2025-05-09 20:01:01, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_139131 3908 bp mRNA linear PRI 07-JUL-2013 DEFINITION Homo sapiens nucleoporin 98kDa (NUP98), transcript variant 2, mRNA. ACCESSION NM_139131 VERSION NM_139131.3 GI:296040485 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3908) AUTHORS Di Nunzio,F., Fricke,T., Miccio,A., Valle-Casuso,J.C., Perez,P., Souque,P., Rizzi,E., Severgnini,M., Mavilio,F., Charneau,P. and Diaz-Griffero,F. TITLE Nup153 and Nup98 bind the HIV-1 core and contribute to the early steps of HIV-1 replication JOURNAL Virology 440 (1), 8-18 (2013) PUBMED 23523133 REMARK GeneRIF: The roles of NUP153 and nup98 in the integration and replication of HIV-1 in human Jurkat lymphocytes are reported. REFERENCE 2 (bases 1 to 3908) AUTHORS Funasaka,T., Balan,V., Raz,A. and Wong,R.W. TITLE Nucleoporin Nup98 mediates galectin-3 nuclear-cytoplasmic trafficking JOURNAL Biochem. Biophys. Res. Commun. 434 (1), 155-161 (2013) PUBMED 23541576 REMARK GeneRIF: Nup98 RNA interference significantly suppresses downstream mRNA expression in the ss-catenin pathway, while nuclear galectin-3 binds to ss-catenin to inhibit transcriptional activity. REFERENCE 3 (bases 1 to 3908) AUTHORS Liang,Y., Franks,T.M., Marchetto,M.C., Gage,F.H. and Hetzer,M.W. TITLE Dynamic association of NUP98 with the human genome JOURNAL PLoS Genet. 9 (2), E1003308 (2013) PUBMED 23468646 REMARK GeneRIF: This work demonstrates for the first time that NUP98 dynamically associates with the human genome during differentiation, revealing a role of a nuclear pore protein in regulating developmental gene expression programs. REFERENCE 4 (bases 1 to 3908) AUTHORS Singer,S., Zhao,R., Barsotti,A.M., Ouwehand,A., Fazollahi,M., Coutavas,E., Breuhahn,K., Neumann,O., Longerich,T., Pusterla,T., Powers,M.A., Giles,K.M., Leedman,P.J., Hess,J., Grunwald,D., Bussemaker,H.J., Singer,R.H., Schirmacher,P. and Prives,C. TITLE Nuclear pore component Nup98 is a potential tumor suppressor and regulates posttranscriptional expression of select p53 target genes JOURNAL Mol. Cell 48 (5), 799-810 (2012) PUBMED 23102701 REMARK GeneRIF: Nup98 functions as a potential tumor suppressor and regulates posttranscriptional expression of select p53 target genes. REFERENCE 5 (bases 1 to 3908) AUTHORS Rajani,K.R., Pettit Kneller,E.L., McKenzie,M.O., Horita,D.A., Chou,J.W. and Lyles,D.S. TITLE Complexes of vesicular stomatitis virus matrix protein with host Rae1 and Nup98 involved in inhibition of host transcription JOURNAL PLoS Pathog. 8 (9), E1002929 (2012) PUBMED 23028327 REMARK GeneRIF: vesicular stomatitis virus M protein interacted efficiently with Rae1-Nup98 complexes associated with the chromatin fraction of host nuclei, consistent with an effect on host transcription REFERENCE 6 (bases 1 to 3908) AUTHORS Stutz,F., Izaurralde,E., Mattaj,I.W. and Rosbash,M. TITLE A role for nucleoporin FG repeat domains in export of human immunodeficiency virus type 1 Rev protein and RNA from the nucleus JOURNAL Mol. Cell. Biol. 16 (12), 7144-7150 (1996) PUBMED 8943370 REFERENCE 7 (bases 1 to 3908) AUTHORS Hu,T., Guan,T. and Gerace,L. TITLE Molecular and functional characterization of the p62 complex, an assembly of nuclear pore complex glycoproteins JOURNAL J. Cell Biol. 134 (3), 589-601 (1996) PUBMED 8707840 REFERENCE 8 (bases 1 to 3908) AUTHORS Borrow,J., Shearman,A.M., Stanton,V.P. Jr., Becher,R., Collins,T., Williams,A.J., Dube,I., Katz,F., Kwong,Y.L., Morris,C., Ohyashiki,K., Toyama,K., Rowley,J. and Housman,D.E. TITLE The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9 JOURNAL Nat. Genet. 12 (2), 159-167 (1996) PUBMED 8563754 REFERENCE 9 (bases 1 to 3908) AUTHORS Nakamura,T., Largaespada,D.A., Lee,M.P., Johnson,L.A., Ohyashiki,K., Toyama,K., Chen,S.J., Willman,C.L., Chen,I.M., Feinberg,A.P., Jenkins,N.A., Copeland,N.G. and Shaughnessy,J.D. Jr. TITLE Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia JOURNAL Nat. Genet. 