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2025-05-09 19:13:04, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_002077 4899 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens golgin A1 (GOLGA1), mRNA.
ACCESSION NM_002077
VERSION NM_002077.3 GI:221625465
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4899)
AUTHORS Jing,J., Junutula,J.R., Wu,C., Burden,J., Matern,H., Peden,A.A. and
Prekeris,R.
TITLE FIP1/RCP binding to Golgin-97 regulates retrograde transport from
recycling endosomes to the trans-Golgi network
JOURNAL Mol. Biol. Cell 21 (17), 3041-3053 (2010)
PUBMED 20610657
REMARK GeneRIF: FIP1/RCP binding to Golgin-97 is required for tethering
and fusion of recycling endosome-derived retrograde transport
vesicles to the trans-Golgi network.
REFERENCE 2 (bases 1 to 4899)
AUTHORS Letra,A., Menezes,R., Govil,M., Fonseca,R.F., McHenry,T.,
Granjeiro,J.M., Castilla,E.E., Orioli,I.M., Marazita,M.L. and
Vieira,A.R.
TITLE Follow-up association studies of chromosome region 9q and
nonsyndromic cleft lip/palate
JOURNAL Am. J. Med. Genet. A 152A (7), 1701-1710 (2010)
PUBMED 20583170
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 3 (bases 1 to 4899)
AUTHORS Alzhanova,D. and Hruby,D.E.
TITLE A host cell membrane protein, golgin-97, is essential for poxvirus
morphogenesis
JOURNAL Virology 362 (2), 421-427 (2007)
PUBMED 17276477
REMARK GeneRIF: Using RNA interference approach, it was demonstrated that
a cellular trans-Golgi network membrane protein, golgin-97, is
essential for Vaccinia virus replication.
REFERENCE 4 (bases 1 to 4899)
AUTHORS Lock,J.G., Hammond,L.A., Houghton,F., Gleeson,P.A. and Stow,J.L.
TITLE E-cadherin transport from the trans-Golgi network in
tubulovesicular carriers is selectively regulated by golgin-97
JOURNAL Traffic 6 (12), 1142-1156 (2005)
PUBMED 16262725
REMARK GeneRIF: Selective and essential component of the tubulovesicular
carriers transporting E-cadherin out of the trans-Golgi network.
REFERENCE 5 (bases 1 to 4899)
AUTHORS Luke,M.R., Houghton,F., Perugini,M.A. and Gleeson,P.A.
TITLE The trans-Golgi network GRIP-domain proteins form alpha-helical
homodimers
JOURNAL Biochem. J. 388 (PT 3), 835-841 (2005)
PUBMED 15654769
REMARK GeneRIF: The ability of the four mammalian GRIP domain proteins,
p230, golgin-97, GCC88, and GCC185 to interact is reported.
REFERENCE 6 (bases 1 to 4899)
AUTHORS Lu,L., Tai,G. and Hong,W.
TITLE Autoantigen Golgin-97, an effector of Arl1 GTPase, participates in
traffic from the endosome to the trans-golgi network
JOURNAL Mol. Biol. Cell 15 (10), 4426-4443 (2004)
PUBMED 15269279
REMARK GeneRIF: Data show that Arl1 regulates the membrane recruitment of
Golgin-97, which plays a role in transport from the endosome to the
trans-Golgi network.
REFERENCE 7 (bases 1 to 4899)
AUTHORS Lu,L. and Hong,W.
TITLE Interaction of Arl1-GTP with GRIP domains recruits autoantigens
Golgin-97 and Golgin-245/p230 onto the Golgi
JOURNAL Mol. Biol. Cell 14 (9), 3767-3781 (2003)
PUBMED 12972563
REFERENCE 8 (bases 1 to 4899)
AUTHORS Barr,F.A.
TITLE A novel Rab6-interacting domain defines a family of Golgi-targeted
coiled-coil proteins
JOURNAL Curr. Biol. 9 (7), 381-384 (1999)
PUBMED 10209123
REFERENCE 9 (bases 1 to 4899)
AUTHORS Griffith,K.J., Chan,E.K., Lung,C.C., Hamel,J.C., Guo,X., Miyachi,K.
and Fritzler,M.J.
TITLE Molecular cloning of a novel 97-kd Golgi complex autoantigen
associated with Sjogren's syndrome
JOURNAL Arthritis Rheum. 40 (9), 1693-1702 (1997)
PUBMED 9324025
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DA324844.1, U51587.1,
BC032853.1 and AA027278.1.
