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2025-05-09 19:36:48, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001242318 6641 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens phosphodiesterase 7A (PDE7A), transcript variant 3,
mRNA.
ACCESSION NM_001242318
VERSION NM_001242318.2 GI:341823661
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6641)
AUTHORS Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
CONSRTM DREAM investigators
TITLE Variation at the NFATC2 locus increases the risk of
thiazolidinedione-induced edema in the Diabetes REduction
Assessment with ramipril and rosiglitazone Medication (DREAM) study
JOURNAL Diabetes Care 33 (10), 2250-2253 (2010)
PUBMED 20628086
REMARK GeneRIF: Observational study of gene-disease association,
gene-environment interaction, and pharmacogenomic / toxicogenomic.
(HuGE Navigator)
REFERENCE 2 (bases 1 to 6641)
AUTHORS Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
CONSRTM ASCOT investigators; NORDIL investigators; BRIGHT Consortium
TITLE Gene-centric association signals for lipids and apolipoproteins
identified via the HumanCVD BeadChip
JOURNAL Am. J. Hum. Genet. 85 (5), 628-642 (2009)
PUBMED 19913121
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 3 (bases 1 to 6641)
AUTHORS Pekkinen,M., Ahlstrom,M.E., Riehle,U., Huttunen,M.M. and
Lamberg-Allardt,C.J.
TITLE Effects of phosphodiesterase 7 inhibition by RNA interference on
the gene expression and differentiation of human mesenchymal stem
cell-derived osteoblasts
JOURNAL Bone 43 (1), 84-91 (2008)
PUBMED 18420479
REMARK GeneRIF: results show that specific gene silencing with the RNAi
method is a useful tool for inhibiting the gene expression of
specific PDEs and that PDE7 silencing upregulates several
osteogenic genes and increases mineralization
REFERENCE 4 (bases 1 to 6641)
AUTHORS Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
Kim,N.S.
TITLE Transcriptome analysis of human gastric cancer
JOURNAL Mamm. Genome 16 (12), 942-954 (2005)
PUBMED 16341674
REFERENCE 5 (bases 1 to 6641)
AUTHORS Wang,H., Liu,Y., Chen,Y., Robinson,H. and Ke,H.
TITLE Multiple elements jointly determine inhibitor selectivity of cyclic
nucleotide phosphodiesterases 4 and 7
JOURNAL J. Biol. Chem. 280 (35), 30949-30955 (2005)
PUBMED 15994308
REMARK GeneRIF: crystal structure of PDE7A1 catalytic domain complexed
with the inhibitor 3-isobutyl-1-methylxanthine & kinetic analysis
on mutant PDE7A1 and PDE4D2; results show several residues must
work together to switch inhibitor selectivity between PDE4 & PDE7
REFERENCE 6 (bases 1 to 6641)
AUTHORS Han,P., Fletcher,C.F., Copeland,N.G., Jenkins,N.A., Yaremko,L.M.
and Michaeli,T.
TITLE Assignment of the mouse Pde7A gene to the proximal region of
chromosome 3 and of the human PDE7A gene to chromosome 8q13
JOURNAL Genomics 48 (2), 275-276 (1998)
PUBMED 9521885
REFERENCE 7 (bases 1 to 6641)
AUTHORS Han,P., Zhu,X. and Michaeli,T.
TITLE Alternative splicing of the high affinity cAMP-specific
phosphodiesterase (PDE7A) mRNA in human skeletal muscle and heart
JOURNAL J. Biol. Chem. 272 (26), 16152-16157 (1997)
PUBMED 9195912
REFERENCE 8 (bases 1 to 6641)
AUTHORS Bloom,T.J. and Beavo,J.A.
TITLE Identification and tissue-specific expression of PDE7
phosphodiesterase splice variants
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 93 (24), 14188-14192 (1996)
PUBMED 8943082
REFERENCE 9 (bases 1 to 6641)
AUTHORS Milatovich,A., Bolger,G., Michaeli,T. and Francke,U.
