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2025-05-09 19:56:32, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001201548 2372 bp mRNA linear PRI 07-JUL-2013
DEFINITION Homo sapiens solute carrier family 16, member 4 (monocarboxylic
acid transporter 5) (SLC16A4), transcript variant 4, mRNA.
ACCESSION NM_001201548
VERSION NM_001201548.1 GI:319996638
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2372)
AUTHORS Miranda-Goncalves,V., Honavar,M., Pinheiro,C., Martinho,O.,
Pires,M.M., Pinheiro,C., Cordeiro,M., Bebiano,G., Costa,P.,
Palmeirim,I., Reis,R.M. and Baltazar,F.
TITLE Monocarboxylate transporters (MCTs) in gliomas: expression and
exploitation as therapeutic targets
JOURNAL Neuro-oncology 15 (2), 172-188 (2013)
PUBMED 23258846
REMARK GeneRIF: Overexpression of MCT4 is associated with gliomas.
REFERENCE 2 (bases 1 to 2372)
AUTHORS Mogi,A., Koga,K., Aoki,M., Hamasaki,M., Uesugi,N., Iwasaki,A.,
Shirakusa,T., Tamura,K. and Nabeshima,K.
TITLE Expression and role of GLUT-1, MCT-1, and MCT-4 in malignant
pleural mesothelioma
JOURNAL Virchows Arch. 462 (1), 83-93 (2013)
PUBMED 23187830
REMARK GeneRIF: Combined application of GLUT-1, MCT-1, and MCT-4
immunohistochemistry might be useful in differentiating malignant
pleural mesothelioma from reactive mesothelial hyperplasia.
REFERENCE 3 (bases 1 to 2372)
AUTHORS Gerlinger,M., Santos,C.R., Spencer-Dene,B., Martinez,P.,
Endesfelder,D., Burrell,R.A., Vetter,M., Jiang,M., Saunders,R.E.,
Kelly,G., Dykema,K., Rioux-Leclercq,N., Stamp,G., Patard,J.J.,
Larkin,J., Howell,M. and Swanton,C.
TITLE Genome-wide RNA interference analysis of renal carcinoma survival
regulators identifies MCT4 as a Warburg effect metabolic target
JOURNAL J. Pathol. 227 (2), 146-156 (2012)
PUBMED 22362593
REMARK GeneRIF: Data suggest that MCT4 may serve as a novel metabolic
target to reverse the Warburg effect and limit disease progression
in renal cell carcinoma.
REFERENCE 4 (bases 1 to 2372)
AUTHORS Meijer,T.W., Schuurbiers,O.C., Kaanders,J.H., Looijen-Salamon,M.G.,
de Geus-Oei,L.F., Verhagen,A.F., Lok,J., van der Heijden,H.F.,
Rademakers,S.E., Span,P.N. and Bussink,J.
TITLE Differences in metabolism between adeno- and squamous cell
non-small cell lung carcinomas: spatial distribution and prognostic
value of GLUT1 and MCT4
JOURNAL Lung Cancer 76 (3), 316-323 (2012)
PUBMED 22153830
REMARK GeneRIF: High GLUT1 plus high MCT4 expression indicated an
aggressive tumor behavior in adenocarcinomas.
REFERENCE 5 (bases 1 to 2372)
AUTHORS Lean,C.B. and Lee,E.J.
TITLE Genetic variations of the MCT4 (SLC16A3) gene in the Chinese and
Indian populations of Singapore
JOURNAL Drug Metab. Pharmacokinet. 27 (4), 456-464 (2012)
PUBMED 22240841
REMARK GeneRIF: Report SNPs in MCT4 (SLC16A3) gene in the Chinese and
Indian populations of Singapore.
REFERENCE 6 (bases 1 to 2372)
AUTHORS Philp,N.J., Wang,D., Yoon,H. and Hjelmeland,L.M.
