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2025-05-09 19:47:03, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_031268 6862 bp mRNA linear PRI 07-JUL-2013
DEFINITION Homo sapiens 3-phosphoinositide dependent protein kinase-1 (PDPK1),
transcript variant 2, mRNA.
ACCESSION NM_031268 XM_939834
VERSION NM_031268.5 GI:387849237
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6862)
AUTHORS Eser,S., Reiff,N., Messer,M., Seidler,B., Gottschalk,K., Dobler,M.,
Hieber,M., Arbeiter,A., Klein,S., Kong,B., Michalski,C.W.,
Schlitter,A.M., Esposito,I., Kind,A.J., Rad,L., Schnieke,A.E.,
Baccarini,M., Alessi,D.R., Rad,R., Schmid,R.M., Schneider,G. and
Saur,D.
TITLE Selective requirement of PI3K/PDK1 signaling for Kras
oncogene-driven pancreatic cell plasticity and cancer
JOURNAL Cancer Cell 23 (3), 406-420 (2013)
PUBMED 23453624
REMARK GeneRIF: cell-autonomous phosphoinositide 3-kinase and
3-phosphoinositide-dependent protein kinase 1 are key effectors of
oncogenic Kras in the pancreas, mediating cell plasticity,
acinar-to-ductal metaplasia, and pancreatic ductal adenocarcinoma
formation
REFERENCE 2 (bases 1 to 6862)
AUTHORS Raimondi,C., Chikh,A., Wheeler,A.P., Maffucci,T. and Falasca,M.
TITLE A novel regulatory mechanism links PLCgamma1 to PDK1
JOURNAL J. Cell. Sci. 125 (PT 13), 3153-3163 (2012)
PUBMED 22454520
REMARK GeneRIF: PDK1 and PLCgamma1 act on the same signalling cascade, and
the PDK1/PLCgamma1 pathway is required for regulation of cell
invasion.
REFERENCE 3 (bases 1 to 6862)
AUTHORS Kim,M.G., Moon,J.S., Kim,E.J., Lee,S.H. and Oh,J.W.
TITLE Destabilization of PDK1 by Hsp90 inactivation suppresses hepatitis
C virus replication through inhibition of PRK2-mediated viral RNA
polymerase phosphorylation
JOURNAL Biochem. Biophys. Res. Commun. 421 (1), 112-118 (2012)
PUBMED 22490666
REMARK GeneRIF: these findings suggest that Hsp90 plays a critical role in
the regulation of HCV RNA polymerase phosphorylation via the
PDK1-PRK2 signaling pathway.
REFERENCE 4 (bases 1 to 6862)
AUTHORS Kikani,C.K., Verona,E.V., Ryu,J., Shen,Y., Ye,Q., Zheng,L.,
Qian,Z., Sakaue,H., Nakamura,K., Du,J., Ji,Q., Ogawa,W., Sun,L.Z.,
Dong,L.Q. and Liu,F.
TITLE Proliferative and antiapoptotic signaling stimulated by
nuclear-localized PDK1 results in oncogenesis
JOURNAL Sci Signal 5 (249), RA80 (2012)
PUBMED 23131847
REMARK GeneRIF: cytoplasmic localization of PDK1 correlated only with
early-stage, low-risk tumors, whereas nuclear PDK1 localization
correlated with high-risk tumors
Publication Status: Online-Only
REFERENCE 5 (bases 1 to 6862)
AUTHORS Yu,J., Chen,K.S., Li,Y.N., Yang,J. and Zhao,L.
TITLE Silencing of PDK1 gene expression by RNA interference suppresses
growth of esophageal cancer
JOURNAL Asian Pac. J. Cancer Prev. 13 (8), 4147-4151 (2012)
PUBMED 23098536
REMARK GeneRIF: High 3-phosphoinositide-dependent protein kinase 1 is
associated with esophageal cancer.
REFERENCE 6 (bases 1 to 6862)
AUTHORS Meier,R., Alessi,D.R., Cron,P., Andjelkovic,M. and Hemmings,B.A.
