2025-05-09 19:55:46, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001260494 4123 bp mRNA linear PRI 07-JUL-2013 DEFINITION Homo sapiens radixin (RDX), transcript variant 4, mRNA. ACCESSION NM_001260494 VERSION NM_001260494.1 GI:386781586 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 4123) AUTHORS Titushkin,I., Sun,S., Paul,A. and Cho,M. TITLE Control of adipogenesis by ezrin, radixin and moesin-dependent biomechanics remodeling JOURNAL J Biomech 46 (3), 521-526 (2013) PUBMED 23116763 REMARK GeneRIF: Control of adipogenesis by ezrin, radixin and moesin-dependent biomechanics remodeling. REFERENCE 2 (bases 1 to 4123) AUTHORS Zhang,L., Xiao,R., Xiong,J., Leng,J., Ehtisham,A., Hu,Y., Ding,Q., Xu,H., Liu,S., Wang,J., Tang,D.G. and Zhang,Q. TITLE Activated ERM protein plays a critical role in drug resistance of MOLT4 cells induced by CCL25 JOURNAL PLoS ONE 8 (1), E52384 (2013) PUBMED 23326330 REMARK GeneRIF: Data suggest that P-glycoprotein associate with the F-actin cytoskeleton through ezrin/radixin/moesin (ERM) in CCR9/CCL25 induced multidrug resistance of acute T-lymphocytic leukemia (T-ALL) cells. REFERENCE 3 (bases 1 to 4123) AUTHORS Darmellah,A., Rayah,A., Auger,R., Cuif,M.H., Prigent,M., Arpin,M., Alcover,A., Delarasse,C. and Kanellopoulos,J.M. TITLE Ezrin/radixin/moesin are required for the purinergic P2X7 receptor (P2X7R)-dependent processing of the amyloid precursor protein JOURNAL J. Biol. Chem. 287 (41), 34583-34595 (2012) PUBMED 22891241 REMARK GeneRIF: Ezrin/radixin/moesin are required for the purinergic P2X7 receptor (P2X7R)-dependent processing of the amyloid precursor protein. REFERENCE 4 (bases 1 to 4123) AUTHORS Perez-Cornejo,P., Gokhale,A., Duran,C., Cui,Y., Xiao,Q., Hartzell,H.C. and Faundez,V. TITLE Anoctamin 1 (Tmem16A) Ca2+-activated chloride channel stoichiometrically interacts with an ezrin-radixin-moesin network JOURNAL Proc. Natl. Acad. Sci. U.S.A. 109 (26), 10376-10381 (2012) PUBMED 22685202 REMARK GeneRIF: Ano1, ezrin, and moesin/radixin colocalize apically in salivary gland epithelial cells, and overexpression of moesin and Ano1 in HEK cells alters the subcellular localization of both proteins REFERENCE 5 (bases 1 to 4123) AUTHORS Chen,S.D., Song,M.M., Zhong,Z.Q., Li,N., Wang,P.L., Cheng,S., Bai,R.X. and Yuan,H.S. TITLE Knockdown of radixin by RNA interference suppresses the growth of human pancreatic cancer cells in vitro and in vivo JOURNAL Asian Pac. J. Cancer Prev. 13 (3), 753-759 (2012) PUBMED 22631643 REMARK GeneRIF: results suggest that radixin might play a critical role in pancreatic cancer progression, possibly through involvement of down-regulation of TSP-1 and E-cadherin expression. REFERENCE 6 (bases 1 to 4123) AUTHORS Takahashi,K., Sasaki,T., Mammoto,A., Takaishi,K., Kameyama,T., Tsukita,S. and Takai,Y. TITLE Direct interaction of the Rho GDP dissociation inhibitor with ezrin/radixin/moesin initiates the activation of the Rho small G protein JOURNAL J. Biol. Chem. 272 (37), 23371-23375 (1997) PUBMED 9287351 REFERENCE 7 (bases 1 to 4123) AUTHORS Stemmer-Rachamimov,A.O., Gonzalez-Agosti,C., Xu,L., Burwick,J.A., Beauchamp,R., Pinney,D., Louis,D.N. and Ramesh,V. TITLE Expression of NF2-encoded merlin and related ERM family proteins in the human central nervous system JOURNAL J. Neuropathol. Exp. Neurol. 