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2025-05-09 19:48:49, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_177422 3409 bp mRNA linear PRI 08-JUL-2013
DEFINITION Homo sapiens argonaute RISC catalytic component 3 (AGO3),
transcript variant 2, mRNA.
ACCESSION NM_177422
VERSION NM_177422.2 GI:324073531
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3409)
AUTHORS Hu,Q., Tanasa,B., Trabucchi,M., Li,W., Zhang,J., Ohgi,K.A.,
Rose,D.W., Glass,C.K. and Rosenfeld,M.G.
TITLE DICER- and AGO3-dependent generation of retinoic acid-induced DR2
Alu RNAs regulates human stem cell proliferation
JOURNAL Nat. Struct. Mol. Biol. 19 (11), 1168-1175 (2012)
PUBMED 23064648
REMARK GeneRIF: DICER- and AGO3-dependent generation of retinoic
acid-induced DR2 Alu RNAs regulates human stem cell proliferation.
REFERENCE 2 (bases 1 to 3409)
AUTHORS Wang,D., Zhang,Z., O'Loughlin,E., Lee,T., Houel,S., O'Carroll,D.,
Tarakhovsky,A., Ahn,N.G. and Yi,R.
TITLE Quantitative functions of Argonaute proteins in mammalian
development
JOURNAL Genes Dev. 26 (7), 693-704 (2012)
PUBMED 22474261
REMARK GeneRIF: Ago3 is able to load microRNAs efficiently in the absence
of Ago1 and Ago2, despite a significant loss of global microRNA
expression
REFERENCE 3 (bases 1 to 3409)
AUTHORS Omel'ianchuk,N.A., Ponomarenko,P.M. and Ponomarenko,M.P.
TITLE [The nucleotide sequence features of the mature microRNA seem to be
responsible for the affinity to human Ago2 AND Ago3 proteins]
JOURNAL Mol. Biol. (Mosk.) 45 (2), 366-375 (2011)
PUBMED 21634124
REMARK GeneRIF: reliable predictions of miRNA affinity to Ago2 AND Ago3
proteins were made.
REFERENCE 4 (bases 1 to 3409)
AUTHORS Potenza,N., Papa,U. and Russo,A.
TITLE Differential expression of Dicer and Argonaute genes during the
differentiation of human neuroblastoma cells
JOURNAL Cell Biol. Int. 33 (7), 734-738 (2009)
PUBMED 19393748
REMARK GeneRIF: EIF@C3 protein is expressed in both Schwann and
neuron-type differentiating cells.
REFERENCE 5 (bases 1 to 3409)
AUTHORS Weinmann,L., Hock,J., Ivacevic,T., Ohrt,T., Mutze,J., Schwille,P.,
Kremmer,E., Benes,V., Urlaub,H. and Meister,G.
TITLE Importin 8 is a gene silencing factor that targets argonaute
proteins to distinct mRNAs
JOURNAL Cell 136 (3), 496-507 (2009)
PUBMED 19167051
REFERENCE 6 (bases 1 to 3409)
AUTHORS Wu,L., Fan,J. and Belasco,J.G.
TITLE Importance of translation and nonnucleolytic ago proteins for
on-target RNA interference
JOURNAL Curr. Biol. 18 (17), 1327-1332 (2008)
PUBMED 18771919
REMARK GeneRIF: The specificity of RNA interference depends on the
concentration of Ago1, Ago3, and Ago4 relative to Ago2.
REFERENCE 7 (bases 1 to 3409)
AUTHORS Sasaki,T., Shiohama,A., Minoshima,S. and Shimizu,N.
TITLE Identification of eight members of the Argonaute family in the
human genome small star, filled
JOURNAL Genomics 82 (3), 323-330 (2003)
PUBMED 12906857
REFERENCE 8 (bases 1 to 3409)
AUTHORS Doi,N., Zenno,S., Ueda,R., Ohki-Hamazaki,H., Ui-Tei,K. and Saigo,K.
TITLE Short-interfering-RNA-mediated gene silencing in mammalian cells
requires Dicer and eIF2C translation initiation factors
JOURNAL Curr. Biol. 13 (1), 41-46 (2003)
PUBMED 12526743
REFERENCE 9 (bases 1 to 3409)
AUTHORS Carmell,M.A., Xuan,Z., Zhang,M.Q. and Hannon,G.J.