12 (2), 154-158 (1996) PUBMED 8563753 REFERENCE 10 (bases 1 to 3908) AUTHORS Radu,A., Moore,M.S. and Blobel,G. TITLE The peptide repeat domain of nucleoporin Nup98 functions as a docking site in transport across the nuclear pore complex JOURNAL Cell 81 (2), 215-222 (1995) PUBMED 7736573 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB084013.1, U41815.1 and BC041136.1. On May 14, 2010 this sequence version replaced gi:56549641. Summary: Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kDa nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kDa precursor protein. This cleavage results in the 98 kDa nucleoporin as well as a 96 kDa nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kDa nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromosome translocations in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, May 2010]. Transcript Variant: This variant (2) lacks multiple 3' exons but has an alternate 3' sequence including the coding region and UTR, as compared to variant 1. The encoded isoform 2 has a distinct and shorter C-terminus, as compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U41815.1, BC041136.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support ERS025081, ERS025082 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-277 DB084013.1 1-277 278-3404 U41815.1 1-3127 3405-3891 BC041136.1 3154-3640 3892-3908 U41815.1 3614-3630 FEATURES Location/Qualifiers source 1..3908 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="11" /map="11p15.5" gene 1..3908 /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /note="nucleoporin 98kDa" /db_xref="GeneID:4928" /db_xref="HGNC:8068" /db_xref="HPRD:03012" /db_xref="MIM:601021" exon 1..393 /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /inference="alignment:Splign:1.39.8" variation complement(59) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="c" /replace="t" /db_xref="dbSNP:180810726" variation complement(146) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="c" /replace="g" /db_xref="dbSNP:188372818" variation complement(192) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="g" /db_xref="dbSNP:59527098" variation complement(270) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="g" /db_xref="dbSNP:60063096" variation complement(278) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="c" /replace="t" /db_xref="dbSNP:367949661" variation complement(310..311) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="" /replace="gt" /db_xref="dbSNP:144528677" misc_feature 365..367 /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /note="upstream in-frame stop codon" exon 394..497 /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /inference="alignment:Splign:1.39.8" variation complement(412) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="c" /db_xref="dbSNP:72844304" CDS 422..3184 /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /note="isoform 2 is encoded by transcript variant 2; GLFG-repeat containing nucleoporin; Nup98-Nup96; nuclear pore complex protein Nup98-Nup96" /codon_start=1 /product="nuclear pore complex protein Nup98-Nup96 isoform 2" /protein_id="NP_624357.1" /db_xref="GI:21264369" /db_xref="CCDS:CCDS41606.1" /db_xref="GeneID:4928" /db_xref="HGNC:8068" /db_xref="HPRD:03012" /db_xref="MIM:601021" /translation="
MFNKSFGTPFGGGTGGFGTTSTFGQNTGFGTTSGGAFGTSAFGSSNNTGGLFGNSQTKPGGLFGTSSFSQPATSTSTGFGFGTSTGTANTLFGTASTGTSLFSSQNNAFAQNKPTGFGNFGTSTSSGGLFGTTNTTSNPFGSTSGSLFGPSSFTAAPTGTTIKFNPPTGTDTMVKAGVSTNISTKHQCITAMKEYESKSLEELRLEDYQANRKGPQNQVGAGTTTGLFGSSPATSSATGLFSSSTTNSGFAYGQNKTAFGTSTTGFGTNPGGLFGQQNQQTTSLFSKPFGQATTTQNTGFSFGNTSTIGQPSTNTMGLFGVTQASQPGGLFGTATNTSTGTAFGTGTGLFGQTNTGFGAVGSTLFGNNKLTTFGSSTTSAPSFGTTSGGLFGFGTNTSGNSIFGSKPAPGTLGTGLGAGFGTALGAGQASLFGNNQPKIGGPLGTGAFGAPGFNTTTATLGFGAPQAPVALTDPNASAAQQAVLQQHINSLTYSPFGDSPLFRNPMSDPKKKEERLKPTNPAAQKALTTPTHYKLTPRPATRVRPKALQTTGTAKSHLFDGLDDDEPSLANGAFMPKKSIKKLVLKNLNNSNLFSPVNRDSENLASPSEYPENGERFSFLSKPVDENHQQDGDEDSLVSHFYTNPIAKPIPQTPESAGNKHSNSNSVDDTIVALNMRAALRNGLEGSSEETSFHDESLQDDREEIENNSYHMHPAGIILTKVGYYTIPSMDDLAKITNEKGECIVSDFTIGRKGYGSIYFEGDVNLTNLNLDDIVHIRRKEVVVYLDDNQKPPVGEGLNRKAEVTLDGVWPTDKTSRCLIKSPDRLADINYEGRLEAVSRKQGAQFKEYRPETGSWVFKVSHFSKYGLQDSDEEEEEHPSKTSTKKLKTAPLPPASQTTPLQMALNGKPAPPPQVEKKGQ
