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2025-05-12 01:51:01, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_000224 1485 bp mRNA linear PRI 15-JUL-2013
DEFINITION Homo sapiens keratin 18 (KRT18), transcript variant 1, mRNA.
ACCESSION NM_000224
VERSION NM_000224.2 GI:40354193
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1485)
AUTHORS Fortier,A.M., Asselin,E. and Cadrin,M.
TITLE Keratin 8 and 18 loss in epithelial cancer cells increases
collective cell migration and cisplatin sensitivity through
claudin1 up-regulation
JOURNAL J. Biol. Chem. 288 (16), 11555-11571 (2013)
PUBMED 23449973
REMARK GeneRIF: K8/18 expression can influence the phenotype of epithelial
cancer cells at a transcriptional level and supports the hypothesis
that keratins play an active role in cancer progression.
REFERENCE 2 (bases 1 to 1485)
AUTHORS Mathew,J., Loranger,A., Gilbert,S., Faure,R. and Marceau,N.
TITLE Keratin 8/18 regulation of glucose metabolism in normal versus
cancerous hepatic cells through differential modulation of
hexokinase status and insulin signaling
JOURNAL Exp. Cell Res. 319 (4), 474-486 (2013)
PUBMED 23164509
REMARK GeneRIF: A key K8/K18 regulation of glucose metabolism in normal
and cancerous hepatic cells through differential modulations of
mitochondrial hexokinase status and insulin-mediated signaling.
REFERENCE 3 (bases 1 to 1485)
AUTHORS Iyer,S.V., Dange,P.P., Alam,H., Sawant,S.S., Ingle,A.D.,
Borges,A.M., Shirsat,N.V., Dalal,S.N. and Vaidya,M.M.
TITLE Understanding the role of keratins 8 and 18 in neoplastic potential
of breast cancer derived cell lines
JOURNAL PLoS ONE 8 (1), E53532 (2013)
PUBMED 23341946
REMARK GeneRIF: These results indicate the role of K8/18 in modulating
invasion in breast cancer.
REFERENCE 4 (bases 1 to 1485)
AUTHORS Wang,Y., Zhu,J.F., Liu,Y.Y. and Han,G.P.
TITLE An analysis of cyclin D1, cytokeratin 5/6 and cytokeratin 8/18
expression in breast papillomas and papillary carcinomas
JOURNAL Diagn Pathol 8, 8 (2013)
PUBMED 23327593
REMARK GeneRIF: Report keratin 18 expression in breast papillomas and
papillary carcinoma.
Publication Status: Online-Only
REFERENCE 5 (bases 1 to 1485)
AUTHORS Valva,P., Casciato,P., Lezama,C., Galoppo,M., Gadano,A.,
Galdame,O., Galoppo,M.C., Mullen,E., De Matteo,E. and Preciado,M.V.
TITLE Serum apoptosis markers related to liver damage in chronic
hepatitis C: sFas as a marker of advanced fibrosis in children and
adults while M30 of severe steatosis only in children
JOURNAL PLoS ONE 8 (1), E53519 (2013)
PUBMED 23326448
REMARK GeneRIF: Serum sFas could be considered a possible marker of
advanced fibrosis both in pediatric and adult patient with chronic
hepatitis C as well as M30 might be a good predictor of steatosis
severity in children.
REFERENCE 6 (bases 1 to 1485)
AUTHORS Omary,M.B., Baxter,G.T., Chou,C.F., Riopel,C.L., Lin,W.Y. and
Strulovici,B.
TITLE PKC epsilon-related kinase associates with and phosphorylates
cytokeratin 8 and 18
JOURNAL J. Cell Biol. 117 (3), 583-593 (1992)
PUBMED 1374067
REFERENCE 7 (bases 1 to 1485)
AUTHORS Heath,P., Elvin,P., Jenner,D., Gammack,A., Morten,J. and Markham,A.
