LOCUS       NM_006977               1609 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens zinc finger and BTB domain containing 25 (ZBTB25),
            mRNA.
ACCESSION   NM_006977
VERSION     NM_006977.2  GI:40217848
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1609)
  AUTHORS   Benita,Y., Cao,Z., Giallourakis,C., Li,C., Gardet,A. and
            Xavier,R.J.
  TITLE     Gene enrichment profiles reveal T-cell development,
            differentiation, and lineage-specific transcription factors
            including ZBTB25 as a novel NF-AT repressor
  JOURNAL   Blood 115 (26), 5376-5384 (2010)
   PUBMED   20410506
  REMARK    GeneRIF: ZBTB25 functions as a negative regulator of nuclear factor
            of activated T cells (NF-AT) activation, such that RNA interference
            mediated knockdown resulted in enhanced activation of target genes.
REFERENCE   2  (bases 1 to 1609)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   3  (bases 1 to 1609)
  AUTHORS   Chardin,P., Courtois,G., Mattei,M.G. and Gisselbrecht,S.
  TITLE     The KUP gene, located on human chromosome 14, encodes a protein
            with two distant zinc fingers
  JOURNAL   Nucleic Acids Res. 19 (7), 1431-1436 (1991)
   PUBMED   2027750
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC035804.1 and BM550005.1.
            On Dec 19, 2003 this sequence version replaced gi:5902163.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC035804.1, BX094827.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025091 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-92                BC035804.1         10-101
            93-94               BM550005.1         92-93
            95-1609             BC035804.1         104-1618
FEATURES             Location/Qualifiers
     source          1..1609
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q23-q24"
     gene            1..1609
                     /gene="ZBTB25"
                     /gene_synonym="C14orf51; KUP; ZNF46"
                     /note="zinc finger and BTB domain containing 25"
                     /db_xref="GeneID:7597"
                     /db_xref="HGNC:13112"
                     /db_xref="HPRD:01926"
                     /db_xref="MIM:194541"
     exon            1..176
                     /gene="ZBTB25"
                     /gene_synonym="C14orf51; KUP; ZNF46"
                     /inference="alignment:Splign:1.39.8"
     exon            177..356
                     /gene="ZBTB25"
                     /gene_synonym="C14orf51; KUP; ZNF46"
                     /inference="alignment:Splign:1.39.8"
     CDS             184..1491
                     /gene="ZBTB25"
                     /gene_synonym="C14orf51; KUP; ZNF46"
                     /note="zinc finger protein 46; zinc finger protein KUP"
                     /codon_start=1
                     /product="zinc finger and BTB domain-containing protein
                     25"
                     /protein_id="NP_008908.2"
                     /db_xref="GI:40217849"
                     /db_xref="CCDS:CCDS9765.1"
                     /db_xref="GeneID:7597"
                     /db_xref="HGNC:13112"
                     /db_xref="HPRD:01926"
                     /db_xref="MIM:194541"
                     /translation="

MDTASHSLVLLQQLNMQREFGFLCDCTVAIGDVYFKAHRAVLAAFSNYFKMIFIHQTSECIKIQPTDIQPDIFSYLLHIMYTGKGPKQIVDHSRLEEGIRFLHADYLSHIATEMNQVFSPETVQSSNLYGIQISTTQKTVVKQGLEVKEAPSSNSGNRAAVQGDHPQLQLSLAIGLDDGTADQQRACPATQALEEHQKPPVSIKQERCDPESVISQSHPSPSSEVTGPTFTENSVKIHLCHYCGERFDSRSNLRQHLHTHVSGSLPFGVPASILESNDLGEVHPLNENSEALECRRLSSFIVKENEQQPDHTNRGTTEPLQISQVSLISKDTEPVELNCNFSFSRKRKMSCTICGHKFPRKSQLLEHMYTHKGKSYRYNRCQRFGNALAQRFQPYCDSWSDVSLKSSRLSQEHLDLPCALESELTQENVDTILVE

