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2025-05-09 19:54:53, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_004178 1448 bp mRNA linear PRI 07-JUL-2013
DEFINITION Homo sapiens TAR (HIV-1) RNA binding protein 2 (TARBP2), transcript
variant 3, mRNA.
ACCESSION NM_004178
VERSION NM_004178.4 GI:85068544
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1448)
AUTHORS Redfern,A.D., Colley,S.M., Beveridge,D.J., Ikeda,N., Epis,M.R.,
Li,X., Foulds,C.E., Stuart,L.M., Barker,A., Russell,V.J.,
Ramsay,K., Kobelke,S.J., Li,X., Hatchell,E.C., Payne,C.,
Giles,K.M., Messineo,A., Gatignol,A., Lanz,R.B., O'Malley,B.W. and
Leedman,P.J.
TITLE RNA-induced silencing complex (RISC) Proteins PACT, TRBP, and Dicer
are SRA binding nuclear receptor coregulators
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 110 (16), 6536-6541 (2013)
PUBMED 23550157
REMARK GeneRIF: RISC proteins PACT, TRBP, and Dicer, together with PKR,
are steroid receptor RNA activator-binding nuclear receptor
coregulators that are recruited to the promoters of
hormone-regulated genes and regulate the expression of downstream
target genes.
REFERENCE 2 (bases 1 to 1448)
AUTHORS Benoit,M.P., Imbert,L., Palencia,A., Perard,J., Ebel,C.,
Boisbouvier,J. and Plevin,M.J.
TITLE The RNA-binding region of human TRBP interacts with microRNA
precursors through two independent domains
JOURNAL Nucleic Acids Res. 41 (7), 4241-4252 (2013)
PUBMED 23435228
REMARK GeneRIF: Results show that the region of TRBP that binds immature
miRNAs comprises two independent double-stranded RNA-binding
domains connected by a 60-residue flexible linker.
REFERENCE 3 (bases 1 to 1448)
AUTHORS Koh,H.R., Kidwell,M.A., Ragunathan,K., Doudna,J.A. and Myong,S.
TITLE ATP-independent diffusion of double-stranded RNA binding proteins
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 110 (1), 151-156 (2013)
PUBMED 23251028
REMARK GeneRIF: We report an unanticipated dsRNA diffusion behavior of
TRBP, which requires two double-stranded RNA binding domains, and
its correlation with the role of TRBP in promoting Dicer-induced
RNA cleavage.
REFERENCE 4 (bases 1 to 1448)
AUTHORS Zhang,C., Huys,A., Thibault,P.A. and Wilson,J.A.
TITLE Requirements for human Dicer and TRBP in microRNA-122 regulation of
HCV translation and RNA abundance
JOURNAL Virology 433 (2), 479-488 (2012)
PUBMED 22999255
REMARK GeneRIF: Depletion of Dicer and TRBP, proteins involved in miRNA
biogenesis, reduced HCV RNA accumulation, mature duplex miR-122
abundance, and miR-122 directed mRNA translation suppression,
suggesting roles in miR-122 processing.
REFERENCE 5 (bases 1 to 1448)
AUTHORS Lee,H.Y. and Doudna,J.A.
TITLE TRBP alters human precursor microRNA processing in vitro
JOURNAL RNA 18 (11), 2012-2019 (2012)
PUBMED 23006623
REMARK GeneRIF: TRBP is a key regulator of miRNA processing and targeting
in humans.
REFERENCE 6 (bases 1 to 1448)
AUTHORS Gatignol,A., Duarte,M., Daviet,L., Chang,Y.N. and Jeang,K.T.
TITLE Sequential steps in Tat trans-activation of HIV-1 mediated through
cellular DNA, RNA, and protein binding factors
JOURNAL Gene Expr. 5 (4-5), 217-228 (1996)
PUBMED 8723388
REFERENCE 7 (bases 1 to 1448)
AUTHORS Cosentino,G.P., Venkatesan,S., Serluca,F.C., Green,S.R.,
Mathews,M.B. and Sonenberg,N.
TITLE Double-stranded-RNA-dependent protein kinase and TAR RNA-binding
protein form homo- and heterodimers in vivo
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (21), 9445-9449 (1995)
PUBMED 7568151
REFERENCE 8 (bases 1 to 1448)
AUTHORS Kozak,C.A., Gatignol,A., Graham,K., Jeang,K.T. and McBride,O.W.
