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2025-05-09 19:11:22, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001077663 3636 bp mRNA linear PRI 07-JUL-2013
DEFINITION Homo sapiens upregulator of cell proliferation (URGCP), transcript
variant 3, mRNA.
ACCESSION NM_001077663
VERSION NM_001077663.1 GI:117968327
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3636)
AUTHORS Dodurga,Y., Yonguc,G.N., Avci,C.B., Bagci,G., Gunduz,C. and
Satiroglu-Tufan,N.L.
TITLE Investigation of microRNA expression changes in HepG2 cell line in
presence of URG4/URGCP and in absence of URG4/URGCP suppressed by
RNA interference
JOURNAL Mol. Biol. Rep. 39 (12), 11119-11124 (2012)
PUBMED 23053999
REMARK GeneRIF: microRNA profiles were analyzedin HepG2 cells in presence
or absence of URG4/URGCP gene using RNA interference.
REFERENCE 2 (bases 1 to 3636)
AUTHORS Dodurga,Y., Avci,C.B., Susluer,S.Y., Satiroglu Tufan,N.L. and
Gunduz,C.
TITLE The expression of URGCP gene in prostate cancer cell lines:
correlation with rapamycin
JOURNAL Mol. Biol. Rep. 39 (12), 10173-10177 (2012)
PUBMED 23007575
REMARK GeneRIF: Rapamycin diminishes URGCP gene expression in DU145 and
PC3 cells, but increases expression in LNCaP cells.
REFERENCE 3 (bases 1 to 3636)
AUTHORS Xie,C., Song,L.B., Wu,J.H., Li,J., Yun,J.P., Lai,J.M., Xie,D.Y.,
Lin,B.L., Yuan,Y.F., Li,M. and Gao,Z.L.
TITLE Upregulator of cell proliferation predicts poor prognosis in
hepatocellular carcinoma and contributes to hepatocarcinogenesis by
downregulating FOXO3a
JOURNAL PLoS ONE 7 (7), E40607 (2012)
PUBMED 22815774
REMARK GeneRIF: The effects of URGCP/URG4-overexpression or -knockdown on
expression of cell cycle regulators and transcriptional activity of
FOXO3a, were examined.
REFERENCE 4 (bases 1 to 3636)
AUTHORS Oymak,Y., Dodurga,Y., Turedi,A., Yaman,Y., Ozek,G., Carti,O.,
Gunes,B.T., Erbudak,E., Berber,E., Avci,C.B. and Vergin,C.
TITLE Higher expression of the novel gene upregulated gene 4 in two acute
lymphoblastic leukemia patients with poor prednisolone response
JOURNAL Acta Haematol. 128 (2), 73-76 (2012)
PUBMED 22677619
REMARK GeneRIF: higher expression of URG4 in our 2 patients suggests that
URG4 might be involved in leukemogenesis
REFERENCE 5 (bases 1 to 3636)
AUTHORS Satiroglu-Tufan,N.L., Dodurga,Y., Gok,D., Cetinkaya,A. and
Feitelson,M.A.
TITLE RNA interference-mediated URG4 gene silencing diminishes cyclin D1
mRNA expression in HepG2 cells
JOURNAL Genet. Mol. Res. 9 (3), 1557-1567 (2010)
PUBMED 20714998
REMARK GeneRIF: The data suggest that URG4 may play an important role in
the development of hepatocellular carcinoma by partially regulating
the expression of cyclin D1.
Publication Status: Online-Only
REFERENCE 6 (bases 1 to 3636)
AUTHORS Huang,J., Zhu,B., Lu,L., Lian,Z., Wang,Y., Yang,X.,
Satiroglu-Tufan,N.L., Liu,J. and Luo,Z.
TITLE The expression of novel gene URG4 in osteosarcoma: correlation with
patients' prognosis
JOURNAL Pathology 41 (2), 149-154 (2009)
PUBMED 18972316
REMARK GeneRIF: URG4 may play important roles in the development of
osteosarcoma, and might be a useful molecular marker for predicting
the prognosis of osteosarcoma.
REFERENCE 7 (bases 1 to 3636)
AUTHORS Song,J., Xie,H., Lian,Z., Yang,G., Du,R., Du,Y., Zou,X., Jin,H.,
Gao,J., Liu,J. and Fan,D.
