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2025-05-09 19:32:38, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_003110 3132 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens Sp2 transcription factor (SP2), mRNA.
ACCESSION NM_003110 NM_138406
VERSION NM_003110.5 GI:125625356
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3132)
AUTHORS Ito,H., Murakami,M., Furuhata,A., Gao,S., Yoshida,K., Sobue,S.,
Hagiwara,K., Takagi,A., Kojima,T., Suzuki,M., Banno,Y., Tanaka,K.,
Tamiya-Koizumi,K., Kyogashima,M., Nozawa,Y. and Murate,T.
TITLE Transcriptional regulation of neutral sphingomyelinase 2 gene
expression of a human breast cancer cell line, MCF-7, induced by
the anti-cancer drug, daunorubicin
JOURNAL Biochim. Biophys. Acta 1789 (11-12), 681-690 (2009)
PUBMED 19698806
REMARK GeneRIF: Data show that three Sp1 motifs located between -148 and
-42bp upstream of the first exon were important in basic as well as
in DA-induced NSMase2 promoter activity.
REFERENCE 2 (bases 1 to 3132)
AUTHORS Wheeler,H.E., Metter,E.J., Tanaka,T., Absher,D., Higgins,J.,
Zahn,J.M., Wilhelmy,J., Davis,R.W., Singleton,A., Myers,R.M.,
Ferrucci,L. and Kim,S.K.
TITLE Sequential use of transcriptional profiling, expression
quantitative trait mapping, and gene association implicates MMP20
in human kidney aging
JOURNAL PLoS Genet. 5 (10), E1000685 (2009)
PUBMED 19834535
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 3 (bases 1 to 3132)
AUTHORS Letourneur,M., Valentino,L., Travagli-Gross,J., Bertoglio,J. and
Pierre,J.
TITLE Sp2 regulates interferon-gamma-mediated socs1 gene expression
JOURNAL Mol. Immunol. 46 (11-12), 2151-2160 (2009)
PUBMED 19482358
REMARK GeneRIF: Despite the absence of Sp2 in the 5'-upstream sequence of
the human promoter, silencing of Sp2 by RNA interference clearly
demonstrated that Sp2 is required for IFN-gamma-induced regulation
of socs1 mRNA both in human and mouse.
REFERENCE 4 (bases 1 to 3132)
AUTHORS Sun,J.M., Chen,H.Y. and Davie,J.R.
TITLE Differential distribution of unmodified and phosphorylated histone
deacetylase 2 in chromatin
JOURNAL J. Biol. Chem. 282 (45), 33227-33236 (2007)
PUBMED 17827154
REFERENCE 5 (bases 1 to 3132)
AUTHORS Das,A., Fernandez-Zapico,M.E., Cao,S., Yao,J., Fiorucci,S.,
Hebbel,R.P., Urrutia,R. and Shah,V.H.
TITLE Disruption of an SP2/KLF6 repression complex by SHP is required for
farnesoid X receptor-induced endothelial cell migration
JOURNAL J. Biol. Chem. 281 (51), 39105-39113 (2006)
PUBMED 17071613
REMARK GeneRIF: an SP2/KLF6 repression complex by SHP is required for
farnesoid X receptor-induced endothelial cell migration
REFERENCE 6 (bases 1 to 3132)
AUTHORS Moorefield,K.S., Fry,S.J. and Horowitz,J.M.
TITLE Sp2 DNA binding activity and trans-activation are negatively
regulated in mammalian cells
JOURNAL J. Biol. Chem. 279 (14), 13911-13924 (2004)
PUBMED 14726517
REFERENCE 7 (bases 1 to 3132)
AUTHORS Rotheneder,H., Geymayer,S. and Haidweger,E.
TITLE Transcription factors of the Sp1 family: interaction with E2F and
regulation of the murine thymidine kinase promoter
JOURNAL J. Mol. Biol. 293 (5), 1005-1015 (1999)
PUBMED 10547281
REFERENCE 8 (bases 1 to 3132)
AUTHORS Philipsen,S. and Suske,G.
TITLE A tale of three fingers: the family of mammalian Sp/XKLF
transcription factors
JOURNAL Nucleic Acids Res. 27 (15), 2991-3000 (1999)
PUBMED 10454592
REMARK Review article
REFERENCE 9 (bases 1 to 3132)
AUTHORS Scohy,S., Van Vooren,P., Szpirer,C. and Szpirer,J.