TITLE Mitogenic activation, phosphorylation, and nuclear translocation of
protein kinase Bbeta
JOURNAL J. Biol. Chem. 272 (48), 30491-30497 (1997)
PUBMED 9374542
REFERENCE 7 (bases 1 to 6862)
AUTHORS Shaw,M., Cohen,P. and Alessi,D.R.
TITLE Further evidence that the inhibition of glycogen synthase
kinase-3beta by IGF-1 is mediated by PDK1/PKB-induced
phosphorylation of Ser-9 and not by dephosphorylation of Tyr-216
JOURNAL FEBS Lett. 416 (3), 307-311 (1997)
PUBMED 9373175
REFERENCE 8 (bases 1 to 6862)
AUTHORS Alessi,D.R., Deak,M., Casamayor,A., Caudwell,F.B., Morrice,N.,
Norman,D.G., Gaffney,P., Reese,C.B., MacDougall,C.N., Harbison,D.,
Ashworth,A. and Bownes,M.
TITLE 3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural
and functional homology with the Drosophila DSTPK61 kinase
JOURNAL Curr. Biol. 7 (10), 776-789 (1997)
PUBMED 9368760
REFERENCE 9 (bases 1 to 6862)
AUTHORS Moser,B.A., Dennis,P.B., Pullen,N., Pearson,R.B., Williamson,N.A.,
Wettenhall,R.E., Kozma,S.C. and Thomas,G.
TITLE Dual requirement for a newly identified phosphorylation site in
p70s6k
JOURNAL Mol. Cell. Biol. 17 (9), 5648-5655 (1997)
PUBMED 9271440
REFERENCE 10 (bases 1 to 6862)
AUTHORS Alessi,D.R., James,S.R., Downes,C.P., Holmes,A.B., Gaffney,P.R.,
Reese,C.B. and Cohen,P.
TITLE Characterization of a 3-phosphoinositide-dependent protein kinase
which phosphorylates and activates protein kinase Balpha
JOURNAL Curr. Biol. 7 (4), 261-269 (1997)
PUBMED 9094314
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AC093525.3, BC033494.1 and AC141586.2.
On May 17, 2012 this sequence version replaced gi:60498970.
Transcript Variant: This variant (2) lacks three consecutive exons
in the coding region, but maintains the reading frame, compared to
variant 1. The encoded isoform (2) is shorter than isoform 1.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC033494.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025083, ERS025084 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-87 AC093525.3 55190-55276 c
88-4478 BC033494.1 1-4391
4479-6862 AC141586.2 62525-64908 c
FEATURES Location/Qualifiers
source 1..6862
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="16"
/map="16p13.3"
gene 1..6862
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/note="3-phosphoinositide dependent protein kinase-1"
/db_xref="GeneID:5170"
/db_xref="HGNC:8816"
/db_xref="MIM:605213"
exon 1..173
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/inference="alignment:Splign:1.39.8"
variation 30
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="t"
/db_xref="dbSNP:191389305"
CDS 150..1439
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/EC_number="2.7.11.1"
/note="isoform 2 is encoded by transcript variant 2;
PkB-like 1; PkB kinase like gene 1"
/codon_start=1
/product="3-phosphoinositide-dependent protein kinase 1
isoform 2"
/protein_id="NP_112558.2"
/db_xref="GI:47680169"
/db_xref="CCDS:CCDS10473.1"
/db_xref="GeneID:5170"
/db_xref="HGNC:8816"
/db_xref="MIM:605213"
/translation="
MARTTSQLYDAVPIQSSVVLCSCPSPSMVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYATRANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPKLTAYLPAMSEDDEDCYGNYDNLLSQFGCMQVSSSSSSHSLSASDTGLPQRSGSNIEQYIHDLDSNSFELDLQFSEDEKRLLLEKQAGGNPWHQFVENNLILKMGPVDKRKGLFARRRQLLLTEGPHLYYVDPVNKVLKGEIPWSQELRPEAKNFKTFFVHTPNRTYYLMDPSGNAHKWCRKIQEVWRQRYQSHPDAAVQ
"
misc_feature 174..176
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphotyrosine, by SRC and INSR; propagated from
UniProtKB/Swiss-Prot (O15530.1); phosphorylation site"
misc_feature 174..176
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:01819"
misc_feature 222..224
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(O15530.1); phosphorylation site"
misc_feature 222..224
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 246..248
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:05556"
misc_feature <390..794
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/note="Protein Kinases, catalytic domain; Region:
PKc_like; cl09925"
/db_xref="CDD:213116"
misc_feature order(390..407,498..509)
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/note="activation loop (A-loop); other site"
/db_xref="CDD:173623"
misc_feature 489..491
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:05556"
misc_feature 489..491
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 489..491
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 501..503
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 885..887
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:01819"
