2025-05-09 20:11:16, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001199253 3380 bp mRNA linear PRI 17-APR-2013 DEFINITION Homo sapiens shugoshin-like 1 (S. pombe) (SGOL1), transcript variant B3, mRNA. ACCESSION NM_001199253 VERSION NM_001199253.1 GI:312922336 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3380) AUTHORS Greenwood,T.A., Akiskal,H.S., Akiskal,K.K. and Kelsoe,J.R. CONSRTM Bipolar Genome Study TITLE Genome-wide association study of temperament in bipolar disorder reveals significant associations with three novel Loci JOURNAL Biol. Psychiatry 72 (4), 303-310 (2012) PUBMED 22365631 REFERENCE 2 (bases 1 to 3380) AUTHORS Liu,L., Zhang,N., Liu,J., Min,J., Ma,N., Liu,N., Liu,Y. and Zhang,H. TITLE Lentivirus-mediated siRNA interference targeting SGO-1 inhibits human NSCLC cell growth JOURNAL Tumour Biol. 33 (2), 515-521 (2012) PUBMED 22161216 REMARK GeneRIF: Lentivirus-mediated siRNA interference targeting SGO-1 inhibits human NSCLC cell growth REFERENCE 3 (bases 1 to 3380) AUTHORS Kahyo,T., Iwaizumi,M., Shinmura,K., Matsuura,S., Nakamura,T., Watanabe,Y., Yamada,H. and Sugimura,H. TITLE A novel tumor-derived SGOL1 variant causes abnormal mitosis and unstable chromatid cohesion JOURNAL Oncogene 30 (44), 4453-4463 (2011) PUBMED 21532624 REMARK GeneRIF: These results suggest that SGOL1-P1 may function as a negative factor to native SGOL1, and that abundant expression of SGOL1-P1 may be responsible for chromosomal instability. REFERENCE 4 (bases 1 to 3380) AUTHORS Kang,J., Chaudhary,J., Dong,H., Kim,S., Brautigam,C.A. and Yu,H. TITLE Mitotic centromeric targeting of HP1 and its binding to Sgo1 are dispensable for sister-chromatid cohesion in human cells JOURNAL Mol. Biol. Cell 22 (8), 1181-1190 (2011) PUBMED 21346195 REMARK GeneRIF: HP1alpha binding by INCENP or Shugoshin 1 (Sgo1) is dispensable for centromeric cohesion protection during mitosis of human cells, but might regulate yet unknown interphase functions of the chromosome passenger complex (CPC) or Sgo1 at the centromeres. REFERENCE 5 (bases 1 to 3380) AUTHORS Okamoto,N., Kuwahara,K., Ohta,K., Kitabatake,M., Takagi,K., Mizuta,H., Kondo,E. and Sakaguchi,N. TITLE Germinal center-associated nuclear protein (GANP) is involved in mRNA export of Shugoshin-1 required for centromere cohesion and in sister-chromatid exchange JOURNAL Genes Cells 15 (5), 471-484 (2010) PUBMED 20384790 REMARK GeneRIF: Data show that human germinal center-associated nuclear protein (GANP) is critically involved in cell proliferation at the mitotic phase through its selective support of shugoshin-1 mRNA export. REFERENCE 6 (bases 1 to 3380) AUTHORS Wang,X. and Dai,W. TITLE Shugoshin, a guardian for sister chromatid segregation JOURNAL Exp. Cell Res. 310 (1), 1-9 (2005) PUBMED 16112668 REMARK GeneRIF: A comprehensive review of Sgo1 function in eukaryote at meiosis and mitosis. Review article REFERENCE 7 (bases 1 to 3380) AUTHORS McGuinness,B.E., Hirota,T., Kudo,N.R., Peters,J.M. and Nasmyth,K. TITLE Shugoshin prevents dissociation of cohesin from centromeres during mitosis in vertebrate cells JOURNAL PLoS Biol. 3 (3), E86 (2005) PUBMED 15737064 REMARK GeneRIF: A shugoshin-like protein associates with centromeres during prophase and disappears at the onset of anaphase REFERENCE 8 (bases 1 to 3380) AUTHORS Kitajima,T.S., Hauf,S., Ohsugi,M., Yamamoto,T. and