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2025-05-09 12:17:19, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_152431 3214 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens piwi-like RNA-mediated gene silencing 4 (PIWIL4),
mRNA.
ACCESSION NM_152431
VERSION NM_152431.2 GI:221316710
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3214)
AUTHORS Su,C., Ren,Z.J., Wang,F., Liu,M., Li,X. and Tang,H.
TITLE PIWIL4 regulates cervical cancer cell line growth and is involved
in down-regulating the expression of p14ARF and p53
JOURNAL FEBS Lett. 586 (9), 1356-1362 (2012)
PUBMED 22483988
REMARK GeneRIF: PIWIL4 might play an oncogenic role in cervical cancer
REFERENCE 2 (bases 1 to 3214)
AUTHORS Greither,T., Koser,F., Kappler,M., Bache,M., Lautenschlager,C.,
Gobel,S., Holzhausen,H.J., Wach,S., Wurl,P. and Taubert,H.
TITLE Expression of human Piwi-like genes is associated with prognosis
for soft tissue sarcoma patients
JOURNAL BMC Cancer 12, 272 (2012)
PUBMED 22748119
REMARK GeneRIF: we identified a significant association between the
expression of Piwi-like 2 and 4 mRNAs and the tumor-specific
survival of soft tissue sarcoma patients.
Publication Status: Online-Only
REFERENCE 3 (bases 1 to 3214)
AUTHORS Gu,A., Ji,G., Shi,X., Long,Y., Xia,Y., Song,L., Wang,S. and Wang,X.
TITLE Genetic variants in Piwi-interacting RNA pathway genes confer
susceptibility to spermatogenic failure in a Chinese population
JOURNAL Hum. Reprod. 25 (12), 2955-2961 (2010)
PUBMED 20940137
REMARK GeneRIF: An SNP in the 3'untranslated region of HIWI2 and a
non-synonymous SNP in HIWI3 were significantly associated with an
altered risk of oligozoospermia.
GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 4 (bases 1 to 3214)
AUTHORS Kim,J.S., Choi,Y.Y., Jin,G., Kang,H.G., Choi,J.E., Jeon,H.S.,
Lee,W.K., Kim,D.S., Kim,C.H., Kim,Y.J., Son,J.W., Jung,T.H. and
Park,J.Y.
TITLE Association of a common AGO1 variant with lung cancer risk: a
two-stage case-control study
JOURNAL Mol. Carcinog. 49 (10), 913-921 (2010)
PUBMED 20721975
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 5 (bases 1 to 3214)
AUTHORS Li,L., Yu,C., Gao,H. and Li,Y.
TITLE Argonaute proteins: potential biomarkers for human colon cancer
JOURNAL BMC Cancer 10, 38 (2010)
PUBMED 20146808
REMARK GeneRIF: EIF2C2-4 and PIWIL4 appear increased in advanced tumors
with distant metastasis, suggesting they may promote tumor invasion
Publication Status: Online-Only
REFERENCE 6 (bases 1 to 3214)
AUTHORS Sonuga-Barke,E.J., Lasky-Su,J., Neale,B.M., Oades,R., Chen,W.,
Franke,B., Buitelaar,J., Banaschewski,T., Ebstein,R., Gill,M.,
Anney,R., Miranda,A., Mulas,F., Roeyers,H., Rothenberger,A.,
Sergeant,J., Steinhausen,H.C., Thompson,M., Asherson,P. and
Faraone,S.V.
TITLE Does parental expressed emotion moderate genetic effects in ADHD?
An exploration using a genome wide association scan
JOURNAL Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (8), 1359-1368
(2008)
PUBMED 18846501
REFERENCE 7 (bases 1 to 3214)
AUTHORS Sugimoto,K., Kage,H., Aki,N., Sano,A., Kitagawa,H., Nagase,T.,
Yatomi,Y., Ohishi,N. and Takai,D.