misc_feature 945..947
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 954..956
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 996..998
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1137..1400
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/note="3-Phosphoinositide dependent protein kinase 1
(PDK1) pleckstrin homology (PH) domain; Region: PH_PDK1;
cd01262"
/db_xref="CDD:176338"
misc_feature order(1143..1166,1182..1205,1212..1232,1254..1271,
1275..1295,1305..1325,1332..1349,1359..1394)
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/note="core domain; other site"
/db_xref="CDD:176338"
misc_feature order(1143..1145,1149..1151,1182..1184,1188..1190,
1194..1196)
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/note="putative phosphoinositide binding site [chemical
binding]; other site"
/db_xref="CDD:176338"
misc_feature 1221..1223
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:01819"
misc_feature 1305..1307
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:05556"
exon 174..434
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/inference="alignment:Splign:1.39.8"
variation 198
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="t"
/db_xref="dbSNP:76505791"
variation 200
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:61747742"
variation 200
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:200979773"
variation 247
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:61747743"
variation 271
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:55824600"
variation 362
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:79145795"
variation 380
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:372064092"
variation 410
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:758319"
variation 410
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:369990948"
variation 431
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="c"
/db_xref="dbSNP:146388630"
exon 435..477
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/inference="alignment:Splign:1.39.8"
exon 478..553
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/inference="alignment:Splign:1.39.8"
variation 513
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:370069297"
variation 522
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:373278831"
variation 524
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:139543796"
variation 532
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:144186731"
variation 542
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:200735205"
exon 554..622
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/inference="alignment:Splign:1.39.8"
exon 623..719
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/inference="alignment:Splign:1.39.8"
exon 720..893
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/inference="alignment:Splign:1.39.8"
exon 894..1111
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/inference="alignment:Splign:1.39.8"
variation 928
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:370279457"
variation 938
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="g"
/db_xref="dbSNP:377095764"
variation 946
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="g"
/db_xref="dbSNP:200076126"
variation 961
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:370494924"
variation 972
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:76887737"
variation 973
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:75824263"
variation 974
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:75077217"
variation 976
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:139732994"
variation 978
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:201780963"
variation 1000
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:149931764"
variation 1053
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="g"
/db_xref="dbSNP:145034828"
variation 1067
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:145594574"
variation 1075
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:374111988"
variation 1086
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="g"
/replace="t"
/db_xref="dbSNP:142153837"
exon 1112..1169
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/inference="alignment:Splign:1.39.8"
variation 1128
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:374649760"
exon 1170..1322
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/inference="alignment:Splign:1.39.8"
exon 1323..6862