TITLE Localisation of a cDNA clone for human cytokeratin 18 to chromosome
17p11-p12 by in situ hybridisation
JOURNAL Hum. Genet. 85 (6), 669-670 (1990)
PUBMED 1699878
REFERENCE 8 (bases 1 to 1485)
AUTHORS Waseem,A., Gough,A.C., Spurr,N.K. and Lane,E.B.
TITLE Localization of the gene for human simple epithelial keratin 18 to
chromosome 12 using polymerase chain reaction
JOURNAL Genomics 7 (2), 188-194 (1990)
PUBMED 1693358
REFERENCE 9 (bases 1 to 1485)
AUTHORS Waseem,A., Alexander,C.M., Steel,J.B. and Lane,E.B.
TITLE Embryonic simple epithelial keratins 8 and 18: chromosomal location
emphasizes difference from other keratin pairs
JOURNAL New Biol. 2 (5), 464-478 (1990)
PUBMED 1705144
REFERENCE 10 (bases 1 to 1485)
AUTHORS Romano,V., Hatzfeld,M., Magin,T.M., Zimbelmann,R., Franke,W.W.,
Maier,G. and Ponstingl,H.
TITLE Cytokeratin expression in simple epithelia. I. Identification of
mRNA coding for human cytokeratin no. 18 by a cDNA clone
JOURNAL Differentiation 30 (3), 244-253 (1986)
PUBMED 2422083
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from CD106591.1, X12881.1 and
BC000180.2.
This sequence is a reference standard in the RefSeqGene project.
On Dec 24, 2003 this sequence version replaced gi:4557887.
Summary: KRT18 encodes the type I intermediate filament chain
keratin 18. Keratin 18, together with its filament partner keratin
8, are perhaps the most commonly found members of the intermediate
filament gene family. They are expressed in single layer epithelial
tissues of the body. Mutations in this gene have been linked to
cryptogenic cirrhosis. Two transcript variants encoding the same
protein have been found for this gene. [provided by RefSeq, Jul
2008].
Transcript Variant: This variant (1) represents the longer
transcript. Variants 1 and 2 both encode the same protein.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK223093.1, BC072017.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025082 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-772 CD106591.1 1-772
773-1467 X12881.1 704-1398
1468-1485 BC000180.2 1394-1411
FEATURES Location/Qualifiers
source 1..1485
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="12"
/map="12q13"
gene 1..1485
/gene="KRT18"
/gene_synonym="CYK18; K18"
/note="keratin 18"
/db_xref="GeneID:3875"
/db_xref="HGNC:6430"
/db_xref="HPRD:01020"
/db_xref="MIM:148070"
exon 1..532
/gene="KRT18"
/gene_synonym="CYK18; K18"
/inference="alignment:Splign:1.39.8"
variation 30
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="g"
/replace="t"
/db_xref="dbSNP:7978102"
variation 62
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="c"
/db_xref="dbSNP:368939913"
variation 65
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:372353986"
variation 76
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:376817240"
variation 80
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:200298277"
variation 84
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:199517515"
variation 90
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:373418568"
variation 97
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:201934812"
variation 100
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="t"
/db_xref="dbSNP:200362147"
variation 101
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:267607653"
variation 104..105
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:11551630"
variation 105
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:376727372"
variation 109
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:201179094"
CDS 116..1408
/gene="KRT18"
/gene_synonym="CYK18; K18"
/note="cytokeratin 18; cell proliferation-inducing protein
46; CK-18; keratin-18; cytokeratin-18; cell
proliferation-inducing gene 46 protein"
/codon_start=1
/product="keratin, type I cytoskeletal 18"
/protein_id="NP_000215.1"
/db_xref="GI:4557888"
/db_xref="CCDS:CCDS31809.1"
/db_xref="GeneID:3875"
/db_xref="HGNC:6430"
/db_xref="HPRD:01020"
/db_xref="MIM:148070"
/translation="
MSFTTRSTFSTNYRSLGSVQAPSYGARPVSSAASVYAGAGGSGSRISVSRSTSFRGGMGSGGLATGIAGGLAGMGGIQNEKETMQSLNDRLASYLDRVRSLETENRRLESKIREHLEKKGPQVRDWSHYFKIIEDLRAQIFANTVDNARIVLQIDNARLAADDFRVKYETELAMRQSVENDIHGLRKVIDDTNITRLQLETEIEALKEELLFMKKNHEEEVKGLQAQIASSGLTVEVDAPKSQDLAKIMADIRAQYDELARKNREELDKYWSQQIEESTTVVTTQSAEVGAAETTLTELRRTVQSLEIDLDSMRNLKASLENSLREVEARYALQMEQLNGILLHLESELAQTRAEGQRQAQEYEALLNIKVKLEAEIATYRRLLEDGEDFNLGDALDSSNSMQTIQKTTTRRIVDGKVVSETNDTKVLRH
"
misc_feature 119..352
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P05783.2);
Region: Head"
misc_feature 119..121
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="N-acetylserine; propagated from
UniProtKB/Swiss-Prot (P05783.2); acetylation site"