TITLE The induction of H3K9 methylation by PIWIL4 at the p16Ink4a locus
JOURNAL Biochem. Biophys. Res. Commun. 359 (3), 497-502 (2007)
PUBMED 17544373
REMARK GeneRIF: PIWIL4 plays important roles in the chromatin-modifying
pathway in human somatic cells
REFERENCE 8 (bases 1 to 3214)
AUTHORS Tahbaz,N., Kolb,F.A., Zhang,H., Jaronczyk,K., Filipowicz,W. and
Hobman,T.C.
TITLE Characterization of the interactions between mammalian PAZ PIWI
domain proteins and Dicer
JOURNAL EMBO Rep. 5 (2), 189-194 (2004)
PUBMED 14749716
REFERENCE 9 (bases 1 to 3214)
AUTHORS Sasaki,T., Shiohama,A., Minoshima,S. and Shimizu,N.
TITLE Identification of eight members of the Argonaute family in the
human genome small star, filled
JOURNAL Genomics 82 (3), 323-330 (2003)
PUBMED 12906857
REFERENCE 10 (bases 1 to 3214)
AUTHORS Carmell,M.A., Xuan,Z., Zhang,M.Q. and Hannon,G.J.
TITLE The Argonaute family: tentacles that reach into RNAi, developmental
control, stem cell maintenance, and tumorigenesis
JOURNAL Genes Dev. 16 (21), 2733-2742 (2002)
PUBMED 12414724
REMARK Review article
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
DB091271.1, BC031060.1 and AB079366.1.
On Jan 24, 2009 this sequence version replaced gi:22748904.
Summary: PIWIL4 belongs to the Argonaute family of proteins, which
function in development and maintenance of germline stem cells
(Sasaki et al., 2003 [PubMed 12906857]).[supplied by OMIM, Mar
2008].
##Evidence-Data-START##
Transcript exon combination :: BC031060.1, AB079366.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084, ERS025085 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-208 DB091271.1 1-208
209-2130 BC031060.1 1-1922
2131-3198 AB079366.1 2091-3158
3199-3214 BC031060.1 2991-3006
FEATURES Location/Qualifiers
source 1..3214
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="11"
/map="11q21"
gene 1..3214
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/note="piwi-like RNA-mediated gene silencing 4"
/db_xref="GeneID:143689"
/db_xref="HGNC:18444"
/db_xref="MIM:610315"
exon 1..298
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/inference="alignment:Splign:1.39.8"
variation 30
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="c"
/replace="t"
/db_xref="dbSNP:72963841"
variation 32
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="c"
/replace="t"
/db_xref="dbSNP:190825730"
variation 57
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="g"
/db_xref="dbSNP:368261413"
misc_feature 164..166
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/note="upstream in-frame stop codon"
variation 178
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="c"
/db_xref="dbSNP:374228173"
variation 198
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="g"
/db_xref="dbSNP:377635979"
CDS 212..2770
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/note="piwi-like 4"
/codon_start=1
/product="piwi-like protein 4"
/protein_id="NP_689644.2"
/db_xref="GI:221316711"
/db_xref="CCDS:CCDS31656.1"
/db_xref="GeneID:143689"
/db_xref="HGNC:18444"
/db_xref="MIM:610315"
/translation="
MSGRARVKARGIARSPSATEVGRIQASPLPRSVDLSNNEASSSNGFLGTSRISTNDKYGISSGDAGSTFMERGVKNKQDFMDLSICTREKLAHVRNCKTGSSGIPVKLVTNLFNLDFPQDWQLYQYHVTYIPDLASRRLRIALLYSHSELSNKAKAFDGAILFLSQKLEEKVTELSSETQRGETIKMTITLKRELPSSSPVCIQVFNIIFRKILKKLSMYQIGRNFYNPSEPMEIPQHKLSLWPGFAISVSYFERKLLFSADVSYKVLRNETVLEFMTALCQRTGLSCFTQTCEKQLIGLIVLTRYNNRTYSIDDIDWSVKPTHTFQKRDGTEITYVDYYKQQYDITVSDLNQPMLVSLLKKKRNDNSEAQLAHLIPELCFLTGLTDQATSDFQLMKAVAEKTRLSPSGRQQRLARLVDNIQRNTNARFELETWGLHFGSQISLTGRIVPSEKILMQDHICQPVSAADWSKDIRTCKILNAQSLNTWLILCSDRTEYVAESFLNCLRRVAGSMGFNVDYPKIIKVQENPAAFVRAIQQYVDPDVQLVMCILPSNQKTYYDSIKKYLSSDCPVPSQCVLARTLNKQGMMMSIATKIAMQMTCKLGGELWAVEIPLKSLMVVGIDVCKDALSKDVMVVGCVASVNPRITRWFSRCILQRTMTDVADCLKVFMTGALNKWYKYNHDLPARIIVYRAGVGDGQLKTLIEYEVPQLLSSVAESSSNTSSRLSVIVVRKKCMPRFFTEMNRTVQNPPLGTVVDSEATRNEWYDFYLISQVACRGTVSPTYYNVIYDDNGLKPDHMQRLTFKLCHLYYNWPGIVSVPAPCQYAHKLTFLVAQSIHKEPSLELANHLFYL
"
misc_feature 1019..1369
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/note="PAZ domain, Piwi_like subfamily. In multi-cellular
organisms, the Piwi protein appears to be essential for
the maintenance of germline stem cells. In the Drosophila