TITLE Polarized expression of monocarboxylate transporters in human
retinal pigment epithelium and ARPE-19 cells
JOURNAL Invest. Ophthalmol. Vis. Sci. 44 (4), 1716-1721 (2003)
PUBMED 12657613
REFERENCE 7 (bases 1 to 2372)
AUTHORS Manning Fox,J.E., Meredith,D. and Halestrap,A.P.
TITLE Characterisation of human monocarboxylate transporter 4
substantiates its role in lactic acid efflux from skeletal muscle
JOURNAL J. Physiol. (Lond.) 529 (PT 2), 285-293 (2000)
PUBMED 11101640
REFERENCE 8 (bases 1 to 2372)
AUTHORS Halestrap,A.P. and Price,N.T.
TITLE The proton-linked monocarboxylate transporter (MCT) family:
structure, function and regulation
JOURNAL Biochem. J. 343 (PT 2), 281-299 (1999)
PUBMED 10510291
REMARK Review article
REFERENCE 9 (bases 1 to 2372)
AUTHORS Pilegaard,H., Terzis,G., Halestrap,A. and Juel,C.
TITLE Distribution of the lactate/H+ transporter isoforms MCT1 and MCT4
in human skeletal muscle
JOURNAL Am. J. Physiol. 276 (5 PT 1), E843-E848 (1999)
PUBMED 10329977
REFERENCE 10 (bases 1 to 2372)
AUTHORS Price,N.T., Jackson,V.N. and Halestrap,A.P.
TITLE Cloning and sequencing of four new mammalian monocarboxylate
transporter (MCT) homologues confirms the existence of a
transporter family with an ancient past
JOURNAL Biochem. J. 329 (PT 2), 321-328 (1998)
PUBMED 9425115
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BP345760.1, AK298539.1, U59185.1 and AI245349.1.
Transcript Variant: This variant (4) lacks two alternate exons in
the coding region which results in the use of a downstream start
codon initially in a different reading frame, compared to variant
1. The resulting protein (isoform 4) has a shorter and distinct
N-terminus yet matches most of the protein when it is compared to
isoform 1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK298539.1 [ECO:0000332]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-56 BP345760.1 1-56
57-762 AK298539.1 1-706
763-1309 U59185.1 972-1518
1310-1597 AK298539.1 1254-1541
1598-2269 U59185.1 1787-2458
2270-2372 AI245349.1 1-103 c
FEATURES Location/Qualifiers
source 1..2372
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1p13.3"
gene 1..2372
/gene="SLC16A4"
/gene_synonym="MCT4; MCT5"
/note="solute carrier family 16, member 4 (monocarboxylic
acid transporter 5)"
/db_xref="GeneID:9122"
/db_xref="HGNC:10925"
/db_xref="MIM:603878"
exon 1..218
/gene="SLC16A4"
/gene_synonym="MCT4; MCT5"
/inference="alignment:Splign:1.39.8"
exon 219..337
/gene="SLC16A4"
/gene_synonym="MCT4; MCT5"
/inference="alignment:Splign:1.39.8"
misc_feature 286..288
/gene="SLC16A4"
/gene_synonym="MCT4; MCT5"
/note="upstream in-frame stop codon"
CDS 304..1452
/gene="SLC16A4"
/gene_synonym="MCT4; MCT5"
/note="isoform 4 is encoded by transcript variant 4;
monocarboxylate transporter 4; solute carrier family 16
(monocarboxylic acid transporters), member 4;