misc_feature 134..136
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P05783.2); phosphorylation site"
misc_feature 143..145
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P05783.2); phosphorylation site"
misc_feature 152..154
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 158..160
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P05783.2); phosphorylation site"
misc_feature 167..169
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P05783.2); phosphorylation site"
misc_feature 203..205
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="glycosylation site"
misc_feature 206..208
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="glycosylation site"
misc_feature 206..208
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, alternate; propagated from
UniProtKB/Swiss-Prot (P05783.2); phosphorylation site"
misc_feature 215..217
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by CDK1; propagated from
UniProtKB/Swiss-Prot (P05783.2); phosphorylation site"
misc_feature 215..217
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:00302"
misc_feature 221..223
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphotyrosine; propagated from
UniProtKB/Swiss-Prot (P05783.2); phosphorylation site"
misc_feature 239..241
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P05783.2); phosphorylation site"
misc_feature 260..262
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="glycosylation site"
misc_feature 272..274
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by CAMK, PKC/PRKCE and AURKA;
propagated from UniProtKB/Swiss-Prot (P05783.2);
phosphorylation site"
misc_feature 272..274
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/citation=[6]
/db_xref="HPRD:01498"
misc_feature 272..274
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/citation=[6]
/db_xref="HPRD:02092"
misc_feature 272..274
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/citation=[6]
/db_xref="HPRD:01500"
misc_feature 272..274
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/citation=[6]
/db_xref="HPRD:06532"
misc_feature 293..295
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P05783.2); phosphorylation site"
misc_feature 308..310
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine; propagated from
UniProtKB/Swiss-Prot (P05783.2); phosphorylation site"
misc_feature 308..310
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 323..1234
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P05783.2);
Region: Necessary for interaction with PNN"
misc_feature 344..499
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P05783.2);
Region: Interaction with TRADD"
misc_feature 350..1282
/gene="KRT18"
/gene_synonym="CYK18; K18"
/note="Intermediate filament protein; Region: Filament;
pfam00038"
/db_xref="CDD:200948"
misc_feature 353..1276
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P05783.2);
Region: Rod"
misc_feature 353..460
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P05783.2);
Region: Coil 1A"
misc_feature 413..415
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P05783.2); phosphorylation site"
misc_feature 461..511
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P05783.2);
Region: Linker 1"
misc_feature 506..508
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (P05783.2); acetylation site"
misc_feature 512..787
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P05783.2);
Region: Coil 1B"
misc_feature 644..646
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P05783.2); phosphorylation site"
misc_feature 788..859
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P05783.2);
Region: Linker 12"
misc_feature 827..832
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="Cleavage, by caspase-3, caspase-6 or caspase-7;
propagated from UniProtKB/Swiss-Prot (P05783.2); cleavage
site"
misc_feature 827..829
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="proteolytic cleavage site; modified site"
/db_xref="HPRD:02799"
misc_feature 827..829
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="proteolytic cleavage site; modified site"
/db_xref="HPRD:03457"
misc_feature 827..829
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="proteolytic cleavage site; modified site"
/db_xref="HPRD:03321"
misc_feature 842..1288
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P05783.2);
Region: Interaction with DNAJB6"
misc_feature 860..1276
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P05783.2);
Region: Coil 2"
misc_feature 926..928
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="Stutter; propagated from UniProtKB/Swiss-Prot
(P05783.2); other site"
misc_feature 1019..1021
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine; propagated from
UniProtKB/Swiss-Prot (P05783.2); phosphorylation site"
misc_feature 1070..1072
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P05783.2); phosphorylation site"
misc_feature 1106..1108
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="Stutter; propagated from UniProtKB/Swiss-Prot
(P05783.2); other site"
misc_feature 1277..1405
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P05783.2);
Region: Tail"
misc_feature 1304..1306
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="proteolytic cleavage site; modified site"
/db_xref="HPRD:02799"
misc_feature 1310..1312
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P05783.2); phosphorylation site"
misc_feature 1310..1312
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1325..1327
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine; propagated from
UniProtKB/Swiss-Prot (P05783.2); phosphorylation site"
misc_feature 1391..1393
/gene="KRT18"
/gene_synonym="CYK18; K18"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (P05783.2); acetylation site"
variation 120
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="g"
/db_xref="dbSNP:369198778"
variation 121
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:141170056"
variation 126
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:76301931"
variation 163
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:80354424"
variation 165
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:79476176"
variation 168
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="g"
/db_xref="dbSNP:147350452"
variation 184
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:141066547"
variation 191
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:78514003"
variation 192
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:11551634"
variation 194
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:77825282"
variation 198
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="c"
/db_xref="dbSNP:74379840"
variation 207
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="g"
/replace="t"
/db_xref="dbSNP:374064321"
variation 209
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="g"
/replace="t"
/db_xref="dbSNP:74953757"
variation 217
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:78343594"
variation 227
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="g"
/replace="t"
/db_xref="dbSNP:77999286"
variation 229
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:75380684"
variation 232
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:75174163"
variation 242
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="g"
/db_xref="dbSNP:75441140"
variation 249
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="g"
/db_xref="dbSNP:200221269"
variation 256
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:80004568"
variation 263
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:78479490"
variation 264
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="g"
/replace="t"
/db_xref="dbSNP:11551633"
variation 278
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="c"
/db_xref="dbSNP:78718957"
variation 282
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:76183244"
variation 292
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="g"
/replace="t"
/db_xref="dbSNP:76187914"
variation 295
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:186267053"
variation 308..331
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace=""
/replace="accgggatagccgggggtctggca"
/db_xref="dbSNP:267607417"
variation 310
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="g"
/db_xref="dbSNP:79913669"
variation 316
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:77364359"
variation 320
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:11551624"
variation 353
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:199572098"
variation 367
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:79346135"
variation 384
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:11551641"
variation 390
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:11551623"
variation 397
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:386834224"
variation 420
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="t"
/db_xref="dbSNP:144926827"
variation 422
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:61136606"
variation 424
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="g"
/db_xref="dbSNP:373362435"
variation 431
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:11551638"
variation 445
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:11551621"
variation 457
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="g"
