LOCUS       NM_001179939            1494 bp    mRNA    linear   PLN 17-DEC-2024
DEFINITION  Saccharomyces cerevisiae S288C GTPase-activating protein GYP8
            (GYP8), partial mRNA.
ACCESSION   NM_001179939
VERSION     NM_001179939.1
DBLINK      BioProject: PRJNA128
KEYWORDS    RefSeq.
SOURCE      Saccharomyces cerevisiae S288C
  ORGANISM  Saccharomyces cerevisiae S288C
            Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
            Saccharomycetes; Saccharomycetales; Saccharomycetaceae;
            Saccharomyces.
REFERENCE   1  (bases 1 to 1494)
  AUTHORS   Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M.,
            Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S.,
            Weng,S. and Cherry,J.M.
  TITLE     New data and collaborations at the Saccharomyces Genome Database:
            updated reference genome, alleles, and the Alliance of Genome
            Resources
  JOURNAL   Genetics 220 (4) (2022)
   PUBMED   34897464
REFERENCE   2  (bases 1 to 1494)
  AUTHORS   Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B.,
            Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M.,
            Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and
            Oliver,S.G.
  TITLE     Life with 6000 genes
  JOURNAL   Science 274 (5287), 546 (1996)
   PUBMED   8849441
REFERENCE   3  (bases 1 to 1494)
  AUTHORS   Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M.,
            Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al.
  TITLE     Analysis of the nucleotide sequence of chromosome VI from
            Saccharomyces cerevisiae
  JOURNAL   Nat. Genet. 10 (3), 261-268 (1995)
   PUBMED   7670463
REFERENCE   4  (bases 1 to 1494)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (17-DEC-2024) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   5  (bases 1 to 1494)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (16-JAN-2015) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Protein update by submitter
REFERENCE   6  (bases 1 to 1494)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (04-MAY-2012) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Protein update by submitter
REFERENCE   7  (bases 1 to 1494)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (31-MAR-2011) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Sequence update by submitter
REFERENCE   8  (bases 1 to 1494)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (11-DEC-2009) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by SGD. This record
            is derived from an annotated genomic sequence (NC_001138).
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: SGD
            Annotation Status   :: Full Annotation
            Annotation Version  :: R64-4-1
            URL                 :: http://www.yeastgenome.org/
            ##Genome-Annotation-Data-END##
            COMPLETENESS: incomplete on both ends.
FEATURES             Location/Qualifiers
     source          1..1494
                     /organism="Saccharomyces cerevisiae S288C"
                     /mol_type="mRNA"
                     /strain="S288C"
                     /db_xref="taxon:559292"
                     /chromosome="VI"
     gene            <1..>1494
                     /gene="GYP8"
                     /locus_tag="YFL027C"
                     /db_xref="GeneID:850517"
     CDS             1..1494
                     /gene="GYP8"
                     /locus_tag="YFL027C"
                     /experiment="EXISTENCE:direct assay:GO:0005096 GTPase
                     activator activity [PMID:12189143]"
                     /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
                     [PMID:12189143]"
                     /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome
                     [PMID:36164978]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0016192
                     vesicle-mediated transport [PMID:12189143]"
                     /note="GTPase-activating protein for yeast Rab family
                     members; Ypt1p is the preferred in vitro substrate but
                     also acts on Sec4p, Ypt31p and Ypt32p; involved in the
                     regulation of ER to Golgi vesicle transport; localizes to
                     the ER and peroxisomes"
                     /codon_start=1
                     /product="GTPase-activating protein GYP8"
                     /protein_id="NP_444296.1"
                     /db_xref="GeneID:850517"
                     /db_xref="SGD:S000001867"
                     /translation="

MPLRSLFHTNQSSHDKDALTRGGYNAYLESLSRCDSGKAEEQKGKVISKLLEKKDVRALRYIGLGPLGFVNNSLRKDCWYELLASQLLIDDATEYITPVEKHKDEGQVILDAERSFGGIVDKNLKLQLRKLLVELITRVLRKYPTLNYYQGYHDIVSVFIMCFSWNVTKENGLELENLSLQEEIDMERLFYCIEAFTLLYLRDFMMNSLDFSFEQLRVISSLIKESNMKFYNLFKFDENEPLFAIGSILTIFAHNLKPIDSGDNNLHKILFQIFDMTISMQSMRLPLIIYKNLLLQNASEISKQIEANSDFFENDFDLRHGAIQTVLQKKLYDEALWEEVLQITRKDATTASKKALKRVSLNKYSALLNTACGKPGCFDMSTIIFYLSEQTKMNEHYKEEKYHGVAARSKTRALVQRLGHFLPSKYNRWSKISLLIGIVAILYQLRTTRSLSLVLNLRYMISTKLKDLSHININLHHVSHIWVDPIRDILKLGHPTR"

     misc_feature    4..1491
                     /gene="GYP8"
                     /locus_tag="YFL027C"
                     /note="GTPase-activating protein [General function
                     prediction only]; Region: COG5210"
                     /db_xref="CDD:227535"
ORIGIN      

atgccattaaggtcattatttcatactaatcagagtagccacgacaaagacgcgttgacaaggggaggttataacgcatatctggaatcactttctcgttgtgacagtggaaaggcagaagaacaaaaaggaaaagttatatcaaagttattagagaaaaaagatgtccgagctttgaggtacataggtttagggcctctggggtttgtaaacaactcattaagaaaagattgttggtatgaattattggcgtcccagttgcttattgatgatgcaacagagtacattacaccagtggaaaaacataaagatgaaggtcaggtgatattggatgcagaaaggtcttttggtggaattgtcgacaaaaacttgaaactgcaattgagaaaactactggtggagttaattactcgggtattgagaaagtacccaacgttgaactattaccaaggttatcatgatattgtgtctgttttcatcatgtgttttagttggaatgtcacaaaagagaacggactggaactagaaaatctctcattgcaagaagaaattgatatggaaaggctgttttattgcatcgaagcatttaccctattatatctgagggatttcatgatgaactcactagatttttcatttgagcaattgagagtaatctcttcattgataaaggaatcaaacatgaaattctataatctattcaaatttgacgaaaatgagccccttttcgctattgggtcaatattgacaatctttgcacataatttgaaacctatagatagcggtgacaacaatcttcataaaattcttttccagatatttgacatgacaatatcgatgcaatctatgcgtttacctttgatcatatacaagaacctgctattgcaaaatgcgtctgaaatttcgaagcaaatagaagctaattctgatttcttcgagaacgattttgacctgcgccatggtgctatacaaacagttttacagaaaaaactgtatgatgaggcgctttgggaagaagtcttgcaaataactagaaaagatgcgactactgccagcaagaaggctttgaaacgggtgagtcttaataaatatagtgcattactcaatacagcatgtggaaagccaggatgcttcgatatgagcaccattatcttctatttgagcgaacaaacaaagatgaacgagcattacaaggaagaaaagtatcatggtgtcgccgccagatccaagacaagggcgttggtccaaagacttggccattttttaccctccaaatataacaggtggagcaaaatttctttacttatcgggattgtagctatcctgtaccaattacggactacaaggtcgttgagtttagtactcaatctacgttacatgatctccacaaagttgaaagacttatcacatataaatataaatttgcaccacgttagtcacatctgggtggatccgattagggacattttgaaactggggcatccaactagatag

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