TITLE The Argonaute family: tentacles that reach into RNAi, developmental
control, stem cell maintenance, and tumorigenesis
JOURNAL Genes Dev. 16 (21), 2733-2742 (2002)
PUBMED 12414724
REMARK Review article
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BF979526.1, BC025769.1,
BX104163.1 and AA251146.1.
On Feb 25, 2011 this sequence version replaced gi:29337285.
Summary: This gene encodes a member of the Argonaute family of
proteins which play a role in RNA interference. The encoded protein
is highly basic, contains a PAZ domain and a PIWI domain, and may
play a role in short-interfering-RNA-mediated gene silencing. This
gene is located on chromosome 1 in a tandem cluster of closely
related family members including argonaute 4 and eukaryotic
translation initiation factor 2C, 1. Two transcript variants
encoding distinct isoforms have been identified for this gene.
[provided by RefSeq, Jul 2008].
Transcript Variant: This variant (2) has multiple differences in
the coding region, which causes translation initiation at a
downstream start codon, compared to variant 1. The resulting
protein (isoform b) has a shorter N-terminus than isoform a.
##Evidence-Data-START##
Transcript exon combination :: BC025769.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-176 BF979526.1 6-181
177-3119 BC025769.1 1-2943
3120-3175 BX104163.1 14-69 c
3176-3409 AA251146.1 1-234 c
FEATURES Location/Qualifiers
source 1..3409
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1p34"
gene 1..3409
/gene="AGO3"
/gene_synonym="EIF2C3"
/note="argonaute RISC catalytic component 3"
/db_xref="GeneID:192669"
/db_xref="HGNC:18421"
/db_xref="MIM:607355"
exon 1..364
/gene="AGO3"
/gene_synonym="EIF2C3"
/inference="alignment:Splign:1.39.8"
variation 20
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="a"
/replace="g"
/db_xref="dbSNP:148583974"
variation 107
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="c"
/replace="t"
/db_xref="dbSNP:368650571"
variation 267
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="c"
/replace="t"
/db_xref="dbSNP:372333004"
variation 294
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="c"
/replace="g"
/db_xref="dbSNP:376997221"
variation 304
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="a"
/replace="c"
/db_xref="dbSNP:375614115"
variation 332
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="c"
/replace="t"
/db_xref="dbSNP:367620032"
variation 341
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="g"
/replace="t"
/db_xref="dbSNP:1137693"
variation 364
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="c"
/replace="g"
/db_xref="dbSNP:371705852"
exon 365..536
/gene="AGO3"
/gene_synonym="EIF2C3"
/inference="alignment:Splign:1.39.8"
variation 374
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="g"
/replace="t"
/db_xref="dbSNP:141269853"
variation 382
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="c"
/replace="t"
/db_xref="dbSNP:139647049"
variation 393
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="a"
/replace="g"
/db_xref="dbSNP:372140569"
variation 397
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="a"
/replace="c"
/db_xref="dbSNP:147640766"
variation 426
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="c"
/replace="t"
/db_xref="dbSNP:377039064"
variation 485
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="a"
/replace="g"
/db_xref="dbSNP:369710801"
exon 537..745
/gene="AGO3"
/gene_synonym="EIF2C3"
/inference="alignment:Splign:1.39.8"
variation 593
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="c"
/replace="g"
/db_xref="dbSNP:148843760"
variation 653
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="c"
/replace="g"
/db_xref="dbSNP:370300022"
variation 656
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="a"
/replace="c"
/db_xref="dbSNP:146858503"
variation 662
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="a"
/replace="t"
/db_xref="dbSNP:189436392"
variation 680
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="a"
/replace="c"
/db_xref="dbSNP:78625682"
variation 711
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="a"
/replace="g"
/db_xref="dbSNP:145896554"
variation 734
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="a"
/replace="g"
/db_xref="dbSNP:140942553"
variation 735
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="c"
/replace="t"
/db_xref="dbSNP:374759763"
misc_feature 742..744
/gene="AGO3"
/gene_synonym="EIF2C3"
/note="upstream in-frame stop codon"
exon 746..880
/gene="AGO3"
/gene_synonym="EIF2C3"
/inference="alignment:Splign:1.39.8"
CDS 790..2670
/gene="AGO3"
/gene_synonym="EIF2C3"
/note="isoform b is encoded by transcript variant 2;
argonaute 3; protein argonaute-3; hAgo3; eIF2C 3; eIF-2C
3; argonaute3; eukaryotic translation initiation factor
2C, 3"
/codon_start=1
/product="protein argonaute-3 isoform b"
/protein_id="NP_803171.1"
/db_xref="GI:29337286"
/db_xref="CCDS:CCDS400.1"
/db_xref="GeneID:192669"
/db_xref="HGNC:18421"
/db_xref="MIM:607355"
/translation="
MCEVLDIHNIDEQPRPLTDSHRVKFTKEIKGLKVEVTHCGTMRRKYRVCNVTRRPASHQTFPLQLENGQTVERTVAQYFREKYTLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLVRSANYETDPFVQEFQFKVRDEMAHVTGRVLPAPMLQYGGRNRTVATPSHGVWDMRGKQFHTGVEIKMWAIACFATQRQCREEILKGFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVIKTSPQTLSNLCLKINVKLGGINNILVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPSRYCATVRVQRPRQEIIQDLASMVRELLIQFYKSTRFKPTRIIFYRDGVSEGQFRQVLYYELLAIREACISLEKDYQPGITYIVVQKRHHTRLFCADRTERVGRSGNIPAGTTVDTDITHPYEFDFYLCSHAGIQGTSRPSHYHVLWDDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHVSGQSNGRDPQALAKAVQIHQDTLRTMYFA
"
misc_feature 790..1131
/gene="AGO3"
/gene_synonym="EIF2C3"
/note="PAZ domain, argonaute_like subfamily. Argonaute is
part of the RNA-induced silencing complex (RISC), and is
an endonuclease that plays a key role in the RNA
interference pathway. The PAZ domain has been named after
the proteins Piwi,Argonaut, and Zwille; Region:
PAZ_argonaute_like; cd02846"
/db_xref="CDD:239212"
misc_feature order(925..927,970..972,1012..1014,1024..1026,1078..1080,
1099..1101,1105..1107)
/gene="AGO3"
/gene_synonym="EIF2C3"
/note="nucleic acid-binding interface [nucleotide
binding]; other site"
/db_xref="CDD:239212"
misc_feature 1264..2541
/gene="AGO3"
/gene_synonym="EIF2C3"
/note="Piwi_ago-like: PIWI domain, Argonaute-like
subfamily. Argonaute is the central component of the
RNA-induced silencing complex (RISC) and related
complexes. The PIWI domain is the C-terminal portion of
Argonaute and consists of two subdomains, one of...;
Region: Piwi_ago-like; cd04657"
/db_xref="CDD:240015"
misc_feature order(1675..1677,1687..1689,1723..1734,1741..1743,
1765..1767,1774..1776,1786..1788,1798..1800)
/gene="AGO3"
/gene_synonym="EIF2C3"
/note="5' RNA guide strand anchoring site; other site"
/db_xref="CDD:240015"
misc_feature order(1879..1881,1885..1887,2095..2097,2509..2511)
/gene="AGO3"
/gene_synonym="EIF2C3"
/note="active site"
/db_xref="CDD:240015"
variation 814
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="a"
/replace="c"
/db_xref="dbSNP:368190615"
variation 854
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="a"
/replace="g"
/db_xref="dbSNP:369030612"
exon 881..968
/gene="AGO3"
/gene_synonym="EIF2C3"
/inference="alignment:Splign:1.39.8"
variation 917
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="a"
/replace="g"
/db_xref="dbSNP:202072346"
variation 945
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="a"
/replace="g"
/db_xref="dbSNP:148681750"
exon 969..1116
/gene="AGO3"
/gene_synonym="EIF2C3"
/inference="alignment:Splign:1.39.8"
variation 991
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="a"
/replace="g"
/db_xref="dbSNP:201043874"
variation 1011
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="a"
/replace="g"
/db_xref="dbSNP:200735551"
variation 1046
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="a"
/replace="g"
/db_xref="dbSNP:372692110"
variation 1058
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="c"
/replace="t"
/db_xref="dbSNP:369662141"
variation 1059
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="a"
/replace="g"
/db_xref="dbSNP:144067198"
variation 1089
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="a"
/replace="g"
/db_xref="dbSNP:74645199"
variation 1103
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="a"
/replace="c"
/db_xref="dbSNP:75667149"
exon 1117..1236
/gene="AGO3"
/gene_synonym="EIF2C3"
/inference="alignment:Splign:1.39.8"
variation 1119
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="a"
/replace="c"
/db_xref="dbSNP:76924555"
exon 1237..1359
/gene="AGO3"
/gene_synonym="EIF2C3"
/inference="alignment:Splign:1.39.8"
variation 1258
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="a"
/replace="g"
/db_xref="dbSNP:201835772"
variation 1274
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="a"
/replace="g"
/db_xref="dbSNP:149225833"
variation 1296
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="a"
/replace="g"
/db_xref="dbSNP:41267265"
exon 1360..1493
/gene="AGO3"
/gene_synonym="EIF2C3"
/inference="alignment:Splign:1.39.8"
variation 1486
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="a"
/replace="g"
/db_xref="dbSNP:147063309"
variation 1489
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="c"
/replace="t"
/db_xref="dbSNP:368638136"
exon 1494..1678
/gene="AGO3"
/gene_synonym="EIF2C3"
/inference="alignment:Splign:1.39.8"
variation 1588
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="a"
/replace="t"
/db_xref="dbSNP:199811357"
variation 1629
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="c"
/replace="t"
/db_xref="dbSNP:111591152"
variation 1648
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="a"
/replace="g"
/db_xref="dbSNP:143644991"
variation 1659
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="a"
/replace="g"
/db_xref="dbSNP:138501451"
exon 1679..1838
/gene="AGO3"
/gene_synonym="EIF2C3"
/inference="alignment:Splign:1.39.8"
variation 1691
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="a"
/replace="g"
/db_xref="dbSNP:369221869"
variation 1714
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="a"
/replace="g"
/db_xref="dbSNP:373440270"
variation 1721
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="a"
/replace="c"
/db_xref="dbSNP:200928613"
variation 1737
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="c"
/replace="t"
/db_xref="dbSNP:144600568"
variation 1747
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="a"
/replace="g"
/db_xref="dbSNP:143959736"
variation 1761
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="c"
/replace="t"
/db_xref="dbSNP:111936785"
variation 1803
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="c"
/replace="t"
/db_xref="dbSNP:377736680"
exon 1839..1929
/gene="AGO3"
/gene_synonym="EIF2C3"
/inference="alignment:Splign:1.39.8"
variation 1860
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="a"
/replace="g"
/db_xref="dbSNP:139849193"
variation 1878
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="c"
/replace="t"
/db_xref="dbSNP:151098893"
variation 1881
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="c"
/replace="t"
/db_xref="dbSNP:140083661"
variation 1890
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="c"
/replace="t"
/db_xref="dbSNP:149864052"
exon 1930..2124
/gene="AGO3"
/gene_synonym="EIF2C3"
/inference="alignment:Splign:1.39.8"
variation 1947
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="c"
/replace="t"
/db_xref="dbSNP:201570403"
variation 1957..1958
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace=""
/replace="a"
/db_xref="dbSNP:34104798"
variation 2019
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="a"
/replace="c"
/db_xref="dbSNP:147699389"
variation 2046
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="a"
/replace="g"
/db_xref="dbSNP:143283288"
variation 2085
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="c"