56 (6), 735-742 (1997) PUBMED 9184664 REFERENCE 8 (bases 1 to 4123) AUTHORS Hirao,M., Sato,N., Kondo,T., Yonemura,S., Monden,M., Sasaki,T., Takai,Y., Tsukita,S. and Tsukita,S. TITLE Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway JOURNAL J. Cell Biol. 135 (1), 37-51 (1996) PUBMED 8858161 REFERENCE 9 (bases 1 to 4123) AUTHORS Wilgenbus,K.K., Milatovich,A., Francke,U. and Furthmayr,H. TITLE Molecular cloning, cDNA sequence, and chromosomal assignment of the human radixin gene and two dispersed pseudogenes JOURNAL Genomics 16 (1), 199-206 (1993) PUBMED 8486357 REFERENCE 10 (bases 1 to 4123) AUTHORS Sato,N., Funayama,N., Nagafuchi,A., Yonemura,S., Tsukita,S. and Tsukita,S. TITLE A gene family consisting of ezrin, radixin and moesin. Its specific localization at actin filament/plasma membrane association sites JOURNAL J. Cell. Sci. 103 (PT 1), 131-143 (1992) PUBMED 1429901 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DQ916738.1, AK316061.1, BC047109.1, AP000901.5 and N92548.1. Summary: Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. It is highly similar in sequence to both ezrin and moesin. The radixin gene has been localized by fluorescence in situ hybridization to 11q23. A truncated version representing a pseudogene (RDXP2) was assigned to Xp21.3. Another pseudogene that seemed to lack introns (RDXP1) was mapped to 11p by Southern and PCR analyses. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]. Transcript Variant: This variant (4) lacks two internal coding exons and differs in the 3' region, compared to variant 1. The resulting isoform (3) lacks an internal segment and has a shorter C-terminus, compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK316061.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025098 [ECO:0000348] ##Evidence-Data-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-98 DQ916738.1 1-98 99-1242 AK316061.1 1-1144 1243-2141 BC047109.1 1514-2412 2142-3741 AP000901.5 81593-83192 c 3742-4123 N92548.1 1-382 c FEATURES Location/Qualifiers source 1..4123 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="11" /map="11q23" gene 1..4123 /gene="RDX" /gene_synonym="DFNB24" /note="radixin" /db_xref="GeneID:5962" /db_xref="HGNC:9944" /db_xref="MIM:179410" exon 1..246 /gene="RDX" /gene_synonym="DFNB24" /inference="alignment:Splign:1.39.8" variation 182..183 /gene="RDX" /gene_synonym="DFNB24" /replace="" /replace="a" /db_xref="dbSNP:71053883" exon 247..322 /gene="RDX" /gene_synonym="DFNB24" /inference="alignment:Splign:1.39.8" exon 323..406 /gene="RDX" /gene_synonym="DFNB24" /inference="alignment:Splign:1.39.8" misc_feature 336..338 /gene="RDX" /gene_synonym="DFNB24" /note="upstream in-frame stop codon" CDS 348..1691 /gene="RDX" /gene_synonym="DFNB24" /note="isoform 3 is encoded by transcript variant 4" /codon_start=1 /product="radixin isoform 3" /protein_id="NP_001247423.1" /db_xref="GI:386781587" /db_xref="CCDS:CCDS58172.1" /db_xref="GeneID:5962" /db_xref="HGNC:9944" /db_xref="MIM:179410" /translation="
MLSWNLPFSPIQLANNFLTSVLEQHKLTKEQWEERIQNWHEEHRGMLREDSMMEYLKIAQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERAQLENEKKKREIAEKEKERIEREKEELMERLKQIEEQTIKAQKELEEQTRKALELDQERKRAKEEAERLEKERRAAEEAKSAIAKQAADQMKNQEQLAAELAEFTAKIALLEEAKKKKEEEATEWQHKAFAAQEDLEKTKEELKTVMSAPPPPPPPPVIPPTENEHDEHDENNAEASAELSNEGVMNHRSEEERVTETQKNERVKKQLQALSSELAQARDETKKTQNDVLHAENVKAGRDKYKTLRQIRQGNTKQRIDEFEAM
" misc_feature <411..557 /gene="RDX" /gene_synonym="DFNB24" /note="FERM central domain; Region: FERM_M; pfam00373" /db_xref="CDD:201187" misc_feature <429..557 /gene="RDX" /gene_synonym="DFNB24" /note="Band 4.1 homologues; Region: B41; smart00295" /db_xref="CDD:197635" misc_feature 537..815 /gene="RDX" /gene_synonym="DFNB24" /note="FERM_C domain; Region: FERM_C; cd00836" /db_xref="CDD:176273" misc_feature order(549..572,579..602,606..626,663..668,675..686, 699..719,735..749,774..800) /gene="RDX" /gene_synonym="DFNB24" /note="PH/PTB-like core; other site" /db_xref="CDD:176273" misc_feature order(672..674,678..683,687..695,717..719,780..782, 792..794,801..803,813..815) /gene="RDX" /gene_synonym="DFNB24" /note="peptide binding site [polypeptide binding]; other site" /db_xref="CDD:176273" misc_feature 771..773 /gene="RDX" /gene_synonym="DFNB24" /note="lipid binding site [chemical binding]; lipid-binding site" /db_xref="CDD:176273" misc_feature 996..1688 /gene="RDX" /gene_synonym="DFNB24" /note="Ezrin/radixin/moesin family; Region: ERM; pfam00769" /db_xref="CDD:109812" exon 407..490 /gene="RDX" /gene_synonym="DFNB24" /inference="alignment:Splign:1.39.8" STS 460..598 /gene="RDX" /gene_synonym="DFNB24" /standard_name="RDX" /db_xref="UniSTS:504078" exon 491..637 /gene="RDX" /gene_synonym="DFNB24" /inference="alignment:Splign:1.39.8" exon 638..734 /gene="RDX" /gene_synonym="DFNB24" /inference="alignment:Splign:1.39.8" exon 735..898 /gene="RDX" /gene_synonym="DFNB24" /inference="alignment:Splign:1.39.8" STS 862..1209 /gene="RDX" /gene_synonym="DFNB24" /standard_name="GDB:196850" /db_xref="UniSTS:155890" exon 899..1029 /gene="RDX" /gene_synonym="DFNB24" /inference="alignment:Splign:1.39.8" exon 1030..1190 /gene="RDX" /gene_synonym="DFNB24" /inference="alignment:Splign:1.39.8" exon 1191..1283 /gene="RDX" /gene_synonym="DFNB24" /inference="alignment:Splign:1.39.8" exon 1284..1526 /gene="RDX" /gene_synonym="DFNB24" /inference="alignment:Splign:1.39.8" exon 1527..4119 /gene="RDX" /gene_synonym="DFNB24" /inference="alignment:Splign:1.39.8" STS 1635..1852 /gene="RDX" /gene_synonym="DFNB24" /standard_name="RH27285" /db_xref="UniSTS:87492" STS 1704..1931 /gene="RDX" /gene_synonym="DFNB24" /standard_name="SHGC-12842" /db_xref="UniSTS:71604" variation 1807 /gene="RDX" /gene_synonym="DFNB24" /replace="a" /replace="g" /db_xref="dbSNP:11541502" STS 1815..2726 /gene="RDX" /gene_synonym="DFNB24" /standard_name="RDX_8589" /db_xref="UniSTS:467859" STS 2089..2258 /gene="RDX" /gene_synonym="DFNB24" /standard_name="RH27475" /db_xref="UniSTS:92376" STS 2285..2418 /gene="RDX" /gene_synonym="DFNB24" /standard_name="RH79199" /db_xref="UniSTS:13279" STS 2387..2501 /gene="RDX" /gene_synonym="DFNB24" /standard_name="RH27481" /db_xref="UniSTS:89807" STS 3890..4014 /gene="RDX" /gene_synonym="DFNB24" /standard_name="RH115" /db_xref="UniSTS:31005" polyA_signal 4091..4096 /gene="RDX" /gene_synonym="DFNB24" polyA_site 4119 /gene="RDX" /gene_synonym="DFNB24" ORIGIN
ttggcgctcagtccgcggcgcgaggacggccggccggcagggggaggcgggggggcgccgggcagccccgccttttcccgcggaggcgccgagcggccatattgcggagctgtctgcggtggcggcggcgcctctcgtctcccgcggcccagcgctcgcaccaccgcttctccctccctgtcgcagccgcgccgccgcgcagcgccccagccacacgccggcgggcagaagccgcccgctctccggaaagtgataacagaattcattgaagtggagaatttttaaagaaggtaacaaaaagagaaagaaaatgccgaaaccaatcaacgtaagagtaactacaatggatgctgagctggaatttgccattcagcccaatacaactggcaaacaactttttgaccagtgtattggaacaacacaaactaacaaaagaacagtgggaagaaagaatacagaactggcatgaagaacatagaggaatgttaagggaggattctatgatggaatacctgaagattgcacaagatctagaaatgtatggagtcaactattttgaaataaaaaataaaaaaggaactgaattgtggctaggtgttgatgctttgggtctgaatatttatgagcatgacgacaagttaacacctaaaattggttttccctggagtgaaatcagaaatatttcatttaatgacaaaaaatttgttataaagccaatcgacaaaaaggcacctgattttgtgttttatgcacctcgtctgagaatcaataagcggattttggccttatgtatgggaaaccatgaactatacatgcgaagaaggaagcctgatactattgaagtacaacagatgaaggctcaggctagggaggagaaacatcagaagcagttggaaagggcacaattagagaatgaaaagaagaaaagagaaatagcagaaaaggaaaaggaaagaatagaacgtgaaaaggaagagctaatggaacgtctaaaacaaattgaagagcagacaattaaagctcagaaagaactagaagaacagactcgaaaagctctagaactggatcaagaacgaaaacgagcaaaagaagaagcagaacgacttgaaaaggagcgtcgagctgctgaagaggcaaagtctgccatagcaaaacaagctgccgaccagatgaagaatcaggagcagctagcagcagaacttgctgaattcactgccaagattgcacttctagaggaagccaagaagaaaaaggaagaggaagctactgagtggcaacacaaagcttttgcagcccaggaagacttggaaaagaccaaagaagagttaaaaactgtgatgtctgccccccctccacctccaccaccaccagtcattcctccaacagaaaacgaacatgatgaacacgatgagaataatgctgaagctagtgctgaattatcaaatgaaggggtaatgaaccatagaagcgaggaagaacgtgtaaccgaaacacagaaaaatgagcgtgttaagaagcaacttcaggcattaagttcagaattagcccaagccagagatgaaaccaagaaaacacaaaatgatgttcttcatgctgagaatgttaaagcaggccgtgataagtacaagactctgcgacagattcgacaaggcaatacaaagcagcgtatcgatgagtttgaagcaatgtgagagctgttattttgcatatatgttcttcataagctgaaccaccaacagagaaaagcaggcctttgcagatatgatggaatgcatcccaccttgccaaagcacttacaccagtttgactgtgctagctaaaagacaaatttaaggggagctcttcaacattaaggcagtatgatatcatgcttggttttcttttttcttttggtccagggaatggagaatggtgttccattgcctcttttcacattttttttctttttcttttttttttctgttgaagattaacactaattatcacgtctgacaaatgtgtatgtgtggtttcagttctgtgtacattttaaaggataatggtgaacattttaatgggtttcccttgccctttccatatttaacctatttccacattctctctcactcacattttctcagtgtgcccttctcttatctgccatgtccatagccataattccaccatcatacagatcaggcagtgtttaaaatgatggtaggtagcacagtggacagtctttgatcatcatgtagaatatggctatgaatcaggaaagagattagaacatttaataatgtatgtacagctggtgcttagtttttttttaatctaaatttaattaccttattggatatttgatatttggttatttaatcacagtcatctttaacagcttacactgattggtgttttatctcctgtgatcctttgatggctttttttgcctaccatttcacagaggtttagacagcagtagtagctccctaggagagtttactgatgaaacagcctctgcaagattttaaaagttttgttcttttatagactgatttagaaaaacaaatgattagttaaaaaaagaaaatatacatttgttggtaactaatgttattttttaaaacctggaccttttctggaagggcagcatataaaaacatcagtcccgaggaggggacaacaatactacctcactactacatctgtgatgactggttgttcaaacacaatggagtgtgtaaggtatatgttttataattcataaccatagcctcgatcatcaagaaatactttcgaaatttcattttccttcagaatatcttaagagtgctaaatttttaactgcctttttgtcgagtcaaactgtgggattctgatttgtattaaaattgtaagctcctcactggtatactatcatcctggaggggtgttgtatggctgagcaagagagagagagaatgagagagagactgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtactctgtgtgtgtatgagagagagaaatgctaaccttgtagcatgtgaagaatgtctgtaccttgatacgatagttacataatcagtatatttggtttctagatcactgtgcttattttgtttcaatctctgactaaaaatacttaaatttggtttgttaattcttattttagaaattataattttagtttatattaatttcggttatagcttactgaagaaatctttccagttagaaggaggttctaatattcacatgttctaatactttgtttattgtaaaacagctaaatttggagatacgtaaagccttgttttctctgtgtggttcagctactttccatttggtattacacagtcaaatttacatttatctattaaaattgccattttattaaacattttcatgcacagtagattcaagttgtgtctgaaaatatctcttgtgcttttttgattttgctgactttaaaaggattaatctgggcagacattatgtaaaagaaaggttgcgtttaatatattttttgaactttgtaggacaaaacatagctggttaaccttgaagtgactgttgtaccatggttgtgcacatgcttcagaatcctatggaagagaatattcctacttgcagtacatcaaaggaatggatggtggaccctactattcatgttttgagacataaatgttcactttaaagcaattgcataatagataaaaacctgaactttcattggatttttgttaattttcctcattttgaattatgtgcactaccatagctacatcagtttgatacagtattgaaaaattatcagttatattttgctgtttatgatctatttgtagattaggattaaaatggatttaatccatttttaaggctgtgtgaatttttctaaacaagaaccatttgcaatatggatttcttagagattaaaccaattataacttattagcagtcgcgagcacatgttcatatagtcaatgtaaaaatacactaatgagtatttggtaaatcccagtaggcttttaccattagcataattttgtgttgtacaattaagttacaattacatctctaattttggataatattcattggttaacaataaagtgacaaaagctcatgccttcaaaaaa
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ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:5962 -> Molecular function: GO:0003779 [actin binding] evidence: IEA GeneID:5962 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:5962 -> Biological process: GO:0051693 [actin filament capping] evidence: IEA GeneID:5962 -> Cellular component: GO:0005737 [cytoplasm] evidence: IEA GeneID:5962 -> Cellular component: GO:0005856 [cytoskeleton] evidence: IEA GeneID:5962 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA GeneID:5962 -> Cellular component: GO:0005925 [focal adhesion] evidence: IDA GeneID:5962 -> Cellular component: GO:0019898 [extrinsic to membrane] evidence: IEA GeneID:5962 -> Cellular component: GO:0032154 [cleavage furrow] evidence: IEA
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