LOCUS       NM_001180563            1266 bp    mRNA    linear   PLN 17-DEC-2024
DEFINITION  Saccharomyces cerevisiae S288C ubiquitin-protein ligase RMD5
            (RMD5), partial mRNA.
ACCESSION   NM_001180563
VERSION     NM_001180563.3
DBLINK      BioProject: PRJNA128
KEYWORDS    RefSeq.
SOURCE      Saccharomyces cerevisiae S288C
  ORGANISM  Saccharomyces cerevisiae S288C
            Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
            Saccharomycetes; Saccharomycetales; Saccharomycetaceae;
            Saccharomyces.
REFERENCE   1  (bases 1 to 1266)
  AUTHORS   Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M.,
            Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S.,
            Weng,S. and Cherry,J.M.
  TITLE     New data and collaborations at the Saccharomyces Genome Database:
            updated reference genome, alleles, and the Alliance of Genome
            Resources
  JOURNAL   Genetics 220 (4) (2022)
   PUBMED   34897464
REFERENCE   2  (bases 1 to 1266)
  AUTHORS   Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P.,
            Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C.,
            Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F.,
            Delaveau,T., del Rey,F., Dujon,B., Eide,L.G.,
            Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et
            al.
  TITLE     The nucleotide sequence of Saccharomyces cerevisiae chromosome IV
  JOURNAL   Nature 387 (6632 SUPPL), 75-78 (1997)
   PUBMED   9169867
REFERENCE   3  (bases 1 to 1266)
  AUTHORS   Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B.,
            Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M.,
            Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and
            Oliver,S.G.
  TITLE     Life with 6000 genes
  JOURNAL   Science 274 (5287), 546 (1996)
   PUBMED   8849441
REFERENCE   4  (bases 1 to 1266)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (17-DEC-2024) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   5  (bases 1 to 1266)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (16-JAN-2015) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Protein update by submitter
REFERENCE   6  (bases 1 to 1266)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (06-FEB-2013) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Protein update by submitter
REFERENCE   7  (bases 1 to 1266)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (04-MAY-2012) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Protein update by submitter
REFERENCE   8  (bases 1 to 1266)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (31-MAR-2011) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Sequence update by submitter
REFERENCE   9  (bases 1 to 1266)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (11-DEC-2009) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by SGD. This record
            is derived from an annotated genomic sequence (NC_001136).
            
            On Jul 30, 2012 this sequence version replaced NM_001180563.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: SGD
            Annotation Status   :: Full Annotation
            Annotation Version  :: R64-4-1
            URL                 :: http://www.yeastgenome.org/
            ##Genome-Annotation-Data-END##
            COMPLETENESS: incomplete on both ends.
FEATURES             Location/Qualifiers
     source          1..1266
                     /organism="Saccharomyces cerevisiae S288C"
                     /mol_type="mRNA"
                     /strain="S288C"
                     /db_xref="taxon:559292"
                     /chromosome="IV"
     gene            <1..>1266
                     /gene="RMD5"
                     /locus_tag="YDR255C"
                     /gene_synonym="GID2"
                     /db_xref="GeneID:851842"
     CDS             1..1266
                     /gene="RMD5"
                     /locus_tag="YDR255C"
                     /gene_synonym="GID2"
                     /EC_number="2.3.2.27"
                     /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
                     [PMID:26928762]"
                     /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome
                     [PMID:27663510]"
                     /experiment="EXISTENCE:direct assay:GO:0005829 cytosol
                     [PMID:12686616]"
                     /experiment="EXISTENCE:direct assay:GO:0034657 GID complex
                     [PMID:12686616|PMID:16872538]"
                     /experiment="EXISTENCE:direct assay:GO:0061630 ubiquitin
                     protein ligase activity [PMID:18508925]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0006511
                     ubiquitin-dependent protein catabolic process
                     [PMID:12686616]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0043161
                     proteasome-mediated ubiquitin-dependent protein catabolic
                     process [PMID:12686616]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0045721
                     negative regulation of gluconeogenesis [PMID:12686616]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0061630
                     ubiquitin protein ligase activity [PMID:18508925]"
                     /note="Component of GID Complex that confers ubiquitin
                     ligase (U3) activity; necessary for polyubiquitination and
                     degradation of the gluconeogenic enzyme
                     fructose-1,6-bisphosphatase; forms dimer with Fyv10p that
                     is then recruited to GID Complex by Gid8p; also required
                     for sporulation; conserved protein that has a degenerate
                     RING finger domain"
                     /codon_start=1
                     /product="ubiquitin-protein ligase RMD5"
                     /protein_id="NP_010541.3"
                     /db_xref="GeneID:851842"
                     /db_xref="SGD:S000002663"
                     /translation="