On Jan 27, 2009 this sequence version replaced gi:42490756.
Summary: The Golgi apparatus, which participates in glycosylation
and transport of proteins and lipids in the secretory pathway,
consists of a series of stacked cisternae (flattened membrane
sacs). Interactions between the Golgi and microtubules are thought
to be important for the reorganization of the Golgi after it
fragments during mitosis. This gene encodes one of the golgins, a
family of proteins localized to the Golgi. This encoded protein is
associated with Sjogren's syndrome. [provided by RefSeq, Feb 2010].
##Evidence-Data-START##
Transcript exon combination :: U51587.1, BC032853.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-84 DA324844.1 2-85
85-3420 U51587.1 77-3412
3421-4638 BC032853.1 3391-4608
4639-4809 U51587.1 4629-4799
4810-4899 AA027278.1 1-90 c
FEATURES Location/Qualifiers
source 1..4899
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="9"
/map="9q33.3"
gene 1..4899
/gene="GOLGA1"
/gene_synonym="golgin-97"
/note="golgin A1"
/db_xref="GeneID:2800"
/db_xref="HGNC:4424"
/db_xref="HPRD:03934"
/db_xref="MIM:602502"
exon 1..137
/gene="GOLGA1"
/gene_synonym="golgin-97"
/inference="alignment:Splign:1.39.8"
exon 138..187
/gene="GOLGA1"
/gene_synonym="golgin-97"
/inference="alignment:Splign:1.39.8"
exon 188..477
/gene="GOLGA1"
/gene_synonym="golgin-97"
/inference="alignment:Splign:1.39.8"
misc_feature 274..276
/gene="GOLGA1"
/gene_synonym="golgin-97"
/note="upstream in-frame stop codon"
CDS 343..2646
/gene="GOLGA1"
/gene_synonym="golgin-97"
/note="golgi autoantigen, golgin subfamily a, 1; gap
junction protein, alpha 4, 37kD"
/codon_start=1
/product="Golgin subfamily A member 1"
/protein_id="NP_002068.1"
/db_xref="GI:4504063"
/db_xref="CCDS:CCDS6860.1"
/db_xref="GeneID:2800"
/db_xref="HGNC:4424"
/db_xref="HPRD:03934"
/db_xref="MIM:602502"
/translation="
MFAKLKKKIAEETAVAQRPGGATRIPRSVSKESVASMGADSGDDFASDGSSSREDLSSQLLRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSMRKFQEQNETFQANRAKMAEGLALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRDEMDELEGFQQQELSKIKHMLLKKEESLGKMEQELEARTRELSRTQEELMNSNQMSSDLSQKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQKVTAETQEKEDVITHLQEKVASLEKRLEQNLSGEEHVQELLKEKTLAEQNLEDTRQQLLAARSSQAKAINTLETRVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHVQQQALALEQQFLERTQALEAQIVALERTRAADQTTAEQGMRQLEQENAALKECRNEYERSLQNHQFELKKLKEEWSQREIVSVAMAQALEEVRKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQEILQLERGHNSALLQIHQLQAELEALRTLKAEEAAVVAEQEDLLRLRGPLQAEALSVNESHVTSRAMQDPVFQLPTAGRTPNGEVGAMDLTQLQKEKQDLEQQLLEKNKTIKQMQQRMLELRKTLQKELKIRPDNELFEVREKPGPEMANMAPSVTNNTDLTDAREINFEYLKHVVLKFMSCRESEAFHLIKAVSVLLNFSQEEENMLKETLEYKMSWFGSKPAPKGSIRPSISNPRIPWS
"
misc_feature 463..465
/gene="GOLGA1"
/gene_synonym="golgin-97"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q92805.3); phosphorylation site"
misc_feature 490..492
/gene="GOLGA1"
/gene_synonym="golgin-97"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q92805.3); phosphorylation site"
misc_feature 493..495
/gene="GOLGA1"