TITLE Chromosome localizations of genes for five cAMP-specific
phosphodiesterases in man and mouse
JOURNAL Somat. Cell Mol. Genet. 20 (2), 75-86 (1994)
PUBMED 8009369
REFERENCE 10 (bases 1 to 6641)
AUTHORS Michaeli,T., Bloom,T.J., Martins,T., Loughney,K., Ferguson,K.,
Riggs,M., Rodgers,L., Beavo,J.A. and Wigler,M.
TITLE Isolation and characterization of a previously undetected human
cAMP phosphodiesterase by complementation of cAMP
phosphodiesterase-deficient Saccharomyces cerevisiae
JOURNAL J. Biol. Chem. 268 (17), 12925-12932 (1993)
PUBMED 8389765
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DB460103.1, DR000686.1,
AK292680.1, AK057586.1, AW387924.1, AC055822.10, CN414361.1,
N49050.1 and BM818331.1.
This sequence is a reference standard in the RefSeqGene project.
On Jul 27, 2011 this sequence version replaced gi:334085276.
Summary: The protein encoded by this gene belongs to the cyclic
nucleotide phosphodiesterase (PDE) family, and PDE7 subfamily. This
PDE hydrolyzes the second messenger, cAMP, which is a regulator and
mediator of a number of cellular responses to extracellular
signals. Thus, by regulating the cellular concentration of cAMP,
this protein plays a key role in many important physiological
processes. Alternatively spliced transcript variants encoding
different isoforms have been described for this gene. [provided by
RefSeq, Jul 2011].
Transcript Variant: This variant (3, also called PDE7A1) represents
the longer transcript, and encodes the longer isoform (c).
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK292680.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084, ERS025088 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-125 DB460103.1 1-125
126-214 DR000686.1 350-438
215-1764 AK292680.1 12-1561
1765-3279 AK057586.1 1267-2781
3280-3408 AW387924.1 357-485 c
3409-3547 AC055822.10 84859-84997
3548-4055 CN414361.1 1-508
4056-4360 N49050.1 1-305 c
4361-6579 AC055822.10 85811-88029
6580-6641 BM818331.1 225-286
FEATURES Location/Qualifiers
source 1..6641
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="8"
/map="8q13"
gene 1..6641
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
/note="phosphodiesterase 7A"
/db_xref="GeneID:5150"
/db_xref="HGNC:8791"
/db_xref="MIM:171885"
exon 1..364
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
/inference="alignment:Splign:1.39.8"
misc_feature 80..82
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
/note="upstream in-frame stop codon"
CDS 227..1675
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
/EC_number="3.1.4.17"
/note="isoform c is encoded by transcript variant 3; high
affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A;
phosphodiesterase isozyme 7; TM22"
/codon_start=1
/product="high affinity cAMP-specific 3',5'-cyclic
phosphodiesterase 7A isoform c"
/protein_id="NP_001229247.1"
/db_xref="GI:334085277"
/db_xref="CCDS:CCDS56538.1"
/db_xref="GeneID:5150"
/db_xref="HGNC:8791"
/db_xref="MIM:171885"
/translation="
MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESGLFSHLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFTEWARFSNTRLSQTMLGHVGLNKASWKGLQREQSSSEDTDAAFELNSQLLPQENRLS
"
misc_feature 785..1579
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q13946.2);
Region: Catalytic (By similarity)"
misc_feature 857..1381
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
/note="Metal dependent phosphohydrolases with conserved
'HD' motif; Region: HDc; cd00077"