/db_xref="dbSNP:11551637"
variation 471
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:147945345"
variation 482
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="g"
/replace="t"
/db_xref="dbSNP:11551629"
variation 485
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:11551632"
variation 493
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="g"
/replace="t"
/db_xref="dbSNP:140324943"
variation 498
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="t"
/db_xref="dbSNP:57758506"
exon 533..615
/gene="KRT18"
/gene_synonym="CYK18; K18"
/inference="alignment:Splign:1.39.8"
variation 553
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:370728079"
variation 561
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:200694483"
variation 563
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:59979366"
variation 588
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:369948432"
variation 589
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:78791501"
variation 596
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:11551626"
variation 604
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:77832070"
exon 616..772
/gene="KRT18"
/gene_synonym="CYK18; K18"
/inference="alignment:Splign:1.39.8"
variation 617..618
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:17856017"
variation 627
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="t"
/db_xref="dbSNP:11551625"
variation 640
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:369743947"
variation 691
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:11551628"
variation 692
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:11170343"
variation 700
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:115544685"
variation 714
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:146788536"
variation 718
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="c"
/db_xref="dbSNP:11551622"
variation 766
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:372594060"
variation 767
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:375823747"
exon 773..937
/gene="KRT18"
/gene_synonym="CYK18; K18"
/inference="alignment:Splign:1.39.8"
variation 804
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="g"
/db_xref="dbSNP:58472472"
variation 835
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="c"
/db_xref="dbSNP:1049159"
variation 856
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:17174405"
STS 857..1034
/gene="KRT18"
/gene_synonym="CYK18; K18"
/standard_name="G66248"
/db_xref="UniSTS:230089"
variation 862
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:191325805"
variation 876
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="g"
/db_xref="dbSNP:11551642"
variation 877
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:145578755"
variation 897
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:57354642"
variation 904
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:11551643"
exon 938..1063
/gene="KRT18"
/gene_synonym="CYK18; K18"
/inference="alignment:Splign:1.39.8"
variation 942
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:61696408"
variation 969
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:59112368"
variation 991
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="g"
/replace="t"
/db_xref="dbSNP:141750671"
variation 997
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:150137089"
variation 999
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:267607418"
variation 1005
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:115810585"
variation 1015
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="t"
/db_xref="dbSNP:11551636"
variation 1039
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:149270992"
variation 1040
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:199930351"
exon 1064..1287
/gene="KRT18"
/gene_synonym="CYK18; K18"
/inference="alignment:Splign:1.39.8"
variation 1102
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:371513958"
variation 1103
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:147365823"
variation 1108
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:58138700"
STS 1110..1298
/gene="KRT18"
/gene_synonym="CYK18; K18"
/standard_name="SHGC-11808"
/db_xref="UniSTS:27701"
variation 1117
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="g"
/db_xref="dbSNP:11542066"
variation 1127
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:11551635"
variation 1132
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:372449912"
variation 1133
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:57370769"
STS 1142..1220
/gene="KRT18"
/gene_synonym="CYK18; K18"
/standard_name="G66074"
