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2025-05-09 19:18:15, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001012413 3192 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens shugoshin-like 1 (S. pombe) (SGOL1), transcript
variant C1, mRNA.
ACCESSION NM_001012413
VERSION NM_001012413.2 GI:312922397
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3192)
AUTHORS Greenwood,T.A., Akiskal,H.S., Akiskal,K.K. and Kelsoe,J.R.
CONSRTM Bipolar Genome Study
TITLE Genome-wide association study of temperament in bipolar disorder
reveals significant associations with three novel Loci
JOURNAL Biol. Psychiatry 72 (4), 303-310 (2012)
PUBMED 22365631
REFERENCE 2 (bases 1 to 3192)
AUTHORS Liu,L., Zhang,N., Liu,J., Min,J., Ma,N., Liu,N., Liu,Y. and
Zhang,H.
TITLE Lentivirus-mediated siRNA interference targeting SGO-1 inhibits
human NSCLC cell growth
JOURNAL Tumour Biol. 33 (2), 515-521 (2012)
PUBMED 22161216
REMARK GeneRIF: Lentivirus-mediated siRNA interference targeting SGO-1
inhibits human NSCLC cell growth
REFERENCE 3 (bases 1 to 3192)
AUTHORS Kahyo,T., Iwaizumi,M., Shinmura,K., Matsuura,S., Nakamura,T.,
Watanabe,Y., Yamada,H. and Sugimura,H.
TITLE A novel tumor-derived SGOL1 variant causes abnormal mitosis and
unstable chromatid cohesion
JOURNAL Oncogene 30 (44), 4453-4463 (2011)
PUBMED 21532624
REMARK GeneRIF: These results suggest that SGOL1-P1 may function as a
negative factor to native SGOL1, and that abundant expression of
SGOL1-P1 may be responsible for chromosomal instability.
REFERENCE 4 (bases 1 to 3192)
AUTHORS Kang,J., Chaudhary,J., Dong,H., Kim,S., Brautigam,C.A. and Yu,H.
TITLE Mitotic centromeric targeting of HP1 and its binding to Sgo1 are
dispensable for sister-chromatid cohesion in human cells
JOURNAL Mol. Biol. Cell 22 (8), 1181-1190 (2011)
PUBMED 21346195
REMARK GeneRIF: HP1alpha binding by INCENP or Shugoshin 1 (Sgo1) is
dispensable for centromeric cohesion protection during mitosis of
human cells, but might regulate yet unknown interphase functions of
the chromosome passenger complex (CPC) or Sgo1 at the centromeres.
REFERENCE 5 (bases 1 to 3192)
AUTHORS Okamoto,N., Kuwahara,K., Ohta,K., Kitabatake,M., Takagi,K.,
Mizuta,H., Kondo,E. and Sakaguchi,N.
TITLE Germinal center-associated nuclear protein (GANP) is involved in
mRNA export of Shugoshin-1 required for centromere cohesion and in
sister-chromatid exchange
JOURNAL Genes Cells 15 (5), 471-484 (2010)
PUBMED 20384790
REMARK GeneRIF: Data show that human germinal center-associated nuclear
protein (GANP) is critically involved in cell proliferation at the
mitotic phase through its selective support of shugoshin-1 mRNA
export.
REFERENCE 6 (bases 1 to 3192)
AUTHORS Wang,X. and Dai,W.
TITLE Shugoshin, a guardian for sister chromatid segregation
JOURNAL Exp. Cell Res. 310 (1), 1-9 (2005)
PUBMED 16112668
REMARK GeneRIF: A comprehensive review of Sgo1 function in eukaryote at
meiosis and mitosis.
Review article
REFERENCE 7 (bases 1 to 3192)
AUTHORS McGuinness,B.E., Hirota,T., Kudo,N.R., Peters,J.M. and Nasmyth,K.
TITLE Shugoshin prevents dissociation of cohesin from centromeres during
mitosis in vertebrate cells
JOURNAL PLoS Biol. 3 (3), E86 (2005)
PUBMED 15737064
REMARK GeneRIF: A shugoshin-like protein associates with centromeres
during prophase and disappears at the onset of anaphase
REFERENCE 8 (bases 1 to 3192)
AUTHORS Kitajima,T.S., Hauf,S., Ohsugi,M., Yamamoto,T. and Watanabe,Y.