monocarboxylate transporter 5; MCT 4; MCT 5; solute
carrier family 16 member 4"
/codon_start=1
/product="monocarboxylate transporter 5 isoform 4"
/protein_id="NP_001188477.1"
/db_xref="GI:319996639"
/db_xref="CCDS:CCDS55621.1"
/db_xref="GeneID:9122"
/db_xref="HGNC:10925"
/db_xref="MIM:603878"
/translation="
MGMDDCDSFFPGLGSAFLYQVAAVVTTKYFKKRLALSTAIARSGMGLTFLLAPFTKFLIDLYDWTGALILFGAIALNLVPSSMLLRPIHIKSENNSGIKDKGSSLSAHGPEAHATETHCHETEESTIKDSTTQKAGLPSKNLTVSQNQSEEFYNGPNRNRLLLKSDEESDKVISWSCKQLFDISLFRNPFFYIFTWSFLLSQLAYFIPTFHLVARAKTLGIDIMDASYLVSVAGILETVSQIISGWVADQNWIKKYHYHKSYLILCGITNLLAPLATTFPLLMTYTICFAIFAGGYLALILPVLVDLCRNSTVNRFLGLASFFAGMAVLSGPPIAEIIPSFQAGYMIIPRHTMALSTSLAYAISSLQFPFFLYHWPKDGKTV
"
misc_feature 874..>1308
/gene="SLC16A4"
/gene_synonym="MCT4; MCT5"
/note="The Major Facilitator Superfamily (MFS) is a large
and diverse group of secondary transporters that includes
uniporters, symporters, and antiporters. MFS proteins
facilitate the transport across cytoplasmic or internal
membranes of a variety of...; Region: MFS; cd06174"
/db_xref="CDD:119392"
misc_feature order(916..918,925..933,937..942,991..993,1000..1005,
1012..1014,1024..1029,1033..1038,1180..1185,1192..1197,
1204..1209,1216..1218,1252..1257,1264..1269,1285..1287)
/gene="SLC16A4"
/gene_synonym="MCT4; MCT5"
/note="putative substrate translocation pore; other site"
/db_xref="CDD:119392"
exon 338..499
/gene="SLC16A4"
/gene_synonym="MCT4; MCT5"
/inference="alignment:Splign:1.39.8"
exon 500..1003
/gene="SLC16A4"
/gene_synonym="MCT4; MCT5"
/inference="alignment:Splign:1.39.8"
variation 763
/gene="SLC16A4"
/gene_synonym="MCT4; MCT5"
/replace="a"
/replace="c"
/db_xref="dbSNP:2271885"
exon 1004..1215
/gene="SLC16A4"
/gene_synonym="MCT4; MCT5"
/inference="alignment:Splign:1.39.8"
exon 1216..1309
/gene="SLC16A4"
/gene_synonym="MCT4; MCT5"
/inference="alignment:Splign:1.39.8"
exon 1310..2372
/gene="SLC16A4"
/gene_synonym="MCT4; MCT5"
/inference="alignment:Splign:1.39.8"
STS 1683..1772
/gene="SLC16A4"
/gene_synonym="MCT4; MCT5"
/standard_name="D8S2279"
/db_xref="UniSTS:473907"
STS 2066..2300
/gene="SLC16A4"
/gene_synonym="MCT4; MCT5"
/standard_name="A006B12"
/db_xref="UniSTS:17350"
STS 2066..2300
/gene="SLC16A4"
/gene_synonym="MCT4; MCT5"
/standard_name="G20671"
/db_xref="UniSTS:17349"
STS 2066..2257
/gene="SLC16A4"
/gene_synonym="MCT4; MCT5"
/standard_name="A006B12"
/db_xref="UniSTS:17350"
STS 2066..2257
/gene="SLC16A4"
/gene_synonym="MCT4; MCT5"
/standard_name="G20671"
/db_xref="UniSTS:17349"
variation 2162
/gene="SLC16A4"
/gene_synonym="MCT4; MCT5"
/replace="a"
/replace="g"
/db_xref="dbSNP:11120"
variation 2270
/gene="SLC16A4"
/gene_synonym="MCT4; MCT5"
/replace="c"
/replace="t"
/db_xref="dbSNP:1046002"
ORIGIN