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/inference="alignment:Splign:1.39.8"
STS 1323..2182
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/standard_name="PDPK1_7852"
/db_xref="UniSTS:471709"
variation 1355
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:147843249"
variation 1361
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:141143951"
variation 1377
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="c"
/db_xref="dbSNP:143425561"
variation 1405
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:148008907"
variation 1424
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:201375554"
variation 1427
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:201646295"
variation 1428
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:201983709"
variation 1440
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:141708903"
variation 1450
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:371050359"
variation 1454
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:375625632"
variation 1490
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:368140738"
variation 1491
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:111905533"
variation 1492
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="g"
/replace="t"
/db_xref="dbSNP:374100568"
variation 1547
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:10866"
variation 1584
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:3087784"
variation 1624
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:375635017"
variation 1715
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="g"
/db_xref="dbSNP:148121766"
variation 1735
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:140982354"
variation 1741
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:13335284"
variation 1742
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:369818229"
variation 1745
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:374470586"
variation 1777
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="g"
/replace="t"
/db_xref="dbSNP:371038846"
variation 1848
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="g"
/replace="t"
/db_xref="dbSNP:189787811"
variation 1919..1920
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace=""
/replace="cgggggccgcagctttgtgg"
/db_xref="dbSNP:374612917"
variation 1934
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="g"
/replace="t"
/db_xref="dbSNP:181078294"
variation 1944
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:113332295"
variation 1979
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="c"
/db_xref="dbSNP:375417064"
variation 2066
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:185952911"
variation 2171
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="g"
/db_xref="dbSNP:79745244"
variation 2227
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:138049982"
variation 2322
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="g"
/replace="t"
/db_xref="dbSNP:71386677"
variation 2326
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="g"
/db_xref="dbSNP:142512073"
variation 2439
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:190327635"
variation 2484
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:78560075"
variation 2505
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:138756291"
variation 2589
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:76291069"
variation 2604
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:74003037"
variation 2647
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:144433575"
variation 2691
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:376035884"
variation 2711
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:148393103"
variation 2712
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:141692563"
variation 2727
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="g"
/replace="t"
/db_xref="dbSNP:147153606"
variation 2738
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:183283033"
variation 2825
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:28679688"
variation 2914..2916
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace=""
/replace="tgc"
/db_xref="dbSNP:149315179"
variation 3080
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:370396602"
variation 3092
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:367998725"
variation 3145
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="g"
/db_xref="dbSNP:373772013"
variation 3148
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="g"
/db_xref="dbSNP:372067195"
variation 3246
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:4786296"
variation 3339
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="g"
/replace="t"
/db_xref="dbSNP:4786297"
variation 3393
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:147975625"
variation 3415..3429
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace=""
/replace="gtcctgtgtctccat"
/db_xref="dbSNP:370970044"
variation 3417..3431
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace=""
/replace="cctgtgtctccatgt"
/db_xref="dbSNP:11268185"
variation 3463
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:187363186"
variation 3475
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="g"
/db_xref="dbSNP:28457160"
variation 3507
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="g"
/replace="t"
/db_xref="dbSNP:113716221"
variation 3538
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:190975527"
variation 3628
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:113054936"
variation 3659
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:3112701"
variation 3659
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:28615548"
variation 3687
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:372950862"
variation 3721..3727
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace=""
/replace="cagcccc"
/db_xref="dbSNP:71148147"
variation 3749
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:149131034"
variation 3817
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="g"
/db_xref="dbSNP:71386681"
variation 3817
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="g"
/db_xref="dbSNP:78765961"
variation 3930..3931
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace=""
/replace="a"
/db_xref="dbSNP:199508475"
variation 3941
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:2108863"
variation 4037
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:147659496"
STS 4362..4468
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/standard_name="D16S426E"
/db_xref="UniSTS:147333"
variation 4756
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:182763560"
variation 4866
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:187478880"
variation 4887
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="g"
/db_xref="dbSNP:112319026"
variation 4890
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="c"
/db_xref="dbSNP:191845035"
variation 4895
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:144753105"
variation 4948
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:182493826"
variation 5044
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:11554593"
variation 5108
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:112703875"
variation 5186
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="c"
/db_xref="dbSNP:373860725"
variation 5280
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="c"
/db_xref="dbSNP:367757589"
variation 5289
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:371321013"
variation 5301
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="g"
/replace="t"
/db_xref="dbSNP:368594243"
variation 5374..5379
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace=""
/replace="gtgggg"
/db_xref="dbSNP:33994421"
variation 5479
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace=""
/replace="c"
/db_xref="dbSNP:376887169"
variation 5485
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="g"
/db_xref="dbSNP:56318884"
variation 5525
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:2335110"
variation 5605
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:187543589"
variation 5630
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:2335111"
variation 5632
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:137906061"
variation 5710..5711
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace=""
/replace="cc"
/db_xref="dbSNP:71776175"
variation 5746
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="g"
/db_xref="dbSNP:3095103"
variation 5770
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:369381082"
variation 5825
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:376666016"
variation 5844
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:185737005"
variation 5854
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="c"
/db_xref="dbSNP:190542981"
variation 5892..5893
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace=""
/replace="a"
/db_xref="dbSNP:200815032"
variation 5922
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:200359888"
variation 5976
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="g"
/db_xref="dbSNP:368831914"
variation 6110
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:371727709"
variation 6111
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:929457"
variation 6147
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:201156361"
variation 6212
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:184540154"
variation 6213
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:189062814"
variation 6271..6274
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace=""
/replace="gtaa"
/db_xref="dbSNP:5815128"
variation 6274..6277
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace=""
/replace="agta"
/db_xref="dbSNP:3030674"
variation 6348
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:375159135"
STS 6384..6548
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/standard_name="RH78462"
/db_xref="UniSTS:48236"
variation 6562..6563
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace=""
/replace="tg"
/db_xref="dbSNP:201869822"
variation 6691
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:11554591"
variation 6760..6761
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace=""
/replace="tt"
/db_xref="dbSNP:111618468"
variation 6761..6762
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace=""
/replace="tt"
/db_xref="dbSNP:71726088"
variation 6762
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:11554592"
variation 6767
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:181213412"
variation 6771..6772
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace=""
/replace="tc"
/db_xref="dbSNP:201698119"
variation 6791
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:185318792"
variation 6815
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="t"
/db_xref="dbSNP:189105574"
ORIGIN
gcggcgccgggggcggggggcggcgggcgacggggcgggcgcaggatgagggcggccattgctggggctccgcttcggggaggaggacgctgaggaggcgccgagccgcgcagcgctgcgggggaggcgcccgcgccgacgcggggcccatggccaggaccaccagccagctgtatgacgccgtgcccatccagtccagcgtggtgttatgttcctgcccatccccatcaatggtgaggacccagactgagtccagcacgccccctggcattcctggtggcagcaggcagggccccgccatggacggcactgcagccgagcctcggcccggcgccggctccctgcagcatgcccagcctccgccgcagcctcggaagaagcggcctgaggacttcaagtttgggaaaatccttggggaaggctctttttccacggttgtcctggctcgagaactggcaacctccagagaatatgcgaccagggccaactcattcgtgggaacagcgcagtacgtttctccagagctgctcacggagaagtccgcctgtaagagttcagacctttgggctcttggatgcataatataccagcttgtggcaggactcccaccattccgagctggaaacgagtatcttatatttcagaagatcattaagttggaatatgactttccagaaaaattcttccctaaggcaagagacctcgtggagaaacttttggttttagatgccacaaagcggttaggctgtgaggaaatggaaggatacggacctcttaaagcacacccgttcttcgagtccgtcacgtgggagaacctgcaccagcagacgcctccgaagctcaccgcttacctgccggctatgtcggaagacgacgaggactgctatggcaattatgacaatctcctgagccagtttggctgcatgcaggtgtcttcgtcctcctcctcacactccctgtcagcctccgacacgggcctgccccagaggtcaggcagcaacatagagcagtacattcacgatctggactcgaactcctttgaactggacttacagttttccgaagatgagaagaggttgttgttggagaagcaggctggcggaaacccttggcaccagtttgtagaaaataatttaatactaaagatgggcccagtggataagcggaagggtttatttgcaagacgacgacagctgttgctcacagaaggaccacatttatattatgtggatcctgtcaacaaagttctgaaaggtgaaattccttggtcacaagaacttcgaccagaggccaagaattttaaaactttctttgtccacacgcctaacaggacgtattatctgatggaccccagcgggaacgcacacaagtggtgcaggaagatccaggaggtttggaggcagcgataccagagccacccggacgccgctgtgcagtgacgtggcctgcggccgggctgcccttcgctgccaggacacctgccccagcgcggcttggccgccatccgggacgcttccagaccacctgccagccatcacaaggggaacgcagaggcggaaaccttgcagcatttttatttaaaagaaaagaagaaaaaaaacacccaaccacacaaagaacaaaaccagtaacaaacacaaaggaattcagggtcgctttgcttgctctctgtgctccgtggaggcctccgtgtgccctcgttgccgtggggacccagctccatgcacgtcaacccagtcccgcccagactagtggacagacctggtgtcaccagtttttcctagcatcagtccgaaccatgcgcccgccctgccccaactgtgtgctggtcctgctgtggccgaggggaccgggtgtgtttggctctttatgcccctcccgctgtggtcctggaactcttcaccagggagggagccctgcgggggccgcagctttgtggagggagccgccgtgcttctgtcacctgctccctttcttgcgtctccctgtgatgggcccttaggcctggctgggcccattacatatccctgtggtggctctggtggcagctttctgtggcccctgctgtgttggcaggcaggtttgcgtggtgaggagcgggaggggttggagtggtgcgggagcaggctgccgagtggagggtgccatcgagggctccggatcccttatcctacttagcagtgttggtctctggggctggaagccgagcgcatgctgggagcggtactgtcagaagtgagcccagttagtaccccgctggctcactgcacgagagagtcctgccccgagccctaggtggggccaggaggtgccttggagaagccagccagagcagagagggctgctgacttccgtgtggagcagagaggcctgagggcctcctaaaaggtttaaatgtccacgcctctccagttgctgaagtagggtctgagagaaccctggcatcagcagacccagggtgcttctgtctcctgcagaccacgccagggagtgcagacaccaccgtcacacacgccccttttgtgttttggttcaagtttctcagagcccctcagagcttctacatctgtgcatcagaaatctcacagccttctcatgctgccggctcatctgggcccatagagtgggctttgccagttgctgttgcacaggaggcgagaacagcacacttcaaccccagcttgctggtcggctttcctctagagagagccggttttggggccatttccctttgatgctttggtggccttgccccgctctgcagcacagacaggccagatgcatttgtcctttgcctagctactccccaggtagagagtgctcctggtggcctggcaggtctgggcccttctctccctgcccaggttgtccctggagggcagccctcactccctttgggggagaggcagacattgctgcccacagacctgcctctgactcaactgtgtccaccctccctggtccctacccccaagtcacaggtgactcagcagtgaccctgtgtgccaggccagatccaaactgagagggaaggtgtcgtttttacactgctaatgacgagagtggctctttttagctaggcgagtacagacggggcctgggagggggcagagatgttccccaggccctgcctgtggttcctgcctgggccttggctgctgctgtgtgagagctgcatgtgagcctgtgaccgtgagctggggtgagctgggccgcacctaccctggggccccagggagcaggacgctccggggcccagcacgttgccctgggcctgtggccggagtcggagtcctctctcctcctcctggcttttggaaaggcttggctgtgttggggagtctctcttagccctttcaggaatttctgttcaggcttcctcctcctcatcagctattttacccatctcagaacgtcctgtgtctccatgtaggagagtggctctctcagatctctcagggcgtctggttatagggaaacaagtggagcagggacgtggctttaattggagcactcggctgggctgcttggggagactcttccgtgcgttcttcctctggatagaaccaccacctcctgggcgtcactgacaagctccatcttaacctccaaagccacagaactaggggctcagagccagagctggcagccgccagccaaaatgatgccattgcctgagctgacagccaagcccttctgtgggtcacctttctcctcacccagccccttgctcttcccttttgaaaggcccgtgtgttttctttccttaccctgtgcttgctcatgtctactccggttttctctaccacatccttagagccatcacctggcacgcaggcgccttacattctacggtagaacgtggggtactgtgtgtgcacatagacacacttacgtggaattacagttgtgggtttatccaagatgaggaagatttcacctgctgtttaatagacttggggccatgtgcctccccacacatgggcaaggacaggtggaatgtcgggaccacactgtgcggcttctcggcacaaagcggagggaggctgtggtcgctgccggcctaggtgtcccaggtgccccgcctttctctgggacacagttgggggctggcttctgagggattcctttctcccctctttgtgtggccccagccagggcggtgggcagtcctggtgtagagcacaagcctctccaccctagagaaatgcctctgtaccacggctaccatgtggaaccttaacttgcagaaggcttgttaacaattgttttgagagagatggctggtcatgccacagctgctggggactccgcctactccagccctcttgggacacactgtgggatttgtggcccttccccagaggaattgtggagactgtcccatggaacaaaccctcaggcaccagcacagggctctgggtgactcagtaaaactaacgtttgtctctgacaagatcagctgtaggctcaccggccagagaagaccactgtgagcattttgccgtatatcctgccctgccatttgttcactttttaaactaaaataggaacatccgacacacaccgtttgcatcgtcttctcccttgatattttaagcattttcccatgtcatgagtttctcagaaacatgtttttaacaattgtactatttagtcattgtccatttactataatttatctgaccatttccctactgtaaaatacttaagacggtttctgatttttccactatttaaataatgctgtgatgaatatctttaaaatcttctgatttcttacttttttcccccttagatgcctggaagtggtattttgaggtgaaagagtttgttcattttgaagatatttctgtctctctctcgacctgatgtgtagacgctcacttccagtagcagaaccaccttagttgtgtcttacagattctgaacaaatcggtttctgataagccatgtgttccaaagaatgtctgaataagaccgctctttatttaaatgctaagaggatgtcactactgcaatccatctgtggccgattttttccaagagccaatttccttgttttggttgcaagaacctggctctgcctgcatgtcagctctctgccctccctgctgccgtggctttcaagcgcttggcagaatcttgtacttcgtgtccacaatggtactgaatttgcatctgcacagtcagcagagataacaagtgttgaactgaccttgccacatgcttagtgagtgatttgtaattaagtttatagactcagaaggtatattaggacatttggaatcagtagcagagcaaagcctctttgaaaaaaaccacgtagctgattgggttttacaagagtgcatttgtctcccccttccacccgtggggccccaccttcaggtcttagtggttcacaagagcccagcagccaggctggctttttcattgtagggcgtggttgtcccagctggtgtagatttcaggccgccccccccaactccctgcccacagtgttgcagattgcctggctggcagcaagtccagaccacccaaatttggttggattcttcatttctccactgtagttggggtccattgattgtgcaggggaacgtgcaggaggtttttctaggcaccgtgttcagtgctgcttcactctaccagagattatggccaaattgcacggaatttggtttcttgccctctgaagcctgagggcccccccttgcctggctggttgacagacccggggtggtcactgctgagacttcagagatcgcagctgctgtgagaatacggtgaaggtactttgttctggaagatgttgtcatacacttttccccagttattttcaaacttgacatgagcctatgttgactcactgggtgggggtcccttcttacgcagcacacgtggcaagtgcctgaatcggggctggaggcacttcagagcctctgaggggccaccacttctggcccaaaattgcagggttgtagatgaggctgcctgtggagaactggtgtgaggaggaagctgtttccaacaaagagcactttcatctgttgagatggctgtggtgagcaactgaacgagcctacgtgtgtacctgaattttccccgtaactcatttcttccatatgaagaaacaccaaactatgtacagagaactttttacaaaaggcagaccttttttaagctgtgtaacccacatagcctaaccacctggcagaatgactacgaataggggtcattgtgctggtaaaagcctctattacgactgtaagtaagttggatgttggcaaaattaaattgttacagtatttagagctgctgtagctgttccttcacaacataaaataggataaatgactagtacgtctttcaggtgggtggcaagcagaacatgcgtaatattctctacctggtctgtagctgtaactgtgatgtacagacaaagcaaaaattaaaagaacttatgaaaacaaatgcaatgatactaggatatacacttttgtatttttattcttatataaggttatttgctggctattgttggcctctagttcagtctgtgttatttaaattctaatatatgaattatttgaattgaattcatgttcggggccacgttgttgtatgtattgatgtacagccttgaatgtgaataattattgtaaactatattttacaactttttttctggctttattatataaattttctattgggtcagtgatttaatcatataatttaatgaatctgtttatcctttttttttttccaaatacttgtgctttaggtgtagttaccagatgatgaattttcctcgtatggtcagtagtcttgtaataaaaagcatgtagagtgtaga
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:5170 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IDA
GeneID:5170 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IEA
GeneID:5170 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: TAS
