Home |
Help |
Advanced search
2025-05-09 19:37:39, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_021105 2228 bp mRNA linear PRI 16-JUN-2013
DEFINITION Homo sapiens phospholipid scramblase 1 (PLSCR1), mRNA.
ACCESSION NM_021105
VERSION NM_021105.2 GI:176865826
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2228)
AUTHORS Kusano,S. and Eizuru,Y.
TITLE Interaction of the phospholipid scramblase 1 with HIV-1 Tat results
in the repression of Tat-dependent transcription
JOURNAL Biochem. Biophys. Res. Commun. 433 (4), 438-444 (2013)
PUBMED 23501106
REMARK GeneRIF: Overexpression of PLSCR1 efficiently represses the
Tat-dependent transactivation of the HIV-1 long terminal repeat
(LTR) and reduces the nuclear translocation of Tat.
REFERENCE 2 (bases 1 to 2228)
AUTHORS Ory,S., Ceridono,M., Momboisse,F., Houy,S., Chasserot-Golaz,S.,
Heintz,D., Calco,V., Haeberle,A.M., Espinoza,F.A., Sims,P.J.,
Bailly,Y., Bader,M.F. and Gasman,S.
TITLE Phospholipid scramblase-1-induced lipid reorganization regulates
compensatory endocytosis in neuroendocrine cells
JOURNAL J. Neurosci. 33 (8), 3545-3556 (2013)
PUBMED 23426682
REMARK GeneRIF: Calcium-dependent PLSCR-1 activity is required for
compensatory endocytosis (but not for exocytosis) in neuroendocrine
cells.
REFERENCE 3 (bases 1 to 2228)
AUTHORS Amengual,O., Atsumi,T., Oku,K., Suzuki,E., Horita,T., Yasuda,S. and
Koike,T.
TITLE Phospholipid scramblase 1 expression is enhanced in patients with
antiphospholipid syndrome
JOURNAL Mod Rheumatol 23 (1), 81-88 (2013)
PUBMED 22526829
REMARK GeneRIF: Phospholipid scramblase 1 expression is enhanced in
patients with antiphospholipid syndrome.
REFERENCE 4 (bases 1 to 2228)
AUTHORS Kusano,S. and Eizuru,Y.
TITLE Human phospholipid scramblase 1 interacts with and regulates
transactivation of HTLV-1 Tax
JOURNAL Virology 432 (2), 343-352 (2012)
PUBMED 22789739
REMARK GeneRIF: PLSCR1 may play an important role in the IFN-mediated
repression of Tax-dependent transactivation during HTLV-1
infection.
REFERENCE 5 (bases 1 to 2228)
AUTHORS Cui,W., Li,S.Y., Du,J.F., Zhu,Z.M. and An,P.
TITLE Silencing phospholipid scramblase 1 expression by RNA interference
in colorectal cancer and metastatic liver cancer
JOURNAL HBPD INT 11 (4), 393-400 (2012)
PUBMED 22893466
REMARK GeneRIF: PLSCR1 is overexpressed in colorectal cancer and
metastatic liver cancer. Silencing of PLSCR1 by siRNA inhibits the
proliferation, adhesion, migration and invasion of tumor cells.
REFERENCE 6 (bases 1 to 2228)
AUTHORS Kasukabe,T., Kobayashi,H., Kaneko,Y., Okabe-Kado,J. and Honma,Y.
TITLE Identity of human normal counterpart (MmTRA1b) of mouse
leukemogenesis-associated gene (MmTRA1a) product as plasma membrane
phospholipid scramblase and chromosome mapping of the human
MmTRA1b/phospholipid scramblase gene
JOURNAL Biochem. Biophys. Res. Commun. 249 (2), 449-455 (1998)
PUBMED 9712717
REFERENCE 7 (bases 1 to 2228)
AUTHORS Zhao,J., Zhou,Q., Wiedmer,T. and Sims,P.J.
TITLE Palmitoylation of phospholipid scramblase is required for normal
function in promoting Ca2+-activated transbilayer movement of
membrane phospholipids
JOURNAL Biochemistry 37 (18), 6361-6366 (1998)
PUBMED 9572851
REFERENCE 8 (bases 1 to 2228)
AUTHORS Zhou,Q., Sims,P.J. and Wiedmer,T.
TITLE Identity of a conserved motif in phospholipid scramblase that is
required for Ca2+-accelerated transbilayer movement of membrane
phospholipids
JOURNAL Biochemistry 37 (8), 2356-2360 (1998)
PUBMED 9485382
REFERENCE 9 (bases 1 to 2228)
AUTHORS Zhou,Q., Zhao,J., Stout,J.G., Luhm,R.A., Wiedmer,T. and Sims,P.J.