acagtctttcctcctcccctcaggaagtaaagtccactagcaggagggcctaaatcgtctgagccctccttggctcttacaatgctcacttgttttcacaatgcagcaaaatgaaatgccttagaaaaagagtaacattccagaaaacggtgtaatttatttttcttccttaattgccccatctgtggaggatttctttgctgaacaccacatcaaagggatcttctgcatttaaaatagaagaggcatcatgctgaagagggaggggaaggtccaaccttacactaaaaccctggatggaggatggggatggatgattgtgattcattttttcctggtttgggttctgctttcttataccaagtggctgctgtggtaactaccaaatacttcaaaaaacgattggctctttctacagctattgcccgttctgggatgggactgacttttcttttggcaccctttacaaaattcctgatagatctgtatgactggacaggagcccttatattatttggagctatcgcattgaatttggtgccttctagtatgctcttaagacccatccatatcaaaagtgagaacaattctggtattaaagataaaggcagcagtttgtctgcacatggtccagaggcacatgcaacagaaacacactgccatgagacagaagagtctaccatcaaggacagtactacgcagaaggctggactacctagcaaaaatttaacagtctcacaaaatcaaagtgaagagttctacaatgggcctaacaggaacagactgttattaaagagtgatgaagaaagtgataaggttatttcgtggagctgcaaacaactgtttgacatttctctctttagaaatcctttcttctacatatttacttggtcttttctcctcagtcagttagcatacttcatccctacctttcacctggtagccagagccaaaacactggggattgacatcatggatgcctcttaccttgtttctgtagcaggtatccttgagacggtcagtcagattatttctggatgggttgctgatcaaaactggattaagaagtatcattaccacaagtcttacctcatcctctgcggcatcactaacctgcttgctcctttagccaccacatttccactacttatgacctacaccatctgctttgccatctttgctggtggttacctggcattgatactgcctgtactggttgatctgtgtaggaattctacagtaaacaggtttttgggacttgccagtttctttgctgggatggctgtcctttctggaccacctatagcagaaatcattccttccttccaggctggttatatgattatacccagacatacaatggctctttctacttctctggcatatgctatctcctctcttcagtttcctttttttttgtaccattggccgaaagatggaaaaacagtctgacctgaaagaaagaagactgcaatcaagtgagagctaaacaaaagaaaacctaaactaatgtcattggaaacaaaagcttgaaagaaacacatcgcatctacatttgtaacatgagaaggaaaacaatttttttttttttttttttgagacggagtctcgctctttcgcccaggctggagtgcagtggcgcaatctcggctcactgtaatctccgcctcctgggttcaagggattctcctgcctcagcctcccaagtagctgggactacaggcacacgccaccacacccagctaattttttgtatttttagtagaggcggggtttcaccatgttagccaggatggtctccatctcctgacctcgtgatccgcccgccttgtcctccaaagtgctgggattacaggcatgagccactgggcgcggccagataagtttttaaggttccttcttgctttagcattctgagaaatgtctaattggtagtaagacaagagtaatagcaacctgtattgttagtatttaaccaaataggctaaaattttaatcaggtaccttatgtattaaatagaaatcggaatgtaccataataaatccaaactctcaattacgccatggtaattcagtcactaaaatatgtaaagatagaaaattttttaatttaaagaagtgtgaaacatagccattgattgatcagaattctggaatctgaatattaaaaccttacttagtgactggaatggtatatgctccctccaaaagtttatctttgtttattgattaaaggtaatccttactttctttgtattacttaggttcttaattaaaggtaatccttactttctttgtattacttaggttcttaaatttctatgataaacatgtattgctaaataataaaaagtatataaaaattgctttaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:9122 -> Molecular function: GO:0008028 [monocarboxylic acid transmembrane transporter activity] evidence: TAS
GeneID:9122 -> Molecular function: GO:0015293 [symporter activity] evidence: IEA
GeneID:9122 -> Biological process: GO:0015718 [monocarboxylic acid transport] evidence: TAS
GeneID:9122 -> Cellular component: GO:0005887 [integral to plasma membrane] evidence: TAS
GeneID:9122 -> Cellular component: GO:0016020 [membrane] evidence: TAS
by
@meso_cacase at
DBCLS
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