LOCUS       NM_001013743            1098 bp    mRNA    linear   PRI 15-JUN-2013
DEFINITION  Homo sapiens transmembrane protein 225 (TMEM225), mRNA.
ACCESSION   NM_001013743 XM_290501
VERSION     NM_001013743.1  GI:62000697
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1098)
  AUTHORS   Wu,J.H., Lemaitre,R.N., Manichaikul,A., Guan,W., Tanaka,T., Foy,M.,
            Kabagambe,E.K., Djousse,L., Siscovick,D., Fretts,A.M., Johnson,C.,
            King,I.B., Psaty,B.M., McKnight,B., Rich,S.S., Chen,Y.D.,
            Nettleton,J.A., Tang,W., Bandinelli,S., Jacobs,D.R. Jr.,
            Browning,B.L., Laurie,C.C., Gu,X., Tsai,M.Y., Steffen,L.M.,
            Ferrucci,L., Fornage,M. and Mozaffarian,D.
  TITLE     Genome-wide association study identifies novel loci associated with
            concentrations of four plasma phospholipid fatty acids in the de
            novo lipogenesis pathway: results from the Cohorts for Heart and
            Aging Research in Genomic Epidemiology (CHARGE) consortium
  JOURNAL   Circ Cardiovasc Genet 6 (2), 171-183 (2013)
   PUBMED   23362303
REFERENCE   2  (bases 1 to 1098)
  AUTHORS   Hendrickx,A., Beullens,M., Ceulemans,H., Den Abt,T., Van Eynde,A.,
            Nicolaescu,E., Lesage,B. and Bollen,M.
  TITLE     Docking motif-guided mapping of the interactome of protein
            phosphatase-1
  JOURNAL   Chem. Biol. 16 (4), 365-371 (2009)
   PUBMED   19389623
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY634366.1.
            On Mar 31, 2005 this sequence version replaced gi:42659618.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY634366.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025084, ERS025085 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1098
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.1"
     gene            1..1098
                     /gene="TMEM225"
                     /gene_synonym="PMP22CD"
                     /note="transmembrane protein 225"
                     /db_xref="GeneID:338661"
                     /db_xref="HGNC:32390"
                     /db_xref="HPRD:18492"
     exon            1..389
                     /gene="TMEM225"
                     /gene_synonym="PMP22CD"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    191..193
                     /gene="TMEM225"
                     /gene_synonym="PMP22CD"
                     /note="upstream in-frame stop codon"
     CDS             209..886
                     /gene="TMEM225"
                     /gene_synonym="PMP22CD"
                     /note="PMP22 claudin domain containing; PMP22 claudin
                     domain-containing protein"
                     /codon_start=1
                     /product="transmembrane protein 225"
                     /protein_id="NP_001013765.1"
                     /db_xref="GI:62000698"
                     /db_xref="CCDS:CCDS31697.1"
                     /db_xref="GeneID:338661"
                     /db_xref="HGNC:32390"
                     /db_xref="HPRD:18492"
                     /translation="

MVHVSNRSIQGMNILFSSWAVVLMVMGITLDKWVELISEDERAKMNHSPWMMCCPALWPEDDLKVVRIMMTSSLGLSFLLNLILGMKFTYLIPQNKYIQLFTTILSFFSGISLLWALILYHNKLKQGQSMHFSNYRITWIMYTAYLNVFFLSVCGVLSLLECKLSTSSCTCLNIHKSDNECKESENSIEDISLPECTAMPRSIVRAHTVNSLNKKVQTRHVTWAL

"
     misc_feature    233..295
                     /gene="TMEM225"
                     /gene_synonym="PMP22CD"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6GV28.1);
                     transmembrane region"
     misc_feature    263..688
                     /gene="TMEM225"
                     /gene_synonym="PMP22CD"
                     /note="PMP-22/EMP/MP20/Claudin tight junction; Region:
                     Claudin_2; pfam13903"
                     /db_xref="CDD:206074"
     misc_feature    425..487
                     /gene="TMEM225"
                     /gene_synonym="PMP22CD"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6GV28.1);
                     transmembrane region"
     misc_feature    506..568
                     /gene="TMEM225"
                     /gene_synonym="PMP22CD"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6GV28.1);
                     transmembrane region"
     misc_feature    617..679
                     /gene="TMEM225"
                     /gene_synonym="PMP22CD"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6GV28.1);
                     transmembrane region"
     STS             247..388
                     /gene="TMEM225"
                     /gene_synonym="PMP22CD"
                     /standard_name="RH93164"
                     /db_xref="UniSTS:92500"
     exon            390..536
                     /gene="TMEM225"
                     /gene_synonym="PMP22CD"
                     /inference="alignment:Splign:1.39.8"
     exon            537..671
                     /gene="TMEM225"
                     /gene_synonym="PMP22CD"
                     /inference="alignment:Splign:1.39.8"
     exon            672..1098
                     /gene="TMEM225"
                     /gene_synonym="PMP22CD"
                     /inference="alignment:Splign:1.39.8"
     STS             788..958
                     /gene="TMEM225"
                     /gene_synonym="PMP22CD"
                     /standard_name="RH102553"
                     /db_xref="UniSTS:96887"
     variation       794
                     /gene="TMEM225"
                     /gene_synonym="PMP22CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1939927"
     variation       928
                     /gene="TMEM225"
                     /gene_synonym="PMP22CD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1939928"
     variation       1045
                     /gene="TMEM225"
                     /gene_synonym="PMP22CD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1054041"
ORIGIN      

acagcaggctggccctgatagataacggaagtgaggaagggtgagagttatctatcttctctgttttatagactacttcagcttctgctgttaccaatgcctcagcaaccactgaaagttcagatatcacccttcttgtaactaatcaaatcaaggaagagatctacaaaatagtggtggtggttccagctagaaattttcactcacaatggtgcatgtttcaaatagaagtatccagggtatgaacatacttttctcctcctgggccgtagtcttaatggtgatgggaatcaccttagataaatgggttgaattgatttcagaagatgaaagagccaagatgaaccacagtccttggatgatgtgttgccctgctctttggccagaagatgacctgaaagtggtcaggattatgatgacgtcgagccttggcctttccttcctccttaacttaatcctgggtatgaaattcacctatctgattcctcaaaataaatatatacaactcttcactaccatcctcagtttcttctcaggtatctctctgctctgggcactcatactatatcacaataagctgaagcaaggtcaatccatgcacttctctaattataggatcacctggatcatgtatactgcttacttaaatgttttcttcttgtctgtctgtggagtcctctctctcctagagtgcaagttgtctaccagtagctgtacctgcctgaacatccataaatctgacaacgaatgtaaggaatctgagaattctatcgaagatatttcattaccagaatgcactgcaatgcctcgtagcattgtccgtgcacacactgtgaattccctaaacaaaaaagtccaaacacgtcacgtaacctgggctctgtgatttggcaatctatttcttgcagtatatgctcatctttatggaaaaagctttgtgggtgtgtgctgtgtctccaaccatgttgtctctatttggaattatggttggggtttgtaaaaagatctggaagatggttttttaaaaaatcctggcctgctgaacgaatagtttcttctgcaacatttgttgttaatataataaatattatcatataa

//

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:338661 -> Biological process: GO:0010923 [negative regulation of phosphatase activity] evidence: IDA
            GeneID:338661 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA