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2025-05-09 19:48:50, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001261816 7032 bp mRNA linear PRI 07-JUL-2013
DEFINITION Homo sapiens 3-phosphoinositide dependent protein kinase-1 (PDPK1),
transcript variant 3, mRNA.
ACCESSION NM_001261816
VERSION NM_001261816.1 GI:387849238
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 7032)
AUTHORS Eser,S., Reiff,N., Messer,M., Seidler,B., Gottschalk,K., Dobler,M.,
Hieber,M., Arbeiter,A., Klein,S., Kong,B., Michalski,C.W.,
Schlitter,A.M., Esposito,I., Kind,A.J., Rad,L., Schnieke,A.E.,
Baccarini,M., Alessi,D.R., Rad,R., Schmid,R.M., Schneider,G. and
Saur,D.
TITLE Selective requirement of PI3K/PDK1 signaling for Kras
oncogene-driven pancreatic cell plasticity and cancer
JOURNAL Cancer Cell 23 (3), 406-420 (2013)
PUBMED 23453624
REMARK GeneRIF: cell-autonomous phosphoinositide 3-kinase and
3-phosphoinositide-dependent protein kinase 1 are key effectors of
oncogenic Kras in the pancreas, mediating cell plasticity,
acinar-to-ductal metaplasia, and pancreatic ductal adenocarcinoma
formation
REFERENCE 2 (bases 1 to 7032)
AUTHORS Raimondi,C., Chikh,A., Wheeler,A.P., Maffucci,T. and Falasca,M.
TITLE A novel regulatory mechanism links PLCgamma1 to PDK1
JOURNAL J. Cell. Sci. 125 (PT 13), 3153-3163 (2012)
PUBMED 22454520
REMARK GeneRIF: PDK1 and PLCgamma1 act on the same signalling cascade, and
the PDK1/PLCgamma1 pathway is required for regulation of cell
invasion.
REFERENCE 3 (bases 1 to 7032)
AUTHORS Kim,M.G., Moon,J.S., Kim,E.J., Lee,S.H. and Oh,J.W.
TITLE Destabilization of PDK1 by Hsp90 inactivation suppresses hepatitis
C virus replication through inhibition of PRK2-mediated viral RNA
polymerase phosphorylation
JOURNAL Biochem. Biophys. Res. Commun. 421 (1), 112-118 (2012)
PUBMED 22490666
REMARK GeneRIF: these findings suggest that Hsp90 plays a critical role in
the regulation of HCV RNA polymerase phosphorylation via the
PDK1-PRK2 signaling pathway.
REFERENCE 4 (bases 1 to 7032)
AUTHORS Kikani,C.K., Verona,E.V., Ryu,J., Shen,Y., Ye,Q., Zheng,L.,
Qian,Z., Sakaue,H., Nakamura,K., Du,J., Ji,Q., Ogawa,W., Sun,L.Z.,
Dong,L.Q. and Liu,F.
TITLE Proliferative and antiapoptotic signaling stimulated by
nuclear-localized PDK1 results in oncogenesis
JOURNAL Sci Signal 5 (249), RA80 (2012)
PUBMED 23131847
REMARK GeneRIF: cytoplasmic localization of PDK1 correlated only with
early-stage, low-risk tumors, whereas nuclear PDK1 localization
correlated with high-risk tumors
Publication Status: Online-Only
REFERENCE 5 (bases 1 to 7032)
AUTHORS Yu,J., Chen,K.S., Li,Y.N., Yang,J. and Zhao,L.
TITLE Silencing of PDK1 gene expression by RNA interference suppresses
growth of esophageal cancer
JOURNAL Asian Pac. J. Cancer Prev. 13 (8), 4147-4151 (2012)
PUBMED 23098536
REMARK GeneRIF: High 3-phosphoinositide-dependent protein kinase 1 is
associated with esophageal cancer.
REFERENCE 6 (bases 1 to 7032)
AUTHORS Meier,R., Alessi,D.R., Cron,P., Andjelkovic,M. and Hemmings,B.A.
TITLE Mitogenic activation, phosphorylation, and nuclear translocation of
protein kinase Bbeta
JOURNAL J. Biol. Chem. 272 (48), 30491-30497 (1997)
PUBMED 9374542
REFERENCE 7 (bases 1 to 7032)
AUTHORS Shaw,M., Cohen,P. and Alessi,D.R.
TITLE Further evidence that the inhibition of glycogen synthase
kinase-3beta by IGF-1 is mediated by PDK1/PKB-induced
phosphorylation of Ser-9 and not by dephosphorylation of Tyr-216
JOURNAL FEBS Lett. 416 (3), 307-311 (1997)
PUBMED 9373175
REFERENCE 8 (bases 1 to 7032)
AUTHORS Alessi,D.R., Deak,M., Casamayor,A., Caudwell,F.B., Morrice,N.,
Norman,D.G., Gaffney,P., Reese,C.B., MacDougall,C.N., Harbison,D.,
Ashworth,A. and Bownes,M.
TITLE 3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural
and functional homology with the Drosophila DSTPK61 kinase
JOURNAL Curr. Biol. 7 (10), 776-789 (1997)
PUBMED 9368760
REFERENCE 9 (bases 1 to 7032)
AUTHORS Moser,B.A., Dennis,P.B., Pullen,N., Pearson,R.B., Williamson,N.A.,
Wettenhall,R.E., Kozma,S.C. and Thomas,G.
TITLE Dual requirement for a newly identified phosphorylation site in
p70s6k
JOURNAL Mol. Cell. Biol. 17 (9), 5648-5655 (1997)
PUBMED 9271440
REFERENCE 10 (bases 1 to 7032)
AUTHORS Alessi,D.R., James,S.R., Downes,C.P., Holmes,A.B., Gaffney,P.R.,
Reese,C.B. and Cohen,P.
TITLE Characterization of a 3-phosphoinositide-dependent protein kinase
which phosphorylates and activates protein kinase Balpha
JOURNAL Curr. Biol. 7 (4), 261-269 (1997)
PUBMED 9094314
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AC093525.3, AB209835.1 and AC141586.2.
Transcript Variant: This variant (3) lacks two consecutive exons in
the 3' coding region, which results in a frameshift, compared to
variant 1. The encoded isoform (3) is shorter and has a distinct
C-terminus, compared to isoform 1.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AB209835.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-33 AC093525.3 55244-55276 c
34-1750 AB209835.1 1-1717
1751-7032 AC141586.2 62525-67806 c
FEATURES Location/Qualifiers
source 1..7032
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="16"
/map="16p13.3"
gene 1..7032
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/note="3-phosphoinositide dependent protein kinase-1"
/db_xref="GeneID:5170"
/db_xref="HGNC:8816"
/db_xref="MIM:605213"
exon 1..173
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/inference="alignment:Splign:1.39.8"
variation 30
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="t"
/db_xref="dbSNP:191389305"
CDS 150..1514
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/EC_number="2.7.11.1"
/note="isoform 3 is encoded by transcript variant 3;
PkB-like 1; PkB kinase like gene 1"
/codon_start=1
/product="3-phosphoinositide-dependent protein kinase 1
isoform 3"
/protein_id="NP_001248745.1"
/db_xref="GI:387849239"
/db_xref="CCDS:CCDS58411.1"
/db_xref="GeneID:5170"
/db_xref="HGNC:8816"
/db_xref="MIM:605213"
/translation="
MARTTSQLYDAVPIQSSVVLCSCPSPSMVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPKLTAYLPAMSEDDEDCYGNYDNLLSQFGCMQVSSSSSSHSLSASDTGLPQRSGSNIEQYIHDLDSNSFELDLQFSEDEKRLLLEKQAGGNPCLTGRII
"
misc_feature 174..176
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphotyrosine, by SRC and INSR; propagated from
UniProtKB/Swiss-Prot (O15530.1); phosphorylation site"
misc_feature 222..224
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(O15530.1); phosphorylation site"
misc_feature 387..1175
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/note="Catalytic domain of the Protein Serine/Threonine
Kinase, Phosphoinositide-dependent kinase 1; Region:
STKc_PDK1; cd05581"
/db_xref="CDD:173672"
misc_feature 393..1175
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/note="Serine/Threonine protein kinases, catalytic domain;
Region: S_TKc; smart00220"
/db_xref="CDD:197582"
misc_feature order(411..425,435..437,474..476,480..482,576..578,
624..629,633..635,645..647,651..653,762..764,768..770,
774..779,783..785,813..818,825..827,873..890,969..971,
987..989,996..998)
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/note="active site"
/db_xref="CDD:173672"
misc_feature order(411..422,429..431,435..437,474..476,480..482,
537..539,576..578,624..635,642..647,774..779,783..785,
813..818)
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:173672"
misc_feature order(423..425,645..647,651..653,762..764,768..770,
774..776,825..827,873..890,969..971,987..989,996..998)
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/note="substrate binding site [chemical binding]; other
site"
/db_xref="CDD:173672"
misc_feature order(813..845,864..890)
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/note="activation loop (A-loop); other site"
/db_xref="CDD:173672"
misc_feature 870..872
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by autocatalysis; propagated from
UniProtKB/Swiss-Prot (O15530.1); phosphorylation site"
misc_feature 1209..1211
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine, by MELK; propagated from
UniProtKB/Swiss-Prot (O15530.1); phosphorylation site"
misc_feature 1266..1268
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphotyrosine, by SRC and INSR; propagated from
UniProtKB/Swiss-Prot (O15530.1); phosphorylation site"
misc_feature 1275..1277
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphotyrosine, by SRC and INSR; propagated from
UniProtKB/Swiss-Prot (O15530.1); phosphorylation site"
misc_feature 1326..1328
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(O15530.1); phosphorylation site"
misc_feature 1329..1331
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by MAP3K5; propagated from
UniProtKB/Swiss-Prot (O15530.1); phosphorylation site"
misc_feature 1335..1337
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(O15530.1); phosphorylation site"
misc_feature 1341..1343
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by MAP3K5; propagated from
UniProtKB/Swiss-Prot (O15530.1); phosphorylation site"
misc_feature 1377..1379
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(O15530.1); phosphorylation site"
exon 174..434
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/inference="alignment:Splign:1.39.8"
variation 198
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="t"
/db_xref="dbSNP:76505791"
variation 200
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:61747742"
variation 200
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:200979773"
variation 247
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:61747743"
variation 271
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:55824600"
variation 362
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:79145795"
variation 380
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:372064092"
variation 410
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:758319"
variation 410
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:369990948"
variation 431
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="c"
/db_xref="dbSNP:146388630"
exon 435..477
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/inference="alignment:Splign:1.39.8"
exon 478..615
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/inference="alignment:Splign:1.39.8"
exon 616..760
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/inference="alignment:Splign:1.39.8"
variation 656
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:3743978"
variation 677
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:2041206"
variation 694
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:79495278"
variation 716
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:1056871"
variation 741
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:77608557"
variation 742
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:79032757"
exon 761..858
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/inference="alignment:Splign:1.39.8"
exon 859..934
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/inference="alignment:Splign:1.39.8"
variation 894
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:370069297"
variation 903
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:373278831"
variation 905
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:139543796"
variation 913
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:144186731"
variation 923
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:200735205"
exon 935..1003
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/inference="alignment:Splign:1.39.8"
exon 1004..1100
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/inference="alignment:Splign:1.39.8"
exon 1101..1274
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/inference="alignment:Splign:1.39.8"
exon 1275..1492
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/inference="alignment:Splign:1.39.8"
variation 1309
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:370279457"
variation 1319
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="g"
/db_xref="dbSNP:377095764"
variation 1327
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="g"
/db_xref="dbSNP:200076126"
variation 1342
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:370494924"
variation 1353
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:76887737"
variation 1354
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:75824263"
variation 1355
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:75077217"
variation 1357
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:139732994"
variation 1359
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:201780963"
variation 1381
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:149931764"
variation 1434
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="g"
/db_xref="dbSNP:145034828"
variation 1448
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:145594574"
variation 1456
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:374111988"
variation 1467
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="g"
/replace="t"
/db_xref="dbSNP:142153837"
exon 1493..7032
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/inference="alignment:Splign:1.39.8"
STS 1493..2352
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/standard_name="PDPK1_7852"
/db_xref="UniSTS:471709"
variation 1525
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:147843249"
variation 1531
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:141143951"
variation 1547
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="c"
/db_xref="dbSNP:143425561"
variation 1575
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:148008907"
variation 1594
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:201375554"
variation 1597
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:201646295"
variation 1598
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:201983709"
variation 1610
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:141708903"
variation 1620
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:371050359"
variation 1624
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:375625632"
variation 1660
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:368140738"
variation 1661
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:111905533"
variation 1662
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="g"
/replace="t"
/db_xref="dbSNP:374100568"
variation 1717
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:10866"
variation 1754
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:3087784"
variation 1794
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:375635017"
variation 1885
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="g"
/db_xref="dbSNP:148121766"
variation 1905
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:140982354"
variation 1911
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:13335284"
variation 1912
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:369818229"
variation 1915
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:374470586"
variation 1947
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="g"
/replace="t"
/db_xref="dbSNP:371038846"
variation 2018
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="g"
/replace="t"
/db_xref="dbSNP:189787811"
variation 2089..2090
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace=""
/replace="cgggggccgcagctttgtgg"
/db_xref="dbSNP:374612917"
variation 2104
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="g"
/replace="t"
/db_xref="dbSNP:181078294"
variation 2114
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:113332295"
variation 2149
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="c"
/db_xref="dbSNP:375417064"
variation 2236
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:185952911"
variation 2341
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="g"
/db_xref="dbSNP:79745244"
variation 2397
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:138049982"
variation 2492
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="g"
/replace="t"
/db_xref="dbSNP:71386677"
variation 2496
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="g"
/db_xref="dbSNP:142512073"
variation 2609
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:190327635"
variation 2654
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:78560075"
variation 2675
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:138756291"
variation 2759
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:76291069"
variation 2774
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:74003037"
variation 2817
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:144433575"
variation 2861
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:376035884"
variation 2881
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:148393103"
variation 2882
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:141692563"
variation 2897
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="g"
/replace="t"
/db_xref="dbSNP:147153606"
variation 2908
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:183283033"
variation 2995
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:28679688"
variation 3084..3086
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace=""
/replace="tgc"
/db_xref="dbSNP:149315179"