TITLE Human Bub1 defines the persistent cohesion site along the mitotic
chromosome by affecting Shugoshin localization
JOURNAL Curr. Biol. 15 (4), 353-359 (2005)
PUBMED 15723797
REFERENCE 9 (bases 1 to 3192)
AUTHORS Tang,Z., Sun,Y., Harley,S.E., Zou,H. and Yu,H.
TITLE Human Bub1 protects centromeric sister-chromatid cohesion through
Shugoshin during mitosis
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 101 (52), 18012-18017 (2004)
PUBMED 15604152
REMARK GeneRIF: Bub1 protects centromeric cohesion through Shugoshin in
mitosis
REFERENCE 10 (bases 1 to 3192)
AUTHORS Scanlan,M.J., Gout,I., Gordon,C.M., Williamson,B., Stockert,E.,
Gure,A.O., Jager,D., Chen,Y.T., Mackay,A., O'Hare,M.J. and Old,L.J.
TITLE Humoral immunity to human breast cancer: antigen definition and
quantitative analysis of mRNA expression
JOURNAL Cancer Immun. 1, 4 (2001)
PUBMED 12747765
REMARK Publication Status: Online-Only
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BG530826.1, AB193056.1, AF308299.1 and AC099057.3.
On Nov 30, 2010 this sequence version replaced gi:60302878.
Transcript Variant: This variant (C1) lacks an in-frame internal
exon and the 3' exon, and contains an alternate 3' segment, as
compared to variant A2. The resulting isoform (C1, also known as
1AB) lacks an internal segment and has a shorter and distinct
C-terminus, as compared to isoform A2.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AB187581.1, BX375095.2 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025084 [ECO:0000350]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-153 BG530826.1 2-154
154-938 AB193056.1 186-970
939-1142 AF308299.1 845-1048
1143-3192 AC099057.3 145527-147576 c
FEATURES Location/Qualifiers
source 1..3192
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="3"
/map="3p24.3"
gene 1..3192
/gene="SGOL1"
/gene_synonym="NY-BR-85; SGO; Sgo1"
/note="shugoshin-like 1 (S. pombe)"
/db_xref="GeneID:151648"
/db_xref="HGNC:25088"
/db_xref="HPRD:12377"
/db_xref="MIM:609168"
exon 1..148
/gene="SGOL1"
/gene_synonym="NY-BR-85; SGO; Sgo1"
/inference="alignment:Splign:1.39.8"
misc_feature 138..140
/gene="SGOL1"
/gene_synonym="NY-BR-85; SGO; Sgo1"
/note="upstream in-frame stop codon"
exon 149..297
/gene="SGOL1"
/gene_synonym="NY-BR-85; SGO; Sgo1"
/inference="alignment:Splign:1.39.8"
CDS 156..932
/gene="SGOL1"
/gene_synonym="NY-BR-85; SGO; Sgo1"
/note="isoform C1 is encoded by transcript variant C1;
shugoshin 1AB protein; shugoshin 1CD protein; shugoshin
1EF protein; shugoshin 1GH protein; shugoshin 1KL protein;
hSgo1; serologically defined breast cancer antigen
NY-BR-85"
/codon_start=1
/product="shugoshin-like 1 isoform C1"
/protein_id="NP_001012413.1"
/db_xref="GI:60302879"
/db_xref="CCDS:CCDS46772.1"
/db_xref="GeneID:151648"
/db_xref="HGNC:25088"
/db_xref="HPRD:12377"
/db_xref="MIM:609168"
/translation="
MAKERCLKKSFQDSLEDIKKRMKEKRNKNLAEIGKRRSFIAAPCQIITNTSTLLKNYQDNNKMLVLALENEKSKVKEAQDIILQLRKECYYLTCQLYALKGKLTSQQTVEPAQNQEICSSGMDPNSDDSSRNLFVKDLPQIPLEETELPGQGESFQIEATPPETQQSPHLSLKDITNVSLYPVVKIRRLSLSPKKNKASPAVALPKRRCTASVNYKEPTLASKLRRGDPFTDLCFLNSPIFKQKKDLRRSKKSMKQIQ
"
misc_feature 219..356
/gene="SGOL1"