male germline, Piwi was shown to be involved in the
silencing of retrotransposons in the...; Region:
PAZ_piwi_like; cd02845"
/db_xref="CDD:30330"
misc_feature order(1154..1156,1193..1195,1217..1219,1229..1231,
1283..1285,1328..1330,1334..1336)
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/note="nucleic acid-binding interface [nucleotide
binding]; other site"
/db_xref="CDD:30330"
misc_feature 1391..2716
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/note="Piwi_piwi-like_Euk: PIWI domain, Piwi-like
subfamily found in eukaryotes. This domain is found in
Piwi and closely related proteins, where it is believed to
perform a crucial role in germline cells, via RNA
silencing. RNA silencing refers to a group of...; Region:
Piwi_piwi-like_Euk; cd04658"
/db_xref="CDD:72943"
misc_feature order(1886..1888,1898..1900,1934..1945,1952..1954,
1982..1984,1991..1993,2003..2005,2015..2017)
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/note="5' RNA guide strand anchoring site; other site"
/db_xref="CDD:72943"
misc_feature order(2078..2080,2084..2086,2288..2290,2690..2692)
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/note="active site"
/db_xref="CDD:72943"
variation 236
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="c"
/replace="g"
/db_xref="dbSNP:140949565"
variation 262
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="c"
/replace="t"
/db_xref="dbSNP:149735828"
exon 299..377
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/inference="alignment:Splign:1.39.8"
variation 354
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="c"
/replace="g"
/db_xref="dbSNP:368907778"
exon 378..509
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/inference="alignment:Splign:1.39.8"
variation 396
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="c"
/replace="t"
/db_xref="dbSNP:147845557"
variation 426
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="c"
/replace="g"
/db_xref="dbSNP:141466248"
variation 428
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="g"
/db_xref="dbSNP:372720869"
variation 444
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="g"
/db_xref="dbSNP:12276921"
exon 510..724
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/inference="alignment:Splign:1.39.8"
variation 544
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="c"
/replace="g"
/db_xref="dbSNP:191669581"
variation 565
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="c"
/replace="t"
/db_xref="dbSNP:138151600"
variation 602
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="c"
/db_xref="dbSNP:375398129"
variation 679
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="g"
/db_xref="dbSNP:368513966"
variation 683
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="g"
/db_xref="dbSNP:372240769"
variation 685
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="c"
/replace="t"
/db_xref="dbSNP:368212360"
variation 707
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="c"
/replace="t"
/db_xref="dbSNP:201154153"
variation 711
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="g"
/db_xref="dbSNP:12272255"
variation 719
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="g"
/db_xref="dbSNP:143080347"
exon 725..846
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/inference="alignment:Splign:1.39.8"
variation 730
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="g"
/db_xref="dbSNP:374254224"
variation 792
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="c"
/db_xref="dbSNP:377653349"
variation 811
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="c"
/replace="t"
/db_xref="dbSNP:369750833"
exon 847..927
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/inference="alignment:Splign:1.39.8"
variation 866
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="g"
/db_xref="dbSNP:374149358"
variation 873
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="g"
/db_xref="dbSNP:148185887"
variation 881
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="c"
/replace="t"
/db_xref="dbSNP:368398971"
variation 882
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="c"
/replace="g"
/db_xref="dbSNP:372125531"
variation 896
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="c"
