Home |
Help |
Advanced search
2025-05-09 19:46:11, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_000150 3137 bp mRNA linear PRI 15-JUN-2013
DEFINITION Homo sapiens fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
(FUT6), transcript variant 1, mRNA.
ACCESSION NM_000150
VERSION NM_000150.2 GI:103472034
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3137)
AUTHORS He,M., Wu,C., Xu,J., Guo,H., Yang,H., Zhang,X., Sun,J., Yu,D.,
Zhou,L., Peng,T., He,Y., Gao,Y., Yuan,J., Deng,Q., Dai,X., Tan,A.,
Feng,Y., Zhang,H., Min,X., Yang,X., Zhu,J., Zhai,K., Chang,J.,
Qin,X., Tan,W., Hu,Y., Lang,M., Tao,S., Li,Y., Li,Y., Feng,J.,
Li,D., Kim,S.T., Zhang,S., Zhang,H., Zheng,S.L., Gui,L., Wang,Y.,
Wei,S., Wang,F., Fang,W., Liang,Y., Zhai,Y., Chen,W., Miao,X.,
Zhou,G., Hu,F.B., Lin,D., Mo,Z. and Wu,T.
TITLE A genome wide association study of genetic loci that influence
tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and
alpha fetoprotein and their associations with cancer risk
JOURNAL Gut (2013) In press
PUBMED 23300138
REMARK Publication Status: Available-Online prior to print
REFERENCE 2 (bases 1 to 3137)
AUTHORS Lin,X., Lu,D., Gao,Y., Tao,S., Yang,X., Feng,J., Tan,A., Zhang,H.,
Hu,Y., Qin,X., Kim,S.T., Peng,T., Li,L., Mo,L., Zhang,S.,
Trent,J.M., Mo,Z., Zheng,S.L., Xu,J. and Sun,J.
TITLE Genome-wide association study identifies novel loci associated with
serum level of vitamin B12 in Chinese men
JOURNAL Hum. Mol. Genet. 21 (11), 2610-2617 (2012)
PUBMED 22367966
REFERENCE 3 (bases 1 to 3137)
AUTHORS Guo,Q., Guo,B., Wang,Y., Wu,J., Jiang,W., Zhao,S., Qiao,S. and
Wu,Y.
TITLE Functional analysis of alpha1,3/4-fucosyltransferase VI in human
hepatocellular carcinoma cells
JOURNAL Biochem. Biophys. Res. Commun. 417 (1), 311-317 (2012)
PUBMED 22155250
REMARK GeneRIF: these results suggest that FUT6 plays an important role in
hepatocellular carcinoma growth by regulating the PI3K/Akt
signaling pathway.
REFERENCE 4 (bases 1 to 3137)
AUTHORS Trinchera,M., Malagolini,N., Chiricolo,M., Santini,D., Minni,F.,
Caretti,A. and Dall'olio,F.
TITLE The biosynthesis of the selectin-ligand sialyl Lewis x in
colorectal cancer tissues is regulated by fucosyltransferase VI and
can be inhibited by an RNA interference-based approach
JOURNAL Int. J. Biochem. Cell Biol. 43 (1), 130-139 (2011)
PUBMED 20965272
REMARK GeneRIF: The biosynthesis of the selectin-ligand sialyl Lewis x in
colorectal cancer tissues is regulated by fucosyltransferase VI and
can be inhibited by an RNA interference-based approach.
Erratum:[Int J Biochem Cell Biol. 2011 Nov;43(11):1649-50]
REFERENCE 5 (bases 1 to 3137)
AUTHORS Lauc,G., Essafi,A., Huffman,J.E., Hayward,C., Knezevic,A.,
Kattla,J.J., Polasek,O., Gornik,O., Vitart,V., Abrahams,J.L.,
Pucic,M., Novokmet,M., Redzic,I., Campbell,S., Wild,S.H.,
Borovecki,F., Wang,W., Kolcic,I., Zgaga,L., Gyllensten,U.,
Wilson,J.F., Wright,A.F., Hastie,N.D., Campbell,H., Rudd,P.M. and
Rudan,I.