variation 3250
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:370396602"
variation 3262
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:367998725"
variation 3315
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="g"
/db_xref="dbSNP:373772013"
variation 3318
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="g"
/db_xref="dbSNP:372067195"
variation 3416
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:4786296"
variation 3509
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="g"
/replace="t"
/db_xref="dbSNP:4786297"
variation 3563
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:147975625"
variation 3585..3599
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace=""
/replace="gtcctgtgtctccat"
/db_xref="dbSNP:370970044"
variation 3587..3601
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace=""
/replace="cctgtgtctccatgt"
/db_xref="dbSNP:11268185"
variation 3633
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:187363186"
variation 3645
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="g"
/db_xref="dbSNP:28457160"
variation 3677
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="g"
/replace="t"
/db_xref="dbSNP:113716221"
variation 3708
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:190975527"
variation 3798
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:113054936"
variation 3829
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:3112701"
variation 3829
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:28615548"
variation 3857
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:372950862"
variation 3891..3897
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace=""
/replace="cagcccc"
/db_xref="dbSNP:71148147"
variation 3919
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:149131034"
variation 3987
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="g"
/db_xref="dbSNP:71386681"
variation 3987
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="g"
/db_xref="dbSNP:78765961"
variation 4100..4101
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace=""
/replace="a"
/db_xref="dbSNP:199508475"
variation 4111
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:2108863"
variation 4207
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:147659496"
STS 4532..4638
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/standard_name="D16S426E"
/db_xref="UniSTS:147333"
variation 4926
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:182763560"
variation 5036
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:187478880"
variation 5057
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="g"
/db_xref="dbSNP:112319026"
variation 5060
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="c"
/db_xref="dbSNP:191845035"
variation 5065
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:144753105"
variation 5118
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:182493826"
variation 5214
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:11554593"
variation 5278
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:112703875"
variation 5356
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="c"
/db_xref="dbSNP:373860725"
variation 5450
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="c"
/db_xref="dbSNP:367757589"
variation 5459
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:371321013"
variation 5471
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="g"
/replace="t"
/db_xref="dbSNP:368594243"
variation 5544..5549
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace=""
/replace="gtgggg"
/db_xref="dbSNP:33994421"
variation 5649
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace=""
/replace="c"
/db_xref="dbSNP:376887169"
variation 5655
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="g"
/db_xref="dbSNP:56318884"
variation 5695
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:2335110"
variation 5775
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:187543589"
variation 5800
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:2335111"
variation 5802
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:137906061"
variation 5880..5881
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace=""
/replace="cc"
/db_xref="dbSNP:71776175"
variation 5916
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="g"
/db_xref="dbSNP:3095103"
variation 5940
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:369381082"
variation 5995
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:376666016"
variation 6014
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:185737005"
variation 6024
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="c"