/gene_synonym="golgin-97"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q92805.3); phosphorylation site"
misc_feature 1009..>1404
/gene="GOLGA1"
/gene_synonym="golgin-97"
/note="Peptidase Gluzincin family (thermolysin-like
proteinases, TLPs) includes peptidases M1, M2, M3, M4,
M13, M32 and M36 (fungalysins); Region: GluZincin;
cl14813"
/db_xref="CDD:209905"
misc_feature 2416..2553
/gene="GOLGA1"
/gene_synonym="golgin-97"
/note="golgin-97, RanBP2alpha,Imh1p and p230/golgin-245;
Region: Grip; smart00755"
/db_xref="CDD:197860"
exon 478..568
/gene="GOLGA1"
/gene_synonym="golgin-97"
/inference="alignment:Splign:1.39.8"
exon 569..643
/gene="GOLGA1"
/gene_synonym="golgin-97"
/inference="alignment:Splign:1.39.8"
STS 580..719
/gene="GOLGA1"
/gene_synonym="golgin-97"
/standard_name="GOLGA1-1"
/db_xref="UniSTS:511788"
exon 644..741
/gene="GOLGA1"
/gene_synonym="golgin-97"
/inference="alignment:Splign:1.39.8"
exon 742..774
/gene="GOLGA1"
/gene_synonym="golgin-97"
/inference="alignment:Splign:1.39.8"
exon 775..903
/gene="GOLGA1"
/gene_synonym="golgin-97"
/inference="alignment:Splign:1.39.8"
exon 904..1073
/gene="GOLGA1"
/gene_synonym="golgin-97"
/inference="alignment:Splign:1.39.8"
exon 1074..1185
/gene="GOLGA1"
/gene_synonym="golgin-97"
/inference="alignment:Splign:1.39.8"
exon 1186..1311
/gene="GOLGA1"
/gene_synonym="golgin-97"
/inference="alignment:Splign:1.39.8"
exon 1312..1407
/gene="GOLGA1"
/gene_synonym="golgin-97"
/inference="alignment:Splign:1.39.8"
exon 1408..1503
/gene="GOLGA1"
/gene_synonym="golgin-97"
/inference="alignment:Splign:1.39.8"
exon 1504..1653
/gene="GOLGA1"
/gene_synonym="golgin-97"
/inference="alignment:Splign:1.39.8"
variation 1616
/gene="GOLGA1"
/gene_synonym="golgin-97"
/replace="c"
/replace="t"
/db_xref="dbSNP:634710"
exon 1654..1749
/gene="GOLGA1"
/gene_synonym="golgin-97"
/inference="alignment:Splign:1.39.8"
exon 1750..1839
/gene="GOLGA1"
/gene_synonym="golgin-97"
/inference="alignment:Splign:1.39.8"
exon 1840..1942
/gene="GOLGA1"
/gene_synonym="golgin-97"
/inference="alignment:Splign:1.39.8"
exon 1943..2103
/gene="GOLGA1"
/gene_synonym="golgin-97"
/inference="alignment:Splign:1.39.8"
exon 2104..2247
/gene="GOLGA1"
/gene_synonym="golgin-97"
/inference="alignment:Splign:1.39.8"
exon 2248..2307
/gene="GOLGA1"
/gene_synonym="golgin-97"
/inference="alignment:Splign:1.39.8"
exon 2308..2478
/gene="GOLGA1"
/gene_synonym="golgin-97"
/inference="alignment:Splign:1.39.8"
exon 2479..2565
/gene="GOLGA1"
/gene_synonym="golgin-97"
/inference="alignment:Splign:1.39.8"
exon 2566..4882
/gene="GOLGA1"
/gene_synonym="golgin-97"
/inference="alignment:Splign:1.39.8"
variation 3440
/gene="GOLGA1"
/gene_synonym="golgin-97"
/replace="a"
/replace="t"
/db_xref="dbSNP:1058535"
variation 3691
/gene="GOLGA1"
/gene_synonym="golgin-97"
/replace="c"
/replace="t"
/db_xref="dbSNP:1058540"
STS 3708..3863
/gene="GOLGA1"
/gene_synonym="golgin-97"
/standard_name="D9S1928"
/db_xref="UniSTS:32958"
STS 4551..4695
/gene="GOLGA1"
/gene_synonym="golgin-97"
/standard_name="RH12038"
/db_xref="UniSTS:66221"
STS 4667..4816
/gene="GOLGA1"