TITLE Genomics meets glycomics-the first GWAS study of human N-Glycome
identifies HNF1alpha as a master regulator of plasma protein
fucosylation
JOURNAL PLoS Genet. 6 (12), E1001256 (2010)
PUBMED 21203500
REMARK Publication Status: Online-Only
REFERENCE 6 (bases 1 to 3137)
AUTHORS Cameron,H.S., Szczepaniak,D. and Weston,B.W.
TITLE Expression of human chromosome 19p alpha(1,3)-fucosyltransferase
genes in normal tissues. Alternative splicing, polyadenylation, and
isoforms
JOURNAL J. Biol. Chem. 270 (34), 20112-20122 (1995)
PUBMED 7650030
REFERENCE 7 (bases 1 to 3137)
AUTHORS McCurley,R.S., Recinos,A. III, Olsen,A.S., Gingrich,J.C.,
Szczepaniak,D., Cameron,H.S., Krauss,R. and Weston,B.W.
TITLE Physical maps of human alpha (1,3)fucosyltransferase genes
FUT3-FUT6 on chromosomes 19p13.3 and 11q21
JOURNAL Genomics 26 (1), 142-146 (1995)
PUBMED 7782074
REFERENCE 8 (bases 1 to 3137)
AUTHORS Reguigne-Arnould,I., Couillin,P., Mollicone,R., Faure,S.,
Fletcher,A., Kelly,R.J., Lowe,J.B. and Oriol,R.
TITLE Relative positions of two clusters of human
alpha-L-fucosyltransferases in 19q (FUT1-FUT2) and 19p
(FUT6-FUT3-FUT5) within the microsatellite genetic map of
chromosome 19
JOURNAL Cytogenet. Cell Genet. 71 (2), 158-162 (1995)
PUBMED 7656588
REFERENCE 9 (bases 1 to 3137)
AUTHORS Weston,B.W., Smith,P.L., Kelly,R.J. and Lowe,J.B.
TITLE Molecular cloning of a fourth member of a human alpha
(1,3)fucosyltransferase gene family. Multiple homologous sequences
that determine expression of the Lewis x, sialyl Lewis x, and
difucosyl sialyl Lewis x epitopes
JOURNAL J. Biol. Chem. 267 (34), 24575-24584 (1992)
PUBMED 1339443
REMARK Erratum:[J Biol Chem 1993 Aug 25;268(24):18398]
REFERENCE 10 (bases 1 to 3137)
AUTHORS Koszdin,K.L. and Bowen,B.R.
TITLE The cloning and expression of a human alpha-1,3 fucosyltransferase
capable of forming the E-selectin ligand
JOURNAL Biochem. Biophys. Res. Commun. 187 (1), 152-157 (1992)
PUBMED 1520296
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DA622182.1, DA628976.1,
BC061700.1, DA426469.1 and AC024592.5.
This sequence is a reference standard in the RefSeqGene project.
On May 27, 2006 this sequence version replaced gi:4503814.
Summary: The protein encoded by this gene is a Golgi stack membrane
protein that is involved in the creation of sialyl-Lewis X, an
E-selectin ligand. Mutations in this gene are a cause of
fucosyltransferase-6 deficiency. Two transcript variants encoding
the same protein have been found for this gene. [provided by
RefSeq, Jul 2008].