/db_xref="dbSNP:190542981"
variation 6062..6063
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace=""
/replace="a"
/db_xref="dbSNP:200815032"
variation 6092
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:200359888"
variation 6146
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="g"
/db_xref="dbSNP:368831914"
variation 6280
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:371727709"
variation 6281
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:929457"
variation 6317
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:201156361"
variation 6382
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:184540154"
variation 6383
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="t"
/db_xref="dbSNP:189062814"
variation 6441..6444
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace=""
/replace="gtaa"
/db_xref="dbSNP:5815128"
variation 6444..6447
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace=""
/replace="agta"
/db_xref="dbSNP:3030674"
variation 6518
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:375159135"
STS 6554..6718
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/standard_name="RH78462"
/db_xref="UniSTS:48236"
variation 6732..6733
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace=""
/replace="tg"
/db_xref="dbSNP:201869822"
variation 6861
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:11554591"
variation 6930..6931
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace=""
/replace="tt"
/db_xref="dbSNP:111618468"
variation 6931..6932
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace=""
/replace="tt"
/db_xref="dbSNP:71726088"
variation 6932
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:11554592"
variation 6937
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:181213412"
variation 6941..6942
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace=""
/replace="tc"
/db_xref="dbSNP:201698119"
variation 6961
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="g"
/db_xref="dbSNP:185318792"
variation 6985
/gene="PDPK1"
/gene_synonym="PDK1; PDPK2; PRO0461"
/replace="a"
/replace="t"
/db_xref="dbSNP:189105574"
ORIGIN
gcggcgccgggggcggggggcggcgggcgacggggcgggcgcaggatgagggcggccattgctggggctccgcttcggggaggaggacgctgaggaggcgccgagccgcgcagcgctgcgggggaggcgcccgcgccgacgcggggcccatggccaggaccaccagccagctgtatgacgccgtgcccatccagtccagcgtggtgttatgttcctgcccatccccatcaatggtgaggacccagactgagtccagcacgccccctggcattcctggtggcagcaggcagggccccgccatggacggcactgcagccgagcctcggcccggcgccggctccctgcagcatgcccagcctccgccgcagcctcggaagaagcggcctgaggacttcaagtttgggaaaatccttggggaaggctctttttccacggttgtcctggctcgagaactggcaacctccagagaatatgcgattaaaattctggagaagcgacatatcataaaagagaacaaggtcccctatgtaaccagagagcgggatgtcatgtcgcgcctggatcaccccttctttgttaagctttacttcacatttcaggacgacgagaagctgtatttcggccttagttatgccaaaaatggagaactacttaaatatattcgcaaaatcggttcattcgatgagacctgtacccgattttacacggctgagattgtgtctgctttagagtacttgcacggcaagggcatcattcacagggaccttaaaccggaaaacattttgttaaatgaagatatgcacatccagatcacagattttggaacagcaaaagtcttatccccagagagcaaacaagccagggccaactcattcgtgggaacagcgcagtacgtttctccagagctgctcacggagaagtccgcctgtaagagttcagacctttgggctcttggatgcataatataccagcttgtggcaggactcccaccattccgagctggaaacgagtatcttatatttcagaagatcattaagttggaatatgactttccagaaaaattcttccctaaggcaagagacctcgtggagaaacttttggttttagatgccacaaagcggttaggctgtgaggaaatggaaggatacggacctcttaaagcacacccgttcttcgagtccgtcacgtgggagaacctgcaccagcagacgcctccgaagctcaccgcttacctgccggctatgtcggaagacgacgaggactgctatggcaattatgacaatctcctgagccagtttggctgcatgcaggtgtcttcgtcctcctcctcacactccctgtcagcctccgacacgggcctgccccagaggtcaggcagcaacatagagcagtacattcacgatctggactcgaactcctttgaactggacttacagttttccgaagatgagaagaggttgttgttggagaagcaggctggcggaaacccttgcctaacaggacgtattatctgatggaccccagcgggaacgcacacaagtggtgcaggaagatccaggaggtttggaggcagcgataccagagccacccggacgccgctgtgcagtgacgtggcctgcggccgggctgcccttcgctgccaggacacctgccccagcgcggcttggccgccatccgggacgcttccagaccacctgccagccatcacaaggggaacgcagaggcggaaaccttgcagcatttttatttaaaagaaaagaagaaaaaaaacacccaaccacacaaagaacaaaaccagtaacaaacacaaaggaattcagggtcgctttgcttgctctctgtgctccgtggaggcctccgtgtgccctcgttgccgtggggacccagctccatgcacgtcaacccagtcccgcccagactagtggacagacctggtgtcaccagtttttcctagcatcagtccgaaccatgcgcccgccctgccccaactgtgtgctggtcctgctgtggccgaggggaccgggtgtgtttggctctttatgcccctcccgctgtggtcctggaactcttcaccagggagggagccctgcgggggccgcagctttgtggagggagccgccgtgcttctgtcacctgctccctttcttgcgtctccctgtgatgggcccttaggcctggctgggcccattacatatccctgtggtggctctggtggcagctttctgtggcccctgctgtgttggcaggcaggtttgcgtggtgaggagcgggaggggttggagtggtgcgggagcaggctgccgagtggagggtgccatcgagggctccggatcccttatcctacttagcagtgttggtctctggggctggaagccgagcgcatgctgggagcggtactgtcagaagtgagcccagttagtaccccgctggctcactgcacgagagagtcctgccccgagccctaggtggggccaggaggtgccttggagaagccagccagagcagagagggctgctgacttccgtgtggagcagagaggcctgagggcctcctaaaaggtttaaatgtccacgcctctccagttgctgaagtagggtctgagagaaccctggcatcagcagacccagggtgcttctgtctcctgcagaccacgccagggagtgcagacaccaccgtcacacacgccccttttgtgttttggttcaagtttctcagagcccctcagagcttctacatctgtgcatcagaaatctcacagccttctcatgctgccggctcatctgggcccatagagtgggctttgccagttgctgttgcacaggaggcgagaacagcacacttcaaccccagcttgctggtcggctttcctctagagagagccggttttggggccatttccctttgatgctttggtggccttgccccgctctgcagcacagacaggccagatgcatttgtcctttgcctagctactccccaggtagagagtgctcctggtggcctggcaggtctgggcccttctctccctgcccaggttgtccctggagggcagccctcactccctttgggggagaggcagacattgctgcccacagacctgcctctgactcaactgtgtccaccctccctggtccctacccccaagtcacaggtgactcagcagtgaccctgtgtgccaggccagatccaaactgagagggaaggtgtcgtttttacactgctaatgacgagagtggctctttttagctaggcgagtacagacggggcctgggagggggcagagatgttccccaggccctgcctgtggttcctgcctgggccttggctgctgctgtgtgagagctgcatgtgagcctgtgaccgtgagctggggtgagctgggccgcacctaccctggggccccagggagcaggacgctccggggcccagcacgttgccctgggcctgtggccggagtcggagtcctctctcctcctcctggcttttggaaaggcttggctgtgttggggagtctctcttagccctttcaggaatttctgttcaggcttcctcctcctcatcagctattttacccatctcagaacgtcctgtgtctccatgtaggagagtggctctctcagatctctcagggcgtctggttatagggaaacaagtggagcagggacgtggctttaattggagcactcggctgggctgcttggggagactcttccgtgcgttcttcctctggatagaaccaccacctcctgggcgtcactgacaagctccatcttaacctccaaagccacagaactaggggctcagagccagagctggcagccgccagccaaaatgatgccattgcctgagctgacagccaagcccttctgtgggtcacctttctcctcacccagccccttgctcttcccttttgaaaggcccgtgtgttttctttccttaccctgtgcttgctcatgtctactccggttttctctaccacatccttagagccatcacctggcacgcaggcgccttacattctacggtagaacgtggggtactgtgtgtgcacatagacacacttacgtggaattacagttgtgggtttatccaagatgaggaagatttcacctgctgtttaatagacttggggccatgtgcctccccacacatgggcaaggacaggtggaatgtcgggaccacactgtgcggcttctcggcacaaagcggagggaggctgtggtcgctgccggcctaggtgtcccaggtgccccgcctttctctgggacacagttgggggctggcttctgagggattcctttctcccctctttgtgtggccccagccagggcggtgggcagtcctggtgtagagcacaagcctctccaccctagagaaatgcctctgtaccacggctaccatgtggaaccttaacttgcagaaggcttgttaacaattgttttgagagagatggctggtcatgccacagctgctggggactccgcctactccagccctcttgggacacactgtgggatttgtggcccttccccagaggaattgtggagactgtcccatggaacaaaccctcaggcaccagcacagggctctgggtgactcagtaaaactaacgtttgtctctgacaagatcagctgtaggctcaccggccagagaagaccactgtgagcattttgccgtatatcctgccctgccatttgttcactttttaaactaaaataggaacatccgacacacaccgtttgcatcgtcttctcccttgatattttaagcattttcccatgtcatgagtttctcagaaacatgtttttaacaattgtactatttagtcattgtccatttactataatttatctgaccatttccctactgtaaaatacttaagacggtttctgatttttccactatttaaataatgctgtgatgaatatctttaaaatcttctgatttcttacttttttcccccttagatgcctggaagtggtattttgaggtgaaagagtttgttcattttgaagatatttctgtctctctctcgacctgatgtgtagacgctcacttccagtagcagaaccaccttagttgtgtcttacagattctgaacaaatcggtttctgataagccatgtgttccaaagaatgtctgaataagaccgctctttatttaaatgctaagaggatgtcactactgcaatccatctgtggccgattttttccaagagccaatttccttgttttggttgcaagaacctggctctgcctgcatgtcagctctctgccctccctgctgccgtggctttcaagcgcttggcagaatcttgtacttcgtgtccacaatggtactgaatttgcatctgcacagtcagcagagataacaagtgttgaactgaccttgccacatgcttagtgagtgatttgtaattaagtttatagactcagaaggtatattaggacatttggaatcagtagcagagcaaagcctctttgaaaaaaaccacgtagctgattgggttttacaagagtgcatttgtctcccccttccacccgtggggccccaccttcaggtcttagtggttcacaagagcccagcagccaggctggctttttcattgtagggcgtggttgtcccagctggtgtagatttcaggccgccccccccaactccctgcccacagtgttgcagattgcctggctggcagcaagtccagaccacccaaatttggttggattcttcatttctccactgtagttggggtccattgattgtgcaggggaacgtgcaggaggtttttctaggcaccgtgttcagtgctgcttcactctaccagagattatggccaaattgcacggaatttggtttcttgccctctgaagcctgagggcccccccttgcctggctggttgacagacccggggtggtcactgctgagacttcagagatcgcagctgctgtgagaatacggtgaaggtactttgttctggaagatgttgtcatacacttttccccagttattttcaaacttgacatgagcctatgttgactcactgggtgggggtcccttcttacgcagcacacgtggcaagtgcctgaatcggggctggaggcacttcagagcctctgaggggccaccacttctggcccaaaattgcagggttgtagatgaggctgcctgtggagaactggtgtgaggaggaagctgtttccaacaaagagcactttcatctgttgagatggctgtggtgagcaactgaacgagcctacgtgtgtacctgaattttccccgtaactcatttcttccatatgaagaaacaccaaactatgtacagagaactttttacaaaaggcagaccttttttaagctgtgtaacccacatagcctaaccacctggcagaatgactacgaataggggtcattgtgctggtaaaagcctctattacgactgtaagtaagttggatgttggcaaaattaaattgttacagtatttagagctgctgtagctgttccttcacaacataaaataggataaatgactagtacgtctttcaggtgggtggcaagcagaacatgcgtaatattctctacctggtctgtagctgtaactgtgatgtacagacaaagcaaaaattaaaagaacttatgaaaacaaatgcaatgatactaggatatacacttttgtatttttattcttatataaggttatttgctggctattgttggcctctagttcagtctgtgttatttaaattctaatatatgaattatttgaattgaattcatgttcggggccacgttgttgtatgtattgatgtacagccttgaatgtgaataattattgtaaactatattttacaactttttttctggctttattatataaattttctattgggtcagtgatttaatcatataatttaatgaatctgtttatcctttttttttttccaaatacttgtgctttaggtgtagttaccagatgatgaattttcctcgtatggtcagtagtcttgtaataaaaagcatgtagagtgtaga
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:5170 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IDA