TITLE Enhanced cell survival of gastric cancer cells by a novel gene URG4
JOURNAL Neoplasia 8 (12), 995-1002 (2006)
PUBMED 17217616
REMARK GeneRIF: URG4 plays an important role in the development of human
gastric cancer by regulating the expression of cyclin D1.
REFERENCE 8 (bases 1 to 3636)
AUTHORS Tsang,H.T., Connell,J.W., Brown,S.E., Thompson,A., Reid,E. and
Sanderson,C.M.
TITLE A systematic analysis of human CHMP protein interactions:
additional MIT domain-containing proteins bind to multiple
components of the human ESCRT III complex
JOURNAL Genomics 88 (3), 333-346 (2006)
PUBMED 16730941
REFERENCE 9 (bases 1 to 3636)
AUTHORS Fu,G.K., Wang,J.T., Yang,J., Au-Young,J. and Stuve,L.L.
TITLE Circular rapid amplification of cDNA ends for high-throughput
extension cloning of partial genes
JOURNAL Genomics 84 (1), 205-210 (2004)
PUBMED 15203218
REFERENCE 10 (bases 1 to 3636)
AUTHORS Tufan,N.L., Lian,Z., Liu,J., Pan,J., Arbuthnot,P., Kew,M.,
Clayton,M.M., Zhu,M. and Feitelson,M.A.
TITLE Hepatitis Bx antigen stimulates expression of a novel cellular
gene, URG4, that promotes hepatocellular growth and survival
JOURNAL Neoplasia 4 (4), 355-368 (2002)
PUBMED 12082552
REMARK GeneRIF: URG4 may be a natural effector of HBxAg that contributes
importantly to multistep hepatocarcinogenesis.
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
DA240479.1, DA316326.1, AK026185.1, DR421788.1, AK000661.1 and
AL833744.1.
Summary: URG4 is upregulated in the presence of hepatitis B virus
(HBV)-encoded X antigen (HBxAg) and may contribute to the
development of hepatocellular carcinoma by promoting hepatocellular
growth and survival (Tufan et al., 2002 [PubMed
12082552]).[supplied by OMIM, Mar 2008].
Transcript Variant: This variant (3) represents the more frequently
occurring transcript and it encodes the longest protein (isoform
3).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: DA313524.1, BX648505.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025082, ERS025085 [ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
gene product(s) localized to mito. :: inferred from homology
##RefSeq-Attributes-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-7 DA240479.1 1-7
8-555 DA316326.1 1-548
556-1844 AK026185.1 170-1458
1845-2380 DR421788.1 130-665
2381-3607 AK000661.1 525-1751
3608-3636 AL833744.1 2148-2176
FEATURES Location/Qualifiers
source 1..3636
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="7"
/map="7p13"
gene 1..3636
/gene="URGCP"
/gene_synonym="URG4"
/note="upregulator of cell proliferation"
/db_xref="GeneID:55665"
/db_xref="HGNC:30890"
/db_xref="MIM:610337"
exon 1..71
/gene="URGCP"
/gene_synonym="URG4"
/inference="alignment:Splign:1.39.8"
CDS 58..2853
/gene="URGCP"
/gene_synonym="URG4"
/note="isoform 3 is encoded by transcript variant 3;
up-regulated gene 4; HBxAg up-regulated gene 4 protein;
HBV X protein up-regulated gene 4 protein; up-regulator of
cell proliferation"
/codon_start=1
/product="up-regulator of cell proliferation isoform 3"
/protein_id="NP_001071131.1"
/db_xref="GI:117968328"
/db_xref="CCDS:CCDS47578.1"
/db_xref="GeneID:55665"
/db_xref="HGNC:30890"
/db_xref="MIM:610337"
/translation="
MASPGIEVELLGKGHSDLGEVAPEIKASERRTAVAIADLEWREMEGDDCEFRYGDGTNEAQDNDFPTVERSRLQEMLSLLGLETYQVQKLSLQDSLQISFDSMKNWAPQVPKDLPWNFLRKLQALNADARNTTMVLDVLPDARPVEKESQMEEEIIYWDPADDLAADIYSFSELPTPDTPVNPLDLLCALLLSSDSFLQQEIALKMALCQFALPLVLPDSENHYHTFLLWAMRGIVRTWWSQPPRGMGSFREDSVVLSRAPAFAFVRMDVSSNSKSQLLNAVLSPGHRQWDCFWHRDLNLGTNAREISDGLVEISWFFPSGREDLDIFPEPVAFLNLRGDIGSHWLQFKLLTEISSAVFILTDNISKKEYKLLYSMKESTTKYYFILSPYRGKRNTNLRFLNKLIPVLKIDHSHVLVKVSSTDSDSFVKRIRAIVGNVLRAPCRRVSVEDMAHAARKLGLKVDEDCEECQKAKDRMERITRKIKDSDAYRRDELRLQGDPWRKAAQVEKEFCQLQWAVDPPEKHRAELRRRLLELRMQQNGHDPSSGVQEFISGISSPSLSEKQYFLRWMEWGLARVAQPRLRQPPETLLTLRPKHGGTTDVGEPLWPEPLGVEHFLREMGQFYEAESCLVEAGRLPAGQRRFAHFPGLASELLLTGLPLELIDGSTLSMPVRWVTGLLKELHVRLERRSRLVVLSTVGVPGTGKSTLLNTMFGLRFATGKSCGPRGAFMQLITVAEGFSQDLGCDHILVIDSGGLIGGALTSAGDRFELEASLATLLMGLSNVTVISLAETKDIPAAILHAFLRLEKTGHMPNYQFVYQNLHDVSVPGPRPRDKRQLLDPPGDLSRAAAQMEKQGDGFRALAGLAFCDPEKQHIWHIPGLWHGAPPMAAVSLAYSEAIFELKRCLLENIRNGLSNQNKNIQQLIELVRRL
"
misc_feature <1300..1458
/gene="URGCP"
/gene_synonym="URG4"
/note="Protein of unknown function (DUF460); Region:
DUF460; pfam04312"
/db_xref="CDD:146773"
misc_feature 2161..>2433
/gene="URGCP"
/gene_synonym="URG4"
/note="P-loop containing Nucleoside Triphosphate
Hydrolases; Region: P-loop_NTPase; cl09099"
/db_xref="CDD:214148"
misc_feature order(2161..2178,2320..2322)
/gene="URGCP"
/gene_synonym="URG4"
/note="GTP/Mg2+ binding site [chemical binding]; other
site"
/db_xref="CDD:206648"
misc_feature 2161..2175
/gene="URGCP"
/gene_synonym="URG4"
/note="G1 box; other site"
/db_xref="CDD:206648"
misc_feature 2242..2250
/gene="URGCP"
/gene_synonym="URG4"
/note="Switch I region; other site"
/db_xref="CDD:206648"
misc_feature 2311..2322
/gene="URGCP"
/gene_synonym="URG4"
/note="G3 box; other site"
/db_xref="CDD:206648"
misc_feature order(2317..2322,2404..2409)
/gene="URGCP"
/gene_synonym="URG4"
/note="Switch II region; other site"
/db_xref="CDD:206648"
exon 72..98
/gene="URGCP"
/gene_synonym="URG4"
/inference="alignment:Splign:1.39.8"
exon 99..169
/gene="URGCP"
/gene_synonym="URG4"
/inference="alignment:Splign:1.39.8"
exon 170..220
/gene="URGCP"
/gene_synonym="URG4"
/inference="alignment:Splign:1.39.8"
exon 221..259
/gene="URGCP"
/gene_synonym="URG4"
/inference="alignment:Splign:1.39.8"
variation 258
/gene="URGCP"
/gene_synonym="URG4"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:17423654"
exon 260..3618
/gene="URGCP"
/gene_synonym="URG4"
/inference="alignment:Splign:1.39.8"
variation 1338
/gene="URGCP"
/gene_synonym="URG4"
/replace="c"
/replace="t"
/db_xref="dbSNP:17172256"
variation 1515
/gene="URGCP"
/gene_synonym="URG4"
/replace="a"
/replace="g"
/db_xref="dbSNP:2232098"
variation 1649