TITLE Molecular cloning of human plasma membrane phospholipid scramblase.
A protein mediating transbilayer movement of plasma membrane
phospholipids
JOURNAL J. Biol. Chem. 272 (29), 18240-18244 (1997)
PUBMED 9218461
REFERENCE 10 (bases 1 to 2228)
AUTHORS Basse,F., Stout,J.G., Sims,P.J. and Wiedmer,T.
TITLE Isolation of an erythrocyte membrane protein that mediates
Ca2+-dependent transbilayer movement of phospholipid
JOURNAL J. Biol. Chem. 271 (29), 17205-17210 (1996)
PUBMED 8663431
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
DR005513.1, AF098642.1 and BC032718.1.
On Apr 8, 2008 this sequence version replaced gi:10863876.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC032718.1, AB006746.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-133 DR005513.1 26-158
134-284 AF098642.1 1-151
285-2228 BC032718.1 33-1976
FEATURES Location/Qualifiers
source 1..2228
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="3"
/map="3q23"
gene 1..2228
/gene="PLSCR1"
/gene_synonym="MMTRA1B"
/note="phospholipid scramblase 1"
/db_xref="GeneID:5359"
/db_xref="HGNC:9092"
/db_xref="HPRD:08855"
/db_xref="MIM:604170"
exon 1..375
/gene="PLSCR1"
/gene_synonym="MMTRA1B"
/inference="alignment:Splign:1.39.8"
STS 134..375
/gene="PLSCR1"
/gene_synonym="MMTRA1B"
/standard_name="PMC229255P5"
/db_xref="UniSTS:272172"
misc_feature 257..259
/gene="PLSCR1"
/gene_synonym="MMTRA1B"
/note="upstream in-frame stop codon"
variation 285
/gene="PLSCR1"
/gene_synonym="MMTRA1B"
/replace="a"
/replace="g"
/db_xref="dbSNP:1061307"
exon 376..401
/gene="PLSCR1"
/gene_synonym="MMTRA1B"
/inference="alignment:Splign:1.39.8"
CDS 389..1345
/gene="PLSCR1"
/gene_synonym="MMTRA1B"
/note="PL scramblase 1; erythrocyte phospholipid
scramblase; ca(2+)-dependent phospholipid scramblase 1"
/codon_start=1
/product="phospholipid scramblase 1"
/protein_id="NP_066928.1"
/db_xref="GI:10863877"
/db_xref="CCDS:CCDS3135.1"
/db_xref="GeneID:5359"
/db_xref="HGNC:9092"
/db_xref="HPRD:08855"
/db_xref="MIM:604170"
/translation="
MDKQNSQMNASHPETNLPVGYPPQYPPTAFQGPPGYSGYPGPQVSYPPPPAGHSGPGPAGFPVPNQPVYNQPVYNQPVGAAGVPWMPAPQPPLNCPPGLEYLSQIDQILIHQQIELLEVLTGFETNNKYEIKNSFGQRVYFAAEDTDCCTRNCCGPSRPFTLRIIDNMGQEVITLERPLRCSSCCCPCCLQEIEIQAPPGVPIGYVIQTWHPCLPKFTIQNEKREDVLKISGPCVVCSCCGDVDFEIKSLDEQCVVGKISKHWTGILREAFTDADNFGIQFPLDLDVKMKAVMIGACFLIDFMFFESTGSQEQKSGVW
"
misc_feature 440..466
/gene="PLSCR1"
/gene_synonym="MMTRA1B"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (O15162.1);
Region: SH3-binding 1 (Potential)"
misc_feature 452..463
/gene="PLSCR1"
/gene_synonym="MMTRA1B"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (O15162.1);
Region: WW-binding 1 (Potential)"
misc_feature 485..496
/gene="PLSCR1"
/gene_synonym="MMTRA1B"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (O15162.1);
Region: WW-binding 2 (Potential)"
misc_feature 512..538
/gene="PLSCR1"
/gene_synonym="MMTRA1B"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (O15162.1);
Region: SH3-binding 2 (Potential)"
misc_feature 593..595
/gene="PLSCR1"
/gene_synonym="MMTRA1B"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphotyrosine, by ABL; propagated from
UniProtKB/Swiss-Prot (O15162.1); phosphorylation site"
misc_feature 593..595
/gene="PLSCR1"
/gene_synonym="MMTRA1B"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:01809"
misc_feature 608..610
/gene="PLSCR1"
/gene_synonym="MMTRA1B"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphotyrosine, by ABL; propagated from
UniProtKB/Swiss-Prot (O15162.1); phosphorylation site"
misc_feature 608..610
/gene="PLSCR1"