GeneID:5170 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IEA
GeneID:5170 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: TAS
GeneID:5170 -> Molecular function: GO:0004676 [3-phosphoinositide-dependent protein kinase activity] evidence: IDA
GeneID:5170 -> Molecular function: GO:0005158 [insulin receptor binding] evidence: IEA
GeneID:5170 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:5170 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:5170 -> Molecular function: GO:0016301 [kinase activity] evidence: EXP
GeneID:5170 -> Molecular function: GO:0019901 [protein kinase binding] evidence: IEA
GeneID:5170 -> Biological process: GO:0003323 [type B pancreatic cell development] evidence: IEA
GeneID:5170 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
GeneID:5170 -> Biological process: GO:0006355 [regulation of transcription, DNA-dependent] evidence: IEA
GeneID:5170 -> Biological process: GO:0006468 [protein phosphorylation] evidence: IDA
GeneID:5170 -> Biological process: GO:0006469 [negative regulation of protein kinase activity] evidence: IDA
GeneID:5170 -> Biological process: GO:0006972 [hyperosmotic response] evidence: IEA
GeneID:5170 -> Biological process: GO:0007173 [epidermal growth factor receptor signaling pathway] evidence: TAS
GeneID:5170 -> Biological process: GO:0007268 [synaptic transmission] evidence: TAS
GeneID:5170 -> Biological process: GO:0007596 [blood coagulation] evidence: TAS
GeneID:5170 -> Biological process: GO:0008286 [insulin receptor signaling pathway] evidence: TAS
GeneID:5170 -> Biological process: GO:0008543 [fibroblast growth factor receptor signaling pathway] evidence: TAS
GeneID:5170 -> Biological process: GO:0010594 [regulation of endothelial cell migration] evidence: IEA
GeneID:5170 -> Biological process: GO:0010667 [negative regulation of cardiac muscle cell apoptotic process] evidence: IEA
GeneID:5170 -> Biological process: GO:0018107 [peptidyl-threonine phosphorylation] evidence: IDA
GeneID:5170 -> Biological process: GO:0030036 [actin cytoskeleton organization] evidence: TAS
GeneID:5170 -> Biological process: GO:0030168 [platelet activation] evidence: TAS
GeneID:5170 -> Biological process: GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway] evidence: IDA
GeneID:5170 -> Biological process: GO:0031295 [T cell costimulation] evidence: TAS
GeneID:5170 -> Biological process: GO:0032148 [activation of protein kinase B activity] evidence: IDA
GeneID:5170 -> Biological process: GO:0032869 [cellular response to insulin stimulus] evidence: IMP
GeneID:5170 -> Biological process: GO:0034122 [negative regulation of toll-like receptor signaling pathway] evidence: IEA
GeneID:5170 -> Biological process: GO:0035556 [intracellular signal transduction] evidence: IDA
GeneID:5170 -> Biological process: GO:0038095 [Fc-epsilon receptor signaling pathway] evidence: TAS
GeneID:5170 -> Biological process: GO:0043122 [regulation of I-kappaB kinase/NF-kappaB cascade] evidence: IMP
GeneID:5170 -> Biological process: GO:0043304 [regulation of mast cell degranulation] evidence: IEA
GeneID:5170 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
GeneID:5170 -> Biological process: GO:0046777 [protein autophosphorylation] evidence: TAS
GeneID:5170 -> Biological process: GO:0048011 [neurotrophin TRK receptor signaling pathway] evidence: TAS
GeneID:5170 -> Biological process: GO:0048015 [phosphatidylinositol-mediated signaling] evidence: TAS
GeneID:5170 -> Biological process: GO:0048041 [focal adhesion assembly] evidence: IEA
GeneID:5170 -> Biological process: GO:0050852 [T cell receptor signaling pathway] evidence: TAS
GeneID:5170 -> Biological process: GO:0090004 [positive regulation of establishment of protein localization to plasma membrane] evidence: IMP
GeneID:5170 -> Biological process: GO:0097191 [extrinsic apoptotic signaling pathway] evidence: IMP
GeneID:5170 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
GeneID:5170 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:5170 -> Cellular component: GO:0005737 [cytoplasm] evidence: IEA
GeneID:5170 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:5170 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA
GeneID:5170 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
GeneID:5170 -> Cellular component: GO:0005925 [focal adhesion] evidence: IEA
GeneID:5170 -> Cellular component: GO:0016020 [membrane] evidence: IEA
GeneID:5170 -> Cellular component: GO:0016023 [cytoplasmic membrane-bounded vesicle] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_001248745 -> EC 2.7.11.1
by
@meso_cacase at
DBCLS
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