Watanabe,Y. TITLE Human Bub1 defines the persistent cohesion site along the mitotic chromosome by affecting Shugoshin localization JOURNAL Curr. Biol. 15 (4), 353-359 (2005) PUBMED 15723797 REFERENCE 9 (bases 1 to 3380) AUTHORS Tang,Z., Sun,Y., Harley,S.E., Zou,H. and Yu,H. TITLE Human Bub1 protects centromeric sister-chromatid cohesion through Shugoshin during mitosis JOURNAL Proc. Natl. Acad. Sci. U.S.A. 101 (52), 18012-18017 (2004) PUBMED 15604152 REMARK GeneRIF: Bub1 protects centromeric cohesion through Shugoshin in mitosis REFERENCE 10 (bases 1 to 3380) AUTHORS Scanlan,M.J., Gout,I., Gordon,C.M., Williamson,B., Stockert,E., Gure,A.O., Jager,D., Chen,Y.T., Mackay,A., O'Hare,M.J. and Old,L.J. TITLE Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression JOURNAL Cancer Immun. 1, 4 (2001) PUBMED 12747765 REMARK Publication Status: Online-Only COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB163747.1, AB193059.1, AF308299.1 and AC099057.3. Transcript Variant: This variant (B3) has an alternate 5' UTR exon, lacks an in-frame internal segment and the 3' exon, and contains an alternate 3' segment, as compared to variant A2. The resulting isoform (B1, also known as 1CD) lacks an internal segment and has a shorter and distinct C-terminus, as compared to isoform A2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB193059.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support ERS025081, ERS025084 [ECO:0000350] ##Evidence-Data-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-105 DB163747.1 1-105 106-1126 AB193059.1 1-1021 1127-1330 AF308299.1 845-1048 1331-3380 AC099057.3 145527-147576 c FEATURES Location/Qualifiers source 1..3380 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="3" /map="3p24.3" gene 1..3380 /gene="SGOL1" /gene_synonym="NY-BR-85; SGO; Sgo1" /note="shugoshin-like 1 (S. pombe)" /db_xref="GeneID:151648" /db_xref="HGNC:25088" /db_xref="MIM:609168" exon 1..285 /gene="SGOL1" /gene_synonym="NY-BR-85; SGO; Sgo1" /inference="alignment:Splign:1.39.8" misc_feature 275..277 /gene="SGOL1" /gene_synonym="NY-BR-85; SGO; Sgo1" /note="upstream in-frame stop codon" exon 286..434 /gene="SGOL1" /gene_synonym="NY-BR-85; SGO; Sgo1" /inference="alignment:Splign:1.39.8" CDS 293..1120 /gene="SGOL1" /gene_synonym="NY-BR-85; SGO; Sgo1" /note="isoform B1 is encoded by transcript variant B3; shugoshin 1AB protein; shugoshin 1CD protein; shugoshin 1EF protein; shugoshin 1GH protein; shugoshin 1KL protein; hSgo1; serologically defined breast cancer antigen NY-BR-85" /codon_start=1 /product="shugoshin-like 1 isoform B1" /protein_id="NP_001186182.1" /db_xref="GI:312922337" /db_xref="CCDS:CCDS46774.1" /db_xref="GeneID:151648" /db_xref="HGNC:25088" /db_xref="MIM:609168" /translation="
MAKERCLKKSFQDSLEDIKKRMKEKRNKNLAEIGKRRSFIAAPCQIITNTSTLLKNYQDNNKMLVLALENEKSKVKEAQDIILQLRKECYYLTCQLYALKGKLTSQQTVEPAQNQEICSSGMDPNSDDSSRNLFVKDLPQIPLEETELPGQGESFQIEDQIPTIPQDTLGVDFDSATPPETQQSPHLSLKDITNVSLYPVVKIRRLSLSPKKNKASPAVALPKRRCTASVNYKEPTLASKLRRGDPFTDLCFLNSPIFKQKKDLRRSKKSMKQIQ