/db_xref="CDD:28958"
misc_feature order(872..874,980..985,1310..1312)
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
/note="Zn2+ binding site [ion binding]; other site"
/db_xref="CDD:28958"
misc_feature 983..985
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
/note="Mg2+ binding site [ion binding]; other site"
/db_xref="CDD:28958"
exon 365..425
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
/inference="alignment:Splign:1.39.8"
exon 426..509
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
/inference="alignment:Splign:1.39.8"
variation 453
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
/replace="a"
/replace="g"
/db_xref="dbSNP:11557049"
exon 510..661
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
/inference="alignment:Splign:1.39.8"
exon 662..725
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
/inference="alignment:Splign:1.39.8"
exon 726..821
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
/inference="alignment:Splign:1.39.8"
exon 822..922
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
/inference="alignment:Splign:1.39.8"
exon 923..1054
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
/inference="alignment:Splign:1.39.8"
exon 1055..1146
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
/inference="alignment:Splign:1.39.8"
exon 1147..1291
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
/inference="alignment:Splign:1.39.8"
exon 1292..1388
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
/inference="alignment:Splign:1.39.8"
exon 1389..1469
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
/inference="alignment:Splign:1.39.8"
exon 1470..6631
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
/inference="alignment:Splign:1.39.8"
variation 1576
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
/replace="c"
/replace="t"
/db_xref="dbSNP:5002418"
STS 1687..1936
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
/standard_name="RH75847"
/db_xref="UniSTS:85511"
polyA_signal 2570..2575
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
polyA_site 2601
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
STS 2941..3096
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
/standard_name="RH91483"
/db_xref="UniSTS:83716"
STS 3067..3207
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
/standard_name="D8S2079"
/db_xref="UniSTS:76580"
polyA_signal 3261..3266
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
polyA_site 3295
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
STS 5309..5690
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
/standard_name="GDB:631802"
/db_xref="UniSTS:158429"
variation 6579
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
/replace="c"
/replace="g"
/db_xref="dbSNP:2048648"
polyA_signal 6607..6612
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
variation 6614
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
/replace="a"
/replace="g"
/db_xref="dbSNP:4366113"
polyA_site 6631
/gene="PDE7A"
/gene_synonym="HCP1; PDE7"
ORIGIN
