2025-05-09 18:53:09, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_005999 2667 bp mRNA linear PRI 17-APR-2013 DEFINITION Homo sapiens translin-associated factor X (TSNAX), mRNA. ACCESSION NM_005999 VERSION NM_005999.2 GI:20302159 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2667) AUTHORS Philip,F., Guo,Y., Aisiku,O. and Scarlata,S. TITLE Phospholipase Cbeta1 is linked to RNA interference of specific genes through translin-associated factor X JOURNAL FASEB J. 26 (12), 4903-4913 (2012) PUBMED 22889834 REMARK GeneRIF: Data show a novel role of phospholipase Cbeta1 (PLCbeta1) in gene regulation through translin-associated factor X (TRAX) association. REFERENCE 2 (bases 1 to 2667) AUTHORS Ram Murthy,A., Purushottam,M., Kiran Kumar,H.B., ValliKiran,M., Krishna,N., Jayramu Sriharsha,K., Janardhan Reddy,Y.C., Ghosh,S. and Jain,S. TITLE Gender-specific association of TSNAX/DISC1 locus for schizophrenia and bipolar affective disorder in South Indian population JOURNAL J. Hum. Genet. 57 (8), 523-530 (2012) PUBMED 22673686 REMARK GeneRIF: Our results provide further evidence for sex-dependent effects of the TSNAX/DISC1 locus in the aetiology of schizophrenia and bipolar affective disorder REFERENCE 3 (bases 1 to 2667) AUTHORS Gupta,G.D. and Kumar,V. TITLE Identification of nucleic acid binding sites on translin-associated factor X (TRAX) protein JOURNAL PLoS ONE 7 (3), E33035 (2012) PUBMED 22427937 REMARK GeneRIF: TRAX binds to ssDNA and two regions in TRAX, designated TRAXB2 and TRAXB3, mediate nucleic acid binding activity of the trax-translin heteromeric complex. REFERENCE 4 (bases 1 to 2667) AUTHORS Ye,X., Huang,N., Liu,Y., Paroo,Z., Huerta,C., Li,P., Chen,S., Liu,Q. and Zhang,H. TITLE Structure of C3PO and mechanism of human RISC activation JOURNAL Nat. Struct. Mol. Biol. 18 (6), 650-657 (2011) PUBMED 21552258 REMARK GeneRIF: C3PO endonuclease is an asymmetric octamer barrel consisting of six translin and two TRAX subunits which activates RISC by degrading the Ago2-nicked passenger strand of siRNA. REFERENCE 5 (bases 1 to 2667) AUTHORS Jagannathan,K., Calhoun,V.D., Gelernter,J., Stevens,M.C., Liu,J., Bolognani,F., Windemuth,A., Ruano,G., Assaf,M. and Pearlson,G.D. TITLE Genetic associations of brain structural networks in schizophrenia: a preliminary study JOURNAL Biol. Psychiatry 68 (7), 657-666 (2010) PUBMED 20691427 REMARK GeneRIF: Observational study of gene-disease association. (HuGE Navigator) REFERENCE 6 (bases 1 to 2667) AUTHORS Erdemir,T., Bilican,B., Oncel,D., Goding,C.R. and Yavuzer,U. TITLE DNA damage-dependent interaction of the nuclear matrix protein C1D with Translin-associated factor X (TRAX) JOURNAL J. Cell. Sci. 115 (PT 1), 207-216 (2002) PUBMED 11801738 REFERENCE 7 (bases 1 to 2667) AUTHORS Chennathukuzhi,V.M., Kurihara,Y., Bray,J.D. and Hecht,N.B. TITLE Trax (translin-associated factor X), a primarily cytoplasmic protein, inhibits the binding of TB-RBP (translin) to RNA JOURNAL J. Biol. Chem. 