/db_xref="UniSTS:230065"
variation 1151
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:143380812"
STS 1185..1354
/gene="KRT18"
/gene_synonym="CYK18; K18"
/standard_name="PMC17321P1"
/db_xref="UniSTS:271636"
variation 1201
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:144702029"
variation 1232
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="g"
/db_xref="dbSNP:17467"
variation 1257
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:147541172"
variation 1259
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="c"
/db_xref="dbSNP:11551627"
STS 1273..1453
/gene="KRT18"
/gene_synonym="CYK18; K18"
/standard_name="STS-N95819"
/db_xref="UniSTS:81461"
exon 1288..1467
/gene="KRT18"
/gene_synonym="CYK18; K18"
/inference="alignment:Splign:1.39.8"
variation 1343
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="c"
/db_xref="dbSNP:1063607"
variation 1345
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="g"
/db_xref="dbSNP:386834225"
variation 1347
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:148580152"
variation 1350
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:146080391"
variation 1351
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:142940942"
variation 1383
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:200552337"
variation 1397
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="c"
/replace="t"
/db_xref="dbSNP:709170"
variation 1435
/gene="KRT18"
/gene_synonym="CYK18; K18"
/replace="a"
/replace="g"
/db_xref="dbSNP:377238570"
polyA_signal 1448..1453
/gene="KRT18"
/gene_synonym="CYK18; K18"
polyA_site 1467
/gene="KRT18"
/gene_synonym="CYK18; K18"
ORIGIN
tccggggcgggggcggggcctcactctgcgatataactcgggtcgcgcggctcgcgcaggccgccaccgtcgtccgcaaagcctgagtcctgtcctttctctctccccggacagcatgagcttcaccactcgctccaccttctccaccaactaccggtccctgggctctgtccaggcgcccagctacggcgcccggccggtcagcagcgcggccagcgtctatgcaggcgctgggggctctggttcccggatctccgtgtcccgctccaccagcttcaggggcggcatggggtccgggggcctggccaccgggatagccgggggtctggcaggaatgggaggcatccagaacgagaaggagaccatgcaaagcctgaacgaccgcctggcctcttacctggacagagtgaggagcctggagaccgagaaccggaggctggagagcaaaatccgggagcacttggagaagaagggaccccaggtcagagactggagccattacttcaagatcatcgaggacctgagggctcagatcttcgcaaatactgtggacaatgcccgcatcgttctgcagattgacaatgcccgtcttgctgctgatgactttagagtcaagtatgagacagagctggccatgcgccagtctgtggagaacgacatccatgggctccgcaaggtcattgatgacaccaatatcacacgactgcagctggagacagagatcgaggctctcaaggaggagctgctcttcatgaagaagaaccacgaagaggaagtaaaaggcctacaagcccagattgccagctctgggttgaccgtggaggtagatgcccccaaatctcaggacctcgccaagatcatggcagacatccgggcccaatatgacgagctggctcggaagaaccgagaggagctagacaagtactggtctcagcagattgaggagagcaccacagtggtcaccacacagtctgctgaggttggagctgctgagacgacgctcacagagctgagacgtacagtccagtccttggagatcgacctggactccatgagaaatctgaaggccagcttggagaacagcctgagggaggtggaggcccgctacgccctacagatggagcagctcaacgggatcctgctgcaccttgagtcagagctggcacagacccgggcagagggacagcgccaggcccaggagtatgaggccctgctgaacatcaaggtcaagctggaggctgagatcgccacctaccgccgcctgctggaagatggcgaggactttaatcttggtgatgccttggacagcagcaactccatgcaaaccatccaaaagaccaccacccgccggatagtggatggcaaagtggtgtctgagaccaatgacaccaaagttctgaggcattaagccagcagaagcagggtaccctttggggagcaggaggccaataaaaagttcagagttcaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:3875 -> Molecular function: GO:0005198 [structural molecule activity] evidence: IEA
GeneID:3875 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:3875 -> Molecular function: GO:0097110 [scaffold protein binding] evidence: IPI
GeneID:3875 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:3875 -> Biological process: GO:0007049 [cell cycle] evidence: IEA
GeneID:3875 -> Biological process: GO:0009653 [anatomical structure morphogenesis] evidence: TAS
GeneID:3875 -> Biological process: GO:0019048 [modulation by virus of host morphology or physiology] evidence: IEA
GeneID:3875 -> Biological process: GO:0033209 [tumor necrosis factor-mediated signaling pathway] evidence: IEA
GeneID:3875 -> Biological process: GO:0043000 [Golgi to plasma membrane CFTR protein transport] evidence: IDA
GeneID:3875 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: IDA
GeneID:3875 -> Cellular component: GO:0005730 [nucleolus] evidence: IEA
GeneID:3875 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:3875 -> Cellular component: GO:0005815 [microtubule organizing center] evidence: IDA
GeneID:3875 -> Cellular component: GO:0005882 [intermediate filament] evidence: IDA
GeneID:3875 -> Cellular component: GO:0034451 [centriolar satellite] evidence: IDA
GeneID:3875 -> Cellular component: GO:0045095 [keratin filament] evidence: IDA
GeneID:3875 -> Cellular component: GO:0048471 [perinuclear region of cytoplasm] evidence: IEA
by
@meso_cacase at
DBCLS
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