcccagtgctgggaccctttaagagcagtctgaatgccagaatggataaccgttttgctacagcatttgtaattgcttgtgtgcttagcctcatttccaccatctacatggcagcctccattggcacagacttctggtatgaatatcgaagtccagttcaagaaaattccagtgatttgaataaaagcatctgggatgaattcattagtgatgaggcagatgaaaagacttataatgatgcactttttcgatacaatggcacagtgggattgtggagacggtgtatcaccatacccaaaaacatgcattggtatagcccaccagaaaggacagagtcatttgatgtggtcacaaaatgtgtgagtttcacactaactgagcagttcatggagaaatttgttgatcccggaaaccacaatagcgggattgatctccttaggacctatctttggcgttgccagttccttttaccttttgtgagtttaggtttgatgtgctttggggctttgatcggactttgtgcttgcatttgccgaagcttatatcccaccattgccacgggcattctccatctccttgcaggtctgtgtacactgggctcagtaagttgttatgttgctggaattgaactactccaccagaaactagagctccctgacaatgtatccggtgaatttggatggtccttctgcctggcttgtgtctctgctcccttacagttcatggcttctgctctcttcatctgggctgctcacaccaaccggaaagagtacaccttaatgaaggcatatcgtgtggcatgagcaagaaactgcctgctttacaattgccatttttatttttttaaaataatactgatattttccccacctctcaattgtttttaatttttatttgtggatataccattttattatgaaaatctattttatttatacacattcaccactaaatacacacttaataccactaaaatttatgtggtttactttaagcgatgccatctttcaaataaactaatctaggtctagacagaaagaaatggatagagacttgacacaaatttatgaaagaaaattgggagtaggaatgtgaccgaaaacaagttgtgctaatgtctgttagacttttcagtaaaactaaagtaactgtatctgttcaactaaaaactctatattagtttctttgggaaacctctcatcgtcaaaactttatgttcactttgctgttgtagatagccagtcaaccagcagtattagtgctgttttcaaagatttaagctctataaaattgggaaattatctaagatcattttccctaagcattgacacatagcttcatctgaggtgagatatggcagctgtttgtatctgcactgtgtctgtctacaaaaagtgaaaaatacagtgtttacttgaaattttaactttgtaactgcaagaattccagttcagccgggcgaggattagtattatttttaactctccgtaagattttcagtaccaccaaattgttttggattttttttctttcctcttcacataccagggttattaaaagtgtgctttctttttacattatattacagttacaaggtaaaattcctcaactgctatttatttattccagcccagtactataaagaacgtttcaccataatgaccctccagagctgggaaacctaccacaagatctaaagttctggctgtccattaacctccaactatggtctttatttcttgtggtaatatgatgtgcctttccttgcctaaatcccttcctggtgtgtatcaacattatttaatgtcttctaattcagtcatttttttataagtatgtctataaacattgaactttaaaaaacttatttatttattccactactgtagcaattgacagattaaaaaaatgtaacttcataatttcttaccataacctcaatgtcttttttaaaaaataaaattaaaaatgaaaagagactcaattgtaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:56650 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA
by
@meso_cacase at
DBCLS
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