276 (16), 13256-13263 (2001) PUBMED 11278549 REFERENCE 8 (bases 1 to 2667) AUTHORS Millar,J.K., Christie,S., Semple,C.A. and Porteous,D.J. TITLE Chromosomal location and genomic structure of the human translin-associated factor X gene (TRAX; TSNAX) revealed by intergenic splicing to DISC1, a gene disrupted by a translocation segregating with schizophrenia JOURNAL Genomics 67 (1), 69-77 (2000) PUBMED 10945471 REFERENCE 9 (bases 1 to 2667) AUTHORS Meng,G., Aoki,K., Tokura,K., Nakahara,K., Inazawa,J. and Kasai,M. TITLE Genomic structure and chromosomal localization of the gene encoding TRAX, a Translin-associated factor X JOURNAL J. Hum. Genet. 45 (5), 305-308 (2000) PUBMED 11043515 REFERENCE 10 (bases 1 to 2667) AUTHORS Aoki,K., Ishida,R. and Kasai,M. TITLE Isolation and characterization of a cDNA encoding a Translin-like protein, TRAX JOURNAL FEBS Lett. 401 (2-3), 109-112 (1997) PUBMED 9013868 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X95073.1. On Apr 24, 2002 this sequence version replaced gi:5174730. Summary: This gene encodes a protein which specifically interacts with translin, a DNA-binding protein that binds consensus sequences at breakpoint junctions of chromosomal translocations. The encoded protein contains bipartite nuclear targeting sequences that may provide nuclear transport for translin, which lacks any nuclear targeting motifs. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X95073.1, BC011797.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025081, ERS025082 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. FEATURES Location/Qualifiers source 1..2667 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="1" /map="1q42.1" gene 1..2667 /gene="TSNAX" /gene_synonym="TRAX" /note="translin-associated factor X" /db_xref="GeneID:7257" /db_xref="HGNC:12380" /db_xref="HPRD:04270" /db_xref="MIM:602964" exon 1..174 /gene="TSNAX" /gene_synonym="TRAX" /inference="alignment:Splign:1.39.8" variation 36 /gene="TSNAX" /gene_synonym="TRAX" /replace="c" /replace="g" /replace="t" /db_xref="dbSNP:201291945" variation 44 /gene="TSNAX" /gene_synonym="TRAX" /replace="c" /replace="g" /db_xref="dbSNP:181613867" variation 122 /gene="TSNAX" /gene_synonym="TRAX" /replace="g" /replace="t" /db_xref="dbSNP:370832150" CDS 159..1031 /gene="TSNAX" /gene_synonym="TRAX" /note="translin-like protein" /codon_start=1 /product="translin-associated protein X" /protein_id="NP_005990.1" /db_xref="GI:5174731" /db_xref="CCDS:CCDS1596.1" /db_xref="GeneID:7257" /db_xref="HGNC:12380" /db_xref="HPRD:04270" /db_xref="MIM:602964" /translation="
MSNKEGSGGFRKRKHDNFPHNQRREGKDVNSSSPVMLAFKSFQQELDARHDKYERLVKLSRDITVESKRTIFLLHRITSAPDMEDILTESEIKLDGVRQKIFQVAQELSGEDMHQFHRAITTGLQEYVEAVSFQHFIKTRSLISMDEINKQLIFTTEDNGKENKTPSSDAQDKQFGTWRLRVTPVDYLLGVADLTGELMRMCINSVGNGDIDTPFEVSQFLRQVYDGFSFIGNTGPYEVSKKLYTLKQSLAKVENACYALKVRGSEIPKHMLADVFSVKTEMIDQEEGIS