/gene_synonym="NY-BR-85; SGO; Sgo1"
/note="Shugoshin N-terminal coiled-coil region; Region:
Shugoshin_N; pfam07558"
/db_xref="CDD:203682"
misc_feature 759..836
/gene="SGOL1"
/gene_synonym="NY-BR-85; SGO; Sgo1"
/note="Shugoshin C terminus; Region: Shugoshin_C;
pfam07557"
/db_xref="CDD:191783"
exon 298..494
/gene="SGOL1"
/gene_synonym="NY-BR-85; SGO; Sgo1"
/inference="alignment:Splign:1.39.8"
exon 495..571
/gene="SGOL1"
/gene_synonym="NY-BR-85; SGO; Sgo1"
/inference="alignment:Splign:1.39.8"
exon 572..630
/gene="SGOL1"
/gene_synonym="NY-BR-85; SGO; Sgo1"
/inference="alignment:Splign:1.39.8"
exon 631..820
/gene="SGOL1"
/gene_synonym="NY-BR-85; SGO; Sgo1"
/inference="alignment:Splign:1.39.8"
exon 821..3192
/gene="SGOL1"
/gene_synonym="NY-BR-85; SGO; Sgo1"
/inference="alignment:Splign:1.39.8"
variation 939
/gene="SGOL1"
/gene_synonym="NY-BR-85; SGO; Sgo1"
/replace="c"
/replace="t"
/db_xref="dbSNP:1052930"
STS 1324..1411
/gene="SGOL1"
/gene_synonym="NY-BR-85; SGO; Sgo1"
/standard_name="D8S2279"
/db_xref="UniSTS:473907"
STS 1353..1486
/gene="SGOL1"
/gene_synonym="NY-BR-85; SGO; Sgo1"
/standard_name="D7S2067E"
/db_xref="UniSTS:151120"
STS 1477..2746
/gene="SGOL1"
/gene_synonym="NY-BR-85; SGO; Sgo1"
/standard_name="GDB:631813"
/db_xref="UniSTS:158430"
STS 2726..2831
/gene="SGOL1"
/gene_synonym="NY-BR-85; SGO; Sgo1"
/standard_name="D11S3114"
/db_xref="UniSTS:152207"
STS 2813..2890
/gene="SGOL1"
/gene_synonym="NY-BR-85; SGO; Sgo1"
/standard_name="D8S2279"
/db_xref="UniSTS:473907"
ORIGIN
gaatgtggcggcggtagttccaggcgacggcggacggtggtacggtcctggagggcccagtgcgcggggctagccgtggctggagagcttcgaagagccttgaaatgtgaggaggaggaagatagctgttgcagaagtagtggccaaggcaaaagatggccaaggaaagatgcctgaaaaagtcctttcaagatagtcttgaagacataaagaagcgaatgaaagagaaaaggaataaaaacttggcagagattggcaaacgcaggtcttttatagctgcaccatgccaaataatcaccaacacttctacactgctgaaaaattaccaagacaacaacaaaatgttagttttagctttggaaaatgaaaaatccaaagtgaaagaagcccaagatatcatcctacagctgagaaaagaatgttactatctcacatgtcagctatatgcattgaaaggaaaacttacatcacaacaaacagtagaacctgctcagaaccaggaaatatgttcctctggaatggaccccaatagtgatgacagctccagaaatttatttgtgaaggatttaccgcaaattcctcttgaagaaactgaacttccaggacaaggagaatcatttcaaatagaagctacaccacctgaaactcagcagtcacctcatcttagcctgaaggatatcaccaatgtctccttgtatcctgttgtgaaaatcagaagactttctctttctccaaaaaagaataaagcaagcccagcagtggctctgcctaaacgtaggtgcacagccagcgtgaactataaggagcccaccctcgcttcgaaactgagaagaggggacccttttacagatttgtgttttttgaattctcctattttcaagcagaaaaaggatttgagacgttctaaaaaaagtatgaaacaaatacaatgaaggttttgttggatattgtttaaattcaatctacacctctttctgttgcttcaggagaggatctgtaagagtacacaaacagagtgagccattgccatagaatattctcttgacaggaccctagctcataaacatttcttcagaactatacttcaaatgggatgctttgtattaaaactttaataaatttaatttattttttcttttgaatataaataactgagcttaagcattatcatcatatcgatttcttatgctgcctaaacctcttaattttagtcgaaatatatctttttttttttttggaggcggaatttcattcttgttgcccaggctggagtgcaatggcacgatctcagcttaccgcaacctccgcctcccaggttcaagcgattctcctgcctcagactcccgagtagctgggactacaggcatgtgccactacgcccggctaattttgtatttttagtagagacagggtttctccatgttggtcaggttgctctcaaactcccaacctcaggtgatctgcccacctcggcctcccaaagtgctgggattactgagccactgtgcccagcccaaaatgtatcttatacaaacattgtagaaatgaataatgattactcaaataagatcttttaattataagcttctggcatctctatttttcccttaagtaggggatactaaagtgaatgattttctaagaggatcttttgaaactctttagtacaatatttgagtaaaataaattattgtggatcttttgaaactctgtgtagtattcgagtaaaataaatatttgacatttacagtagggtacaccctaagttgtttatgaattccttataccactgttatatttaatttttcagataaaatatgtatgggaaaatgactagagaaattgattcttttttaggctcagggacaagataagtgactaattgtgaaccccaagctctaattgtatgttcagagtgatgtctccataaaattacaaatgtcatgtactttcagggtagctccttatttagtcagaaatctcagagattaaatgtgtgaatatttagggtttttgcatatttttgaccaaccaatgaaagcgaattagttcagtttagaaagtttgatgtctatacttgtatatacctctttaaattttagaactttgtaggttattcatttttaaagagcaataaagtttgtataagatagtgattgctttccttctattctttaaatatcaaaaatagagtatctctctgtcttcactattctcatccttggacatttcctctcccctccccttggtattctcttttttgaggggggggtgttctaggtgagttaatccttagtattttcagtagtcattgctataaaactctcagcttcccctccatactttcaacctaacacttctctctcccaacttatctctgtgtaatctcccagttcatgattaacaaattataattttattgagggactgttctaatcctgatatctcagattttcttggctgttatctccctatctttctgtattctatgtcagtcagagccaaaatccttttcatcatcccaaatttttctatccgccacatcactgattcatacaccctagtcttccatcacagtctcttaatttttaagttttttttttcttactactcccttcatacttattctttaatttcatggaaacactagagtagctatcttaaactaagactacagaccattaaaaagtcagtttctcagccaggcacgagaaactactaacacctgtaatcccagcactttgggaggccaaggcgggcagatcacgagaggtcaaggagatcgagaccatcctggctaatacggtgaaaccccgtctctactaaaaatagaaaaaattagccaggcgcctgtagtcccagctacttgggaggctgaggcaggagaacggcgtgaacccgggaggcggagcttgcagtgagccgagatggtgccactgcactccagcctgggtgacagagcgagactccatctcaaaaaaaaaaaaaaaacagtttctcagtccatgtaaccacctttcaaatgatcagtagccatatgtggctagtggttaccatattagacaattgaggaaatattgaacatttccatcatcacagaaagtacagttggactatgggccaaatctagcacaccacctgcttctggatggtcttcaacctaagaatagtttttacgtttttaaatagttg
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:151648 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:151648 -> Biological process: GO:0000278 [mitotic cell cycle] evidence: TAS
GeneID:151648 -> Biological process: GO:0007059 [chromosome segregation] evidence: IDA
GeneID:151648 -> Biological process: GO:0007067 [mitosis] evidence: IEA
GeneID:151648 -> Biological process: GO:0008608 [attachment of spindle microtubules to kinetochore] evidence: IDA
GeneID:151648 -> Biological process: GO:0010457 [centriole-centriole cohesion] evidence: IDA
GeneID:151648 -> Biological process: GO:0045132 [meiotic chromosome segregation] evidence: IEA
GeneID:151648 -> Biological process: GO:0051301 [cell division] evidence: IEA
GeneID:151648 -> Cellular component: GO:0000775 [chromosome, centromeric region] evidence: IDA
GeneID:151648 -> Cellular component: GO:0000776 [kinetochore] evidence: IDA
GeneID:151648 -> Cellular component: GO:0000777 [condensed chromosome kinetochore] evidence: IEA
GeneID:151648 -> Cellular component: GO:0000779 [condensed chromosome, centromeric region] evidence: IDA
GeneID:151648 -> Cellular component: GO:0000780 [condensed nuclear chromosome, centromeric region] evidence: IEA
GeneID:151648 -> Cellular component: GO:0000922 [spindle pole] evidence: IDA
GeneID:151648 -> Cellular component: GO:0005813 [centrosome] evidence: IDA
GeneID:151648 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:151648 -> Cellular component: GO:0030892 [mitotic cohesin complex] evidence: IDA
by
@meso_cacase at
DBCLS
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