" misc_feature 293..820 /gene="SGOL1" /gene_synonym="NY-BR-85; SGO; Sgo1" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (Q5FBB7.1); Region: Necessary for interaction with PPP2CA and PPP2R1A" misc_feature 332..334 /gene="SGOL1" /gene_synonym="NY-BR-85; SGO; Sgo1" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine, by NEK2; propagated from UniProtKB/Swiss-Prot (Q5FBB7.1); phosphorylation site" misc_feature 356..493 /gene="SGOL1" /gene_synonym="NY-BR-85; SGO; Sgo1" /note="Shugoshin N-terminal coiled-coil region; Region: Shugoshin_N; pfam07558" /db_xref="CDD:203682" misc_feature 947..1024 /gene="SGOL1" /gene_synonym="NY-BR-85; SGO; Sgo1" /note="Shugoshin C terminus; Region: Shugoshin_C; pfam07557" /db_xref="CDD:191783" exon 435..631 /gene="SGOL1" /gene_synonym="NY-BR-85; SGO; Sgo1" /inference="alignment:Splign:1.39.8" exon 632..708 /gene="SGOL1" /gene_synonym="NY-BR-85; SGO; Sgo1" /inference="alignment:Splign:1.39.8" exon 709..767 /gene="SGOL1" /gene_synonym="NY-BR-85; SGO; Sgo1" /inference="alignment:Splign:1.39.8" exon 768..818 /gene="SGOL1" /gene_synonym="NY-BR-85; SGO; Sgo1" /inference="alignment:Splign:1.39.8" exon 819..1008 /gene="SGOL1" /gene_synonym="NY-BR-85; SGO; Sgo1" /inference="alignment:Splign:1.39.8" exon 1009..3380 /gene="SGOL1" /gene_synonym="NY-BR-85; SGO; Sgo1" /inference="alignment:Splign:1.39.8" variation 1127 /gene="SGOL1" /gene_synonym="NY-BR-85; SGO; Sgo1" /replace="c" /replace="t" /db_xref="dbSNP:1052930" STS 1512..1599 /gene="SGOL1" /gene_synonym="NY-BR-85; SGO; Sgo1" /standard_name="D8S2279" /db_xref="UniSTS:473907" STS 1541..1674 /gene="SGOL1" /gene_synonym="NY-BR-85; SGO; Sgo1" /standard_name="D7S2067E" /db_xref="UniSTS:151120" STS 1665..2934 /gene="SGOL1" /gene_synonym="NY-BR-85; SGO; Sgo1" /standard_name="GDB:631813" /db_xref="UniSTS:158430" STS 2914..3019 /gene="SGOL1" /gene_synonym="NY-BR-85; SGO; Sgo1" /standard_name="D11S3114" /db_xref="UniSTS:152207" STS 3001..3078 /gene="SGOL1" /gene_synonym="NY-BR-85; SGO; Sgo1" /standard_name="D8S2279" /db_xref="UniSTS:473907" ORIGIN
aatggaggagcgaggcggaaaatttcgaatgtggcggcggtagttccaggcgacggcggacggtggtacggtcctggagggcccagtgcgcggggctagccgtggctggagagcttcgaagagccttgaaatgtgaggaggaggaagatagctgttgcagaagtagtggccaaggtatcgttctggacgcgcctgcggcaggagggtcgccgcgtccacttccgccagccccacctccccccggccttcctggagtccctgaaagaggaagaagtaggttttaaggcaaaagatggccaaggaaagatgcctgaaaaagtcctttcaagatagtcttgaagacataaagaagcgaatgaaagagaaaaggaataaaaacttggcagagattggcaaacgcaggtcttttatagctgcaccatgccaaataatcaccaacacttctacactgctgaaaaattaccaagacaacaacaaaatgttagttttagctttggaaaatgaaaaatccaaagtgaaagaagcccaagatatcatcctacagctgagaaaagaatgttactatctcacatgtcagctatatgcattgaaaggaaaacttacatcacaacaaacagtagaacctgctcagaaccaggaaatatgttcctctggaatggaccccaatagtgatgacagctccagaaatttatttgtgaaggatttaccgcaaattcctcttgaagaaactgaacttccaggacaaggagaatcatttcaaatagaagatcagatacctactattcctcaagacacactgggagttgattttgattcagctacaccacctgaaactcagcagtcacctcatcttagcctgaaggatatcaccaatgtctccttgtatcctgttgtgaaaatcagaagactttctctttctccaaaaaagaataaagcaagcccagcagtggctctgcctaaacgtaggtgcacagccagcgtgaactataaggagcccaccctcgcttcgaaactgagaagaggggacccttttacagatttgtgttttttgaattctcctattttcaagcagaaaaaggatttgagacgttctaaaaaaagtatgaaacaaatacaatgaaggttttgttggatattgtttaaattcaatctacacctctttctgttgcttcaggagaggatctgtaagagtacacaaacagagtgagccattgccatagaatattctcttgacaggaccctagctcataaacatttcttcagaactatacttcaaatgggatgctttgtattaaaactttaataaatttaatttattttttcttttgaatataaataactgagcttaagcattatcatcatatcgatttcttatgctgcctaaacctcttaattttagtcgaaatatatctttttttttttttggaggcggaatttcattcttgttgcccaggctggagtgcaatggcacgatctcagcttaccgcaacctccgcctcccaggttcaagcgattctcctgcctcagactcccgagtagctgggactacaggcatgtgccactacgcccggctaattttgtatttttagtagagacagggtttctccatgttggtcaggttgctctcaaactcccaacctcaggtgatctgcccacctcggcctcccaaagtgctgggattactgagccactgtgcccagcccaaaatgtatcttatacaaacattgtagaaatgaataatgattactcaaataagatcttttaattataagcttctggcatctctatttttcccttaagtaggggatactaaagtgaatgattttctaagaggatcttttgaaactctttagtacaatatttgagtaaaataaattattgtggatcttttgaaactctgtgtagtattcgagtaaaataaatatttgacatttacagtagggtacaccctaagttgtttatgaattccttataccactgttatatttaatttttcagataaaatatgtatgggaaaatgactagagaaattgattcttttttaggctcagggacaagataagtgactaattgtgaaccccaagctctaattgtatgttcagagtgatgtctccataaaattacaaatgtcatgtactttcagggtagctccttatttagtcagaaatctcagagattaaatgtgtgaatatttagggtttttgcatatttttgaccaaccaatgaaagcgaattagttcagtttagaaagtttgatgtctatacttgtatatacctctttaaattttagaactttgtaggttattcatttttaaagagcaataaagtttgtataagatagtgattgctttccttctattctttaaatatcaaaaatagagtatctctctgtcttcactattctcatccttggacatttcctctcccctccccttggtattctcttttttgaggggggggtgttctaggtgagttaatccttagtattttcagtagtcattgctataaaactctcagcttcccctccatactttcaacctaacacttctctctcccaacttatctctgtgtaatctcccagttcatgattaacaaattataattttattgagggactgttctaatcctgatatctcagattttcttggctgttatctccctatctttctgtattctatgtcagtcagagccaaaatccttttcatcatcccaaatttttctatccgccacatcactgattcatacaccctagtcttccatcacagtctcttaatttttaagttttttttttcttactactcccttcatacttattctttaatttcatggaaacactagagtagctatcttaaactaagactacagaccattaaaaagtcagtttctcagccaggcacgagaaactactaacacctgtaatcccagcactttgggaggccaaggcgggcagatcacgagaggtcaaggagatcgagaccatcctggctaatacggtgaaaccccgtctctactaaaaatagaaaaaattagccaggcgcctgtagtcccagctacttgggaggctgaggcaggagaacggcgtgaacccgggaggcggagcttgcagtgagccgagatggtgccactgcactccagcctgggtgacagagcgagactccatctcaaaaaaaaaaaaaaaacagtttctcagtccatgtaaccacctttcaaatgatcagtagccatatgtggctagtggttaccatattagacaattgaggaaatattgaacatttccatcatcacagaaagtacagttggactatgggccaaatctagcacaccacctgcttctggatggtcttcaacctaagaatagtttttacgtttttaaatagttg
//
ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:151648 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:151648 -> Biological process: GO:0000278 [mitotic cell cycle] evidence: TAS GeneID:151648 -> Biological process: GO:0007059 [chromosome segregation] evidence: IDA GeneID:151648 -> Biological process: GO:0007067 [mitosis] evidence: IEA GeneID:151648 -> Biological process: GO:0008608 [attachment of spindle microtubules to kinetochore] evidence: IDA GeneID:151648 -> Biological process: GO:0010457 [centriole-centriole cohesion] evidence: IDA GeneID:151648 -> Biological process: GO:0045132 [meiotic chromosome segregation] evidence: IEA GeneID:151648 -> Biological process: GO:0051301 [cell division] evidence: IEA GeneID:151648 -> Cellular component: GO:0000775 [chromosome, centromeric region] evidence: IDA GeneID:151648 -> Cellular component: GO:0000776 [kinetochore] evidence: IDA GeneID:151648 -> Cellular component: GO:0000777 [condensed chromosome kinetochore] evidence: IEA GeneID:151648 -> Cellular component: GO:0000779 [condensed chromosome, centromeric region] evidence: IDA GeneID:151648 -> Cellular component: GO:0000780 [condensed nuclear chromosome, centromeric region] evidence: IEA GeneID:151648 -> Cellular component: GO:0000922 [spindle pole] evidence: IDA GeneID:151648 -> Cellular component: GO:0005813 [centrosome] evidence: IDA GeneID:151648 -> Cellular component: GO:0005829 [cytosol] evidence: TAS GeneID:151648 -> Cellular component: GO:0030892 [mitotic cohesin complex] evidence: IDA
by
@meso_cacase at
DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.