" misc_feature 255..257 /gene="TSNAX" /gene_synonym="TRAX" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (Q99598.1); phosphorylation site" misc_feature 255..257 /gene="TSNAX" /gene_synonym="TRAX" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 306..953 /gene="TSNAX" /gene_synonym="TRAX" /note="Translin family; Region: Translin; pfam01997" /db_xref="CDD:202084" misc_feature 360..362 /gene="TSNAX" /gene_synonym="TRAX" /experiment="experimental evidence, no additional details recorded" /note="N6-acetyllysine; propagated from UniProtKB/Swiss-Prot (Q99598.1); acetylation site" misc_feature 375..782 /gene="TSNAX" /gene_synonym="TRAX" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (Q99598.1); Region: Interaction with C1D" exon 175..279 /gene="TSNAX" /gene_synonym="TRAX" /inference="alignment:Splign:1.39.8" variation 176 /gene="TSNAX" /gene_synonym="TRAX" /replace="a" /replace="g" /db_xref="dbSNP:201798398" variation 189 /gene="TSNAX" /gene_synonym="TRAX" /replace="a" /replace="g" /db_xref="dbSNP:201535941" variation 208 /gene="TSNAX" /gene_synonym="TRAX" /replace="a" /replace="g" /db_xref="dbSNP:144584692" variation 212 /gene="TSNAX" /gene_synonym="TRAX" /replace="c" /replace="t" /db_xref="dbSNP:138421350" variation 222 /gene="TSNAX" /gene_synonym="TRAX" /replace="c" /replace="t" /db_xref="dbSNP:11559026" variation 239 /gene="TSNAX" /gene_synonym="TRAX" /replace="a" /replace="g" /db_xref="dbSNP:145791121" variation 259 /gene="TSNAX" /gene_synonym="TRAX" /replace="c" /replace="t" /db_xref="dbSNP:199769657" variation 270 /gene="TSNAX" /gene_synonym="TRAX" /replace="a" /replace="g" /db_xref="dbSNP:143038752" exon 280..394 /gene="TSNAX" /gene_synonym="TRAX" /inference="alignment:Splign:1.39.8" variation 301 /gene="TSNAX" /gene_synonym="TRAX" /replace="c" /replace="g" /db_xref="dbSNP:183434354" variation 307 /gene="TSNAX" /gene_synonym="TRAX" /replace="a" /replace="g" /db_xref="dbSNP:371162355" variation 326 /gene="TSNAX" /gene_synonym="TRAX" /replace="c" /replace="t" /db_xref="dbSNP:201913509" variation 380 /gene="TSNAX" /gene_synonym="TRAX" /replace="c" /replace="t" /db_xref="dbSNP:148380834" exon 395..525 /gene="TSNAX" /gene_synonym="TRAX" /inference="alignment:Splign:1.39.8" variation 406 /gene="TSNAX" /gene_synonym="TRAX" /replace="c" /replace="t" /db_xref="dbSNP:375022282" variation 432 /gene="TSNAX" /gene_synonym="TRAX" /replace="a" /replace="g" /db_xref="dbSNP:369133346" variation 445 /gene="TSNAX" /gene_synonym="TRAX" /replace="a" /replace="g" /db_xref="dbSNP:372784677" variation 458 /gene="TSNAX" /gene_synonym="TRAX" /replace="a" /replace="g" /db_xref="dbSNP:375003403" variation 492 /gene="TSNAX" /gene_synonym="TRAX" /replace="g" /replace="t" /db_xref="dbSNP:150826166" exon 526..653 /gene="TSNAX" /gene_synonym="TRAX" /inference="alignment:Splign:1.39.8" variation 542 /gene="TSNAX" /gene_synonym="TRAX" /replace="a" /replace="g" /db_xref="dbSNP:371105358" variation 619 /gene="TSNAX" /gene_synonym="TRAX" /replace="c" /replace="t" /db_xref="dbSNP:367646519" variation 623 /gene="TSNAX" /gene_synonym="TRAX" /replace="a" /replace="g" /db_xref="dbSNP:372994168" variation 634 /gene="TSNAX" /gene_synonym="TRAX" /replace="a" /replace="g" /db_xref="dbSNP:145493559" variation 647..649 /gene="TSNAX" /gene_synonym="TRAX" /replace="" /replace="taa" /db_xref="dbSNP:369619096" variation 652 /gene="TSNAX" /gene_synonym="TRAX" /replace="a" /replace="c" /db_xref="dbSNP:372798782" exon 654..2650 /gene="TSNAX" /gene_synonym="TRAX" /inference="alignment:Splign:1.39.8" variation 668 /gene="TSNAX" /gene_synonym="TRAX" /replace="a" /replace="g" /db_xref="dbSNP:139691651" variation 702 /gene="TSNAX" /gene_synonym="TRAX" /replace="c" /replace="g" /db_xref="dbSNP:189489803" variation 780 /gene="TSNAX" /gene_synonym="TRAX" /replace="a" /replace="g" /db_xref="dbSNP:181169848" variation 926 /gene="TSNAX" /gene_synonym="TRAX" /replace="g" /replace="t" /db_xref="dbSNP:377373726" variation 968 /gene="TSNAX" /gene_synonym="TRAX" /replace="c" /replace="t" /db_xref="dbSNP:145053034" variation 1039 /gene="TSNAX" /gene_synonym="TRAX" /replace="c" /replace="t" /db_xref="dbSNP:111926694" variation 1054 /gene="TSNAX" /gene_synonym="TRAX" /replace="a" /replace="g" /db_xref="dbSNP:185754637" variation 1058 /gene="TSNAX" /gene_synonym="TRAX" /replace="c" /replace="g" /db_xref="dbSNP:199944382" variation 1065 /gene="TSNAX" /gene_synonym="TRAX" /replace="a" /replace="g" /db_xref="dbSNP:112715796" variation 1070 /gene="TSNAX" /gene_synonym="TRAX" /replace="c" /replace="g" /db_xref="dbSNP:371153577" variation 1073 /gene="TSNAX" /gene_synonym="TRAX" /replace="a" /replace="g" /db_xref="dbSNP:373312904" variation 1107 /gene="TSNAX" /gene_synonym="TRAX" /replace="a" /replace="g" /db_xref="dbSNP:369810418" variation 1147 /gene="TSNAX" /gene_synonym="TRAX" /replace="c" /replace="t" /db_xref="dbSNP:188899570" variation 1191 /gene="TSNAX" /gene_synonym="TRAX" /replace="c" /replace="g" /db_xref="dbSNP:148861194" variation 1212 /gene="TSNAX" /gene_synonym="TRAX" /replace="c" /replace="t" /db_xref="dbSNP:114928340" variation 1290 /gene="TSNAX" /gene_synonym="TRAX" /replace="c" /replace="t" /db_xref="dbSNP:368428203" variation 1322 /gene="TSNAX" /gene_synonym="TRAX" /replace="" /replace="t" /db_xref="dbSNP:369330657" variation 1332 /gene="TSNAX" /gene_synonym="TRAX" /replace="a" /replace="g" /db_xref="dbSNP:114394437" variation 1353 /gene="TSNAX" /gene_synonym="TRAX" /replace="c" /replace="g" /db_xref="dbSNP:374748935" variation 1361 /gene="TSNAX" /gene_synonym="TRAX" /replace="c" /replace="t" /db_xref="dbSNP:181600126" variation 1425 /gene="TSNAX" /gene_synonym="TRAX" /replace="c" /replace="t" /db_xref="dbSNP:3767751" variation 1451 /gene="TSNAX" /gene_synonym="TRAX" /replace="a" /replace="t" /db_xref="dbSNP:112946426" variation 1456 /gene="TSNAX" /gene_synonym="TRAX" /replace="c" /replace="t" /db_xref="dbSNP:115520414" variation 1507 /gene="TSNAX" /gene_synonym="TRAX" /replace="c" /replace="t" /db_xref="dbSNP:116367331" variation 1577 /gene="TSNAX" /gene_synonym="TRAX" /replace="c" /replace="t" /db_xref="dbSNP:148148079" STS 1580..1854 /gene="TSNAX" /gene_synonym="TRAX" /standard_name="D11S3316" /db_xref="UniSTS:152558" variation 1590 /gene="TSNAX" /gene_synonym="TRAX" /replace="a" /replace="g" /db_xref="dbSNP:186429063" variation 1617 /gene="TSNAX" /gene_synonym="TRAX" /replace="c" /replace="t" /db_xref="dbSNP:372516831" variation 1634 /gene="TSNAX" /gene_synonym="TRAX" /replace="a" /replace="g" /db_xref="dbSNP:111586163" variation 1674 /gene="TSNAX" /gene_synonym="TRAX" /replace="a" /replace="g" /db_xref="dbSNP:141931499" variation 1798 /gene="TSNAX" /gene_synonym="TRAX" /replace="c" /replace="t" /db_xref="dbSNP:192468128" variation 1799 /gene="TSNAX" /gene_synonym="TRAX" /replace="a" /replace="g" /db_xref="dbSNP:182509708" variation 1806 /gene="TSNAX" /gene_synonym="TRAX" /replace="c" /replace="t" /db_xref="dbSNP:186191723" variation 1845 /gene="TSNAX" /gene_synonym="TRAX" /replace="a" /replace="c" /replace="t" /db_xref="dbSNP:190846479" polyA_site 1849 /gene="TSNAX" /gene_synonym="TRAX" /experiment="experimental evidence, no additional details recorded" variation 1957..1958 /gene="TSNAX" /gene_synonym="TRAX" /replace="" /replace="a" /db_xref="dbSNP:34977046" variation 2008..2009 /gene="TSNAX" /gene_synonym="TRAX" /replace="" /replace="t" /db_xref="dbSNP:201439547" variation 2090 /gene="TSNAX" /gene_synonym="TRAX" /replace="g" /replace="t" /db_xref="dbSNP:201405858" variation 2149 /gene="TSNAX" /gene_synonym="TRAX" /replace="a" /replace="g" /db_xref="dbSNP:201269097" variation 2206 /gene="TSNAX" /gene_synonym="TRAX" /replace="g" /replace="t" /db_xref="dbSNP:112800684" variation 2310 /gene="TSNAX" /gene_synonym="TRAX" /replace="c" /replace="t" /db_xref="dbSNP:182395025" variation 2312 /gene="TSNAX" /gene_synonym="TRAX" /replace="a" /replace="g" /db_xref="dbSNP:201073158" variation 2351 /gene="TSNAX" /gene_synonym="TRAX" /replace="a" /replace="g" /db_xref="dbSNP:147330696" STS 2479..2597 /gene="TSNAX" /gene_synonym="TRAX" /standard_name="SHGC-58926" /db_xref="UniSTS:94479" polyA_signal 2625..2630 /gene="TSNAX" /gene_synonym="TRAX" polyA_site 2650 /gene="TSNAX" /gene_synonym="TRAX" /experiment="experimental evidence, no additional details recorded" ORIGIN
acgtgagaggagacttccggccactgcgttgtagtcggcccggctgcaaagcgtttttctgcaggctgttttcccaggttccctcggcctgtacctcgcgcactcctcttgctccaggtccttcagtctccgctcgtctcaccgtaggctgtgacgacatgagcaacaaagaaggatcaggagggttcaggaaaaggaagcatgacaatttcccacataaccaaagaagagaagggaaggatgttaattcatcttcacccgtgatgttggcctttaaatcatttcagcaggaacttgatgcaaggcatgacaaatatgagagacttgtgaaacttagtcgggatataactgttgaaagtaaaaggacaatttttctcctccataggattacaagtgctcctgatatggaagatatattgactgaatcagaaattaaattggatggtgtcagacaaaagatattccaggtagcccaagagctatcaggggaagatatgcatcagttccatcgagccattactacaggactacaggaatatgtggaagctgtctcttttcaacacttcatcaaaacacgatcattaattagtatggatgaaattaataaacaattgatatttacgactgaagacaatgggaaagaaaataaaactccctcctctgatgcacaggataagcagtttggtacttggagactgagagtcacacctgtcgattaccttctgggagtggctgacttaactggagaattgatgcggatgtgtattaacagtgtggggaatggggacattgataccccctttgaagtgagccagtttttacgtcaggtttatgatgggttttcattcattggcaacactggaccttacgaggtttctaagaagctgtataccttgaaacaaagtttggccaaagtggagaatgcttgttatgccttgaaagtcagagggtcagaaattccaaaacatatgttggcagatgtgttttcagttaaaacagaaatgatagatcaagaagagggcatttcttagaatctaacgttactcagttactaattcttttgagaactcctaagagaccaatttgtaagacttatttagtatttcatttaactttattgtggcttttacatagaaacatattcagttgtacttgttttaaattgtatacaagctgtacataaaattagccaaatgaatcatttcttatatcttattcatgaaagtttgcatacagatgtttgcatatatgcctttttgaatttttgctggttaacctttatcatttatctttgtaatgtgaacatgcttcagagtgtaccttttgccataacctattttaatttactttttctgaagtttggagtgataatttttagtggaagcaatttgtaatttaagttggtagttatattatatatagaaaagattttttagttaaacttctggacatgagcgtcctgtttaaatttcttgttaatatcgtgccaagcctcaaaaataggcttattccatggaacaagaattaaaaatgaataagctatcaatatataatttaagtacaagtttaggctgggcgtggtggctcacgcctgtaatcccagcactttgggaggccgaggtaggcagatcacgaggtcaagagatcaagaccagcctgaccaacgtggcgaaacctcgtctctactagaaatacaaaaattagctggatatggtggtatgtgcctgtaatcccagctacttgggaggctgaggcaggagactcgcttgaacctgggaggcagaggttgcagtgagccgagattgcgccactgcactccagcctgggtaacagagcaagactccatctcaaaaaaagaaagaaagaaaaaagaaagtacaagtttataaagtattatagtgaaaaattcgcattctggctgattttaagccatttaaaatttatataaaacaaccttccataaaaatttgacaggtgcccagatgttgctttctccatttattttttgtttttttttaatcacagtaggtctgatagagaattggagctaaattataatatttttgttggtaaagttgagttatatacttgtacatacaatggaaatgcttttagtagtgattatttagcaatttttgtttttgttatattaggcatgtttggaggctttcctattctagcatttaaatttaaattttattaaaattaaataatttaaatctagcatttaaatttaaataatttaagtctagcatttacttttaaataattataatgaagttttgaaatactaagttaatccagacctttagttgtcccatggtgttaataaagttgccaaagaagatgtattatgaacaattcagcaataagacaattgtcaacacagttgagaataacaatggtaatcgttagtaatatttagaattggaatttgcctactgaaatagttatagatgattacttgtgatgtgaaactgaattgagcatgacaaccagacatttccagttggttttgtaagttttgagaatctagatactgggttttattttttgaaagattagctctgtttgtaagggctgattccttgaaaatgtaattttccagaaaaacacctaaagaaaataaaacatggacatgcctagtaaaaaaaaaaaaaaaaaaaa
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ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:7257 -> Molecular function: GO:0003677 [DNA binding] evidence: TAS GeneID:7257 -> Molecular function: GO:0008565 [protein transporter activity] evidence: TAS GeneID:7257 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IEA GeneID:7257 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA GeneID:7257 -> Biological process: GO:0007275 [multicellular organismal development] evidence: IEA GeneID:7257 -> Biological process: GO:0007283 [spermatogenesis] evidence: IEA GeneID:7257 -> Biological process: GO:0015031 [protein transport] evidence: TAS GeneID:7257 -> Biological process: GO:0030154 [cell differentiation] evidence: IEA GeneID:7257 -> Cellular component: GO:0005634 [nucleus] evidence: IEA GeneID:7257 -> Cellular component: GO:0005794 [Golgi apparatus] evidence: IEA GeneID:7257 -> Cellular component: GO:0048471 [perinuclear region of cytoplasm] evidence: IEA
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