/gene="URGCP"
/gene_synonym="URG4"
/replace="a"
/replace="g"
/db_xref="dbSNP:2232099"
variation 1776
/gene="URGCP"
/gene_synonym="URG4"
/replace="a"
/replace="c"
/db_xref="dbSNP:2232100"
variation 1785
/gene="URGCP"
/gene_synonym="URG4"
/replace="a"
/replace="g"
/db_xref="dbSNP:2232101"
variation 1796
/gene="URGCP"
/gene_synonym="URG4"
/replace="c"
/replace="t"
/db_xref="dbSNP:2232102"
variation 1845
/gene="URGCP"
/gene_synonym="URG4"
/replace="c"
/replace="t"
/db_xref="dbSNP:2232103"
variation 1860
/gene="URGCP"
/gene_synonym="URG4"
/replace="c"
/replace="t"
/db_xref="dbSNP:2232104"
variation 2106
/gene="URGCP"
/gene_synonym="URG4"
/replace="c"
/replace="t"
/db_xref="dbSNP:2232105"
variation 2146
/gene="URGCP"
/gene_synonym="URG4"
/replace="a"
/replace="g"
/db_xref="dbSNP:2232106"
variation 2337
/gene="URGCP"
/gene_synonym="URG4"
/replace="c"
/replace="t"
/db_xref="dbSNP:2232107"
variation 2392
/gene="URGCP"
/gene_synonym="URG4"
/replace="a"
/replace="c"
/db_xref="dbSNP:2232108"
variation 2628
/gene="URGCP"
/gene_synonym="URG4"
/replace="c"
/replace="t"
/db_xref="dbSNP:2232109"
variation 2981
/gene="URGCP"
/gene_synonym="URG4"
/replace="c"
/replace="g"
/db_xref="dbSNP:1468405"
STS 3232..3363
/gene="URGCP"
/gene_synonym="URG4"
/standard_name="RH103374"
/db_xref="UniSTS:97701"
STS 3467..3525
/gene="URGCP"
/gene_synonym="URG4"
/standard_name="STS-Z40982"
/db_xref="UniSTS:64179"
STS 3469..3593
/gene="URGCP"
/gene_synonym="URG4"
/standard_name="SHGC-36996"
/db_xref="UniSTS:13584"
variation 3471
/gene="URGCP"
/gene_synonym="URG4"
/replace="c"
/replace="t"
/db_xref="dbSNP:1043200"
polyA_signal 3587..3592
/gene="URGCP"
/gene_synonym="URG4"
polyA_site 3607
/gene="URGCP"
/gene_synonym="URG4"
polyA_site 3618
/gene="URGCP"
/gene_synonym="URG4"
ORIGIN
gagccgcggccgcgcggaggaagcgaaggaggcgggagcggagacctcgctgcgctcatggcgtcgcccgggatagaagtggaattactgggcaaagggcattcagatttgggagaagtagccccagaaataaaagcatcagagagacgaacagctgtggccattgcagatttggaatggagagaaatggaaggagatgattgcgagttccgttatggagatggtacaaatgaggctcaggacaatgattttccaacagtggagagaagcaggcttcaagaaatgctgtcacttttgggcctagagacgtaccaggtccagaaactcagcctccaggactctctgcagatcagttttgacagtatgaagaactgggcccctcaggttcccaaagacttgccctggaatttcctcaggaagttgcaggccctcaatgctgatgccaggaataccactatggtgctggacgtgctcccagacgccaggcctgtggagaaggagagccagatggaagaggagatcatctactgggacccagctgatgaccttgctgccgacatttattccttttctgagctgcccacccctgatacgccagtgaaccccttagaccttctctgtgccctgctgctctcctcagacagtttcctgcaacaagaaatagcgttgaaaatggccctctgccagtttgcactcccactcgtgttgcctgactcggagaaccactaccatacatttctgctgtgggccatgcggggcattgtgaggacatggtggtcccagcccccaaggggcatggggagcttccgggaagacagcgtggtcttgtccagggcgcccgccttcgccttcgtgcgcatggacgtcagtagcaactccaagtcccagcttctcaacgccgtcctcagcccgggccacaggcagtgggactgcttctggcatcgggacctcaacttgggcaccaatgcccgggagatttcggatgggttggtagaaatttcctggttttttcccagcggaagggaggacttggacattttcccagaacctgtggcctttctgaacctgagaggtgacatcgggtctcactggctgcagtttaagctcttgacagaaatctcctccgctgtgtttatattgactgacaatatcagtaagaaggaatacaaattgctgtactccatgaaggagtcaaccacaaaatactacttcatcctgagtccctaccgtgggaagcgcaacacaaacctgagatttctgaataagttaattcctgtgctgaaaatagaccactcacatgtcctggtaaaggtcagcagcactgacagcgacagcttcgtgaagaggatccgggccatcgttgggaatgtgctgcgggcaccctgcaggcgggtatctgtggaggacatggcgcacgcagcccgcaaactgggcctaaaggtcgacgaggactgtgaggagtgtcagaaagcgaaagaccggatggagaggattaccaggaaaatcaaagactcggatgcctacagaagggacgagctgaggctgcagggggacccctggagaaaggcagcccaagtggagaaggagttctgccagctccagtgggccgtggacccccctgagaagcacagggctgagctgaggcggcggctgctagaacttcgaatgcagcagaacggccatgatccctcctcgggggtgcaggagttcatctcggggatcagcagcccctccttgagtgagaagcagtacttcctgaggtggatggagtggggcctggcacgggtggcccagccgcgactgagacagcctccggagacgcttctcaccctgagaccaaagcatgggggcaccacagacgtgggggagccgctctggcctgagcccctaggggtggaacacttcttgcgggagatgggacagttttatgaggctgagagctgtcttgtggaggcagggaggctgccggcaggccagaggcgttttgcccacttcccaggcttggcctcggagctgctgctgacagggctgcctctggagctaatcgatgggagcacgctgagcatgcccgtccgctgggtcacagggctcctgaaggagctgcacgtccgactggagagacggtcaaggctggtggttctgtcaaccgtcggggtgccaggcacgggcaagtccacactcctcaacaccatgtttgggctgcggtttgccacagggaagagctgcggtcctcgaggggccttcatgcagctcatcacagtggctgagggcttcagccaggacctgggctgtgaccacatcctggtgatagactccgggggcttgataggtggggccttgacgtcagctggggacagatttgagctggaggcttccttggccactctgctcatgggactgagcaatgtcaccgtgatcagtctagctgaaaccaaggacattccagcagctattctgcatgcatttctgaggttagaaaaaacggggcacatgcccaactaccagtttgtataccagaaccttcatgatgtatctgttcccggccctaggcccagagacaagagacagctcctggatccacctggtgacctgagcagggctgcagcccagatggagaaacagggcgacggcttccgggcactggcaggcctggccttctgcgaccctgagaagcagcacatctggcacatcccaggcctgtggcacggagcacctcccatggccgcagtgagcttggcctacagtgaagccatatttgaattgaagagatgcctactcgaaaacatcaggaacggcttgtcgaaccaaaacaaaaacatccagcagctcattgagctggtgagacggctgtgagtgtgcagagaaacccagttcaggtgtaggaggctgctgtgggcagccctgtctgatggggcacccgtgtggggctgtgctctggtgcctgagaatggctggtgcccaatcgacatgagaagacgaggaaaagacagggtttggagtctcctcaacagtgttaaaagaggaagtgacctcacagaccagctcagagatgttaccaagaatatcacagcccccagggtagggagacaagcagcagtttgttctgtctcagctcctgtcaaggatcctgcggggtgggccctctgtatagctgctctctgtcactggcccctggagtgggagcagcgtccttagtcactgcaggcccaggcgggcaggtggtcccaggacagaggtggggaagttgtcctgaggaagcagaagtaggccttgctcccgcccaacccaagggcctccagtggaccagcattcaagatgtgagtgcccgtggtgtgcaaggcactcccatggcaccgtatttattgactgatctgtgaaggcttccctgacccctgcccaggaagagttcactggtcgctctgttgtgccccacagcactttgttatacctctgccacacacttcacgcagcgcgttgtaactcatgtgtttacatgtctgtccccccagactgtgagctccttgagggcagggactgtacattctccagctctgtgtccccagggcctggcacattgtagacgcttaataaatgtctgttaaatgaatgagtgcacaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:55665 -> Molecular function: GO:0005525 [GTP binding] evidence: IEA
GeneID:55665 -> Biological process: GO:0007049 [cell cycle] evidence: IEA
GeneID:55665 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
GeneID:55665 -> Cellular component: GO:0005737 [cytoplasm] evidence: IEA
by
@meso_cacase at
DBCLS
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