TITLE Genetic mapping in human and mouse of the locus encoding TRBP, a
protein that binds the TAR region of the human immunodeficiency
virus (HIV-1)
JOURNAL Genomics 25 (1), 66-72 (1995)
PUBMED 7774957
REFERENCE 9 (bases 1 to 1448)
AUTHORS Gatignol,A., Buckler,C. and Jeang,K.T.
TITLE Relatedness of an RNA-binding motif in human immunodeficiency virus
type 1 TAR RNA-binding protein TRBP to human P1/dsI kinase and
Drosophila staufen
JOURNAL Mol. Cell. Biol. 13 (4), 2193-2202 (1993)
PUBMED 8455607
REFERENCE 10 (bases 1 to 1448)
AUTHORS Gatignol,A., Buckler-White,A., Berkhout,B. and Jeang,K.T.
TITLE Characterization of a human TAR RNA-binding protein that activates
the HIV-1 LTR
JOURNAL Science 251 (5001), 1597-1600 (1991)
PUBMED 2011739
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BC002419.2 and M60801.1.
On Jan 18, 2006 this sequence version replaced gi:19743837.
Summary: HIV-1, the causative agent of acquired immunodeficiency
syndrome (AIDS), contains an RNA genome that produces a
chromosomally integrated DNA during the replicative cycle.
Activation of HIV-1 gene expression by the transactivator Tat is
dependent on an RNA regulatory element (TAR) located downstream of
the transcription initiation site. The protein encoded by this gene
binds between the bulge and the loop of the HIV-1 TAR RNA
regulatory element and activates HIV-1 gene expression in synergy
with the viral Tat protein. Alternative splicing results in
multiple transcript variants encoding different isoforms. This gene
also has a pseudogene. [provided by RefSeq, Jul 2008].
Transcript Variant: This variant (3) lacks an internal segment in
the 5' region, and uses a downstream AUG codon for translation, as
compared to variant 1. The encoded isoform (b) thus has a shorter
N-terminus, as compared to isoform a.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: M60801.1 [ECO:0000332]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-32 BC002419.2 1-32
33-452 M60801.1 1-420
453-1448 BC002419.2 901-1896
FEATURES Location/Qualifiers
source 1..1448
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="12"
/map="12q12-q13"
gene 1..1448
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/note="TAR (HIV-1) RNA binding protein 2"
/db_xref="GeneID:6895"
/db_xref="HGNC:11569"
/db_xref="MIM:605053"
exon 1..81
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/inference="alignment:Splign:1.39.8"
exon 82..246
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/inference="alignment:Splign:1.39.8"
CDS 87..1124
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/note="isoform b is encoded by transcript variant 3; TAR
(HIV) RNA-binding protein 2; TAR (HIV) RNA binding protein
2; TAR RNA-binding protein 2; trans-activation responsive
RNA-binding protein; TAR RNA binding protein 2;
RISC-loading complex subunit TARBP2; TAR (HIV) RNA-binding
protein TRBP1; trans-activation-responsive RNA-binding
protein"
/codon_start=1
/product="RISC-loading complex subunit TARBP2 isoform b"
/protein_id="NP_004169.3"
/db_xref="GI:19743838"
/db_xref="CCDS:CCDS41791.1"
/db_xref="GeneID:6895"
/db_xref="HGNC:11569"
/db_xref="MIM:605053"
/translation="
MLAANPGKTPISLLQEYGTRIGKTPVYDLLKAEGQAHQPNFTFRVTVGDTSCTGQGPSKKAAKHKAAEVALKHLKGGSMLEPALEDSSSFSPLDSSLPEDIPVFTAAAAATPVPSVVLTRSPPMELQPPVSPQQSECNPVGALQELVVQKGWRLPEYTVTQESGPAHRKEFTMTCRVERFIEIGSGTSKKLAKRNAAAKMLLRVHTVPLDARDGNEVEPDDDHFSIGVGSRLDGLRNRGPGCTWDSLRNSVGEKILSLRSCSLGSLGALGPACCRVLSELSEEQAFHVSYLDIEELSLSGLCQCLVELSTQPATVCHGSATTREAARGEAARRALQYLKIMAGSK
"
misc_feature 111..>260
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/note="Double-stranded RNA binding motif. Binding is not
sequence specific but is highly specific for double
stranded RNA. Found in a variety of proteins including
dsRNA dependent protein kinase PKR, RNA helicases,
Drosophila staufen protein, E. coli RNase III; Region:
DSRM; cd00048"
/db_xref="CDD:28930"
misc_feature order(111..113,129..134,255..260)
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/note="dsRNA binding site [nucleotide binding]; other
site"
/db_xref="CDD:28930"
misc_feature 498..689
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/note="Double-stranded RNA binding motif. Binding is not
sequence specific but is highly specific for double
stranded RNA. Found in a variety of proteins including
dsRNA dependent protein kinase PKR, RNA helicases,
Drosophila staufen protein, E. coli RNase III; Region:
DSRM; cd00048"
/db_xref="CDD:28930"
misc_feature order(498..500,516..521,645..656,663..665)
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/note="dsRNA binding site [nucleotide binding]; other
site"
/db_xref="CDD:28930"
variation 97
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:143690659"
variation 102
