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2025-05-12 01:52:03, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001040183 2188 bp mRNA linear PRI 17-APR-2013 DEFINITION Homo sapiens claudin domain containing 1 (CLDND1), transcript variant 3, mRNA. ACCESSION NM_001040183 VERSION NM_001040183.1 GI:93588623 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2188) AUTHORS Liu,Y., Sun,W., Zhang,K., Zheng,H., Ma,Y., Lin,D., Zhang,X., Feng,L., Lei,W., Zhang,Z., Guo,S., Han,N., Tong,W., Feng,X., Gao,Y. and Cheng,S. TITLE Identification of genes differentially expressed in human primary lung squamous cell carcinoma JOURNAL Lung Cancer 56 (3), 307-317 (2007) PUBMED 17316888 REMARK GeneRIF: A cDNA library consisting of 220 upregulated genes in tumour tissue was established and named as LSCC. Differential expression was confirmed in five of these genes, including IGFBP5, SQLE, RAP2B, CLDN1, and TBL1XR1. REFERENCE 2 (bases 1 to 2188) AUTHORS Lamesch,P., Li,N., Milstein,S., Fan,C., Hao,T., Szabo,G., Hu,Z., Venkatesan,K., Bethel,G., Martin,P., Rogers,J., Lawlor,S., McLaren,S., Dricot,A., Borick,H., Cusick,M.E., Vandenhaute,J., Dunham,I., Hill,D.E. and Vidal,M. TITLE hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes JOURNAL Genomics 89 (3), 307-315 (2007) PUBMED 17207965 REFERENCE 3 (bases 1 to 2188) AUTHORS Fayein,N.A., Stankoff,B., Auffray,C. and Devignes,M.D. TITLE Characterization of tissue expression and full-length coding sequence of a novel human gene mapping at 3q12.1 and transcribed in oligodendrocytes JOURNAL Gene 289 (1-2), 119-129 (2002) PUBMED 12036590 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB461184.1, AC021660.16, CD520771.1, BU784186.1, EB386420.1 and AA811441.1. Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 6 encode the same isoform (a). ##Evidence-Data-START## Transcript exon combination :: BG707128.1, CD520771.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025081, ERS025082 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-11 DB461184.1 1-11 12-12 AC021660.16 119164-119164 13-185 DB461184.1 13-185 186-916 CD520771.1 3-733 917-1370 BU784186.1 153-606 1371-2033 EB386420.1 65-727 2034-2188 AA811441.1 1-155 c FEATURES Location/Qualifiers source 1..2188 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="3" /map="3q12.1" gene 1..2188 /gene="CLDND1" /gene_synonym="C3orf4; GENX-3745" /note="claudin domain containing 1" /db_xref="GeneID:56650" /db_xref="HGNC:1322" exon 1..218 /gene="CLDND1" /gene_synonym="C3orf4; GENX-3745" /inference="alignment:Splign:1.39.8" misc_feature 184..186 /gene="CLDND1" /gene_synonym="C3orf4; GENX-3745" /note="upstream in-frame stop codon" exon 219..523 /gene="CLDND1" /gene_synonym="C3orf4; GENX-3745" /inference="alignment:Splign:1.39.8" variation 228 /gene="CLDND1" /gene_synonym="C3orf4; GENX-3745" /replace="c" /replace="g" /db_xref="dbSNP:11553648" CDS 232..993 /gene="CLDND1" /gene_synonym="C3orf4; GENX-3745" /note="isoform a is encoded by transcript variant 3; claudin domain containing 1 protein; claudin domain-containing protein 1; membrane protein GENX-3745" /codon_start=1 /product="claudin domain-containing protein 1 isoform a" /protein_id="NP_001035273.1" /db_xref="GI:93588624" /db_xref="CCDS:CCDS2930.1" /db_xref="GeneID:56650" /db_xref="HGNC:1322" /translation="
MDNRFATAFVIACVLSLISTIYMAASIGTDFWYEYRSPVQENSSDLNKSIWDEFISDEADEKTYNDALFRYNGTVGLWRRCITIPKNMHWYSPPERTESFDVVTKCVSFTLTEQFMEKFVDPGNHNSGIDLLRTYLWRCQFLLPFVSLGLMCFGALIGLCACICRSLYPTIATGILHLLAGLCTLGSVSCYVAGIELLHQKLELPDNVSGEFGWSFCLACVSAPLQFMASALFIWAAHTNRKEYTLMKAYRVA
"
misc_feature 244..306
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9NY35.1);
transmembrane region"
misc_feature 280..933
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/note="PMP-22/EMP/MP20/Claudin tight junction; Region:
Claudin_2; pfam13903"
/db_xref="CDD:206074"
misc_feature 652..714
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9NY35.1);
transmembrane region"
misc_feature 754..816
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9NY35.1);
transmembrane region"
misc_feature 877..939
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9NY35.1);
transmembrane region"
variation 242
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/replace="a"
/replace="g"
/db_xref="dbSNP:11553643"
