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2025-05-09 19:19:06, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_017920 3609 bp mRNA linear PRI 07-JUL-2013
DEFINITION Homo sapiens upregulator of cell proliferation (URGCP), transcript
variant 1, mRNA.
ACCESSION NM_017920
VERSION NM_017920.3 GI:117968346
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3609)
AUTHORS Dodurga,Y., Yonguc,G.N., Avci,C.B., Bagci,G., Gunduz,C. and
Satiroglu-Tufan,N.L.
TITLE Investigation of microRNA expression changes in HepG2 cell line in
presence of URG4/URGCP and in absence of URG4/URGCP suppressed by
RNA interference
JOURNAL Mol. Biol. Rep. 39 (12), 11119-11124 (2012)
PUBMED 23053999
REMARK GeneRIF: microRNA profiles were analyzedin HepG2 cells in presence
or absence of URG4/URGCP gene using RNA interference.
REFERENCE 2 (bases 1 to 3609)
AUTHORS Dodurga,Y., Avci,C.B., Susluer,S.Y., Satiroglu Tufan,N.L. and
Gunduz,C.
TITLE The expression of URGCP gene in prostate cancer cell lines:
correlation with rapamycin
JOURNAL Mol. Biol. Rep. 39 (12), 10173-10177 (2012)
PUBMED 23007575
REMARK GeneRIF: Rapamycin diminishes URGCP gene expression in DU145 and
PC3 cells, but increases expression in LNCaP cells.
REFERENCE 3 (bases 1 to 3609)
AUTHORS Xie,C., Song,L.B., Wu,J.H., Li,J., Yun,J.P., Lai,J.M., Xie,D.Y.,
Lin,B.L., Yuan,Y.F., Li,M. and Gao,Z.L.
TITLE Upregulator of cell proliferation predicts poor prognosis in
hepatocellular carcinoma and contributes to hepatocarcinogenesis by
downregulating FOXO3a
JOURNAL PLoS ONE 7 (7), E40607 (2012)
PUBMED 22815774
REMARK GeneRIF: The effects of URGCP/URG4-overexpression or -knockdown on
expression of cell cycle regulators and transcriptional activity of
FOXO3a, were examined.
REFERENCE 4 (bases 1 to 3609)
AUTHORS Oymak,Y., Dodurga,Y., Turedi,A., Yaman,Y., Ozek,G., Carti,O.,
Gunes,B.T., Erbudak,E., Berber,E., Avci,C.B. and Vergin,C.
TITLE Higher expression of the novel gene upregulated gene 4 in two acute
lymphoblastic leukemia patients with poor prednisolone response
JOURNAL Acta Haematol. 128 (2), 73-76 (2012)
PUBMED 22677619
REMARK GeneRIF: higher expression of URG4 in our 2 patients suggests that
URG4 might be involved in leukemogenesis
REFERENCE 5 (bases 1 to 3609)
AUTHORS Satiroglu-Tufan,N.L., Dodurga,Y., Gok,D., Cetinkaya,A. and
Feitelson,M.A.
TITLE RNA interference-mediated URG4 gene silencing diminishes cyclin D1
mRNA expression in HepG2 cells
JOURNAL Genet. Mol. Res. 9 (3), 1557-1567 (2010)
PUBMED 20714998
REMARK GeneRIF: The data suggest that URG4 may play an important role in
the development of hepatocellular carcinoma by partially regulating
the expression of cyclin D1.
Publication Status: Online-Only
REFERENCE 6 (bases 1 to 3609)
AUTHORS Huang,J., Zhu,B., Lu,L., Lian,Z., Wang,Y., Yang,X.,
Satiroglu-Tufan,N.L., Liu,J. and Luo,Z.
TITLE The expression of novel gene URG4 in osteosarcoma: correlation with
patients' prognosis
JOURNAL Pathology 41 (2), 149-154 (2009)
PUBMED 18972316
REMARK GeneRIF: URG4 may play important roles in the development of
osteosarcoma, and might be a useful molecular marker for predicting
the prognosis of osteosarcoma.
REFERENCE 7 (bases 1 to 3609)
AUTHORS Song,J., Xie,H., Lian,Z., Yang,G., Du,R., Du,Y., Zou,X., Jin,H.,
Gao,J., Liu,J. and Fan,D.