TITLE Assignment1 of Sp genes to rat chromosome bands 7q36 (Sp1),
10q31-->q32.1 (Sp2), 3q24-->q31 (Sp3) and 6q33 (Sp4) and of the SP2
gene to human chromosome bands 17q21.3-->q22 by in situ
hybridization
JOURNAL Cytogenet. Cell Genet. 81 (3-4), 273-274 (1998)
PUBMED 9730617
REFERENCE 10 (bases 1 to 3132)
AUTHORS Kingsley,C. and Winoto,A.
TITLE Cloning of GT box-binding proteins: a novel Sp1 multigene family
regulating T-cell receptor gene expression
JOURNAL Mol. Cell. Biol. 12 (10), 4251-4261 (1992)
PUBMED 1341900
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DB451570.1, BC016680.2,
M97190.1 and BC033814.2.
On Feb 9, 2007 this sequence version replaced gi:41281667.
Summary: This gene encodes a member of the Sp subfamily of Sp/XKLF
transcription factors. Sp family proteins are sequence-specific
DNA-binding proteins characterized by an amino-terminal
trans-activation domain and three carboxy-terminal zinc finger
motifs. This protein contains the least conserved DNA-binding
domain within the Sp subfamily of proteins, and its DNA sequence
specificity differs from the other Sp proteins. It localizes
primarily within subnuclear foci associated with the nuclear
matrix, and can activate or in some cases repress expression from
different promoters. [provided by RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC033814.2, BC016680.2 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025083 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-107 DB451570.1 1-107
108-743 BC016680.2 1-636
744-1714 M97190.1 619-1589
1715-2585 BC016680.2 1608-2478
2586-3132 BC033814.2 2465-3011
FEATURES Location/Qualifiers
source 1..3132
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="17"
/map="17q21.32"
gene 1..3132
/gene="SP2"
/note="Sp2 transcription factor"
/db_xref="GeneID:6668"
/db_xref="HGNC:11207"
/db_xref="MIM:601801"
exon 1..144
/gene="SP2"
/inference="alignment:Splign:1.39.8"
variation 86
/gene="SP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:370406238"
CDS 138..1979
/gene="SP2"
/codon_start=1
/product="transcription factor Sp2"
/protein_id="NP_003101.3"
/db_xref="GI:125625357"
/db_xref="CCDS:CCDS11521.2"
/db_xref="GeneID:6668"
/db_xref="HGNC:11207"
/db_xref="MIM:601801"
/translation="
MSDPQTSMAATAAVSPSDYLQPAASTTQDSQPSPLALLAATCSKIGPPAVEAAVTPPAPPQPTPRKLVPIKPAPLPLSPGKNSFGILSSKGNILQIQGSQLSASYPGGQLVFAIQNPTMINKGTRSNANIQYQAVPQIQASNSQTIQVQPNLTNQIQIIPGTNQAIITPSPSSHKPVPIKPAPIQKSSTTTTPVQSGANVVKLTGGGGNVTLTLPVNNLVNASDTGAPTQLLTESPPTPLSKTNKKARKKSLPASQPPVAVAEQVETVLIETTADNIIQAGNNLLIVQSPGGGQPAVVQQVQVVPPKAEQQQVVQIPQQALRVVQAASATLPTVPQKPSQNFQIQAAEPTPTQVYIRTPSGEVQTVLVQDSPPATAAATSNTTCSSPASRAPHLSGTSKKHSAAILRKERPLPKIAPAGSIISLNAAQLAAAAQAMQTININGVQVQGVPVTITNTGGQQQLTVQNVSGNNLTISGLSPTQIQLQMEQALAGETQPGEKRRRMACTCPNCKDGEKRSGEQGKKKHVCHIPDCGKTFRKTSLLRAHVRLHTGERPFVCNWFFCGKRFTRSDELQRHARTHTGDKRFECAQCQKRFMRSDHLTKHYKTHLVTKNL
"
misc_feature 369..371
/gene="SP2"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q02086.3); phosphorylation site"
misc_feature 1761..1841
/gene="SP2"
/note="Zinc-finger double domain; Region: zf-H2C2_2;
pfam13465"
/db_xref="CDD:205643"
misc_feature 1848..1919
/gene="SP2"
/note="Zinc-finger double domain; Region: zf-H2C2_2;
pfam13465"
/db_xref="CDD:205643"
misc_feature 1893..1958
/gene="SP2"
/note="Zinc finger, C2H2 type; Region: zf-C2H2; cl15478"
/db_xref="CDD:210117"
exon 145..221
/gene="SP2"
/inference="alignment:Splign:1.39.8"
variation 167
/gene="SP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:139803722"
variation 195
/gene="SP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:144611436"
variation 207
/gene="SP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:113705698"
exon 222..1196
/gene="SP2"
/inference="alignment:Splign:1.39.8"
variation 298
/gene="SP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:112053164"
variation 322
/gene="SP2"
/replace="a"
/replace="c"
/db_xref="dbSNP:201198537"
variation 473
/gene="SP2"
/replace="c"
/replace="g"
/db_xref="dbSNP:376159721"
variation 477
/gene="SP2"
/replace="a"
/replace="c"
/db_xref="dbSNP:370407425"
variation 516
/gene="SP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:369065007"
variation 523
/gene="SP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:373308287"
variation 527
/gene="SP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:377521057"
variation 529
/gene="SP2"
/replace="a"
/replace="c"
/db_xref="dbSNP:371106023"
variation 598
/gene="SP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:200254744"
variation 650