/replace="g"
/db_xref="dbSNP:201395825"
variation 907
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="g"
/db_xref="dbSNP:11020843"
variation 916
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="t"
/db_xref="dbSNP:16920646"
exon 928..1125
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/inference="alignment:Splign:1.39.8"
variation 935
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="c"
/replace="g"
/db_xref="dbSNP:377011346"
variation 949
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="c"
/replace="t"
/db_xref="dbSNP:7110167"
variation 977
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="c"
/db_xref="dbSNP:142289424"
variation 1012
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="c"
/replace="t"
/db_xref="dbSNP:145516372"
variation 1013
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="c"
/replace="t"
/db_xref="dbSNP:139701137"
variation 1017
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="g"
/db_xref="dbSNP:200530015"
variation 1045
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="c"
/replace="t"
/db_xref="dbSNP:148847419"
variation 1046
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="g"
/db_xref="dbSNP:377575537"
variation 1069
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="g"
/replace="t"
/db_xref="dbSNP:201677848"
variation 1086
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="c"
/replace="t"
/db_xref="dbSNP:149581818"
variation 1098
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="g"
/db_xref="dbSNP:189372927"
variation 1115
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="g"
/db_xref="dbSNP:144295355"
exon 1126..1237
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/inference="alignment:Splign:1.39.8"
variation 1186
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="c"
/replace="g"
/db_xref="dbSNP:374054983"
variation 1191
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="t"
/db_xref="dbSNP:11020845"
variation 1192
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="g"
/db_xref="dbSNP:11020846"
variation 1197
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="g"
/db_xref="dbSNP:149372122"
variation 1208
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="g"
/db_xref="dbSNP:199802393"
variation 1214
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="t"
/db_xref="dbSNP:188883167"
variation 1231
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="c"
/replace="t"
/db_xref="dbSNP:139758117"
exon 1238..1361
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/inference="alignment:Splign:1.39.8"
variation 1249
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="c"
/replace="t"
/db_xref="dbSNP:145301752"
variation 1253
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="g"
/db_xref="dbSNP:147602287"
variation 1257
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="c"
/replace="t"
/db_xref="dbSNP:185092971"
variation 1260
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="c"
/db_xref="dbSNP:369955037"
variation 1263
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="g"
/replace="t"
/db_xref="dbSNP:373486887"
variation 1264
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="g"
/db_xref="dbSNP:7119735"
variation 1274
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="g"
/db_xref="dbSNP:34492831"
variation 1319
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="c"
/replace="g"
/db_xref="dbSNP:57607909"
variation 1352
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="c"
/replace="t"
/db_xref="dbSNP:148862743"
exon 1362..1479
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/inference="alignment:Splign:1.39.8"
variation 1368
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="c"
/replace="t"
/db_xref="dbSNP:376747740"
variation 1402
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="g"
/db_xref="dbSNP:140982729"
variation 1420
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="g"
/db_xref="dbSNP:145231995"
variation 1437
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="g"
/db_xref="dbSNP:373512883"
variation 1439
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="c"
/replace="t"
/db_xref="dbSNP:137890247"