" misc_feature 2192..2194 /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 2204..2206 /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 2237..2239 /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 2237..2239 /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 2411..2413 /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 2588..3010 /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /note="Nucleoporin autopeptidase; Region: Nucleoporin2; pfam04096" /db_xref="CDD:202886" misc_feature 2885..2887 /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 3008..3010 /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /experiment="experimental evidence, no additional details recorded" /note="proteolytic cleavage site; modified site" /db_xref="HPRD:03012" misc_feature 3032..3034 /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 3032..3034 /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" variation complement(459) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="c" /replace="g" /db_xref="dbSNP:375758302" variation complement(496) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="g" /db_xref="dbSNP:201643505" exon 498..599 /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /inference="alignment:Splign:1.39.8" variation complement(513) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="c" /replace="t" /db_xref="dbSNP:371864624" variation complement(514) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="c" /replace="t" /db_xref="dbSNP:377383450" variation complement(583) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="c" /replace="t" /db_xref="dbSNP:147797843" variation complement(584) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="c" /replace="t" /db_xref="dbSNP:201001086" exon 600..776 /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /inference="alignment:Splign:1.39.8" variation complement(628) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="c" /replace="t" /db_xref="dbSNP:371498196" variation complement(638) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="g" /db_xref="dbSNP:368818596" variation complement(654) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="g" /replace="t" /db_xref="dbSNP:374160172" variation complement(674) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="g" /db_xref="dbSNP:79912970" variation complement(682) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="g" /db_xref="dbSNP:201999358" variation complement(691) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="c" /replace="t" /db_xref="dbSNP:148608250" variation complement(764) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="g" /db_xref="dbSNP:200536174" variation complement(769) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="c" /db_xref="dbSNP:61756125" exon 777..916 /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /inference="alignment:Splign:1.39.8" variation complement(785) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="g" /db_xref="dbSNP:376676025" variation complement(799) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="c" /replace="t" /db_xref="dbSNP:149542589" variation complement(893) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="t" /db_xref="dbSNP:199563619" variation complement(916) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="c" /replace="t" /db_xref="dbSNP:34160712" exon 917..1024 /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /inference="alignment:Splign:1.39.8" variation complement(923) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="g" /db_xref="dbSNP:150774282" variation complement(924) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="c" /db_xref="dbSNP:141741442" variation complement(1010) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="g" /db_xref="dbSNP:138890550" exon 1025..1205 /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /inference="alignment:Splign:1.39.8" variation complement(1086) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="g" /db_xref="dbSNP:200555087" variation complement(1102) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="g" /db_xref="dbSNP:145045544" variation complement(1112) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="c" /replace="t" /db_xref="dbSNP:142828548" variation complement(1114) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="c" /replace="t" /db_xref="dbSNP:202133026" variation complement(1130) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="g" /db_xref="dbSNP:148092095" variation complement(1204) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="c" /replace="t" /db_xref="dbSNP:143629914" exon 1206..1369 /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /inference="alignment:Splign:1.39.8" variation complement(1207) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="c" /replace="t" /db_xref="dbSNP:373808051" variation complement(1215) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="g" /replace="t" /db_xref="dbSNP:370439005" variation complement(1223) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="g" /db_xref="dbSNP:149008676" variation complement(1273) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="c" /replace="g" /db_xref="dbSNP:145859584" variation complement(1288) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="c" /replace="t" /db_xref="dbSNP:201623628" variation complement(1298) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="g" /db_xref="dbSNP:61732810" variation complement(1306) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="c" /replace="g" /db_xref="dbSNP:146870554" variation complement(1313) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="g" /db_xref="dbSNP:142518872" variation complement(1336) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="c" /replace="g" /db_xref="dbSNP:376607536" variation complement(1365) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="c" /db_xref="dbSNP:375025381" exon 1370..1507 /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /inference="alignment:Splign:1.39.8" variation complement(1374) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="c" /replace="t" /db_xref="dbSNP:17854092" variation complement(1424) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="g" /db_xref="dbSNP:373436118" variation complement(1426) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="g" /db_xref="dbSNP:375278329" variation complement(1484) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="g" /db_xref="dbSNP:112768729" variation complement(1506) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="c" /replace="t" /db_xref="dbSNP:201706881" exon 1508..1595 /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /inference="alignment:Splign:1.39.8" variation complement(1547) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="g" /db_xref="dbSNP:17854091" variation complement(1554) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="c" /replace="g" /db_xref="dbSNP:144324099" variation complement(1577) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="g" /db_xref="dbSNP:139501642" variation complement(1595) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="g" /replace="t" /db_xref="dbSNP:77202950" exon 1596..1688 /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /inference="alignment:Splign:1.39.8" variation complement(1611) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="c" /replace="g" /db_xref="dbSNP:61756122" variation complement(1613) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="g" /db_xref="dbSNP:144302699" variation complement(1640) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="c" /replace="t" /db_xref="dbSNP:200590634" variation complement(1659) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="c" /replace="g" /db_xref="dbSNP:142489324" exon 1689..1829 /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /inference="alignment:Splign:1.39.8" variation complement(1708) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="g" /db_xref="dbSNP:200905492" variation complement(1709) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="t" /db_xref="dbSNP:367854149" variation complement(1713) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="c" /replace="t" /db_xref="dbSNP:374040380" variation complement(1754) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="g" /db_xref="dbSNP:148494011" variation complement(1760) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="g" /db_xref="dbSNP:371012107" variation complement(1780) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="c" /replace="t" /db_xref="dbSNP:116722638" variation complement(1789) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="g" /db_xref="dbSNP:112872083" variation complement(1791..1792) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="" /replace="cccccccc" /db_xref="dbSNP:138733588" variation complement(1824) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="c" /replace="t" /db_xref="dbSNP:141781729" exon 1830..1963 /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /inference="alignment:Splign:1.39.8" variation complement(1919) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="c" /replace="g" /db_xref="dbSNP:139926792" variation complement(1948) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="g" /replace="t" /db_xref="dbSNP:145990724" variation complement(1961) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="g" /db_xref="dbSNP:375880092" exon 1964..2151 /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /inference="alignment:Splign:1.39.8" variation complement(2034) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="c" /replace="g" /db_xref="dbSNP:201892076" variation complement(2045) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="c" /db_xref="dbSNP:61751339" variation complement(2085) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="g" /db_xref="dbSNP:138185414" variation complement(2086) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="g" /db_xref="dbSNP:150834776" variation complement(2098) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="c" /replace="t" /db_xref="dbSNP:200777395" variation complement(2100) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="g" /db_xref="dbSNP:375158212" variation complement(2113) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="c" /replace="t" /db_xref="dbSNP:372044168" variation complement(2150) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="g" /db_xref="dbSNP:369707859" exon 2152..2268 /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /inference="alignment:Splign:1.39.8" variation complement(2187) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="g" /db_xref="dbSNP:371706295" variation complement(2217) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="g" /db_xref="dbSNP:374449874" variation complement(2266) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="g" /db_xref="dbSNP:113608212" exon 2269..2567 /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /inference="alignment:Splign:1.39.8" variation complement(2288) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="c" /replace="g" /db_xref="dbSNP:141414455" variation complement(2333) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="g" /db_xref="dbSNP:148384795" variation complement(2348) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="g" /db_xref="dbSNP:370282092" variation complement(2349) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="c" /replace="g" /db_xref="dbSNP:146900414" variation complement(2354) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="c" /replace="g" /db_xref="dbSNP:368460255" variation complement(2357) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="g" /db_xref="dbSNP:142605965" variation complement(2404) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="c" /replace="t" /db_xref="dbSNP:138493671" variation complement(2450) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="c" /replace="t" /db_xref="dbSNP:61751338" variation complement(2457) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="c" /db_xref="dbSNP:61751337" variation complement(2463) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="g" /db_xref="dbSNP:149061794" variation complement(2483) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="g" /db_xref="dbSNP:374646043" variation complement(2494) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="g" /db_xref="dbSNP:201614203" variation complement(2502) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="g" /db_xref="dbSNP:144942373" variation complement(2517) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="c" /db_xref="dbSNP:149885647" variation complement(2520) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="g" /db_xref="dbSNP:140077767" variation complement(2528) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="g" /db_xref="dbSNP:201732861" variation complement(2553) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="g" /db_xref="dbSNP:146654145" variation complement(2555) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="g" /db_xref="dbSNP:199699766" exon 2568..2681 /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /inference="alignment:Splign:1.39.8" variation complement(2622) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="c" /replace="t" /db_xref="dbSNP:373207404" variation complement(2634) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="g" /db_xref="dbSNP:143505361" variation complement(2651) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="g" /db_xref="dbSNP:200120984" variation complement(2656) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="c" /replace="t" /db_xref="dbSNP:375991427" exon 2682..2820 /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /inference="alignment:Splign:1.39.8" variation complement(2708) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="g" /db_xref="dbSNP:367859929" variation complement(2719) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="g" /db_xref="dbSNP:376900132" variation complement(2754) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="g" /db_xref="dbSNP:35147370" variation complement(2771) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="g" /db_xref="dbSNP:375285730" variation complement(2810) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="g" /db_xref="dbSNP:139946113" exon 2821..2998 /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /inference="alignment:Splign:1.39.8" variation complement(2959) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="c" /replace="g" /db_xref="dbSNP:372879919" variation complement(2970) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="g" /db_xref="dbSNP:370540387" variation complement(2992) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="c" /replace="g" /db_xref="dbSNP:377112892" exon 2999..3898 /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /inference="alignment:Splign:1.39.8" variation complement(3002) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="g" /replace="t" /db_xref="dbSNP:368862259" variation complement(3052) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="g" /db_xref="dbSNP:146002237" variation complement(3054) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="g" /db_xref="dbSNP:371985812" variation complement(3058) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="g" /db_xref="dbSNP:35803045" variation complement(3061) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="c" /replace="t" /db_xref="dbSNP:201111479" variation complement(3069) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="c" /replace="g" /db_xref="dbSNP:372467190" variation complement(3080) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="c" /replace="t" /db_xref="dbSNP:34135902" variation complement(3086) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="t" /db_xref="dbSNP:7124834" variation complement(3088) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="c" /replace="t" /db_xref="dbSNP:202116197" variation complement(3093) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="c" /replace="t" /db_xref="dbSNP:375585822" variation complement(3105) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="c" /replace="g" /db_xref="dbSNP:144722829" variation complement(3114) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="c" /replace="t" /db_xref="dbSNP:371207748" variation complement(3117) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="c" /replace="t" /db_xref="dbSNP:149360555" variation complement(3118) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="g" /db_xref="dbSNP:201225431" variation complement(3119) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="c" /replace="t" /db_xref="dbSNP:61756123" variation complement(3132) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="c" /replace="t" /db_xref="dbSNP:139055389" variation complement(3141) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="g" /replace="t" /db_xref="dbSNP:367647619" variation complement(3178) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="c" /db_xref="dbSNP:373803547" variation complement(3192) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="t" /db_xref="dbSNP:370431238" variation