LOCUS       NM_001180165            1680 bp    mRNA    linear   PLN 17-DEC-2024
DEFINITION  Saccharomyces cerevisiae S288C Pho2p (PHO2), partial mRNA.
ACCESSION   NM_001180165
VERSION     NM_001180165.1
DBLINK      BioProject: PRJNA128
KEYWORDS    RefSeq.
SOURCE      Saccharomyces cerevisiae S288C
  ORGANISM  Saccharomyces cerevisiae S288C
            Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
            Saccharomycetes; Saccharomycetales; Saccharomycetaceae;
            Saccharomyces.
REFERENCE   1  (bases 1 to 1680)
  AUTHORS   Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M.,
            Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S.,
            Weng,S. and Cherry,J.M.
  TITLE     New data and collaborations at the Saccharomyces Genome Database:
            updated reference genome, alleles, and the Alliance of Genome
            Resources
  JOURNAL   Genetics 220 (4) (2022)
   PUBMED   34897464
REFERENCE   2  (bases 1 to 1680)
  AUTHORS   Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P.,
            Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C.,
            Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F.,
            Delaveau,T., del Rey,F., Dujon,B., Eide,L.G.,
            Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et
            al.
  TITLE     The nucleotide sequence of Saccharomyces cerevisiae chromosome IV
  JOURNAL   Nature 387 (6632 SUPPL), 75-78 (1997)
   PUBMED   9169867
REFERENCE   3  (bases 1 to 1680)
  AUTHORS   Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B.,
            Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M.,
            Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and
            Oliver,S.G.
  TITLE     Life with 6000 genes
  JOURNAL   Science 274 (5287), 546 (1996)
   PUBMED   8849441
REFERENCE   4  (bases 1 to 1680)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (17-DEC-2024) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   5  (bases 1 to 1680)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (16-JAN-2015) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Protein update by submitter
REFERENCE   6  (bases 1 to 1680)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (06-FEB-2013) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Protein update by submitter
REFERENCE   7  (bases 1 to 1680)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (04-MAY-2012) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Protein update by submitter
REFERENCE   8  (bases 1 to 1680)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (31-MAR-2011) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Sequence update by submitter
REFERENCE   9  (bases 1 to 1680)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (11-DEC-2009) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by SGD. This record
            is derived from an annotated genomic sequence (NC_001136).
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: SGD
            Annotation Status   :: Full Annotation
            Annotation Version  :: R64-4-1
            URL                 :: http://www.yeastgenome.org/
            ##Genome-Annotation-Data-END##
            COMPLETENESS: incomplete on both ends.
FEATURES             Location/Qualifiers
     source          1..1680
                     /organism="Saccharomyces cerevisiae S288C"
                     /mol_type="mRNA"
                     /strain="S288C"
                     /db_xref="taxon:559292"
                     /chromosome="IV"
     gene            <1..>1680
                     /gene="PHO2"
                     /locus_tag="YDL106C"
                     /gene_synonym="BAS2; GRF10"
                     /db_xref="GeneID:851452"
     CDS             1..1680
                     /gene="PHO2"
                     /locus_tag="YDL106C"
                     /gene_synonym="BAS2; GRF10"
                     /experiment="EXISTENCE:direct assay:GO:0000978 RNA
                     polymerase II cis-regulatory region sequence-specific DNA
                     binding [PMID:2664469]"
                     /experiment="EXISTENCE:direct assay:GO:0001228 DNA-binding
                     transcription activator activity, RNA polymerase
                     II-specific [PMID:3303332|PMID:7902583|PMID:9566882]"
                     /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
                     [PMID:1493793|PMID:22932476]"
                     /experiment="EXISTENCE:direct assay:GO:0005829 cytosol
                     [PMID:22932476]"
                     /experiment="EXISTENCE:direct assay:GO:0006141 regulation
                     of purine nucleobase metabolic process [PMID:1495962]"
                     /experiment="EXISTENCE:direct assay:GO:0043388 positive
                     regulation of DNA binding [PMID:8355698]"
                     /experiment="EXISTENCE:direct assay:GO:0043565
                     sequence-specific DNA binding [PMID:19111667]"
                     /experiment="EXISTENCE:genetic interaction:GO:0001228
                     DNA-binding transcription activator activity, RNA
                     polymerase II-specific [PMID:7902583|PMID:9566882]"
                     /experiment="EXISTENCE:genetic interaction:GO:0045937
                     positive regulation of phosphate metabolic process
                     [PMID:3915785]"
                     /experiment="EXISTENCE:genetic interaction:GO:0045944
                     positive regulation of transcription by RNA polymerase II
                     [PMID:7902583|PMID:3915785]"
                     /experiment="EXISTENCE:genetic interaction:GO:0120213
                     regulation of histidine biosynthetic process
                     [PMID:3303332]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0001228
                     DNA-binding transcription activator activity, RNA
                     polymerase II-specific
                     [PMID:3303332|PMID:7902583|PMID:9566882]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0006141
                     regulation of purine nucleobase metabolic process
                     [PMID:1495962]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0006338
                     chromatin remodeling [PMID:2196175]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0043388
                     positive regulation of DNA binding [PMID:7902583]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0045944
                     positive regulation of transcription by RNA polymerase II
                     [PMID:7902583|PMID:3303332]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0120213
                     regulation of histidine biosynthetic process
                     [PMID:3303332]"
                     /experiment="EXISTENCE:mutant phenotype:GO:2000679
                     positive regulation of transcription regulatory region DNA
                     binding [PMID:9354395]"
                     /note="Homeobox transcription factor; regulatory targets
                     include genes involved in phosphate metabolism; binds
                     cooperatively with Pho4p to the PHO5 promoter;
                     phosphorylation of Pho2p facilitates interaction with
                     Pho4p; relocalizes to the cytosol in response to hypoxia"
                     /codon_start=1
                     /product="Pho2p"
                     /protein_id="NP_010177.1"
                     /db_xref="GeneID:851452"
                     /db_xref="SGD:S000002264"
                     /translation="