variation 1449
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="g"
/db_xref="dbSNP:201952078"
exon 1480..1591
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/inference="alignment:Splign:1.39.8"
variation 1488
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="g"
/db_xref="dbSNP:112072842"
variation 1494
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="g"
/db_xref="dbSNP:199854126"
variation 1506
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="t"
/db_xref="dbSNP:374638361"
variation 1517
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="c"
/db_xref="dbSNP:145908122"
variation 1549
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="c"
/replace="t"
/db_xref="dbSNP:367640527"
variation 1586
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="c"
/replace="t"
/db_xref="dbSNP:148131551"
exon 1592..1776
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/inference="alignment:Splign:1.39.8"
variation 1603
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="g"
/db_xref="dbSNP:146142445"
variation 1660
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="t"
/db_xref="dbSNP:150673764"
variation 1668
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="c"
/db_xref="dbSNP:35885673"
variation 1681
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="g"
/db_xref="dbSNP:376209717"
variation 1708
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="g"
/db_xref="dbSNP:624184"
variation 1709
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="g"
/db_xref="dbSNP:140141244"
variation 1725
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="g"
/replace="t"
/db_xref="dbSNP:76578146"
variation 1732
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="g"
/db_xref="dbSNP:143752404"
exon 1777..1849
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/inference="alignment:Splign:1.39.8"
variation 1837
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="t"
/db_xref="dbSNP:375509888"
variation 1847
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="g"
/db_xref="dbSNP:593690"
exon 1850..2050
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/inference="alignment:Splign:1.39.8"
variation 1854
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="c"
/replace="t"
/db_xref="dbSNP:377279345"
variation 1881
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="c"
/replace="t"
/db_xref="dbSNP:148698493"
variation 1937
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="c"
/replace="t"
/db_xref="dbSNP:370900833"
variation 1954
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="c"
/replace="t"
/db_xref="dbSNP:373909687"
variation 1973
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="g"
/db_xref="dbSNP:116084295"
variation 1996
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="c"
/replace="t"
/db_xref="dbSNP:114896849"
variation 1997
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="g"
/db_xref="dbSNP:377761223"
variation 2020
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="c"
/replace="t"
/db_xref="dbSNP:193226316"
variation 2021
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="g"
/db_xref="dbSNP:371297833"
variation 2050
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="c"
/replace="t"
/db_xref="dbSNP:112991769"
exon 2051..2154
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/inference="alignment:Splign:1.39.8"
variation 2072
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="g"
/db_xref="dbSNP:140154259"
variation 2077
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="c"
/replace="t"
/db_xref="dbSNP:368398055"
variation 2096
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="c"
/replace="t"
/db_xref="dbSNP:145352568"
variation 2125
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="c"
/replace="t"
/db_xref="dbSNP:146415204"
variation 2131
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="c"
/db_xref="dbSNP:17852889"
exon 2155..2225
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/inference="alignment:Splign:1.39.8"
variation 2155
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="g"
/db_xref="dbSNP:140818509"
exon 2226..2379