ggtcctggtaattggcgccgcggccgccgcggagccttcccgccggcggcccgagcggagggctggggttggggaggcgtgagcgcggcttcccagcccggggtcggtccccgcccgccctgcccccgtctcggcccggagcccccgagccgcggccccctcccactgcaggggccggcggccgcggcagggcgggcgccgcgcggaggcagggcgggcgtattcaatggaagtgtgttaccagctgccggtactgcccctggacaggccggtcccccagcacgtcctcagccgccgaggagccatcagcttcagctccagctccgctctcttcggctgccccaatccccggcagctctctcagaggcgtggagctatttcctatgacagttctgatcagactgcattatacattcgtatgctaggagatgtacgtgtaaggagccgagcaggatttgaatcagaaagaagaggttctcacccatatattgattttcgtattttccactctcaatctgaaattgaagtgtctgtctctgcaaggaatatcagaaggctactaagtttccagcgatatcttagatcttcacgcttttttcgtggtactgcggtttcaaattccctaaacattttagatgatgattataatggacaagccaagtgtatgctggaaaaagttggaaattggaattttgatatctttctatttgatagactaacaaatggaaatagtctagtaagcttaacctttcatttatttagtcttcatggattaattgagtacttccatttagatatgatgaaacttcgtagatttttagttatgattcaagaagattaccacagtcaaaatccttaccataacgcagtccacgctgcggatgttactcaggccatgcactgttacttaaaggaacctaagcttgccaattctgtaactccttgggatatcttgctgagcttaattgcagctgccactcatgatctggatcatccaggtgttaatcaacctttccttattaaaactaaccattacttggcaactttatacaagaatacctcagtactggaaaatcaccactggagatctgcagtgggcttattgagagaatcaggcttattctcacatctgccattagaaagcaggcaacaaatggagacacagataggtgctctgatactagccacagacatcagtcgccagaatgagtatctgtctttgtttaggtcccatttggatagaggtgatttatgcctagaagacaccagacacagacatttggttttacagatggctttgaaatgtgctgatatttgtaacccatgtcggacgtgggaattaagcaagcagtggagtgaaaaagtaacggaggaattcttccatcaaggagatatagaaaaaaaatatcatttgggtgtgagtccactttgcgatcgtcacactgaatctattgccaacatccagattggttttatgacttacctagtggagcctttatttacagaatgggccaggttttccaatacaaggctatcccagacaatgcttggacacgtggggctgaataaagccagctggaagggactgcagagagaacagtcgagcagtgaggacactgatgctgcatttgagttgaactcacagttattacctcaggaaaatcggttatcataacccccagaaccagtgggacaaactgcctcctggaggtttttagaaatgtgaaatggggtcttgaggtgagagaacttaactcttgactgccaaggtttccaagtgagtgatgccagccagcattatttatttccaagatttcctctgttggatcatttgaacccacttgttaattgcaagacccgaacatacagcaatatgaatttggctttcatgtgaaaccttgaatatgcaaagcccagcaggagagaatccgaaaggagtaacaaaggaagttttgatatgtgccacgactttttcaaagcatctaatcttcaaaacgtgaaacttgaattgttcagcaacaatctcttggaatttaaccagtctgatgcaacaatgtgtatcttgtaccttccactaagttctctctgagaaaatggaaatgtgaagtgcccagcctctgctgcctctggcaagacaatgtttacaaatcaactctgaaaatattggttctaaattgccttggagcatgattgtgaaggaaccactcaaacaaatttaaagatcaaactttagactgcagctctttccccctggtttgcctttttcttctttggatgccaccaaagcctcccatttgctatagttttatttcatgcactggaaactgagcatttatcgtagagtaccgccaagctttcactccagtgccgtttggcaatgcaattttttttagcaattagtttttaatttggggtgggaggggaagaacaccaatgtcctagctgtattatgattctgcagtgaagacattgcatgttgttttcactactgtacacttgacctgcacatgcgagaaaaaggtggaatgtttaaaacaccataatcagctcagggtatttgccaatctgaaataaaagtgggatgggagagtgtgtccttcagatcaagggtactaaagtccctttcgctgcagtgagtgagaggtatgttgtgtgtgaatgtacggatgtgtgtttgcgtgcatgtttgtgcatgtgtgactgtgcatgttatgtttctccatgtgggcaaagatttgaaatgtaagcttttatttattattttagaatgtgacataatgagcagccacactcgggggaggggaaggttggtaggtaagctgtaacagattgctccagttgccttaaactatgcacatagctaagtgaccaaacttcttgttttgatttgaaaaaagtgcattgttttcttgtccctccctttgatgaaacgttaccctttgacgggccttttgatgtgaacagatgttttctaggacaaactataaggactaattttaaacttcaaacattccacttttgtaatttgttttaaattgttttatgtatagtaagcacaactgtaatctagttttaagagaaaccggtgctttcttttagttcatttgtatttcccttgttactgtaaaagactgtttattaattgtttacagtttgttgcaacagccattttcttgggagaaagcttgagtgtaaagccatttgtaaaaggctttgccatactcattttaatatgtgcctgttgctgttaacttttgatgaataaaaacctatcttttcatatttttatctttgacatttaccttataactcaatcttttggaaaacacaatgctaaattacaaggaaatcaaagttagcttcttggctcttgtaattcatccctcagatgtttactcagtccgagcttatctactaatgactcaccttgcaagtgagtaagcagaagcccagttagggctgttggagtcctgactaacacaggggagaggtcagctttgagccaggccttttgttcctacagtggtgaactgcataagacatcagcaagtcttgcaagtactaaaatactagttgtatttatttctatcaatcattggcctttttaaagtgataagaaaaggccactccactctacttgattgatatcagttgtaaacaaggtaccactgtgccattccctatatcttcccaggtccaactcattagaagggatatggtgcaaacttctaaatcaaacacattaacatattatttgtacagaagagtgttgatgtccaatagaaacagaatccaagccacataattttcggttttctagtagccacatttagaaaacatggaattaattttagtaacatctattccaatacgtccaaaatattgtatcactttaaaatgtcaatataaaaacaattagatgtttttacattcttttggggggtactaagtctttgaaatccagtgtatattgtgtacttacagcacatctcaatttggactagtcatatctcaggcacccaatatccacatgtggctagtggctaccatattggacagtgtgggtatagaggtctgagggtagtagaggaatatggtcagctggtcactctcgtgagatggccataccttggcctatatttaatgtgtacagaaagtctgataactcagatccttaaaaattcaggcccactgtttcagtacatagagagtggaactatcatggcaaacccacattaaccaagctcacagtaactatttttttaaaacactatcaatattttaatttacagtgagaaatgtaactatcaattattctctccctttaggcaaatcttcctgggaagccaaattatgagcagctggtgagcatggattctgagcaagggaagcaagttgcctcgtgcacccatgtccctttgggtgcacagaagacccatgtcttctgtgatattcatgtttgtggaccagggtaccctcttcccctggaaggtgctagagattctctgccagtagttgcttctctacatcagcttctgattggcacatgcattaaataacgtcattacctcaagccttgtttcagttgagcttacctgggctccattctgcctgtatacatgattgcttctgctctgatccattgtttctcttatagtttgaaactgaaaagatcatcctatttccacattctcaggggaactgtgggtgtggctcccatttcctgcctacacatataataaacccattgaaaagttgttttattatgtatatgtgggaatcaccttctatagcccttttgtttttttttttttttgagacagggtctcgctgctaactaggctggagtgcagtggcatgatcactgcagcctccacctcctaggctcaagcaatcctcccacctcagcctcctgagtgccaccacaccacccagctaatttttttttttttttttttttttttttttgagacagagccttgctctgtcgcccaggctggagtgcagtgccgcgatattggctcactgcaagttccgcctcccgggttcacgccattctcctcattctcctgcctcagtctcccaggtcgctgggactacaggcgcccgccaccaggccctgctaatttttttgtactttattagtagagttagggtttcaccatgttagccaggatggtctcaatctcctgacctcgtgatccgcccgcctcggcctcccatagtgctgggattacaggcgtgagccaccgtgcccggccagctaattttttaagaacatttttgtggccgggcatggtggctcacacctgtaatcccagcactttgggaggctgaggtgggtggatcacctgaggtcgggagttcgagaccagtctggccaacatggtgaaaccccatctctactaaaaatgcaaaaattagctgggcgtggtggcgcattcctgtaatcccagctactcgggaggctgaggcggaagaattgcttgaacccaggtggcggaggttgcaaggagcagagattgtgctactgcactccagcctaggtgacagagcaagactctgtctcaaaaaaaaaaaaaaaacttttttatagagacagggtctctctttgttggcttggctggtcttgaactcttgggctcaagcagtcctgccaccgtggcctctcaaagtgctgggattacaggtgtgagacactgcatcaggcctatagctccacttaaatacgacctatattactggaatatttttttctaaaaaattttaggaaacagttaaatatttaaaagattacttttttaaaaagcaagtaaatattacagaacagaatgcaaaatttattttacatgggagactaaaaattttcacacacatggccaccctttgggcctcttggctcaacatttcaggggctgagggagtctctgctctaggagtaaaaggtccttggagagaaaattttgacaagtcctaactttaaaaaagaaaaattggttcctggtcaatatttgtactcactgtaaatgtgatggttggtaatgatactctgtataaaagtaaaaatcatattttatgtcctttgcaaacaaatatatttgtacctgaggtacagattagaggtgctagtaattccttgaagattctgaaaatgatctttttttccaaaatgctttcttggtttttattaaactttctattttcttaaaactctcacatcaggtatttccagtgttttcaagcatgtataaatattttaatgtataaatgttgtttaaaatcccctcaatcggtatctcctgattgagaaaatacacagtgaccaatagctaataggaattcagtattgctttcaaagaaatgtgcatattaatcactgtagcatctgcatacatttgaaacacggagtaatacaggtctgtgcaagaattagcagcttgttccttgctaataatgacttgtgtcatctggaaggcccccaagagcccatggtctacaggtggaatgaccaccacttgggagtgagctgatggagagcacccagcaggtctcctccatcttcctggttcctgtgctcaccatagggctggtgtacattgggccattaataaacgtttgttgaacaaattaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:5150 -> Molecular function: GO:0004115 [3',5'-cyclic-AMP phosphodiesterase activity] evidence: IDA
GeneID:5150 -> Molecular function: GO:0004115 [3',5'-cyclic-AMP phosphodiesterase activity] evidence: TAS
GeneID:5150 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
GeneID:5150 -> Biological process: GO:0006198 [cAMP catabolic process] evidence: IEA
GeneID:5150 -> Biological process: GO:0007165 [signal transduction] evidence: NAS
GeneID:5150 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_001229247 -> EC 3.1.4.17
by
@meso_cacase at
DBCLS
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