/gene_synonym="golgin-97"
/standard_name="SHGC-32296"
/db_xref="UniSTS:21281"
variation 4689
/gene="GOLGA1"
/gene_synonym="golgin-97"
/replace="c"
/replace="t"
/db_xref="dbSNP:1058555"
polyA_signal 4784..4789
/gene="GOLGA1"
/gene_synonym="golgin-97"
polyA_site 4802
/gene="GOLGA1"
/gene_synonym="golgin-97"
polyA_site 4809
/gene="GOLGA1"
/gene_synonym="golgin-97"
polyA_site 4815
/gene="GOLGA1"
/gene_synonym="golgin-97"
polyA_site 4819
/gene="GOLGA1"
/gene_synonym="golgin-97"
polyA_site 4827
/gene="GOLGA1"
/gene_synonym="golgin-97"
polyA_signal 4856..4861
/gene="GOLGA1"
/gene_synonym="golgin-97"
polyA_site 4882
/gene="GOLGA1"
/gene_synonym="golgin-97"
ORIGIN
cttccggcgcgctgggagacgtgcggttccgggtcgctgctcggctcgccggctgggcggtgggggttggtgacgcgggccggggctcacgagaggcccgggaggcggggctttgctggcttcccagagagaggcaggacagaatgctttgacctccaagctgttttaaatctagtagataagccagatcctgtgttgccataagcccttggcccacatttaagtgggaatgcagctagcttggatgtctgaaactttgtaggcgcctctgtctgaatcctgaacacaggcaccaggactactgagagctcgtcatctgtgcaggatagccacacagcaaacatgtttgcaaaactgaagaagaaaattgcagaagagactgctgttgctcagaggccaggaggtgctactaggatcccacggtctgtgagcaaggaatcagttgcctcaatgggagctgactcaggagatgactttgcttccgatggaagcagctccagagaagatctttcatcccagcttctgagaaggaatgaacagatacggaagttagaggccagactttctgactatgctgaacaggtccgaaacttgcagaagataaaagagaagcttgaaattgcattagaaaaacaccaggattcttccatgcggaaatttcaagagcagaatgagacattccaagccaacagagccaaaatggcagaaggactggctttggcattagccagaaaggaccaggaatggtcagaaaagatggatcagcttgaaaaggagaaaaatattctgacagcccagttacaggaaatgaagaaccagagtatgaatcttttccaaaggagagatgaaatggatgaattagaggggttccagcagcaggaactaagtaaaataaagcacatgcttttaaaaaaagaagaaagtctagggaaaatggaacaagaattggaggcacgaaccagagaacttagtcgtacccaggaggagttgatgaactccaatcagatgtcatcagacttaagccagaagctagaagaattgcagagacactactcaacgctggaagagcagagagatcatgtgatagcttcaaaaacaggtgcagaaagtaagatcacagccctggaacaaaaggaacaagagctccaagcactcattcagcagctttccattgatttgcaaaaggtcactgctgaaactcaagagaaagaagacgttatcacacatttgcaagagaaggttgcatccttggagaagagactagaacagaacttatcaggagaagaacacgtgcaagaactcctgaaagagaaaacacttgctgagcagaatttggaggataccagacaacagctcttggcagccagaagcagccaggctaaggccattaacaccctggagactcgggtgagagaactggagcagaccttgcaggcctctgaggagcagctccaacagagcaagggcattgtggctgcccaggaaactcagatacaggagctcgctgccgccaaccaggagagcagccatgtgcagcagcaggcccttgctctggagcagcagttcttggagcgcacccaggcgctagaagcccagatagtggccctggagagaacgcgggcagctgaccagaccaccgcagagcaagggatgagacaactggagcaagaaaatgcagcccttaaagaatgcaggaatgaatatgaacgttctttacaaaatcaccaatttgaactaaagaagctgaaggaagaatggagccaaagagaaattgtgagcgtggccatggctcaagccctggaggaggtgcggaagcaaagggaagagttccagcaacaggcagctaacctgacagccataatagacgagaaggaacagaatctgcgggaaaaaaccgaagtgcttctccagaaagagcaggagattctccagctggagcgaggtcacaactctgccctgctgcagatacaccagctgcaggccgagctggaggccctgaggaccctcaaggcggaggaggctgcagtggtcgcggagcaggaggacctgctgaggctgcggggcccattgcaggccgaagcactctcagtcaatgagtcgcacgtgacctcgagggccatgcaggaccctgtgttccagcttccaactgcaggaagaacaccaaatggtgaggttggggccatggatctcacacagctacagaaggagaaacaggacttggagcagcaacttctggagaaaaataagaccataaagcagatgcagcagcggatgctggagctccggaagactctgcagaaggagctgaaaatcagacccgataatgagctcttcgaagtccgggagaaacctggacctgagatggcaaacatggcgccttccgtcacgaataacactgacctgacagatgcccgcgagatcaactttgagtaccttaaacatgtggttttaaaattcatgtcttgtcgcgaatccgaggcttttcatcttataaaagctgtgtcagtgttgctgaacttttcccaagaggaggagaacatgctcaaggaaactctggaatataagatgtcatggtttgggtccaaaccagctcccaagggcagcatccggccgtctatctcaaaccctcggataccatggtcctagaggggactacccaaggatggagctccgtgggttgacactttttctgtgaaaagaacactgacacaccagtctgggtgggtttttaatcactgtaactgcagtattttgtacaagtgtctaaacattgtttacaagactaaggcccacttccctgcaggctgacctgaacctcagggggtagctgatcctgtcattctggtcaccaaacaggagggtcctggcactacccagatttccacagtgctgctaatatcccagctccagccagcaccccatctgcacctgaatcctctaacttcacggtagcacttacagctgaagccatcagcatctggcaggcacacctgagtcaccatgtagcgctgctactggaggtagagacggccctttgagatggtgcccagcaggccaaacccacctgcctctgccaggaacagccaactccatgggaactctatgggagtggcttttaaaaattcagatgagttagaagctttttatcccttcctctcaagaaaatattctttcaccctgtctctcaaaccacctagaactttagaggatccatctttaagggccggtgtggatgaatgagaaaatgcacctttctgacagtatctccactttacttaagaaaactagcaaatatatgaaaagacccttagtaccaaatacactcaattgcctttttaatgaatgtacttgtcttggataggttgctggtaaaccattttaaactattttttatagctgaagttcttcactactataaacatgtcttctgtactataaaatccatttaactggtgttcttaaaatcagagcgtccagaggaaattcttcctaaaactaggattcctgttcctttgtcttctcactcgcactctggcactgctccctctgaagtgcagtgggatctcgtgtgctttgtcttgattctgtgctgcgctgccgctgggcgatgcagaccacctgtcttctactgaaggacagtccgctgtctccagtgggggcagcagctgtcccccagcctcgatggagacactggggcagtctgccttgtctgtggagctgctctctctccctcatcccaccccaaatacttaaaatgacactacacccagacggcgcccagctggctgcagcacttgtagcatgcacatgactctggtagtaaccaacaaaaacttgttttatggattcctcgtttactgaggaaagggaacatgctggttctggaaaagccacaatattgaatctaaaaggaaaccgtttattgtttgatgaaagtttcactggttaaataaaaaactaaattaataactggagcctctaaatttattatccattatccagtgatggaaagttgtatttctcaatcatgcttagggccaaaataggtatataaaatgtgtcacagaaaaacacgcatttgcaacgttaacctaacgaaatttccatgaagaaccaagtcagggcagcatctccttagtcccagctcaggctctctgccttccagaggccgcttctccagtgactaacctcctcctctggctcctccttgcagacagttatcccttgtttagaacacgaatttccatttacctggtgggaacacgaaacaggagtctcttctgttctgcaagtttgatgggtaagaggtagccttttttcaaagtaggatttcctttttcaactgttccaggaaagaatctctaagactgggtagctcacagccagccaaaggcagctacatttccacagaagcccgtccgctgcctccgtggcttctccagccattgaactggtcccacacgcaccccaggccccactcctcggcagtttcaggtgtagctgtggggcccgttcctaggtctgtactcactttagggaggcttcactgactaggctttcctcctgcatgttgaatttccttcagctttaagaggaagagtggaataaatattctaagtgatttaatgcactttgacttgtataaaactttctgtgttagcgacggtatctatagccctttatacgagcgatggatcttgagctctccttccatgttgtaaatagggattgtattcttgaaaactgctgtagcaaattcatctgtggtgcaatacactttttgattaaagctcttcaatccagatgcaactacaatggattttactagtttggtgtgtcagtatttctttgactcattaaatctggtattttgtgtctcataaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:2800 -> Biological process: GO:0000042 [protein targeting to Golgi] evidence: IEA
GeneID:2800 -> Cellular component: GO:0005794 [Golgi apparatus] evidence: TAS
GeneID:2800 -> Cellular component: GO:0005802 [trans-Golgi network] evidence: IEA
GeneID:2800 -> Cellular component: GO:0032580 [Golgi cisterna membrane] evidence: IEA
GeneID:2800 -> Cellular component: GO:0048471 [perinuclear region of cytoplasm] evidence: IEA
by
@meso_cacase at
DBCLS
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