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/inference="alignment:Splign:1.39.8"
variation 2243
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="c"
/replace="t"
/db_xref="dbSNP:200109578"
variation 2254
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="c"
/replace="t"
/db_xref="dbSNP:144624654"
variation 2270
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="c"
/replace="t"
/db_xref="dbSNP:138314594"
exon 2380..2505
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/inference="alignment:Splign:1.39.8"
variation 2397
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="c"
/replace="t"
/db_xref="dbSNP:149230455"
variation 2444
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="c"
/replace="t"
/db_xref="dbSNP:374387055"
variation 2445
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="g"
/db_xref="dbSNP:200281918"
variation 2483
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="g"
/replace="t"
/db_xref="dbSNP:143334859"
variation 2500
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="c"
/replace="t"
/db_xref="dbSNP:148353195"
exon 2506..2653
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/inference="alignment:Splign:1.39.8"
variation 2515
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="c"
/replace="t"
/db_xref="dbSNP:16920720"
variation 2540
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="c"
/replace="t"
/db_xref="dbSNP:200987345"
variation 2587
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="c"
/replace="t"
/db_xref="dbSNP:201026049"
variation 2593
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="g"
/db_xref="dbSNP:371621083"
variation 2652
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="c"
/replace="t"
/db_xref="dbSNP:200034919"
variation 2653
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="g"
/db_xref="dbSNP:138259800"
exon 2654..3199
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/inference="alignment:Splign:1.39.8"
variation 2714
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="c"
/db_xref="dbSNP:201776961"
variation 2777
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="g"
/db_xref="dbSNP:200888943"
variation 2793
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="t"
/db_xref="dbSNP:376200008"
variation 2811
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="g"
/db_xref="dbSNP:367759730"
variation 2838
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="g"
/replace="t"
/db_xref="dbSNP:188676168"
variation 2896
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace=""
/replace="a"
/db_xref="dbSNP:34504891"
variation 2897
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="c"
/db_xref="dbSNP:191685906"
variation 2925
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="g"
/db_xref="dbSNP:58916959"
variation 2931
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="t"
/db_xref="dbSNP:139257722"
variation 2948
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="c"
/replace="t"
/db_xref="dbSNP:375357411"
variation 2964
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="t"
/db_xref="dbSNP:7928838"
variation 2965
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="g"
/db_xref="dbSNP:143178181"
STS 2969..3129
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/standard_name="RH94119"
/db_xref="UniSTS:86568"
variation 2984
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="g"
/db_xref="dbSNP:6483351"
variation 2990..2991
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace=""
/replace="at"
/db_xref="dbSNP:371081621"
variation 3054
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="a"
/replace="g"
/db_xref="dbSNP:182730875"
variation 3075
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="c"
/replace="t"
/db_xref="dbSNP:147483847"
variation 3091
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="c"
/replace="t"
/db_xref="dbSNP:508485"
variation 3166
/gene="PIWIL4"
/gene_synonym="HIWI2; MIWI2"
/replace="c"
/replace="g"
/db_xref="dbSNP:78621441"
ORIGIN