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:201806294"
variation 107
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="a"
/replace="c"
/db_xref="dbSNP:138314225"
variation 115
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:372439760"
variation 147
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:200955588"
variation 182
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:143814054"
variation 208
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="a"
/replace="t"
/db_xref="dbSNP:374404200"
variation 223
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:368515319"
exon 247..349
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/inference="alignment:Splign:1.39.8"
variation 313
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="c"
/replace="g"
/db_xref="dbSNP:146234229"
variation 314
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="g"
/replace="t"
/db_xref="dbSNP:138922911"
exon 350..445
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/inference="alignment:Splign:1.39.8"
variation 368
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="c"
/replace="g"
/db_xref="dbSNP:375489701"
variation 374
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:141294828"
variation 409
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="c"
/replace="g"
/db_xref="dbSNP:183009410"
variation 431
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="a"
/replace="t"
/db_xref="dbSNP:371431074"
exon 446..518
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/inference="alignment:Splign:1.39.8"
variation 451
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="c"
/replace="g"
/db_xref="dbSNP:150772647"
variation 452
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:374358069"
variation 453
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:139126157"
variation 454
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="c"
/replace="g"
/db_xref="dbSNP:374557769"
variation 475
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:149488319"
variation 498..499
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace=""
/replace="aa"
/db_xref="dbSNP:71687518"
variation 503
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:145961214"
exon 519..636
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/inference="alignment:Splign:1.39.8"
variation 521
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:139830544"
variation 551
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:200766710"
variation 558
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="a"
/replace="c"
/db_xref="dbSNP:199668545"
variation 586
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="a"
/replace="c"
/db_xref="dbSNP:3203547"
variation 612
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="a"
/replace="c"
/db_xref="dbSNP:140420856"
variation 617
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:377165322"
exon 637..764
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/inference="alignment:Splign:1.39.8"
variation 638
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:200876264"
variation 677
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:190258088"
variation 678
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="g"
/replace="t"
/db_xref="dbSNP:368267516"
variation 695
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:370797559"
variation 701
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:146166955"
variation 704
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:112692079"
variation 720
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:148798022"
exon 765..966
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/inference="alignment:Splign:1.39.8"
variation 775
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:1126500"
variation 812
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:369459694"
variation 848
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:374237346"
variation 909
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:202227515"
variation 947
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:370082621"
variation 965
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:61499963"
exon 967..1407
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/inference="alignment:Splign:1.39.8"
variation 1021
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:372769309"
variation 1023
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:151303646"
STS 1026..1398
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/standard_name="TARBP2__5191"
/db_xref="UniSTS:466499"
variation 1084
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:140535249"
STS 1099..1263
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/standard_name="STS-R72841"
/db_xref="UniSTS:67883"
STS 1125..1399
