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2025-05-09 19:29:17, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_015169 1724 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens RRS1 ribosome biogenesis regulator homolog (S.
cerevisiae) (RRS1), mRNA.
ACCESSION NM_015169
VERSION NM_015169.3 GI:46094056
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1724)
AUTHORS Gambe,A.E., Matsunaga,S., Takata,H., Ono-Maniwa,R., Baba,A.,
Uchiyama,S. and Fukui,K.
TITLE A nucleolar protein RRS1 contributes to chromosome congression
JOURNAL FEBS Lett. 583 (12), 1951-1956 (2009)
PUBMED 19465021
REMARK GeneRIF: RNA interference experiments revealed that RRS1-depleted
cells show abnormalities in chromosome alignment and spindle
organization, which result in mitotic delay.
REFERENCE 2 (bases 1 to 1724)
AUTHORS Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E.,
Lamond,A.I. and Mann,M.
TITLE Nucleolar proteome dynamics
JOURNAL Nature 433 (7021), 77-83 (2005)
PUBMED 15635413
REFERENCE 3 (bases 1 to 1724)
AUTHORS Scherl,A., Coute,Y., Deon,C., Calle,A., Kindbeiter,K.,
Sanchez,J.C., Greco,A., Hochstrasser,D. and Diaz,J.J.
TITLE Functional proteomic analysis of human nucleolus
JOURNAL Mol. Biol. Cell 13 (11), 4100-4109 (2002)
PUBMED 12429849
REFERENCE 4 (bases 1 to 1724)
AUTHORS Andersen,J.S., Lyon,C.E., Fox,A.H., Leung,A.K., Lam,Y.W., Steen,H.,
Mann,M. and Lamond,A.I.
TITLE Directed proteomic analysis of the human nucleolus
JOURNAL Curr. Biol. 12 (1), 1-11 (2002)
PUBMED 11790298
REFERENCE 5 (bases 1 to 1724)
AUTHORS Tsuno,A., Miyoshi,K., Tsujii,R., Miyakawa,T. and Mizuta,K.
TITLE RRS1, a conserved essential gene, encodes a novel regulatory
protein required for ribosome biogenesis in Saccharomyces
cerevisiae
JOURNAL Mol. Cell. Biol. 20 (6), 2066-2074 (2000)
PUBMED 10688653
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
D25218.1 and BC001811.2.
On Apr 2, 2004 this sequence version replaced gi:34147329.
##Evidence-Data-START##
Transcript is intronless :: BC013043.2 [ECO:0000345]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-1606 D25218.1 1-1606
1607-1724 BC001811.2 1592-1709
FEATURES Location/Qualifiers
source 1..1724
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="8"
/map="8q13.1"
gene 1..1724
/gene="RRS1"
/note="RRS1 ribosome biogenesis regulator homolog (S.
cerevisiae)"
/db_xref="GeneID:23212"
/db_xref="HGNC:17083"
/db_xref="HPRD:15277"
exon 1..1706
/gene="RRS1"
/inference="alignment:Splign:1.39.8"
variation 21
/gene="RRS1"
/replace="g"
/replace="t"
/db_xref="dbSNP:61731580"
variation 33
/gene="RRS1"
/replace="c"
/replace="g"
/db_xref="dbSNP:375243098"
variation 62
/gene="RRS1"
/replace="a"
/replace="g"
/db_xref="dbSNP:368205159"
variation 67
/gene="RRS1"
/replace="a"
/replace="c"
/db_xref="dbSNP:200931864"
variation 94
/gene="RRS1"
/replace="a"
/replace="g"
/db_xref="dbSNP:371967186"
variation 96
/gene="RRS1"
/replace="a"
/replace="g"
/db_xref="dbSNP:201048399"
variation 100
/gene="RRS1"
/replace="g"
/replace="t"
/db_xref="dbSNP:144911629"
variation 102
/gene="RRS1"
/replace="a"
/replace="g"
/db_xref="dbSNP:371431459"
CDS 105..1202
/gene="RRS1"
/note="homolog of yeast ribosome biogenesis regulatory
protein RRS1; ribosome biogenesis regulatory protein RRS1
homolog"
/codon_start=1
/product="ribosome biogenesis regulatory protein homolog"
/protein_id="NP_055984.1"
/db_xref="GI:14719402"
/db_xref="CCDS:CCDS6189.1"
/db_xref="GeneID:23212"
/db_xref="HGNC:17083"
/db_xref="HPRD:15277"
/translation="