complement(3199) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="c" /replace="t" /db_xref="dbSNP:150519608" variation complement(3213) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="t" /db_xref="dbSNP:377195304" variation complement(3249) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="g" /db_xref="dbSNP:116034442" STS 3269..3385 /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /standard_name="SHGC-106541" /db_xref="UniSTS:169929" variation complement(3275) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="c" /db_xref="dbSNP:113258937" variation complement(3325) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="g" /db_xref="dbSNP:113679864" STS 3476..3724 /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /standard_name="RH18062" /db_xref="UniSTS:73995" variation complement(3522..3523) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="" /replace="ca" /db_xref="dbSNP:36088476" variation complement(3523..3524) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="" /replace="ag" /db_xref="dbSNP:200207788" variation complement(3556) /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" /replace="a" /replace="t" /db_xref="dbSNP:59685395" polyA_signal 3870..3875 /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" polyA_site 3898 /gene="NUP98" /gene_synonym="ADIR2; NUP196; NUP96" ORIGIN
aaccgcggcggcgaggggcgggactccacggccctctcaccgctcctaccctgtgcctccccgaactccttctgcccctcctcttccctctcgccccttcccccttcagttcggtttcaaaagacgcgttgcccaatgaataacagggtcgacccagagtggcggccgcgtccaccaattcgcggacggcgagggcggagcgtccgcaacgagcctctgacgccgggcggcgtgtgacgcagtcgggccctctgcgcgctgcgcccgaagcggcggtcggtggcaggggtggtagcggcggcggcgacggtttcgtgggggccgcgcgctgctctgtgagcggcgggtggcagcaggggactcctgacacttccccttccccaccgaaccgcgctttctgaaacaaagactcattttgaagatgtttaacaaatcatttggaacaccctttgggggtggcacaggtggctttggcacaacttcaacatttggacagaatactggctttggcactactagtggaggggcatttggaacatctgcatttggttctagcaacaatactggaggcctctttggaaattcacagactaaaccaggaggattgtttggaaccagttcatttagccagccagctacctccacaagcactggctttgggtttggtacgtcaacaggaacagcaaataccttgtttggaactgcaagcacagggaccagtctcttctcatcccaaaacaatgcctttgcacaaaataaaccaactggctttggcaattttggaaccagtactagcagtggaggactctttggaaccacaaataccacctctaatccttttggcagcacatctggctccctctttgggccaagtagttttacagctgctcctactgggactactattaaatttaaccctccaactggtacagatactatggtcaaagctggagttagcactaacataagtaccaagcaccagtgtattactgctatgaaagaatatgaaagcaagtcactagaggaacttcgtttagaggattatcaggctaacaggaagggcccacagaaccaggtgggagcaggtaccacaactggcttgtttgggtcttctccagccacttccagcgcaacaggactcttcagctcctccaccactaattcaggctttgcatatggtcagaacaaaactgcctttggaactagtacaactggatttggaacaaatccaggtggtctctttggccaacagaatcagcagactaccagcctcttcagcaaaccatttggccaggctacaaccacccagaacactggcttttcctttggtaataccagcaccataggacagccaagcaccaacaccatgggattatttggagtaacccaagcctcacagcctggaggtctttttgggacagctacaaacaccagcactgggacagcatttggaacaggaacaggtctctttgggcagaccaatactggatttggtgctgttggttcgaccctgtttggcaataacaagcttactacatttggaagcagcacaaccagtgcaccttcatttggtacaaccagtggcgggctctttggttttggcacaaataccagtgggaatagtatttttggaagtaaaccagcacctgggactcttggaactgggcttggtgcaggatttggaacagctcttggtgctggacaggcatctttgtttgggaacaaccaacctaagattggagggcctcttggtacaggagcctttggggcccctggatttaatactacgacagccactttgggctttggagccccccaggccccagtagctttgacagatccaaatgcttctgctgcccagcaggctgttctccagcagcacatcaatagtctaacatactcaccttttggagactctcctctcttccggaatccgatgtcagaccctaagaagaaggaagagagattgaaaccaacaaatccagcagcccagaaggctcttactacacctactcattataaactgacaccccgccctgccactagagtccggccaaaggctttacaaacaacaggcacagccaagtcacatctctttgatgggctggatgacgatgaaccatccctagccaatggagcattcatgcccaagaagagcattaagaagttggttttgaagaaccttaataatagcaatctcttttctcctgttaatcgtgattcagaaaatctagcttcaccatctgaatatccagaaaatggagagagatttagtttcctaagcaaacctgttgatgagaatcaccagcaggatggagatgaagattcccttgtttcacatttttatactaaccctattgccaaacctattcctcaaaccccagaaagtgctggaaataaacacagcaacagcaacagtgtggatgataccattgttgcattaaacatgcgtgctgctttgcgaaatgggctggaaggaagcagtgaagaaacgtcttttcatgatgagtcacttcaggatgaccgagaagaaatagaaaataattcttaccatatgcacccagcaggtattattctcactaaggttggttactatactattccatctatggatgaccttgctaaaattaccaatgaaaaaggagagtgcattgtctctgatttcactattggtcggaaaggttatggttcaatctattttgaaggagatgtgaatttgacaaatctaaatttggatgatattgtgcatatccggaggaaagaagtagttgtctacttagatgataaccaaaaaccacctgtgggtgaagggctaaataggaaggctgaagttacattggatggagtttggccaacagataaaacatctcgttgtttaataaagagcccagatcgccttgctgatatcaactatgaaggaagattggaagcagtttcaaggaaacagggagctcaattcaaagaataccggcctgaaactggttcttgggtgtttaaggtctcccatttttctaagtatggccttcaggattctgatgaagaggaggaggagcatccgtctaaaactagtacaaagaagttgaagactgctcctttgcctcctgcaagccagactacgcccttgcagatggctcttaatggcaaacctgcacctccacctcaggtagagaaaaaaggacagtgaatttgaatggaatccgtgataccgaagttgaaagcaagtcattcagctaatacaaagctgttttatgacccttggaactttgaagagtacaaacattggcaatcacgttgaaacaagtgcaagggagggcgtgaggtcttgcaggcatctgtctttttactggagagatttaaagaattctcttgctgtttggattattcctctacagattgtcatttttaaaccctttgttctctctcatttggacttgctgaattctctgctcagtgattaacttaagatttgctcatgtgggttcatgcacagtaaattctgcctttattgactacctgatgtgcagtttaatctttttctttacctccatggttttttaaaagttaaattagctttctgaaagggtttttaatctccatttttttaaagttgtttgcttatacttcgggtaaccttgatatttgtattttaatagtacataatctttatgaaaaatagtttgggaatgtaaatgaattattatttggcttggggagattagggcctacattgtttatcgcaattacttgtatcattgatacgggatttctttgtaaagcatcctctacctctcagctgctgaaagctagacctttggtattttccatgctataattcttatggctgctgaaatgtgtggtttttatgatttattaaataatctcttaggaggcatttctgaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:4928 -> Molecular function: GO:0005215 [transporter activity] evidence: TAS GeneID:4928 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:4928 -> Molecular function: GO:0017056 [structural constituent of nuclear pore] evidence: IMP GeneID:4928 -> Molecular function: GO:0017056 [structural constituent of nuclear pore] evidence: NAS GeneID:4928 -> Molecular function: GO:0042277 [peptide binding] evidence: IEA GeneID:4928 -> Biological process: GO:0000059 [protein import into nucleus, docking] evidence: NAS GeneID:4928 -> Biological process: GO:0000278 [mitotic cell cycle] evidence: TAS GeneID:4928 -> Biological process: GO:0005975 [carbohydrate metabolic process] evidence: TAS GeneID:4928 -> Biological process: GO:0006260 [DNA replication] evidence: IMP GeneID:4928 -> Biological process: GO:0006913 [nucleocytoplasmic transport] evidence: TAS GeneID:4928 -> Biological process: GO:0006999 [nuclear pore organization] evidence: NAS GeneID:4928 -> Biological process: GO:0007077 [mitotic nuclear envelope disassembly] evidence: TAS GeneID:4928 -> Biological process: GO:0008645 [hexose transport] evidence: TAS GeneID:4928 -> Biological process: GO:0010827 [regulation of glucose transport] evidence: TAS GeneID:4928 -> Biological process: GO:0015758 [glucose transport] evidence: TAS GeneID:4928 -> Biological process: GO:0016032 [viral process] evidence: TAS GeneID:4928 -> Biological process: GO:0019048 [modulation by virus of host morphology or physiology] evidence: IEA GeneID:4928 -> Biological process: GO:0019221 [cytokine-mediated signaling pathway] evidence: TAS GeneID:4928 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS GeneID:4928 -> Biological process: GO:0051028 [mRNA transport] evidence: IEA GeneID:4928 -> Biological process: GO:0051292 [nuclear pore complex assembly] evidence: IMP GeneID:4928 -> Biological process: GO:0055085 [transmembrane transport] evidence: TAS GeneID:4928 -> Cellular component: GO:0000776 [kinetochore] evidence: IDA GeneID:4928 -> Cellular component: GO:0005635 [nuclear envelope] evidence: IDA GeneID:4928 -> Cellular component: GO:0005635 [nuclear envelope] evidence: TAS GeneID:4928 -> Cellular component: GO:0005643 [nuclear pore] evidence: IDA GeneID:4928 -> Cellular component: GO:0005643 [nuclear pore] evidence: NAS GeneID:4928 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS GeneID:4928 -> Cellular component: GO:0005829 [cytosol] evidence: TAS GeneID:4928 -> Cellular component: GO:0031080 [nuclear pore outer ring] evidence: IDA GeneID:4928 -> Cellular component: GO:0031080 [nuclear pore outer ring] evidence: NAS GeneID:4928 -> Cellular component: GO:0031965 [nuclear membrane] evidence: IDA GeneID:4928 -> Cellular component: GO:0034399 [nuclear periphery] evidence: IDA GeneID:4928 -> Cellular component: GO:0042405 [nuclear inclusion body] evidence: IDA GeneID:4928 -> Cellular component: GO:0044615 [nuclear pore nuclear basket] evidence: IDA
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@meso_cacase at
DBCLS
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