TITLE Enhanced cell survival of gastric cancer cells by a novel gene URG4
JOURNAL Neoplasia 8 (12), 995-1002 (2006)
PUBMED 17217616
REMARK GeneRIF: URG4 plays an important role in the development of human
gastric cancer by regulating the expression of cyclin D1.
REFERENCE 8 (bases 1 to 3609)
AUTHORS Tsang,H.T., Connell,J.W., Brown,S.E., Thompson,A., Reid,E. and
Sanderson,C.M.
TITLE A systematic analysis of human CHMP protein interactions:
additional MIT domain-containing proteins bind to multiple
components of the human ESCRT III complex
JOURNAL Genomics 88 (3), 333-346 (2006)
PUBMED 16730941
REFERENCE 9 (bases 1 to 3609)
AUTHORS Fu,G.K., Wang,J.T., Yang,J., Au-Young,J. and Stuve,L.L.
TITLE Circular rapid amplification of cDNA ends for high-throughput
extension cloning of partial genes
JOURNAL Genomics 84 (1), 205-210 (2004)
PUBMED 15203218
REFERENCE 10 (bases 1 to 3609)
AUTHORS Tufan,N.L., Lian,Z., Liu,J., Pan,J., Arbuthnot,P., Kew,M.,
Clayton,M.M., Zhu,M. and Feitelson,M.A.
TITLE Hepatitis Bx antigen stimulates expression of a novel cellular
gene, URG4, that promotes hepatocellular growth and survival
JOURNAL Neoplasia 4 (4), 355-368 (2002)
PUBMED 12082552
REMARK GeneRIF: URG4 may be a natural effector of HBxAg that contributes
importantly to multistep hepatocarcinogenesis.
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
DA240479.1, BC018426.1, DR421788.1, AK000661.1 and AL833744.1.
On Nov 15, 2006 this sequence version replaced gi:19923541.
Summary: URG4 is upregulated in the presence of hepatitis B virus
(HBV)-encoded X antigen (HBxAg) and may contribute to the
development of hepatocellular carcinoma by promoting hepatocellular
growth and survival (Tufan et al., 2002 [PubMed
12082552]).[supplied by OMIM, Mar 2008].
Transcript Variant: This variant (1) lacks an alterate segment,
compared to variant 3. The resulting protein (isoform 1) lacks an
internal segment when it is compared to isoform 3.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: DA326542.1, BC018426.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025083, ERS025085 [ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
gene product(s) localized to mito. :: inferred from homology
##RefSeq-Attributes-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-42 DA240479.1 1-42
43-1802 BC018426.1 1-1760
1803-2353 DR421788.1 115-665
2354-3580 AK000661.1 525-1751
3581-3609 AL833744.1 2148-2176
FEATURES Location/Qualifiers
source 1..3609
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="7"
/map="7p13"
gene 1..3609
/gene="URGCP"
/gene_synonym="URG4"
/note="upregulator of cell proliferation"
/db_xref="GeneID:55665"
/db_xref="HGNC:30890"
/db_xref="MIM:610337"
exon 1..71
/gene="URGCP"
/gene_synonym="URG4"
/inference="alignment:Splign:1.39.8"
CDS 58..2826
/gene="URGCP"
/gene_synonym="URG4"
/note="isoform 1 is encoded by transcript variant 1;
up-regulated gene 4; HBxAg up-regulated gene 4 protein;