/replace="t"
/db_xref="dbSNP:373780763"
exon 2125..2259
/gene="AGO3"
/gene_synonym="EIF2C3"
/inference="alignment:Splign:1.39.8"
variation 2147..2148
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace=""
/replace="c"
/db_xref="dbSNP:5773515"
variation 2204
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="c"
/replace="t"
/db_xref="dbSNP:138068024"
variation 2214
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="a"
/replace="g"
/db_xref="dbSNP:368356934"
exon 2260..2361
/gene="AGO3"
/gene_synonym="EIF2C3"
/inference="alignment:Splign:1.39.8"
variation 2296
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="a"
/replace="g"
/db_xref="dbSNP:370775699"
variation 2328
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="c"
/replace="t"
/db_xref="dbSNP:145947091"
exon 2362..2561
/gene="AGO3"
/gene_synonym="EIF2C3"
/inference="alignment:Splign:1.39.8"
variation 2430
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="a"
/replace="g"
/db_xref="dbSNP:79043007"
variation 2460
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="c"
/replace="t"
/db_xref="dbSNP:148771081"
exon 2562..3387
/gene="AGO3"
/gene_synonym="EIF2C3"
/inference="alignment:Splign:1.39.8"
variation 2564
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="c"
/replace="t"
/db_xref="dbSNP:111316219"
variation 2607
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="a"
/replace="g"
/db_xref="dbSNP:376625988"
variation 2664
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="c"
/replace="t"
/db_xref="dbSNP:61743816"
variation 2695
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="a"
/replace="g"
/db_xref="dbSNP:372307716"
STS 2750..2968
/gene="AGO3"
/gene_synonym="EIF2C3"
/standard_name="SHGC-74579"
/db_xref="UniSTS:44843"
variation 2909
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="a"
/replace="g"
/db_xref="dbSNP:181505762"
variation 2915
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="a"
/replace="g"
/db_xref="dbSNP:144063400"
variation 3082
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="a"
/replace="t"
/db_xref="dbSNP:186097878"
variation 3113
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="c"
/replace="t"
/db_xref="dbSNP:190878180"
STS 3217..3341
/gene="AGO3"
/gene_synonym="EIF2C3"
/standard_name="RH102469"
/db_xref="UniSTS:96803"
variation 3219
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="g"
/replace="t"
/db_xref="dbSNP:145974637"
variation 3237
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="a"
/replace="g"
/db_xref="dbSNP:184219370"
variation 3251..3252
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace=""
/replace="t"
/db_xref="dbSNP:150584454"
variation 3377
/gene="AGO3"
/gene_synonym="EIF2C3"
/replace="a"
/replace="g"
/db_xref="dbSNP:140115844"
polyA_site 3387
/gene="AGO3"
/gene_synonym="EIF2C3"
ORIGIN
gagcttccggggcggccccgggcaggtcggcggcggcggcccgcagtcgtggaggagcggtgggagcgtcggcggccgcgggcgatgcaacttccggacgggactcccctctgtccgcgcctcacatctccccttcctctcgcctagtcctgtgccgttttccgtccgcgactcttccggcccagagctttcggagtgcggttgctcaggggaagccgtcgccgcccccgcctcggggccgagtgagagtgcccgtcgcgtcgcgccgcgtcgccccccgggccgcctccttgccgccagtggcgggctccgttctccctcgaagcactccccccagctccatgaatggaaatcggctccgcaggacccgctggggcccagcccctactcatggtgcccagaagacctggctatggcaccatgggcaaacccattaaactgctggctaactgttttcaagttgaaatcccaaagattgatgtctacctctatgaggtagatattaaaccagacaagtgtcctaggagagtgaacaggtagatttagacgttactttacctggggaaggtggaaaagatcgacctttcaaggtgtcaatcaaatttgtctctcgggtgagttggcacctactgcatgaagtactgacaggacggaccttgcctgagccactggaattagacaagccaatcagcactaaccctgtccatgccgttgatgtggtgctacgacatctgccctccatgaatttctgccactgccttctacaaagcacaacctgtaattcagttcatgtgtgaagttcttgatattcataatattgatgagcaaccaagacctctgactgattctcatcgggtaaaattcaccaaagagataaaaggtttgaaggttgaagtgactcattgtggaacaatgagacggaaataccgtgtttgtaatgtaacaaggaggcctgccagtcatcaaacctttcctttacagttagaaaacggccaaactgtggagagaacagtagcgcagtatttcagagaaaagtatactcttcagctgaagtacccgcaccttccctgtctgcaagtcgggcaggaacagaaacacacctacctgccactagaagtctgtaatattgtggcagggcaacgatgtatcaagaagctaacagacaatcagacttccactatgatcaaggcaacagcaagatctgcaccagatagacaagaggaaattagcagattggtaagaagtgcaaattatgaaacagatccatttgttcaggagtttcaatttaaagttcgggatgaaatggctcatgtaactggacgcgtacttccagcacctatgctccagtatggaggacggaatcggacagtagcaacaccgagccatggagtatgggacatgcgagggaaacaattccacacaggagttgaaatcaaaatgtgggctatcgcttgttttgccacacagaggcagtgcagagaagaaatattgaagggtttcacagaccagctgcgtaagatttctaaggatgcagggatgcccatccagggccagccatgcttctgcaaatatgcacagggggcagacagcgtagagcccatgttccggcatctcaagaacacatattctggcctacagcttattatcgtcatcctgccggggaagacaccagtgtatgcggaagtgaaacgtgtaggagacacacttttgggtatggctacacaatgtgttcaagtcaagaatgtaataaaaacatctcctcaaactctgtcaaacttgtgcctaaagataaatgttaaactcggagggatcaataatattcttgtacctcatcaaagaccttctgtgttccagcaaccagtgatctttttgggagccgatgtcactcatccacctgctggtgatggaaagaagccttctattgctgctgttgtaggtagtatggatgcacacccaagcagatactgtgccacagtaagagttcagagaccccgacaggagatcatccaggacttggcctccatggtccgggaacttcttattcaattttataagtcaactcggttcaagcctactcgtatcatcttttatcgggatggtgtttcagaggggcagtttaggcaggtattatattatgaactactagcaattcgagaagcctgcatcagtttggagaaagactatcaacctggaataacctacattgtagttcagaagagacatcacactcgattattttgtgctgataggacagaaagggttggaagaagtggcaatatcccagctggaacaacagttgatacagacattacacacccatatgagttcgatttttacctctgtagccatgctggaatacagggtaccagtcgtccttcacactatcatgttttatgggatgataactgctttactgcagatgaacttcagctgctaacttaccagctctgccacacttacgtacgctgtacacgatctgtttctatacctgcaccagcgtattatgctcacctggtagcatttagagccagatatcatcttgtggacaaagaacatgacagtgctgaaggaagtcacgtttcaggacaaagcaatgggcgagatccacaagctcttgccaaggctgtacagattcaccaagataccttacgcacaatgtacttcgcttaaatagtccaagtatattctctgagaggaagtactgaaagatgaattgacatacaacgtatgtttccagtgaagtcaattgagtaaggacacctccagccatacagaaaccaacactgtgtgggggccaaggtctgatccttatgttaatacaaggaagattgtttacttcatcaaggaacacagcatcattatgcaatatgaaaccagccaactgctttttgtgcggtctcctataggaagtatcgcaattgttttgttttcatttcttgtagtctaacccttttaatgcctttacctcaagttgcttggcagcacaactatctttgcaaaaaaaagtaaagaaaaagtaaatgatggtttaaaaaatacacaccttcatgaataatcaaagtgatttttcagaattatgtgtgcaaaaaattaatgtgcattcatatattcttgtaaaaggtgtctgtgtatttttaaaatatatacatccatacttcatatgcatatatatctagatctggattgataatagatatatatgtgtctgttatatattttagagttcattccattggggaattttctttcccttttattctacccccactaccgcctttatttctctatttcccttgccttcatcacctacatttttttcccagtcctaccagtgacattcaaatgttgatgtatctggttcgtttgaatataaaatatggcaaactaaaaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:192669 -> Molecular function: GO:0003723 [RNA binding] evidence: IEA
GeneID:192669 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:192669 -> Biological process: GO:0006402 [mRNA catabolic process] evidence: IDA
GeneID:192669 -> Biological process: GO:0007173 [epidermal growth factor receptor signaling pathway] evidence: TAS
GeneID:192669 -> Biological process: GO:0007219 [Notch signaling pathway] evidence: TAS
GeneID:192669 -> Biological process: GO:0008543 [fibroblast growth factor receptor signaling pathway] evidence: TAS
GeneID:192669 -> Biological process: GO:0010467 [gene expression] evidence: TAS
GeneID:192669 -> Biological process: GO:0035278 [negative regulation of translation involved in gene silencing by miRNA] evidence: IDA
GeneID:192669 -> Biological process: GO:0038095 [Fc-epsilon receptor signaling pathway] evidence: TAS
GeneID:192669 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
GeneID:192669 -> Biological process: GO:0048011 [neurotrophin TRK receptor signaling pathway] evidence: TAS
GeneID:192669 -> Biological process: GO:0048015 [phosphatidylinositol-mediated signaling] evidence: TAS
GeneID:192669 -> Biological process: GO:0072091 [regulation of stem cell proliferation] evidence: IMP
GeneID:192669 -> Cellular component: GO:0000932 [cytoplasmic mRNA processing body] evidence: IEA
GeneID:192669 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:192669 -> Cellular component: GO:0035068 [micro-ribonucleoprotein complex] evidence: IEA
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@meso_cacase at
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