Transcript Variant: This variant (1) represents the longer
transcript. Variants 1 and 2 both encode the same protein.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BM781603.1, DA916285.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084, ERS025092 [ECO:0000348]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-91 DA622182.1 2-92
92-130 DA628976.1 87-125
131-906 BC061700.1 121-896
907-1184 DA426469.1 1-278
1185-1263 BC061700.1 1047-1125
1264-3137 AC024592.5 10240-12113 c
FEATURES Location/Qualifiers
source 1..3137
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="19"
/map="19p13.3"
gene 1..3137
/gene="FUT6"
/gene_synonym="FCT3A; FT1A; Fuc-TVI; FucT-VI"
/note="fucosyltransferase 6 (alpha (1,3)
fucosyltransferase)"
/db_xref="GeneID:2528"
/db_xref="HGNC:4017"
/db_xref="HPRD:00651"
/db_xref="MIM:136836"
exon 1..1055
/gene="FUT6"
/gene_synonym="FCT3A; FT1A; Fuc-TVI; FucT-VI"
/inference="alignment:Splign:1.39.8"
STS 944..2365
/gene="FUT6"
/gene_synonym="FCT3A; FT1A; Fuc-TVI; FucT-VI"
/db_xref="UniSTS:481220"
exon 1056..1183
/gene="FUT6"
/gene_synonym="FCT3A; FT1A; Fuc-TVI; FucT-VI"
/inference="alignment:Splign:1.39.8"
exon 1184..3137
/gene="FUT6"
/gene_synonym="FCT3A; FT1A; Fuc-TVI; FucT-VI"
/inference="alignment:Splign:1.39.8"
misc_feature 1190..1192
/gene="FUT6"
/gene_synonym="FCT3A; FT1A; Fuc-TVI; FucT-VI"
/note="upstream in-frame stop codon"
CDS 1196..2275
/gene="FUT6"
/gene_synonym="FCT3A; FT1A; Fuc-TVI; FucT-VI"
/EC_number="2.4.1.65"
/note="galactoside 3-L-fucosyltransferase;
fucosyltransferase VI"
/codon_start=1
/product="alpha-(1,3)-fucosyltransferase"
/protein_id="NP_000141.1"
/db_xref="GI:4503815"
/db_xref="CCDS:CCDS12152.1"
/db_xref="GeneID:2528"
/db_xref="HGNC:4017"
/db_xref="HPRD:00651"
/db_xref="MIM:136836"
/translation="
MDPLGPAKPQWSWRCCLTTLLFQLLMAVCFFSYLRVSQDDPTVYPNGSRFPDSTGTPAHSIPLILLWTWPFNKPIALPRCSEMVPGTADCNITADRKVYPQADAVIVHHREVMYNPSAQLPRSPRRQGQRWIWFSMESPSHCWQLKAMDGYFNLTMSYRSDSDIFTPYGWLEPWSGQPAHPPLNLSAKTELVAWAVSNWGPNSARVRYYQSLQAHLKVDVYGRSHKPLPQGTMMETLSRYKFYLAFENSLHPDYITEKLWRNALEAWAVPVVLGPSRSNYERFLPPDAFIHVDDFQSPKDLARYLQELDKDHARYLSYFRWRETLRPRSFSWALAFCKACWKLQEESRYQTRGIAAWFT
"
misc_feature 1232..2269
/gene="FUT6"
/gene_synonym="FCT3A; FT1A; Fuc-TVI; FucT-VI"
/note="Glycosyltransferase family 10 (fucosyltransferase);
Region: Glyco_transf_10; pfam00852"
/db_xref="CDD:144445"
misc_feature 1238..1297
/gene="FUT6"
/gene_synonym="FCT3A; FT1A; Fuc-TVI; FucT-VI"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P51993.1);
transmembrane region"
variation 1565
/gene="FUT6"
/gene_synonym="FCT3A; FT1A; Fuc-TVI; FucT-VI"
/replace="c"
/replace="t"
/db_xref="dbSNP:778805"
STS 1645..2362
/gene="FUT6"
/gene_synonym="FCT3A; FT1A; Fuc-TVI; FucT-VI"
/standard_name="FUT6_V46"
/db_xref="UniSTS:277258"
variation 1794
/gene="FUT6"
/gene_synonym="FCT3A; FT1A; Fuc-TVI; FucT-VI"