variation 292
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/replace="a"
/replace="t"
/db_xref="dbSNP:11553647"
variation 308
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/replace="c"
/replace="g"
/db_xref="dbSNP:11553642"
variation 332
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/replace="a"
/replace="g"
/db_xref="dbSNP:11553639"
variation 410
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/replace="a"
/replace="g"
/db_xref="dbSNP:11553646"
variation 477
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/replace="a"
/replace="c"
/db_xref="dbSNP:11553650"
exon 524..634
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/inference="alignment:Splign:1.39.8"
exon 635..772
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/inference="alignment:Splign:1.39.8"
variation 726
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/replace="a"
/replace="t"
/db_xref="dbSNP:11553641"
variation 729
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/replace="c"
/replace="t"
/db_xref="dbSNP:35994971"
exon 773..2179
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/inference="alignment:Splign:1.39.8"
variation 915
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/replace="g"
/replace="t"
/db_xref="dbSNP:11553649"
STS 975..1065
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/standard_name="D3S2932E"
/db_xref="UniSTS:150916"
variation 1898
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/replace="a"
/replace="g"
/db_xref="dbSNP:11553644"
STS 1942..2144
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
/standard_name="D3S3109"
/db_xref="UniSTS:80916"
polyA_signal 2146..2151
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
polyA_signal 2152..2157
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
polyA_site 2169
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
polyA_site 2179
/gene="CLDND1"
/gene_synonym="C3orf4; GENX-3745"
ORIGIN
tatcgccgcctcagacagctttcagtctgtccctcctacaactcccacaaggcccctcggccccgggccgcggcccggcccggagtgggggcgggcggaggcgcgggagttatggagggggcgggctctgcagggaagtgcgtcagaggaggcgcggggagagtagggtgctgtggtctgagctagagggtgaagctggcggagcaggaggatgggcgtctgaatgccagaatggataaccgttttgctacagcatttgtaattgcttgtgtgcttagcctcatttccaccatctacatggcagcctccattggcacagacttctggtatgaatatcgaagtccagttcaagaaaattccagtgatttgaataaaagcatctgggatgaattcattagtgatgaggcagatgaaaagacttataatgatgcactttttcgatacaatggcacagtgggattgtggagacggtgtatcaccatacccaaaaacatgcattggtatagcccaccagaaaggacagagtcatttgatgtggtcacaaaatgtgtgagtttcacactaactgagcagttcatggagaaatttgttgatcccggaaaccacaatagcgggattgatctccttaggacctatctttggcgttgccagttccttttaccttttgtgagtttaggtttgatgtgctttggggctttgatcggactttgtgcttgcatttgccgaagcttatatcccaccattgccacgggcattctccatctccttgcaggtctgtgtacactgggctcagtaagttgttatgttgctggaattgaactactccaccagaaactagagctccctgacaatgtatccggtgaatttggatggtccttctgcctggcttgtgtctctgctcccttacagttcatggcttctgctctcttcatctgggctgctcacaccaaccggaaagagtacaccttaatgaaggcatatcgtgtggcatgagcaagaaactgcctgctttacaattgccatttttatttttttaaaataatactgatattttccccacctctcaattgtttttaatttttatttgtggatataccattttattatgaaaatctattttatttatacacattcaccactaaatacacacttaataccactaaaatttatgtggtttactttaagcgatgccatctttcaaataaactaatctaggtctagacagaaagaaatggatagagacttgacacaaatttatgaaagaaaattgggagtaggaatgtgaccgaaaacaagttgtgctaatgtctgttagacttttcagtaaaactaaagtaactgtatctgttcaactaaaaactctatattagtttctttgggaaacctctcatcgtcaaaactttatgttcactttgctgttgtagatagccagtcaaccagcagtattagtgctgttttcaaagatttaagctctataaaattgggaaattatctaagatcattttccctaagcattgacacatagcttcatctgaggtgagatatggcagctgtttgtatctgcactgtgtctgtctacaaaaagtgaaaaatacagtgtttacttgaaattttaactttgtaactgcaagaattccagttcagccgggcgaggattagtattatttttaactctccgtaagattttcagtaccaccaaattgttttggattttttttctttcctcttcacataccagggttattaaaagtgtgctttctttttacattatattacagttacaaggtaaaattcctcaactgctatttatttattccagcccagtactataaagaacgtttcaccataatgaccctccagagctgggaaacctaccacaagatctaaagttctggctgtccattaacctccaactatggtctttatttcttgtggtaatatgatgtgcctttccttgcctaaatcccttcctggtgtgtatcaacattatttaatgtcttctaattcagtcatttttttataagtatgtctataaacattgaactttaaaaaacttatttatttattccactactgtagcaattgacagattaaaaaaatgtaacttcataatttcttaccataacctcaatgtcttttttaaaaaataaaattaaaaatgaaaagagactcaattgtaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:56650 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA
by
@meso_cacase at
DBCLS
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