MSELLDSFETEFAKFYTDSNLEETNLQKCLDHTHEFKSQLKKLKAHLNKHIQESKPEVYNKLSDKEKQKFKRKRELIIEKLSKSQRQWDHSVKKQIKYVSQQSNRFNKSTLNKLKEFDIDSVYVNKLPKETMENVNEAIGYHILRYSIDNMPLGNKNEAFQYLKDVYGITNKESTEFIEMGQIVHDLKKGDTESCLKWCSNEMESLSSNHTALSSLKFDLYTLSAMQIVKHGNPVELYYQITQNAPLDCFRHREKELMQNVVPLLTKSLIGQPIEDIDSKVNKELKECTSLFIKEYCAAKHIFFDSPLFLIVLSGLISFQFFIKYKTIRELAHVDWTTKDELPFDVKLPDFLTHFHPIFICPVLKEETTTENPPYSLACHHIISKKALDRLSKNGTITFKCPYCPVNTSMSSTKKVRFVML"

     misc_feature    37..1254
                     /gene="RMD5"
                     /locus_tag="YDR255C"
                     /gene_synonym="GID2"
                     /note="Uncharacterized conserved protein, contains RING
                     Zn-finger [General function prediction only]; Region:
                     COG5109"
                     /db_xref="CDD:227440"
ORIGIN      

atgtctgaattactagatagctttgagacagagtttgcgaaattttataccgacagcaatctggaagagacaaaccttcaaaaatgtcttgatcatactcatgaattcaagagtcaattaaagaagttgaaagcgcacttaaacaagcatattcaggaatcaaaaccagaagtctataataagctgagtgataaggagaaacaaaagtttaagagaaaaagagaactaattattgagaagctaagcaagtcacagaggcaatgggaccattcagtaaagaaacaaataaagtacgtttctcagcagtcgaatcgcttcaacaaaagcacgctgaacaaattaaaagaatttgatatagatagcgtatatgtcaataaattaccgaaagagacaatggaaaatgttaatgaagccatcggttaccatattttgaggtatagtatagacaacatgccattaggaaataaaaatgaggctttccagtatctaaaagatgtctacggaattactaataaagaatctactgaatttattgagatgggccaaatcgtacatgatcttaaaaagggtgacacagaaagctgtctgaaatggtgctccaatgaaatggaaagcttatcatctaaccatacggctttatcgtccctaaaatttgatttatacactttgtcagcaatgcagatagtgaagcatggaaatccggtagagttgtactaccaaataacacagaacgcacccctggattgctttagacatagggagaaggaattaatgcaaaacgtcgtaccattattaactaaatcgctaataggtcaacctattgaagatattgattctaaagtaaataaggaattaaaagaatgcacgtcgttatttataaaagaatattgtgctgcaaaacatattttctttgactctcccttgtttttgatagtattgagtggtttaatttctttccaatttttcatcaaatacaaaaccatcagggagttagcgcacgttgactggactacgaaagatgagttgccatttgatgtcaagttaccagattttctgactcatttccatccgatcttcatctgtcccgtcttaaaggaggaaaccactacagaaaatcctccttattcactggcatgccatcacatcatttctaaaaaggcgctagacagattatcgaagaacggaacaattactttcaagtgcccatactgccccgtaaatacttcaatgagcagtacaaaaaaggttcgttttgttatgctttga

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