HBV X protein up-regulated gene 4 protein; up-regulator of
cell proliferation"
/codon_start=1
/product="up-regulator of cell proliferation isoform 1"
/protein_id="NP_060390.3"
/db_xref="GI:117968347"
/db_xref="CCDS:CCDS47577.1"
/db_xref="GeneID:55665"
/db_xref="HGNC:30890"
/db_xref="MIM:610337"
/translation="
MASPGHSDLGEVAPEIKASERRTAVAIADLEWREMEGDDCEFRYGDGTNEAQDNDFPTVERSRLQEMLSLLGLETYQVQKLSLQDSLQISFDSMKNWAPQVPKDLPWNFLRKLQALNADARNTTMVLDVLPDARPVEKESQMEEEIIYWDPADDLAADIYSFSELPTPDTPVNPLDLLCALLLSSDSFLQQEIALKMALCQFALPLVLPDSENHYHTFLLWAMRGIVRTWWSQPPRGMGSFREDSVVLSRAPAFAFVRMDVSSNSKSQLLNAVLSPGHRQWDCFWHRDLNLGTNAREISDGLVEISWFFPSGREDLDIFPEPVAFLNLRGDIGSHWLQFKLLTEISSAVFILTDNISKKEYKLLYSMKESTTKYYFILSPYRGKRNTNLRFLNKLIPVLKIDHSHVLVKVSSTDSDSFVKRIRAIVGNVLRAPCRRVSVEDMAHAARKLGLKVDEDCEECQKAKDRMERITRKIKDSDAYRRDELRLQGDPWRKAAQVEKEFCQLQWAVDPPEKHRAELRRRLLELRMQQNGHDPSSGVQEFISGISSPSLSEKQYFLRWMEWGLARVAQPRLRQPPETLLTLRPKHGGTTDVGEPLWPEPLGVEHFLREMGQFYEAESCLVEAGRLPAGQRRFAHFPGLASELLLTGLPLELIDGSTLSMPVRWVTGLLKELHVRLERRSRLVVLSTVGVPGTGKSTLLNTMFGLRFATGKSCGPRGAFMQLITVAEGFSQDLGCDHILVIDSGGLIGGALTSAGDRFELEASLATLLMGLSNVTVISLAETKDIPAAILHAFLRLEKTGHMPNYQFVYQNLHDVSVPGPRPRDKRQLLDPPGDLSRAAAQMEKQGDGFRALAGLAFCDPEKQHIWHIPGLWHGAPPMAAVSLAYSEAIFELKRCLLENIRNGLSNQNKNIQQLIELVRRL
"
misc_feature <1273..1431
/gene="URGCP"
/gene_synonym="URG4"
/note="Protein of unknown function (DUF460); Region:
DUF460; pfam04312"
/db_xref="CDD:146773"
misc_feature 2134..>2406
/gene="URGCP"
/gene_synonym="URG4"
/note="P-loop containing Nucleoside Triphosphate
Hydrolases; Region: P-loop_NTPase; cl09099"
/db_xref="CDD:213113"
misc_feature order(2134..2151,2293..2295)
/gene="URGCP"
/gene_synonym="URG4"
/note="GTP/Mg2+ binding site [chemical binding]; other
site"
/db_xref="CDD:206648"
misc_feature 2134..2148
/gene="URGCP"
/gene_synonym="URG4"
/note="G1 box; other site"
/db_xref="CDD:206648"
misc_feature 2215..2223
/gene="URGCP"
/gene_synonym="URG4"
/note="Switch I region; other site"
/db_xref="CDD:206648"
misc_feature 2284..2295
/gene="URGCP"
/gene_synonym="URG4"
/note="G3 box; other site"
/db_xref="CDD:206648"
misc_feature order(2290..2295,2377..2382)
/gene="URGCP"
/gene_synonym="URG4"
/note="Switch II region; other site"
/db_xref="CDD:206648"
misc_feature 2392..2394
/gene="URGCP"
/gene_synonym="URG4"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 2404..2406
/gene="URGCP"
/gene_synonym="URG4"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
exon 72..142
/gene="URGCP"
/gene_synonym="URG4"
/inference="alignment:Splign:1.39.8"
exon 143..193
/gene="URGCP"
/gene_synonym="URG4"
/inference="alignment:Splign:1.39.8"
exon 194..232
/gene="URGCP"
/gene_synonym="URG4"
/inference="alignment:Splign:1.39.8"
variation 231
/gene="URGCP"
/gene_synonym="URG4"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:17423654"
exon 233..3591
/gene="URGCP"
/gene_synonym="URG4"
/inference="alignment:Splign:1.39.8"
variation 1311
/gene="URGCP"
/gene_synonym="URG4"
/replace="c"
/replace="t"
/db_xref="dbSNP:17172256"