/gene_synonym="MMTRA1B"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:01809"
misc_feature 638..664
/gene="PLSCR1"
/gene_synonym="MMTRA1B"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (O15162.1);
Region: SH3-binding 3 (Potential)"
misc_feature 644..1309
/gene="PLSCR1"
/gene_synonym="MMTRA1B"
/note="Scramblase; Region: Scramblase; pfam03803"
/db_xref="CDD:190757"
misc_feature 869..871
/gene="PLSCR1"
/gene_synonym="MMTRA1B"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine, by PKC; propagated from
UniProtKB/Swiss-Prot (O15162.1); phosphorylation site"
misc_feature 869..871
/gene="PLSCR1"
/gene_synonym="MMTRA1B"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:01501"
misc_feature 1157..1186
/gene="PLSCR1"
/gene_synonym="MMTRA1B"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (O15162.1);
Region: Nuclear localization signal"
misc_feature 1253..1303
/gene="PLSCR1"
/gene_synonym="MMTRA1B"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (O15162.1);
transmembrane region"
exon 402..482
/gene="PLSCR1"
/gene_synonym="MMTRA1B"
/inference="alignment:Splign:1.39.8"
exon 483..700
/gene="PLSCR1"
/gene_synonym="MMTRA1B"
/inference="alignment:Splign:1.39.8"
exon 701..743
/gene="PLSCR1"
/gene_synonym="MMTRA1B"
/inference="alignment:Splign:1.39.8"
exon 744..964
/gene="PLSCR1"
/gene_synonym="MMTRA1B"
/inference="alignment:Splign:1.39.8"
exon 965..1126
/gene="PLSCR1"
/gene_synonym="MMTRA1B"
/inference="alignment:Splign:1.39.8"
exon 1127..1288
/gene="PLSCR1"
/gene_synonym="MMTRA1B"
/inference="alignment:Splign:1.39.8"
variation 1172
/gene="PLSCR1"
/gene_synonym="MMTRA1B"
/replace="c"
/replace="t"
/db_xref="dbSNP:343320"
exon 1289..2210
/gene="PLSCR1"
/gene_synonym="MMTRA1B"
/inference="alignment:Splign:1.39.8"
STS 1317..1451
/gene="PLSCR1"
/gene_synonym="MMTRA1B"
/standard_name="SHGC-77431"
/db_xref="UniSTS:48456"
STS 1950..2081
/gene="PLSCR1"
/gene_synonym="MMTRA1B"
/standard_name="SHGC-77437"
/db_xref="UniSTS:51388"
ORIGIN
caccggacaaacgtctctggagtctctccaatgagcaagaaagcaagtcgggggtaggggaggggcctcacaccagggggtgggcgcagtccctcctccagctccttcaccctccagtagtctcgtgggtccccgagcgccagcgcgggaaccgggaaaaggaaaccgtgttgtgtacgtaagattcaggaaacgaaaccaggagccgcgggtgttggcgcaaaggttactcccagacccttttccggctgacttctgagaaggttgcgcagcagctgtgcccggcagtctagaggcgcagaagaggaagccatcgcctggccccggctctctggaccttgtctcgctcgggagcggaaacagcggcagccagagaactgttttaatcatggacaaacaaaactcacagatgaatgcttctcacccggaaacaaacttgccagttgggtatcctcctcagtatccaccgacagcattccaaggacctccaggatatagtggctaccctgggccccaggtcagctacccacccccaccagccggccattcaggtcctggcccagctggctttcctgtcccaaatcagccagtgtataatcagccagtatataatcagccagttggagctgcaggggtaccatggatgccagcgccacagcctccattaaactgtccacctggattagaatatttaagtcagatagatcagatactgattcatcagcaaattgaacttctggaagttttaacaggttttgaaactaataacaaatatgaaattaagaacagctttggacagagggtttactttgcagcggaagatactgattgctgtacccgaaattgctgtgggccatctagaccttttaccttgaggattattgataatatgggtcaagaagtcataactctggagagaccactaagatgtagcagctgttgttgtccctgctgccttcaggagatagaaatccaagctcctcctggtgtaccaataggttatgttattcagacttggcacccatgtctaccaaagtttacaattcaaaatgagaaaagagaggatgtactaaaaataagtggtccatgtgttgtgtgcagctgttgtggagatgttgattttgagattaaatctcttgatgaacagtgtgtggttggcaaaatttccaagcactggactggaattttgagagaggcatttacagacgctgataactttggaatccagttccctttagaccttgatgttaaaatgaaagctgtaatgattggtgcctgtttcctcattgacttcatgttttttgaaagcactggcagccaggaacaaaaatcaggagtgtggtagtggattagtgaaagtctcctcaggaaatctgaagtctgtatattgattgagactatctaaactcatacctgtatgaattaagctgtaaggcctgtagctctggttgtatacttttgcttttcaaattatagtttatcttctgtataactgatttataaaggtttttgtacattttttaatactcattgtcaatttgagaaaaaggacatatgagtttttgcatttattaatgaaacttcctttgaaaaactgctttgaattatgatctctgattcattgtccattttactaccaaatattaactaaggccttattaatttttatataaattatatcttgtcctattaaatctagttacaatttatttcatgcataagagctaatgttattttgcaaatgccatatattcaaaaaagctcaaagataattttctttactattatgttcaaataatattcaatatgcatattatctttaaaaagttaaatgtttttttaatcttcaagaaatcatgctacacttaacttctcctagaagctaatctataccataatattttcatattcacaagatattaaattaccaattttcaaattattgttagtaaagaacaaaatgattctctcccaaagaaagacacattttaaatactccttcactctaaaactctggtattataacttttgaaagttaatatttctacatgaaatgtttagctcttacactctatccttcctagaaaatggtaattgagattactcagatattaattaaatacaatatcatatatatattcacagagtataaacctaaataatgatctattagattcaaatatttgaaataaaaacttgatttttttgtaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:5359 -> Molecular function: GO:0001077 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] evidence: IDA
GeneID:5359 -> Molecular function: GO:0003677 [DNA binding] evidence: IEA
GeneID:5359 -> Molecular function: GO:0005154 [epidermal growth factor receptor binding] evidence: IPI
GeneID:5359 -> Molecular function: GO:0005509 [calcium ion binding] evidence: IDA
GeneID:5359 -> Molecular function: GO:0005509 [calcium ion binding] evidence: NAS
GeneID:5359 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:5359 -> Molecular function: GO:0017124 [SH3 domain binding] evidence: IDA
GeneID:5359 -> Molecular function: GO:0017128 [phospholipid scramblase activity] evidence: IDA
GeneID:5359 -> Molecular function: GO:0019899 [enzyme binding] evidence: IPI
GeneID:5359 -> Molecular function: GO:0042609 [CD4 receptor binding] evidence: IPI
GeneID:5359 -> Biological process: GO:0006659 [phosphatidylserine biosynthetic process] evidence: ISS
GeneID:5359 -> Biological process: GO:0006915 [apoptotic process] evidence: IDA
GeneID:5359 -> Biological process: GO:0006953 [acute-phase response] evidence: ISS
GeneID:5359 -> Biological process: GO:0010628 [positive regulation of gene expression] evidence: IMP
GeneID:5359 -> Biological process: GO:0017121 [phospholipid scrambling] evidence: IDA
GeneID:5359 -> Biological process: GO:0030168 [platelet activation] evidence: NAS
GeneID:5359 -> Biological process: GO:0033003 [regulation of mast cell activation] evidence: ISS
GeneID:5359 -> Biological process: GO:0035456 [response to interferon-beta] evidence: IMP
GeneID:5359 -> Biological process: GO:0045071 [negative regulation of viral genome replication] evidence: IMP
GeneID:5359 -> Biological process: GO:0045089 [positive regulation of innate immune response] evidence: IMP
GeneID:5359 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IDA
GeneID:5359 -> Biological process: GO:0051607 [defense response to virus] evidence: IMP
GeneID:5359 -> Biological process: GO:0060368 [regulation of Fc receptor mediated stimulatory signaling pathway] evidence: ISS
GeneID:5359 -> Biological process: GO:2000373 [positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity] evidence: IDA
GeneID:5359 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:5359 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
GeneID:5359 -> Cellular component: GO:0005794 [Golgi apparatus] evidence: IDA
GeneID:5359 -> Cellular component: GO:0005829 [cytosol] evidence: IDA
GeneID:5359 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA
GeneID:5359 -> Cellular component: GO:0005887 [integral to plasma membrane] evidence: IDA
GeneID:5359 -> Cellular component: GO:0031012 [extracellular matrix] evidence: IDA
GeneID:5359 -> Cellular component: GO:0045121 [membrane raft] evidence: IDA
by
@meso_cacase at
DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.