MMEEFSYDHDFNTHFATDLDYLQHDQQQQQQQQHDQQHNQQQQPQPQPIQTQNLEHDHDQHTNDMSASSNASDSGPQRPKRTRAKGEALDVLKRKFEINPTPSLVERKKISDLIGMPEKNVRIWFQNRRAKLRKKQHGSNKDTIPSSQSRDIANDYDRGSTDNNLVTTTSTSSIFHDEDLTFFDRIPLNSNNNYYFFDICSITVGSWNRMKSGALQRRNFQSIKELRNLSPIKINNIMSNATDLMVLISKKNSEINYFFSAMANNTKILFRIFFPLSSVTNCSLTLETDDDIINSNNTSDKNNSNTNNDDDNDDNSNEDNDNSSEDKRNAKDNFGELKLTVTRSPTFAVYFLNNAPDEDPNLNNQWSICDDFSEGRQVNDAFVGGSNIPHTLKGLQKSLRFMNSLILDYKSSNEILPTINTAIPTAAVPQQNIAPPFLNTNSSATDSNPNTNLEDSLFFDHDLLSSSITNTNNGQGSNNGRQASKDDTLNLLDTTVNSNNNHNANNEENHLAQEHLSNDADIVANPNDHLLSLPTDSELPNTPDFLKNTNELTDEHRWI"

     misc_feature    157..549
                     /gene="PHO2"
                     /locus_tag="YDL106C"
                     /gene_synonym="BAS2; GRF10"
                     /note="Homeodomain-containing transcription factor
                     [Transcription]; Region: COG5576"
                     /db_xref="CDD:227863"
ORIGIN      

atgatggaagaattctcgtacgatcacgattttaacacacattttgctacagatttggattatttgcaacatgaccaacaacaacaacaacagcaacaacatgatcaacaacataatcaacagcaacaaccacaaccacaaccaattcaaactcaaaacctggagcacgaccacgaccaacatactaatgatatgagtgcttcatcgaatgcatcagatagtggacctcaaaggcccaagaggactcgcgcaaagggtgaagcactagatgtgctaaagcgtaaatttgaaataaatccaacaccctctttggtagaaagaaagaaaatatcagatctgataggaatgcctgaaaaaaacgtcagaatttggtttcagaacagaagagctaaattgaggaaaaagcagcatggaagtaataaggacacaatcccctcgtcacaatcccgtgatattgccaacgattacgatcgtgggagtacagacaacaatttggtcactacaacaagtacttcatccatatttcacgatgaagacctgacttttttcgaccgtattccgctgaacagcaacaacaactattatttttttgacatttgctcaattactgtgggaagttggaatagaatgaaaagcggcgcactgcaaagaaggaactttcagtctataaaggagttgagaaacctatcgccaataaagattaataacataatgtcgaatgccacagatttaatggttttgatatccaagaaaaactcagaaataaactatttttttagtgccatggcaaataatactaaaattctcttcaggatctttttcccattaagttcagtcacgaattgctctctaactttagaaactgacgacgatataataaatagtaacaacacaagcgataaaaacaatagtaatactaataatgatgatgataacgacgataacagtaatgaagacaatgataatagtagtgaggataagaggaatgctaaggataactttggagaattgaagctaacagtcaccagatcacccacttttgctgtttactttttaaataatgctcctgatgaagatccaaatttgaacaatcagtggtccatatgtgatgatttctcagaaggtagacaggtaaatgacgcatttgttggtggttcgaatattcctcacactttgaaaggtttacagaaatcattaagattcatgaattctctaattctagactataaatcatcgaatgaaatattacctacgatcaatacagcgatccccactgctgcagttccacaacagaatattgcccctccctttctgaatacaaattcaagtgcaacagactcaaatccaaatacaaatttagaagattctctcttcttcgatcatgatctgttatcgagttcgataaccaacaccaacaacggacaaggctctaataatggacgtcaagctagcaaggatgatacgctcaatttactggatactaccgtcaacagcaataacaatcataatgctaataatgaggagaatcatctagcgcaagaacatttatccaacgatgctgatattgttgcaaatccaaatgatcatttgttgtctttaccgactgatagtgaactcccaaatactccagattttttgaagaacactaacgaactaactgacgagcatagatggatatga

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