MEGQSVEELLAKAEQDEAEKLQRITVHKELELQFDLGNLLASDRNPPTGLRCAGPTPEAELQALARDNTQLLINQLWQLPTERVEEAIVARLPEPTTRLPREKPLPRPRPLTRWQQFARLKGIRPKKKTNLVWDEVSGQWRRRWGYQRARDDTKEWLIEVPGNADPLEDQFAKRIQAKKERVAKNELNRLRNLARAHKMQLPSAAGLHPTGHQSKEELGRAMQVAKVSTASVGRFQERLPKEKVPRGSGKKRKFQPLFGDFAAEKKNQLELLRVMNSKKPQLDVTRATNKQMREEDQEEAAKRRKMSQKGKRKGGRQGPGGKRKGGPPSQGGKRKGGLGGKMNSGPPGLGGKRKGGQRPGGKRRK
"
misc_feature 105..107
/gene="RRS1"
/experiment="experimental evidence, no additional details
recorded"
/note="N-acetylmethionine; propagated from
UniProtKB/Swiss-Prot (Q15050.2); acetylation site"
misc_feature 192..686
/gene="RRS1"
/note="Ribosome biogenesis regulatory protein (RRS1);
Region: RRS1; pfam04939"
/db_xref="CDD:191135"
variation 115
/gene="RRS1"
/replace="a"
/replace="g"
/db_xref="dbSNP:374676415"
variation 116
/gene="RRS1"
/replace="a"
/replace="g"
/db_xref="dbSNP:3739334"
variation 132
/gene="RRS1"
/replace="c"
/replace="t"
/db_xref="dbSNP:199546938"
variation 189
/gene="RRS1"
/replace="a"
/replace="g"
/db_xref="dbSNP:375178198"
variation 194
/gene="RRS1"
/replace="a"
/replace="g"
/db_xref="dbSNP:200355092"
variation 219
/gene="RRS1"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:116590536"
variation 230
/gene="RRS1"
/replace="c"
/replace="g"
/db_xref="dbSNP:148041062"
variation 234
/gene="RRS1"
/replace="a"
/replace="c"
/db_xref="dbSNP:140840609"
variation 253
/gene="RRS1"
/replace="c"
/replace="t"
/db_xref="dbSNP:367878265"
variation 282
/gene="RRS1"
/replace="g"
/replace="t"
/db_xref="dbSNP:11556131"
variation 287
/gene="RRS1"
/replace="a"
/replace="g"
/db_xref="dbSNP:371751925"
variation 415
/gene="RRS1"
/replace="a"
/replace="c"
/db_xref="dbSNP:375781629"
variation 448
/gene="RRS1"
/replace="a"
/replace="t"
/db_xref="dbSNP:369081320"
variation 452
/gene="RRS1"
/replace="c"
/replace="g"
/db_xref="dbSNP:34077648"
variation 481
/gene="RRS1"
/replace="a"
/replace="g"
/db_xref="dbSNP:3739335"
variation 599
/gene="RRS1"
/replace=""
/replace="c"
/db_xref="dbSNP:35778787"
variation 622
/gene="RRS1"
/replace="a"
/replace="g"
/db_xref="dbSNP:111453020"
variation 624
/gene="RRS1"
/replace="c"
/replace="g"
/db_xref="dbSNP:377307457"
variation 628
/gene="RRS1"
/replace="g"
/replace="t"
/db_xref="dbSNP:200841965"
variation 676
/gene="RRS1"
/replace="g"
/replace="t"
/db_xref="dbSNP:3739336"
variation 734
/gene="RRS1"
/replace="c"
/replace="g"
/db_xref="dbSNP:34322476"
variation 737
/gene="RRS1"
/replace="a"
/replace="g"
/db_xref="dbSNP:147364632"
variation 769
/gene="RRS1"
/replace="c"
/replace="t"
/db_xref="dbSNP:137894990"
variation 806
/gene="RRS1"
/replace="c"
/replace="g"
/db_xref="dbSNP:369563321"
variation 815
/gene="RRS1"
/replace="a"
/replace="g"
/db_xref="dbSNP:3739337"
variation 823
/gene="RRS1"
/replace="c"
/replace="t"
/db_xref="dbSNP:144403420"
variation 826
/gene="RRS1"
/replace="a"
/replace="g"
/db_xref="dbSNP:148788428"
variation 840
/gene="RRS1"
/replace="c"
/replace="t"
/db_xref="dbSNP:373983355"
variation 903
/gene="RRS1"
/replace="a"
/replace="t"
/db_xref="dbSNP:144551617"
variation 924
/gene="RRS1"
/replace="a"
/replace="g"
/db_xref="dbSNP:36125898"
variation 951
/gene="RRS1"
/replace="c"
/replace="g"
/db_xref="dbSNP:139651821"
variation 990
/gene="RRS1"
/replace="a"
/replace="g"
/db_xref="dbSNP:115935831"
variation 994
/gene="RRS1"
/replace="a"
/replace="g"
/db_xref="dbSNP:200762868"
variation 995
/gene="RRS1"
/replace="a"
/replace="g"
/db_xref="dbSNP:61747714"
STS 1006..1171
/gene="RRS1"
/standard_name="RH25337"
/db_xref="UniSTS:86936"
variation 1011
/gene="RRS1"
/replace="a"
/replace="t"
/db_xref="dbSNP:200032631"
variation 1066..1067
/gene="RRS1"
/replace=""
/replace="cct"