/replace="a"
/replace="g"
/db_xref="dbSNP:2879401"
variation 1798
/gene="FUT6"
/gene_synonym="FCT3A; FT1A; Fuc-TVI; FucT-VI"
/replace="a"
/replace="g"
/db_xref="dbSNP:4041473"
variation 1799
/gene="FUT6"
/gene_synonym="FCT3A; FT1A; Fuc-TVI; FucT-VI"
/replace="a"
/replace="g"
/db_xref="dbSNP:3964631"
variation 1837
/gene="FUT6"
/gene_synonym="FCT3A; FT1A; Fuc-TVI; FucT-VI"
/replace="c"
/replace="t"
/db_xref="dbSNP:364587"
variation 1883
/gene="FUT6"
/gene_synonym="FCT3A; FT1A; Fuc-TVI; FucT-VI"
/replace="a"
/replace="c"
/db_xref="dbSNP:364637"
variation 1888
/gene="FUT6"
/gene_synonym="FCT3A; FT1A; Fuc-TVI; FucT-VI"
/replace="a"
/replace="g"
/db_xref="dbSNP:443907"
STS 2302..2532
/gene="FUT6"
/gene_synonym="FCT3A; FT1A; Fuc-TVI; FucT-VI"
/standard_name="RH80293"
/db_xref="UniSTS:85240"
STS 2306..2529
/gene="FUT6"
/gene_synonym="FCT3A; FT1A; Fuc-TVI; FucT-VI"
/standard_name="SGC35572"
/db_xref="UniSTS:9344"
variation 2845
/gene="FUT6"
/gene_synonym="FCT3A; FT1A; Fuc-TVI; FucT-VI"
/replace="a"
/replace="g"
/db_xref="dbSNP:778806"
STS 2882..2984
/gene="FUT6"
/gene_synonym="FCT3A; FT1A; Fuc-TVI; FucT-VI"
/standard_name="D11S3114"
/db_xref="UniSTS:152207"
STS 2965..3053
/gene="FUT6"
/gene_synonym="FCT3A; FT1A; Fuc-TVI; FucT-VI"
/standard_name="D8S2279"
/db_xref="UniSTS:473907"
variation 2995
/gene="FUT6"
/gene_synonym="FCT3A; FT1A; Fuc-TVI; FucT-VI"
/replace="c"
/replace="t"
/db_xref="dbSNP:778807"
ORIGIN
aaaaccagtattccagatcatttctctccattccaggaagtttgcatagctccctggacttctgctttgcactgccctgcaggagtgggtggggaaaggaagtggctttgaggcacacagaggggcttgttgaggccaccggaggaagcttctgccaccaatatgggacctgtgcccagcctaccagaagagagcatctgaaaacatgtatcgacatggtaacccctctgcttgaagcctcacatggctccctattgccttggtgctgaacaccctatggctgaccgtggcccagcctctgcaacagctctgcctcctctccagtggtgaagacccagcctgctgagactcctcctgcagttcctcaacatgcctgcatttctgctgcctcagggcctttgcgaaggttgttccttgtaactggaatgcccttccatcccttttttattcaaaaggctgcaattttaattgaagaaagttcccttccaaggttcatgagttgcctgacttgcccaccggtttcctgcaagatcccttggcctggcacttagtgctcaggaaatatttggtgatgggccaactgagtgagaaggtgggatctggtgggaaggaaagcggaaaggtagaaattctgctcacttcctcattcccacctcccaaggaacccctggtgtccctgtggaacccgctttgggaaccggtggttcaggtcagccttttcactttgtactcaaagccacatcgcattgaagccacaggtggggcaaggtcatgcatgacctgagtctccaaatcccttcaccctgtttggttctgcaacggggattaggggagccccacgatttgttttcaaaggatgtccgggctccaggacaggatgccctgggtcacctgatgacaggtgtggtggttggaaagggcctggtttcagctccgggtacacttcctccttccttctgctgcgtggtgtggcctcttccacgtcctcagaatccagctgttactccgtccgcggcctctcagctctagggccctctgcacactggcccccccagtgtcacgggcatccagacgggatccagtgcatcctcttttagaagaaaggcctgtctccagatccccgagtccctctagcatctcccagaaggtgtcagacgcagcagtgtccagggagcggcagcagatactctgacccatggatcccctgggcccggccaagccacagtggtcgtggcgctgctgtctgaccacgctgctgtttcagctgctgatggctgtgtgtttcttctcctatctgcgtgtgtctcaagacgatcccactgtgtaccctaatgggtcccgcttcccagacagcacagggacccccgcccactccatccccctgatcctgctgtggacgtggccttttaacaaacccatagctctgccccgctgctcagagatggtgcctggcacggctgactgcaacatcactgccgaccgcaaggtgtatccacaggcagacgcggtcatcgtgcaccaccgagaggtcatgtacaaccccagtgcccagctcccacgctccccgaggcggcaggggcagcgatggatctggttcagcatggagtccccaagccactgctggcagctgaaagccatggacggatacttcaatctcaccatgtcctaccgcagcgactccgacatcttcacgccctacggctggctggagccgtggtccggccagcctgcccacccaccgctcaacctctcggccaagaccgagctggtggcctgggcagtgtccaactgggggccaaactccgccagggtgcgctactaccagagcctgcaggcccatctcaaggtggacgtgtacggacgctcccacaagcccctgccccagggaaccatgatggagacgctgtcccggtacaagttctatctggccttcgagaactccttgcaccccgactacatcaccgagaagctgtggaggaacgccctggaggcctgggccgtgcccgtggtgctgggccccagcagaagcaactacgagaggttcctgccacccgacgccttcatccacgtggacgacttccagagccccaaggacctggcccggtacctgcaggagctggacaaggaccacgcccgctacctgagctactttcgctggcgggagacgctgcggcctcgctccttcagctgggcactcgctttctgcaaggcctgctggaaactgcaggaggaatccaggtaccagacacgcggcatagcggcttggttcacctgagaggctggtgtggggcctgggctgccaggaacctcattttcctggggcctcacctgagtgggggcctcatctacctaaggactcgtttgcctgaagcttcacctgcctgaggactcacctgcctgggacggtcacctgttgcagcttcacctgcctggggattcacctacctgggtcctcactttcctggggcctcacctgctggagtcttcggtggccaggtatgtcccttacctgggatttcacatgctggcttccaggagcgtcccctgcggaagcctggcctgctggggatgtctcctggggactttgcctactggggacctcggctgttggggactttacctgctgggacctgctcccagagaccttccacactgaatctcacctgctaggagcctcacctgctggggacctcaccctggagggcactgggccctgggaactggcacccatggggccccacccatgagtgatggttctggctgatttgtttgtgatgttgttagccgcctgtgaggggtgcagagagataatcaccgcaccgtttccagatgtaatactgcaaagaaaaccgatgatgaggccgggtgcggtggctcacacctgtaatcccagcactttgggaggccgaggcaggcggatcacaaggtcaggagatcgagaccatcctggccaatatggtgaaacccgtctctactaaaaatacaaaaatttgccgggcgtggtggtgcatgcctgtaatcccagctacttgggaagctgaggcaggagaatcgcttgaaccagagagtcggaggttgcagtaagccgagatcgcgccactgcactccagcctggcgacagagcgagactctgtctc
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:2528 -> Molecular function: GO:0008417 [fucosyltransferase activity] evidence: TAS
GeneID:2528 -> Molecular function: GO:0017060 [3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity] evidence: IEA
GeneID:2528 -> Molecular function: GO:0046920 [alpha-(1->3)-fucosyltransferase activity] evidence: TAS
GeneID:2528 -> Biological process: GO:0006486 [protein glycosylation] evidence: IEA
GeneID:2528 -> Biological process: GO:0006486 [protein glycosylation] evidence: TAS
GeneID:2528 -> Biological process: GO:0036065 [fucosylation] evidence: TAS
GeneID:2528 -> Biological process: GO:0042355 [L-fucose catabolic process] evidence: NAS
GeneID:2528 -> Cellular component: GO:0005794 [Golgi apparatus] evidence: TAS
GeneID:2528 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA
GeneID:2528 -> Cellular component: GO:0032580 [Golgi cisterna membrane] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_000141 -> EC 2.4.1.65
by
@meso_cacase at
DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.