"
     misc_feature    223..>435
                     /gene="ZBTB25"
                     /gene_synonym="C14orf51; KUP; ZNF46"
                     /note="BTB/POZ domain; Region: BTB; pfam00651"
                     /db_xref="CDD:201372"
     misc_feature    901..963
                     /gene="ZBTB25"
                     /gene_synonym="C14orf51; KUP; ZNF46"
                     /note="Zinc finger, C2H2 type; Region: zf-C2H2; cl15478"
                     /db_xref="CDD:210117"
     misc_feature    1234..1296
                     /gene="ZBTB25"
                     /gene_synonym="C14orf51; KUP; ZNF46"
                     /note="Zinc finger, C2H2 type; Region: zf-C2H2; cl15478"
                     /db_xref="CDD:210117"
     exon            357..1577
                     /gene="ZBTB25"
                     /gene_synonym="C14orf51; KUP; ZNF46"
                     /inference="alignment:Splign:1.39.8"
     variation       677
                     /gene="ZBTB25"
                     /gene_synonym="C14orf51; KUP; ZNF46"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1135515"
     variation       855
                     /gene="ZBTB25"
                     /gene_synonym="C14orf51; KUP; ZNF46"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1135516"
     polyA_site      1577
                     /gene="ZBTB25"
                     /gene_synonym="C14orf51; KUP; ZNF46"
ORIGIN      

ctttcccctgctaccagacacgcggtcacgtggggccatcgcgggctgccggcgcgggaagccgcgcgagaggcggccgaggggtgcgtgagtcggcgccactgcttgcagtgcgcggcttgggagcccgcccctcctgcacggaggagtcggcctgccgccgcggcggcatctggaaccacaatggacactgccagccatagccttgttcttctccagcagctgaacatgcagcgagaatttggttttctgtgtgattgcacagttgcaattggagatgtttacttcaaagcccacagagcagtgcttgctgctttttctaactatttcaagatgatatttattcaccaaacaagtgaatgcataaaaatacaaccaactgacatccaacctgacatattcagctatttgttgcacattatgtacacggggaaagggccaaaacagattgtggatcatagtcgtttggaggaagggattcgatttcttcacgccgactacctttctcacattgcaactgaaatgaatcaagtgttctcaccagagactgtgcagtcctcaaatttatatggcattcagatctcaacaacccaaaaaacagttgtcaaacaaggactggaggtcaaagaagctccttccagtaacagtggaaacagagctgctgtccagggtgaccacccccagttgcagttgtctcttgctattggtctggatgatggcactgcagaccagcagagggcctgtcctgccacccaggccctggaggagcaccagaagcccccagtttccatcaagcaggagagatgtgacccagaatctgtgatctcccagagccacccctcaccctcatcagaggtgacaggccccacttttactgaaaacagtgtcaaaatacacttatgccattactgtggggaacgttttgattcccgtagtaacctaaggcaacatctccatacacatgtgtctggatccctgccattcggtgtccctgcttccattctggaaagtaatgaccttggtgaagtgcatccccttaatgaaaacagcgaggcccttgaatgccgcaggctcagctccttcattgttaaggagaatgaacagcagccagaccacaccaaccggggtaccacagagcctttgcagatcagtcaagtatctttgatctccaaagacacagagccagtagaattaaactgtaatttttctttttcaaggaaaagaaaaatgagctgtaccatctgtggtcataaattccctcgaaagagccaattgttggaacacatgtatacacacaaaggtaaatcttacagatataaccgatgccaaaggtttggtaatgcattggcccagagatttcagccatactgtgacagctggtctgatgtctccctgaaaagttctcgcttgtcacaagaacacttagacttgccttgtgccttagagtcagagctcacacaagaaaatgtggatactatcctagttgagtagcagcttctctttcagaatttttataccaattctgaaaaagaaaatttgcgtggcatttttaattcataaattattttcctcctcaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa

//

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:7597 -> Molecular function: GO:0003677 [DNA binding] evidence: IDA
            GeneID:7597 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: TAS
            GeneID:7597 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:7597 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
            GeneID:7597 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
            GeneID:7597 -> Biological process: GO:0010467 [gene expression] evidence: IEP
            GeneID:7597 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
            GeneID:7597 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA