LOCUS       NM_001180014             372 bp    mRNA    linear   PLN 17-DEC-2024
DEFINITION  Saccharomyces cerevisiae S288C alpha-ketoglutarate dehydrogenase
            subunit KGD4 (KGD4), partial mRNA.
ACCESSION   NM_001180014
VERSION     NM_001180014.3
DBLINK      BioProject: PRJNA128
KEYWORDS    RefSeq.
SOURCE      Saccharomyces cerevisiae S288C
  ORGANISM  Saccharomyces cerevisiae S288C
            Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
            Saccharomycetes; Saccharomycetales; Saccharomycetaceae;
            Saccharomyces.
REFERENCE   1  (bases 1 to 372)
  AUTHORS   Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M.,
            Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S.,
            Weng,S. and Cherry,J.M.
  TITLE     New data and collaborations at the Saccharomyces Genome Database:
            updated reference genome, alleles, and the Alliance of Genome
            Resources
  JOURNAL   Genetics 220 (4) (2022)
   PUBMED   34897464
REFERENCE   2  (bases 1 to 372)
  AUTHORS   Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B.,
            Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M.,
            Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and
            Oliver,S.G.
  TITLE     Life with 6000 genes
  JOURNAL   Science 274 (5287), 546 (1996)
   PUBMED   8849441
REFERENCE   3  (bases 1 to 372)
  AUTHORS   Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M.,
            Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al.
  TITLE     Analysis of the nucleotide sequence of chromosome VI from
            Saccharomyces cerevisiae
  JOURNAL   Nat. Genet. 10 (3), 261-268 (1995)
   PUBMED   7670463
REFERENCE   4  (bases 1 to 372)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (17-DEC-2024) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   5  (bases 1 to 372)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (16-JAN-2015) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Protein update by submitter
REFERENCE   6  (bases 1 to 372)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (04-MAY-2012) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Protein update by submitter
REFERENCE   7  (bases 1 to 372)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (31-MAR-2011) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Sequence update by submitter
REFERENCE   8  (bases 1 to 372)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (11-DEC-2009) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by SGD. This record
            is derived from an annotated genomic sequence (NC_001138).
            
            On Jul 30, 2012 this sequence version replaced NM_001180014.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: SGD
            Annotation Status   :: Full Annotation
            Annotation Version  :: R64-4-1
            URL                 :: http://www.yeastgenome.org/
            ##Genome-Annotation-Data-END##
            COMPLETENESS: incomplete on both ends.
FEATURES             Location/Qualifiers
     source          1..372
                     /organism="Saccharomyces cerevisiae S288C"
                     /mol_type="mRNA"
                     /strain="S288C"
                     /db_xref="taxon:559292"
                     /chromosome="VI"
     gene            <1..>372
                     /gene="KGD4"
                     /locus_tag="YFR049W"
                     /gene_synonym="YMR31"
                     /db_xref="GeneID:850610"
     CDS             1..372
                     /gene="KGD4"
                     /locus_tag="YFR049W"
                     /gene_synonym="YMR31"
                     /experiment="EXISTENCE:direct assay:GO:0003735 structural
                     constituent of ribosome [PMID:2693936]"
                     /experiment="EXISTENCE:direct assay:GO:0004591
                     oxoglutarate dehydrogenase (succinyl-transferring)
                     activity [PMID:25165143]"
                     /experiment="EXISTENCE:direct assay:GO:0005739
                     mitochondrion [PMID:24769239|PMID:16823961]"
                     /experiment="EXISTENCE:direct assay:GO:0005761
                     mitochondrial ribosome [PMID:2693936]"
                     /experiment="EXISTENCE:direct assay:GO:0045252
                     oxoglutarate dehydrogenase complex [PMID:25165143]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0004591
                     oxoglutarate dehydrogenase (succinyl-transferring)
                     activity [PMID:25165143]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0006099
                     tricarboxylic acid cycle [PMID:25165143]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0006103
                     2-oxoglutarate metabolic process [PMID:25165143]"
                     /note="Subunit of the mitochondrial alpha-ketoglutarate
                     dehydrogenase; recruits E3 subunit (Lpd1p) to the E1-E2
                     (Kgd1p, Kgd2p) core; exists in two forms derived from a
                     single mRNA translated from two alternative start sites;
                     evolutionarily conserved role in the organization of
                     mitochondrial alpha-KGDH complexes; homolog of human KGD4"
                     /codon_start=1
                     /product="alpha-ketoglutarate dehydrogenase subunit KGD4"
                     /protein_id="NP_116707.3"
                     /db_xref="GeneID:850610"
                     /db_xref="SGD:S000001945"
                     /translation="

MIATPIRLAKSAYEPMIKFVGTRHPLVKHATEVVVHPCATNGMLPGSKECIPVSKFMENYKPFRVVPIKHSANAGLSSSKTSVFVNRPLQKDELASIFELPARFRYKPINEHELESINSGGAW"

     misc_feature    46..366
                     /gene="KGD4"
                     /locus_tag="YFR049W"
                     /gene_synonym="YMR31"
                     /note="Ribosomal protein S36, mitochondrial; Region:
                     S36_mt; pfam10937"
                     /db_xref="CDD:402493"
ORIGIN      

atgattgctacacctataagattagcaaagagtgcatatgagccgatgataaaattcgtcggtacaaggcatcccttagtgaagcatgcaactgaggtcgttgttcatccttgcgctaccaacggaatgttacctggcagcaaagagtgtattccagtgagtaaattcatggaaaattataaaccattccgtgtagtgccaataaagcatagcgctaatgctggtctcagctcgtcaaagacctctgtattcgttaacaggccattgcaaaaagatgagcttgcttccattttcgagctacctgctaggtttcggtacaaacctattaacgagcatgaattggagagcataaatagcggtggtgcatggtga

//