/db_xref="dbSNP:75916741"
variation 1066
/gene="RRS1"
/replace="a"
/replace="g"
/db_xref="dbSNP:34974332"
variation 1098
/gene="RRS1"
/replace="c"
/replace="g"
/db_xref="dbSNP:149763981"
variation 1165
/gene="RRS1"
/replace="a"
/replace="g"
/db_xref="dbSNP:374511161"
variation 1170
/gene="RRS1"
/replace="c"
/replace="g"
/db_xref="dbSNP:369943218"
STS 1207..1532
/gene="RRS1"
/standard_name="D8S1606"
/db_xref="UniSTS:78726"
STS 1211..1405
/gene="RRS1"
/standard_name="RH17390"
/db_xref="UniSTS:3436"
variation 1215
/gene="RRS1"
/replace="c"
/replace="g"
/db_xref="dbSNP:202045199"
variation 1218
/gene="RRS1"
/replace="a"
/replace="g"
/db_xref="dbSNP:200975585"
variation 1279
/gene="RRS1"
/replace="a"
/replace="g"
/db_xref="dbSNP:73253611"
variation 1484..1485
/gene="RRS1"
/replace=""
/replace="t"
/db_xref="dbSNP:148064947"
variation 1494
/gene="RRS1"
/replace="c"
/replace="t"
/db_xref="dbSNP:3210185"
variation 1513
/gene="RRS1"
/replace="c"
/replace="t"
/db_xref="dbSNP:185815880"
STS 1551..1653
/gene="RRS1"
/standard_name="G27361"
/db_xref="UniSTS:40409"
variation 1612
/gene="RRS1"
/replace="c"
/replace="g"
/db_xref="dbSNP:78595779"
variation 1682
/gene="RRS1"
/replace="a"
/replace="g"
/db_xref="dbSNP:190291349"
ORIGIN
gcatcccggcatctgcacgtggttatgctgccggagtttgggccgccactgtaggaaaagtaacttcagctgcagccccaaagcgagtgagccgagccggagccatggagggccagagcgtggaggagctgctcgcaaaggcagagcaggacgaggcagagaagttgcaacgcatcacggtgcacaaggagctggagctgcagtttgacctgggcaacctgctggcgtcggaccggaaccccccgaccgggctgcggtgcgccggacccacgccggaggccgagctacaggccctggcgcgggacaacacgcaactgctcatcaaccagctgtggcagctgcccacggagcgcgtggaagaggcgatagtggcgcggctgccggagcccaccacacgcctgccgcgagagaagcctctgccccgaccgcggccacttacacgctggcagcagttcgcgcgcctcaagggcatccgtcccaagaagaagaccaacctggtgtgggacgaggtgagtggccagtggcggcggcgctggggctaccagcgcgcccgggacgacaccaaagaatggctgattgaggtgcccggcaatgccgaccccttggaggaccagttcgccaagcggattcaggccaagaaggaaagggtggccaagaacgagctgaaccggctgcgtaacctggcccgcgcgcacaagatgcagctgcccagcgcggccggcttgcaccctaccggacaccagagtaaggaggagctgggccgcgccatgcaagtggccaaggtctccaccgcctctgtggggcgctttcaggagcgcctccccaaggagaaggtgccccggggctccggcaagaaaaggaagtttcaaccccttttcggggactttgcagccgagaaaaagaaccagttggagctgcttcgtgtcatgaacagcaagaagcctcagctggatgtgactagggccaccaataagcagatgagggaggaggaccaggaggaggccgccaagaggaggaaaatgagccagaagggcaagagaaagggaggccggcaggggcctgggggcaagaggaaagggggcccgcccagccagggagggaagaggaaagggggcttgggaggcaagatgaattctgggccgcctggcttgggtggcaagagaaaaggaggacagcgcccaggaggaaagaggaggaagtaatagtttctaactgtcggacccgtctgtaaaccaaggactatgaatactaaatgttaagttctaggcaattatacggggactcagaaggacctggccgctgccttcattgagtttaaagggacaggattgcccttccgtcaagaaagtatgtaagtgttggactgcacaaattaatgtttttcccacaaccgagactttggagattaagaacttatttgaggatttaagaattagggaaataatttggtggaaaccgggaatgagttctattcttaaacagcctttttttttctttttaatgttggatatacggcgaggtagagttggccatatttcagagacttagattgacgtatatgtttctgcattatttttacaacaagtttgtgtatcagagcgggagtgcgggggagggaaagaaaacaaacagtttcagaattgaataggcaagtgactgttttaaagattaagtaataaagatgtcttatctagtgtgacttttaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:23212 -> Molecular function: GO:0003674 [molecular_function] evidence: ND
GeneID:23212 -> Biological process: GO:0007080 [mitotic metaphase plate congression] evidence: IMP
GeneID:23212 -> Biological process: GO:0042254 [ribosome biogenesis] evidence: IEA
GeneID:23212 -> Cellular component: GO:0000794 [condensed nuclear chromosome] evidence: IDA
GeneID:23212 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
GeneID:23212 -> Cellular component: GO:0005783 [endoplasmic reticulum] evidence: IEA
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