gtgctcgcgccaacccctacgccccagcgcgccttctccacccacgcacgggcctcggacgcatttccagccccggcgttggttgtggatgctggacatccaccgcctccaggcagtttcgccgtcacaccgtcgccatctgtagccaaagcaaaacatatcctaactgagactttgcagctcttgtggccactctgggctcaccgggaacatgagtggaagagcccgagtgaaggccagaggcatcgcccgcagccccagtgccacagaagtggggcgcatccaagcctcgccattgcctagatctgttgatcttagtaacaatgaagcatcctctagcaatggcttcttgggaacaagcaggatctcaaccaacgataaatatgggatatcttctggtgatgctggaagtaccttcatggaaagaggtgtgaaaaacaaacaggactttatggatttgagtatctgtaccagagaaaaattggcacatgtgagaaattgtaaaacaggttccagtggaatacctgtgaaactggttacaaacctctttaacttagattttccccaagactggcagctataccagtaccatgtgacatatattccagatttagcatctagaaggctgagaattgctttactttatagtcatagtgaactttccaacaaagcaaaagcattcgacggtgccatcctttttctgtcacaaaagctagaagaaaaggtcacagagttgtcaagtgaaactcaaagaggtgagactataaagatgactatcaccctgaagagggagctgccatcaagttctcccgtgtgcatccaggtcttcaatatcatcttcagaaagatcctcaaaaagttgtccatgtaccaaattggacggaacttctataatccttcagagccaatggaaattccccagcacaaattatccctttggcctgggtttgccatttctgtgtcatattttgaaaggaagctcctgtttagtgctgatgtgagttacaaagtcctccggaatgagacggttctggaattcatgactgctctctgtcaaagaactggcttgtcctgtttcacccagacgtgtgagaagcagctaatagggctcattgtccttacaagatacaataacagaacctactccattgatgacattgactggtcagtgaagcccacacacacctttcagaagcgggatggcaccgagatcacctatgtggattactacaagcagcagtatgatattactgtatcggacctgaatcagcccatgcttgttagtctgttaaagaagaagagaaatgacaacagtgaggctcagctcgcccacctgatacctgagctctgctttctaacagggctgactgaccaggcaacatctgatttccagctgatgaaggctgtggctgaaaagacacgtctcagtccttcaggccggcagcagcgcctggccaggcttgtggacaacatccagaggaataccaatgctcgctttgaactagagacctggggactgcattttggaagccagatatctctgactggccggattgtgccttcagaaaaaatattaatgcaagaccacatatgtcaacctgtgtctgctgctgactggtccaaggatattcgaacttgcaagattttaaatgcacagtctttgaatacctggttgattttatgtagcgacagaactgaatatgttgccgagagctttctgaactgcttgagaagagttgcaggttccatgggatttaatgtggactaccccaaaatcataaaagtacaagaaaatccagctgcatttgttagagctatacagcaatatgttgatcctgatgttcagctggtaatgtgcattctgccttctaatcagaagacctattatgattccattaaaaaatatttgagctcagactgcccagtcccaagccaatgtgtgcttgctcggaccttgaataaacagggcatgatgatgagtatcgccaccaagatcgctatgcagatgacttgcaagctcggaggcgagctgtgggctgtggaaatacctttaaagtccctgatggtggtcggtattgatgtctgtaaagatgcactcagcaaggacgtgatggttgttggatgcgtggccagtgttaaccccagaatcaccaggtggttttcccgctgtatccttcagagaacaatgactgatgttgcagattgcttgaaagttttcatgactggagcactcaacaaatggtacaagtacaatcatgatttgccagcacggataattgtgtaccgtgctggtgtaggggatggtcagctgaaaacacttattgaatatgaagtcccacagctgctgagcagtgtggcagaatccagctcaaataccagctcaagactgtcggtgattgtggtcaggaagaagtgcatgccacgattctttaccgaaatgaaccgcactgtacagaaccccccacttggcactgttgtggattcagaagcaacacgtaacgaatggtatgacttttatctgatcagccaggtggcctgccggggaactgttagtcctacctactataatgtcatctatgatgacaacggcttgaagcccgaccatatgcagagacttacattcaaattgtgccacctgtactacaactggccgggcatagtcagtgtcccagcaccatgtcagtatgctcacaagctgacctttctggtggcacaaagcattcataaagaacccagtctggaattagccaaccatctcttctacctgtgatggcatgaactactggcatcactagatggacaatccaagaagaaattggtatactttgtgcaaatctgccataagctcaaggctgtgactggggaaaaagattgagcttagttttcatgtctaggaaaaaaagcaaaacaacttaatctgaaacagttttaaaaaatgtgtgttattttgttttaaagagttgtatgcttggggtaaattttcattgtcatatgtggaatttaaatataccatcatctacaaagaattccacagagttaaatatcttaagttaaacacttaaaataagtgtttgcgtgatattttgatgacagataaacagagtctaattcccaccccaaattttgctgaggttttcttaatgttgtagagcattttgtagagtggtttaaatagttgaaaataaagttcagaacatcaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:143689 -> Molecular function: GO:0034584 [piRNA binding] evidence: ISS
GeneID:143689 -> Biological process: GO:0006417 [regulation of translation] evidence: IEA
GeneID:143689 -> Biological process: GO:0007126 [meiosis] evidence: IEA
GeneID:143689 -> Biological process: GO:0007275 [multicellular organismal development] evidence: IEA
GeneID:143689 -> Biological process: GO:0007283 [spermatogenesis] evidence: ISS
GeneID:143689 -> Biological process: GO:0030154 [cell differentiation] evidence: IEA
GeneID:143689 -> Biological process: GO:0031047 [gene silencing by RNA] evidence: ISS
GeneID:143689 -> Biological process: GO:0034587 [piRNA metabolic process] evidence: ISS
GeneID:143689 -> Biological process: GO:0043046 [DNA methylation involved in gamete generation] evidence: ISS
GeneID:143689 -> Cellular component: GO:0005634 [nucleus] evidence: ISS
GeneID:143689 -> Cellular component: GO:0005737 [cytoplasm] evidence: ISS
GeneID:143689 -> Cellular component: GO:0043186 [P granule] evidence: ISS
GeneID:143689 -> Cellular component: GO:0071547 [piP-body] evidence: ISS
by
@meso_cacase at
DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.