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/standard_name="G42930"
/db_xref="UniSTS:13350"
STS 1131..1326
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/standard_name="STS-M60801"
/db_xref="UniSTS:14039"
variation 1150
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:376072604"
variation 1158
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="g"
/replace="t"
/db_xref="dbSNP:201937693"
variation 1161
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:371130451"
variation 1168
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="c"
/replace="g"
/db_xref="dbSNP:375653873"
variation 1182
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:2531"
STS 1251..1393
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/standard_name="RH39878"
/db_xref="UniSTS:88059"
variation 1315
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:138108626"
variation 1316
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:117830235"
variation 1334
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:143775286"
variation 1362
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:185547953"
polyA_signal 1379..1384
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
variation 1391
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:73313239"
polyA_site 1407
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
ORIGIN
gcctctccagctgcgacacagatggcgcgcgggctcttgggttctgtagttttctcgcgatccaaaaggctccgtgcccaaagcaaatgctggccgccaacccaggcaagaccccgatcagccttctgcaggagtatgggaccagaatagggaagacgcctgtgtacgaccttctcaaagccgagggccaagcccaccagcctaatttcaccttccgggtcaccgttggcgacaccagctgcactggtcagggccccagcaagaaggcagccaagcacaaggcagctgaggtggccctcaaacacctcaaaggggggagcatgctggagccggccctggaggacagcagttctttttctcccctagactcttcactgcctgaggacattccggtttttactgctgcagcagctgctaccccagttccatctgtagtcctaaccaggagcccccccatggaactgcagccccctgtctcccctcagcagtctgagtgcaaccccgttggtgctctgcaggagctggtggtgcagaaaggctggcggttgccggagtacacagtgacccaggagtctgggccagcccaccgcaaagaattcaccatgacctgtcgagtggagcgtttcattgagattgggagtggcacttccaaaaaattggcaaagcggaatgcggcggccaaaatgctgcttcgagtgcacacggtgcctctggatgcccgggatggcaatgaggtggagcctgatgatgaccacttctccattggtgtgggctcccgcctggatggtcttcgaaaccggggcccaggttgcacctgggattctctacgaaattcagtaggagagaagatcctgtccctccgcagttgctccctgggctccctgggtgccctgggccctgcctgctgccgtgtcctcagtgagctctctgaggagcaggcctttcacgtcagctacctggatattgaggagctgagcctgagtggactctgccagtgcctggtggaactgtccacccagccggccactgtgtgtcatggctctgcaaccaccagggaggcagcccgtggtgaggctgcccgccgtgccctgcagtacctcaagatcatggcaggcagcaagtgaagccccagctggactcatggatgtgcaccctttgctccctgctctttctgcctctgggctcatgtatctgcgcagctctggtaccctctgtgggtgccatctctacctctgacacagactgcctgccttgaagctgagaaggcacagggcaaggagccaaggaccacagagcctcagccagcccaggatccgtcctcattttattggtgatgatgaatgggaatgaaatcagggggctgtctactagagcctggaataaatatgctgctttgtggatttttaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:6895 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:6895 -> Molecular function: GO:0035197 [siRNA binding] evidence: IDA
GeneID:6895 -> Molecular function: GO:0042803 [protein homodimerization activity] evidence: IPI
GeneID:6895 -> Biological process: GO:0006355 [regulation of transcription, DNA-dependent] evidence: TAS
GeneID:6895 -> Biological process: GO:0006357 [regulation of transcription from RNA polymerase II promoter] evidence: TAS
GeneID:6895 -> Biological process: GO:0006417 [regulation of translation] evidence: IEA
GeneID:6895 -> Biological process: GO:0006469 [negative regulation of protein kinase activity] evidence: TAS
GeneID:6895 -> Biological process: GO:0010467 [gene expression] evidence: TAS
GeneID:6895 -> Biological process: GO:0030422 [production of siRNA involved in RNA interference] evidence: IDA
GeneID:6895 -> Biological process: GO:0030423 [targeting of mRNA for destruction involved in RNA interference] evidence: IMP
GeneID:6895 -> Biological process: GO:0031054 [pre-miRNA processing] evidence: IDA
GeneID:6895 -> Biological process: GO:0035280 [miRNA loading onto RISC involved in gene silencing by miRNA] evidence: IDA
GeneID:6895 -> Biological process: GO:0045070 [positive regulation of viral genome replication] evidence: IDA
GeneID:6895 -> Biological process: GO:0046782 [regulation of viral transcription] evidence: IDA
GeneID:6895 -> Biological process: GO:0050689 [negative regulation of defense response to virus by host] evidence: IDA
GeneID:6895 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:6895 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:6895 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:6895 -> Cellular component: GO:0016442 [RNA-induced silencing complex] evidence: IDA
GeneID:6895 -> Cellular component: GO:0048471 [perinuclear region of cytoplasm] evidence: IEA
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DBCLS
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