variation 1488
/gene="URGCP"
/gene_synonym="URG4"
/replace="a"
/replace="g"
/db_xref="dbSNP:2232098"
variation 1622
/gene="URGCP"
/gene_synonym="URG4"
/replace="a"
/replace="g"
/db_xref="dbSNP:2232099"
variation 1749
/gene="URGCP"
/gene_synonym="URG4"
/replace="a"
/replace="c"
/db_xref="dbSNP:2232100"
variation 1758
/gene="URGCP"
/gene_synonym="URG4"
/replace="a"
/replace="g"
/db_xref="dbSNP:2232101"
variation 1769
/gene="URGCP"
/gene_synonym="URG4"
/replace="c"
/replace="t"
/db_xref="dbSNP:2232102"
variation 1818
/gene="URGCP"
/gene_synonym="URG4"
/replace="c"
/replace="t"
/db_xref="dbSNP:2232103"
variation 1833
/gene="URGCP"
/gene_synonym="URG4"
/replace="c"
/replace="t"
/db_xref="dbSNP:2232104"
variation 2079
/gene="URGCP"
/gene_synonym="URG4"
/replace="c"
/replace="t"
/db_xref="dbSNP:2232105"
variation 2119
/gene="URGCP"
/gene_synonym="URG4"
/replace="a"
/replace="g"
/db_xref="dbSNP:2232106"
variation 2310
/gene="URGCP"
/gene_synonym="URG4"
/replace="c"
/replace="t"
/db_xref="dbSNP:2232107"
variation 2365
/gene="URGCP"
/gene_synonym="URG4"
/replace="a"
/replace="c"
/db_xref="dbSNP:2232108"
variation 2601
/gene="URGCP"
/gene_synonym="URG4"
/replace="c"
/replace="t"
/db_xref="dbSNP:2232109"
variation 2954
/gene="URGCP"
/gene_synonym="URG4"
/replace="c"
/replace="g"
/db_xref="dbSNP:1468405"
STS 3205..3336
/gene="URGCP"
/gene_synonym="URG4"
/standard_name="RH103374"
/db_xref="UniSTS:97701"
STS 3440..3498
/gene="URGCP"
/gene_synonym="URG4"
/standard_name="STS-Z40982"
/db_xref="UniSTS:64179"
STS 3442..3566
/gene="URGCP"
/gene_synonym="URG4"
/standard_name="SHGC-36996"
/db_xref="UniSTS:13584"
variation 3444
/gene="URGCP"
/gene_synonym="URG4"
/replace="c"
/replace="t"
/db_xref="dbSNP:1043200"
polyA_signal 3560..3565
/gene="URGCP"
/gene_synonym="URG4"
polyA_site 3580
/gene="URGCP"
/gene_synonym="URG4"
polyA_site 3591
/gene="URGCP"
/gene_synonym="URG4"
ORIGIN
gagccgcggccgcgcggaggaagcgaaggaggcgggagcggagacctcgctgcgctcatggcgtcgcccgggcattcagatttgggagaagtagccccagaaataaaagcatcagagagacgaacagctgtggccattgcagatttggaatggagagaaatggaaggagatgattgcgagttccgttatggagatggtacaaatgaggctcaggacaatgattttccaacagtggagagaagcaggcttcaagaaatgctgtcacttttgggcctagagacgtaccaggtccagaaactcagcctccaggactctctgcagatcagttttgacagtatgaagaactgggcccctcaggttcccaaagacttgccctggaatttcctcaggaagttgcaggccctcaatgctgatgccaggaataccactatggtgctggacgtgctcccagacgccaggcctgtggagaaggagagccagatggaagaggagatcatctactgggacccagctgatgaccttgctgccgacatttattccttttctgagctgcccacccctgatacgccagtgaaccccttagaccttctctgtgccctgctgctctcctcagacagtttcctgcaacaagaaatagcgttgaaaatggccctctgccagtttgcactcccactcgtgttgcctgactcggagaaccactaccatacatttctgctgtgggccatgcggggcattgtgaggacatggtggtcccagcccccaaggggcatggggagcttccgggaagacagcgtggtcttgtccagggcgcccgccttcgccttcgtgcgcatggacgtcagtagcaactccaagtcccagcttctcaacgccgtcctcagcccgggccacaggcagtgggactgcttctggcatcgggacctcaacttgggcaccaatgcccgggagatttcggatgggttggtagaaatttcctggttttttcccagcggaagggaggacttggacattttcccagaacctgtggcctttctgaacctgagaggtgacatcgggtctcactggctgcagtttaagctcttgacagaaatctcctccgctgtgtttatattgactgacaatatcagtaagaaggaatacaaattgctgtactccatgaaggagtcaaccacaaaatactacttcatcctgagtccctaccgtgggaagcgcaacacaaacctgagatttctgaataagttaattcctgtgctgaaaatagaccactcacatgtcctggtaaaggtcagcagcactgacagcgacagcttcgtgaagaggatccgggccatcgttgggaatgtgctgcgggcaccctgcaggcgggtatctgtggaggacatggcgcacgcagcccgcaaactgggcctaaaggtcgacgaggactgtgaggagtgtcagaaagcgaaagaccggatggagaggattaccaggaaaatcaaagactcggatgcctacagaagggacgagctgaggctgcagggggacccctggagaaaggcagcccaagtggagaaggagttctgccagctccagtgggccgtggacccccctgagaagcacagggctgagctgaggcggcggctgctagaacttcgaatgcagcagaacggccatgatccctcctcgggggtgcaggagttcatctcggggatcagcagcccctccttgagtgagaagcagtacttcctgaggtggatggagtggggcctggcacgggtggcccagccgcgactgagacagcctccggagacgcttctcaccctgagaccaaagcatgggggcaccacagacgtgggggagccgctctggcctgagcccctaggggtggaacacttcttgcgggagatgggacagttttatgaggctgagagctgtcttgtggaggcagggaggctgccggcaggccagaggcgttttgcccacttcccaggcttggcctcggagctgctgctgacagggctgcctctggagctaatcgatgggagcacgctgagcatgcccgtccgctgggtcacagggctcctgaaggagctgcacgtccgactggagagacggtcaaggctggtggttctgtcaaccgtcggggtgccaggcacgggcaagtccacactcctcaacaccatgtttgggctgcggtttgccacagggaagagctgcggtcctcgaggggccttcatgcagctcatcacagtggctgagggcttcagccaggacctgggctgtgaccacatcctggtgatagactccgggggcttgataggtggggccttgacgtcagctggggacagatttgagctggaggcttccttggccactctgctcatgggactgagcaatgtcaccgtgatcagtctagctgaaaccaaggacattccagcagctattctgcatgcatttctgaggttagaaaaaacggggcacatgcccaactaccagtttgtataccagaaccttcatgatgtatctgttcccggccctaggcccagagacaagagacagctcctggatccacctggtgacctgagcagggctgcagcccagatggagaaacagggcgacggcttccgggcactggcaggcctggccttctgcgaccctgagaagcagcacatctggcacatcccaggcctgtggcacggagcacctcccatggccgcagtgagcttggcctacagtgaagccatatttgaattgaagagatgcctactcgaaaacatcaggaacggcttgtcgaaccaaaacaaaaacatccagcagctcattgagctggtgagacggctgtgagtgtgcagagaaacccagttcaggtgtaggaggctgctgtgggcagccctgtctgatggggcacccgtgtggggctgtgctctggtgcctgagaatggctggtgcccaatcgacatgagaagacgaggaaaagacagggtttggagtctcctcaacagtgttaaaagaggaagtgacctcacagaccagctcagagatgttaccaagaatatcacagcccccagggtagggagacaagcagcagtttgttctgtctcagctcctgtcaaggatcctgcggggtgggccctctgtatagctgctctctgtcactggcccctggagtgggagcagcgtccttagtcactgcaggcccaggcgggcaggtggtcccaggacagaggtggggaagttgtcctgaggaagcagaagtaggccttgctcccgcccaacccaagggcctccagtggaccagcattcaagatgtgagtgcccgtggtgtgcaaggcactcccatggcaccgtatttattgactgatctgtgaaggcttccctgacccctgcccaggaagagttcactggtcgctctgttgtgccccacagcactttgttatacctctgccacacacttcacgcagcgcgttgtaactcatgtgtttacatgtctgtccccccagactgtgagctccttgagggcagggactgtacattctccagctctgtgtccccagggcctggcacattgtagacgcttaataaatgtctgttaaatgaatgagtgcacaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:55665 -> Molecular function: GO:0005525 [GTP binding] evidence: IEA
GeneID:55665 -> Biological process: GO:0007049 [cell cycle] evidence: IEA
GeneID:55665 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
GeneID:55665 -> Cellular component: GO:0005737 [cytoplasm] evidence: IEA
by
@meso_cacase at
DBCLS
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