/gene="SP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:150012782"
variation 659
/gene="SP2"
/replace="a"
/replace="c"
/db_xref="dbSNP:199905768"
variation 671
/gene="SP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:111389976"
variation 697
/gene="SP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:374244316"
variation 698
/gene="SP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:149196682"
variation 703
/gene="SP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:368448436"
variation 704
/gene="SP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:370442344"
variation 725
/gene="SP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:184089381"
variation 744
/gene="SP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:2228253"
variation 749
/gene="SP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:117736384"
variation 759
/gene="SP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:367582453"
variation 769
/gene="SP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:371850352"
variation 783
/gene="SP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:140739569"
variation 791
/gene="SP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:372866839"
variation 794
/gene="SP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:2228251"
variation 803
/gene="SP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:137884512"
variation 815
/gene="SP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:372732502"
variation 816
/gene="SP2"
/replace="g"
/replace="t"
/db_xref="dbSNP:150853499"
variation 853
/gene="SP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:150118323"
variation 854
/gene="SP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:2229358"
variation 880
/gene="SP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:371001586"
variation 901
/gene="SP2"
/replace="c"
/replace="g"
/db_xref="dbSNP:373579505"
variation 947
/gene="SP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:149293764"
variation 956
/gene="SP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:147415907"
variation 980
/gene="SP2"
/replace="a"
/replace="c"
/db_xref="dbSNP:200972130"
variation 992
/gene="SP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:370784122"
variation 1020
/gene="SP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:139762471"
variation 1037
/gene="SP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:143732446"
variation 1044
/gene="SP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:147446062"
variation 1049
/gene="SP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:148511412"
variation 1050
/gene="SP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:142857959"
variation 1070
/gene="SP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:373883531"
variation 1089..1090
/gene="SP2"
/replace=""
/replace="c"
/db_xref="dbSNP:35543662"
variation 1104
/gene="SP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:61753877"
variation 1115
/gene="SP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:200257728"
variation 1134
/gene="SP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:202157380"
variation 1142
/gene="SP2"
/replace="c"
/replace="g"
/db_xref="dbSNP:151058054"
variation 1172
/gene="SP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:78896229"
exon 1197..1509
/gene="SP2"
/inference="alignment:Splign:1.39.8"
variation 1210
/gene="SP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:373140962"
variation 1211
/gene="SP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:139815805"
variation 1214
/gene="SP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:141918529"
variation 1217
/gene="SP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:146862346"
variation 1251
/gene="SP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:140692820"
variation 1275
/gene="SP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:62067380"
variation 1281
/gene="SP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:114228308"
variation 1288
/gene="SP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:202014692"
variation 1306
/gene="SP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:200461216"
variation 1313
/gene="SP2"
/replace="c"
/replace="g"
/db_xref="dbSNP:373795992"
variation 1327
/gene="SP2"
/replace="a"
/replace="c"
/db_xref="dbSNP:373926962"
variation 1350
/gene="SP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:143045442"
variation 1397
/gene="SP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:367814481"
variation 1400