GeneID:5170 -> Molecular function: GO:0004676 [3-phosphoinositide-dependent protein kinase activity] evidence: IDA
GeneID:5170 -> Molecular function: GO:0005158 [insulin receptor binding] evidence: IEA
GeneID:5170 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:5170 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:5170 -> Molecular function: GO:0016301 [kinase activity] evidence: EXP
GeneID:5170 -> Molecular function: GO:0019901 [protein kinase binding] evidence: IEA
GeneID:5170 -> Biological process: GO:0003323 [type B pancreatic cell development] evidence: IEA
GeneID:5170 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
GeneID:5170 -> Biological process: GO:0006355 [regulation of transcription, DNA-dependent] evidence: IEA
GeneID:5170 -> Biological process: GO:0006468 [protein phosphorylation] evidence: IDA
GeneID:5170 -> Biological process: GO:0006469 [negative regulation of protein kinase activity] evidence: IDA
GeneID:5170 -> Biological process: GO:0006972 [hyperosmotic response] evidence: IEA
GeneID:5170 -> Biological process: GO:0007173 [epidermal growth factor receptor signaling pathway] evidence: TAS
GeneID:5170 -> Biological process: GO:0007268 [synaptic transmission] evidence: TAS
GeneID:5170 -> Biological process: GO:0007596 [blood coagulation] evidence: TAS
GeneID:5170 -> Biological process: GO:0008286 [insulin receptor signaling pathway] evidence: TAS
GeneID:5170 -> Biological process: GO:0008543 [fibroblast growth factor receptor signaling pathway] evidence: TAS
GeneID:5170 -> Biological process: GO:0010594 [regulation of endothelial cell migration] evidence: IEA
GeneID:5170 -> Biological process: GO:0010667 [negative regulation of cardiac muscle cell apoptotic process] evidence: IEA
GeneID:5170 -> Biological process: GO:0018107 [peptidyl-threonine phosphorylation] evidence: IDA
GeneID:5170 -> Biological process: GO:0030036 [actin cytoskeleton organization] evidence: TAS
GeneID:5170 -> Biological process: GO:0030168 [platelet activation] evidence: TAS
GeneID:5170 -> Biological process: GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway] evidence: IDA
GeneID:5170 -> Biological process: GO:0031295 [T cell costimulation] evidence: TAS
GeneID:5170 -> Biological process: GO:0032148 [activation of protein kinase B activity] evidence: IDA
GeneID:5170 -> Biological process: GO:0032869 [cellular response to insulin stimulus] evidence: IMP
GeneID:5170 -> Biological process: GO:0034122 [negative regulation of toll-like receptor signaling pathway] evidence: IEA
GeneID:5170 -> Biological process: GO:0035556 [intracellular signal transduction] evidence: IDA
GeneID:5170 -> Biological process: GO:0038095 [Fc-epsilon receptor signaling pathway] evidence: TAS
GeneID:5170 -> Biological process: GO:0043122 [regulation of I-kappaB kinase/NF-kappaB cascade] evidence: IMP
GeneID:5170 -> Biological process: GO:0043304 [regulation of mast cell degranulation] evidence: IEA
GeneID:5170 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
GeneID:5170 -> Biological process: GO:0046777 [protein autophosphorylation] evidence: TAS
GeneID:5170 -> Biological process: GO:0048011 [neurotrophin TRK receptor signaling pathway] evidence: TAS
GeneID:5170 -> Biological process: GO:0048015 [phosphatidylinositol-mediated signaling] evidence: TAS
GeneID:5170 -> Biological process: GO:0048041 [focal adhesion assembly] evidence: IEA
GeneID:5170 -> Biological process: GO:0050852 [T cell receptor signaling pathway] evidence: TAS
GeneID:5170 -> Biological process: GO:0090004 [positive regulation of establishment of protein localization to plasma membrane] evidence: IMP
GeneID:5170 -> Biological process: GO:0097191 [extrinsic apoptotic signaling pathway] evidence: IMP
GeneID:5170 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
GeneID:5170 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:5170 -> Cellular component: GO:0005737 [cytoplasm] evidence: IEA
GeneID:5170 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:5170 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA
GeneID:5170 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
GeneID:5170 -> Cellular component: GO:0005925 [focal adhesion] evidence: IEA
GeneID:5170 -> Cellular component: GO:0016020 [membrane] evidence: IEA
GeneID:5170 -> Cellular component: GO:0016023 [cytoplasmic membrane-bounded vesicle] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_112558 -> EC 2.7.11.1
by
@meso_cacase at
DBCLS
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