/gene="SP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:148217498"
variation 1446
/gene="SP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:184644940"
variation 1457
/gene="SP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:200703641"
variation 1481
/gene="SP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:372727470"
exon 1510..1684
/gene="SP2"
/inference="alignment:Splign:1.39.8"
variation 1603
/gene="SP2"
/replace="a"
/replace="c"
/db_xref="dbSNP:140242891"
variation 1619
/gene="SP2"
/replace="a"
/replace="c"
/db_xref="dbSNP:3190376"
variation 1625
/gene="SP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:138122841"
variation 1626
/gene="SP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:143694248"
variation 1631
/gene="SP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:375180084"
variation 1670
/gene="SP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:147788812"
variation 1679
/gene="SP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:141135915"
exon 1685..1878
/gene="SP2"
/inference="alignment:Splign:1.39.8"
variation 1709
/gene="SP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:78785116"
variation 1715
/gene="SP2"
/replace="g"
/replace="t"
/db_xref="dbSNP:1130932"
variation 1722
/gene="SP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:368951804"
variation 1747
/gene="SP2"
/replace="g"
/replace="t"
/db_xref="dbSNP:202023956"
variation 1754
/gene="SP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:144256408"
variation 1757
/gene="SP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:201575491"
variation 1790
/gene="SP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:148743427"
variation 1838
/gene="SP2"
/replace="a"
/replace="t"
/db_xref="dbSNP:376471731"
variation 1847
/gene="SP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:369515854"
exon 1879..3112
/gene="SP2"
/inference="alignment:Splign:1.39.8"
variation 1898
/gene="SP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:75562971"
variation 1937
/gene="SP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:146350857"
variation 1958
/gene="SP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:139713662"
variation 1966
/gene="SP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:374602267"
variation 1967
/gene="SP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:144476806"
variation 1973
/gene="SP2"
/replace="a"
/replace="c"
/db_xref="dbSNP:200755668"
variation 1988
/gene="SP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:375386987"
variation 1989
/gene="SP2"
/replace="a"
/replace="c"
/db_xref="dbSNP:368742340"
variation 2253
/gene="SP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:187872777"
variation 2361
/gene="SP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:190836947"
variation 2412
/gene="SP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:183394520"
variation 2525
/gene="SP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:367886979"
STS 2553..2669
/gene="SP2"
/standard_name="D17S2015"
/db_xref="UniSTS:69245"
variation 2581..2584
/gene="SP2"
/replace=""
/replace="ct"
/db_xref="dbSNP:35839416"
variation 2581
/gene="SP2"
/replace="a"
/replace="t"
/db_xref="dbSNP:199573009"
variation 2582..2583
/gene="SP2"
/replace=""
/replace="ct"
/db_xref="dbSNP:376983576"
variation 2586..2587
/gene="SP2"
/replace=""
/replace="ct"
/db_xref="dbSNP:72249312"
variation 2590
/gene="SP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:200564346"
variation 2640
/gene="SP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:142039420"
STS 2651..2801
/gene="SP2"
/standard_name="RH25284"
/db_xref="UniSTS:92440"
variation 2757
/gene="SP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:115128706"
variation 2846
/gene="SP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:371765868"
STS 2847..3069
/gene="SP2"
/standard_name="RH17404"
/db_xref="UniSTS:52979"
variation 2860
/gene="SP2"
/replace="c"
/replace="g"
/db_xref="dbSNP:113185113"
variation 2894
/gene="SP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:187398872"
variation 2939
/gene="SP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:12325753"
polyA_signal 2946..2951
/gene="SP2"
variation 2964..2968
/gene="SP2"
/replace=""
/replace="tttat"
/db_xref="dbSNP:371372163"
polyA_site 2967
/gene="SP2"
variation 2968..2973
/gene="SP2"
/replace=""
/replace="ttttta"
/db_xref="dbSNP:369393595"
variation 3003
/gene="SP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:192943368"
variation 3034
/gene="SP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:184804668"
variation 3044
/gene="SP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:375834257"
polyA_signal 3080..3085
/gene="SP2"
variation 3087
/gene="SP2"
/replace="g"
/replace="t"
/db_xref="dbSNP:144701940"
polyA_site 3112
/gene="SP2"
ORIGIN
aatgttccaagcgcttattggtgaaggctgccgtcgctcgggcggtggcgggctccgggattggcggttgcttggcgggcggtgtcaggctctcggtggcggcggaggcggcggaggccagggaggaagatgtcgtaatgagcgatccacagaccagcatggctgccactgctgctgtgagtcccagtgactacctgcagcctgccgcctccaccacccaggactcccagccatctcccttagccctgcttgctgcaacatgtagcaaaattggccctccagcagttgaagctgctgtgacacctcctgctcccccacagcccacaccgcggaaacttgtccctatcaaacctgcccctctccctctcagccccggcaagaatagctttggaatcttgtcctccaaaggaaatatacttcagattcaggggtcacaactgagcgcctcctatcctggagggcagctggtgttcgctatccagaatcccaccatgatcaacaaagggacccgatcaaatgccaatatccagtaccaggcggtccctcagattcaggcaagcaattcccaaaccatccaagtacagcccaatctcaccaaccagatccagatcatccctggcaccaaccaagccatcatcaccccctcaccgtccagtcacaagcctgtccccatcaagccagcccccatccagaagtcgagtacgaccaccacccccgtgcagagcggggccaatgtggtgaagctgacaggtgggggcggcaatgtgacgctcactctgcccgtcaacaaccttgtgaacgccagtgacaccggggcccctactcagctcctcactgaaagccccccaaccccgctgtctaagactaacaagaaagcaaggaagaagagccttcctgcctcccagccccctgtggctgtggctgagcaggtggagacggtgctgatcgagaccaccgcggacaacatcatccaggcaggaaataacctgctcattgttcagagccctggtgggggccagccagctgtggtccagcaggtccaggtggtgccccccaaggccgagcagcagcaggtggtacagatcccccagcaggctctgcgggtggtgcaggcggcatctgccaccctccccactgtaccccagaagccctcccagaactttcagatccaggcagctgagccgacacctactcaggtctacatccgcacgccttccggtgaggtgcagacagtccttgtccaggacagccccccagcaacagctgcagccacctctaacaccacctgtagcagccctgcatcccgtgctccccatctgagtgggaccagcaaaaagcactcagctgcaattctccgaaaagagcgtcccctgccaaagattgccccagccgggagcatcatcagcctgaatgcagcccagttggcggcagctgcccaggcaatgcagaccatcaacatcaatggtgtccaggtccagggcgtgcctgtcaccatcaccaacacaggcgggcagcagcagctgacagtgcagaatgtttctgggaacaacctgaccatcagtgggctgagccccacccagatccagctgcaaatggaacaagccctggccggagagacccagcccggggagaagcggcgccgcatggcctgcacgtgtcccaactgcaaggatggggagaagaggtctggagagcagggcaagaagaagcacgtgtgccacatccccgactgtggcaagacgttccgtaagacgtccttgctgcgtgcccatgtgcgcctgcacactggcgagcggccctttgtctgcaactggttcttctgtgggaagaggttcacacggagtgacgagctccaacggcatgctcgcacccacacaggggacaaacgcttcgagtgcgcccagtgtcagaagcgcttcatgaggagtgaccacctcaccaagcattacaagacccacctggtcacgaagaacttgtaaggccaactgcggcgggaggccctgaagatgcagtcccccacctgtgtcctccctgggcccctggtggaaaggagccctgtggctgccttgggcctgccctcagccccactcctgttctgcaactgtccccacaggaaggggctctgttccctgtattgtcctccttctgaagccccttggctctgccttggcccttcccctcaccacgagctcccggcctgcccagactgtggacactggccgtgcccaatgagacgttctaaaccaggacgcgtgggaacccttatttccaaaggaaaaacatgcatttcactccgtcgaggagcaaagtgagcccctaccccccaccccgatccccgctcccaacactgccggagtcgcgtcatgccatgccccctctcctgcacctccctggccctgccggccactgtggacgccctggggcttggcacccacctctggagaaactcggggccacctccactccatgtgcccagccccgccacaacctctcctccagcacattccagctctatttaaaaagtaaagacacccaccgactcctgatccccctctttttctatggagaacgttgccttatactctacttcagatgatgaacactgtgtactgtgtgtgctttaaagaagttttatttaattgctcccttcttcctttccttgttattcacctccctgatgcctgctttcagttgagggttgggggcaatgatgagcatatgaattttttctcactctagcaattcccttttctaaatgacacagcatttaaactcaaatctggattcagataacagcacctgcacatcctgcacctcctccctctcccttcacctcacccctgcccggcccaagctctacttgtgtacagtgtatattgtataatagacaattgtgtctactacatgtttaaaaacacattgcttgttatttttgaggcttttaaattaaacaaaaatccaactttatttttagttgtaactgcttgaggtatgttttatgaattaagtgacagatttgttatcctttattaacgtactttgttggtcagcactgggctgacaaaaattttttcttgctaataaatttagttgcctgaggcaaaatcttcaaaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:6668 -> Molecular function: GO:0003677 [DNA binding] evidence: IEA
GeneID:6668 -> Molecular function: GO:0042826 [histone deacetylase binding] evidence: IPI
GeneID:6668 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
GeneID:6668 -> Biological process: GO:0001701 [in utero embryonic development] evidence: IEA
GeneID:6668 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
GeneID:6668 -> Biological process: GO:0006357 [regulation of transcription from RNA polymerase II promoter] evidence: TAS
GeneID:6668 -> Biological process: GO:0006955 [immune response] evidence: TAS
GeneID:6668 -> Biological process: GO:0035264 [multicellular organism growth] evidence: IEA
GeneID:6668 -> Biological process: GO:0048144 [fibroblast proliferation] evidence: IEA
GeneID:6668 -> Biological process: GO:0048568 [embryonic organ development] evidence: IEA
GeneID:6668 -> Biological process: GO:0072358 [cardiovascular system development] evidence: IEA
GeneID:6668 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
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