LOCUS       NM_001179849            1188 bp    mRNA    linear   PLN 17-DEC-2024
DEFINITION  Saccharomyces cerevisiae S288C translation initiation factor eIF4A
            (TIF1), partial mRNA.
ACCESSION   NM_001179849
VERSION     NM_001179849.3
DBLINK      BioProject: PRJNA128
KEYWORDS    RefSeq.
SOURCE      Saccharomyces cerevisiae S288C
  ORGANISM  Saccharomyces cerevisiae S288C
            Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
            Saccharomycetes; Saccharomycetales; Saccharomycetaceae;
            Saccharomyces.
REFERENCE   1  (bases 1 to 1188)
  AUTHORS   Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M.,
            Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S.,
            Weng,S. and Cherry,J.M.
  TITLE     New data and collaborations at the Saccharomyces Genome Database:
            updated reference genome, alleles, and the Alliance of Genome
            Resources
  JOURNAL   Genetics 220 (4) (2022)
   PUBMED   34897464
REFERENCE   2  (bases 1 to 1188)
  AUTHORS   Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B.,
            Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M.,
            Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and
            Oliver,S.G.
  TITLE     Life with 6000 genes
  JOURNAL   Science 274 (5287), 546 (1996)
   PUBMED   8849441
REFERENCE   3  (bases 1 to 1188)
  AUTHORS   Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V.,
            Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M.,
            Bossier,P. et al.
  TITLE     Complete DNA sequence of yeast chromosome XI
  JOURNAL   Nature 369 (6479), 371-378 (1994)
   PUBMED   8196765
REFERENCE   4  (bases 1 to 1188)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (17-DEC-2024) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   5  (bases 1 to 1188)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (04-MAY-2012) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Protein update by submitter
REFERENCE   6  (bases 1 to 1188)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (31-MAR-2011) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Sequence update by submitter
REFERENCE   7  (bases 1 to 1188)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (14-DEC-2009) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by SGD. This record
            is derived from an annotated genomic sequence (NC_001143).
            
            On Jul 30, 2012 this sequence version replaced NM_001179849.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: SGD
            Annotation Status   :: Full Annotation
            Annotation Version  :: R64-4-1
            URL                 :: http://www.yeastgenome.org/
            ##Genome-Annotation-Data-END##
            COMPLETENESS: incomplete on both ends.
FEATURES             Location/Qualifiers
     source          1..1188
                     /organism="Saccharomyces cerevisiae S288C"
                     /mol_type="mRNA"
                     /strain="S288C"
                     /db_xref="taxon:559292"
                     /chromosome="XI"
     gene            <1..>1188
                     /gene="TIF1"
                     /locus_tag="YKR059W"
                     /db_xref="GeneID:853933"
     CDS             1..1188
                     /gene="TIF1"
                     /locus_tag="YKR059W"
                     /experiment="EXISTENCE:direct assay:GO:0003743 translation
                     initiation factor activity [PMID:1502180]"
                     /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
                     [PMID:11914276]"
                     /experiment="EXISTENCE:direct assay:GO:0006413
                     translational initiation [PMID:1502180]"
                     /note="Translation initiation factor eIF4A; DEAD-box RNA
                     helicase that couples ATPase activity to mRNA binding and
                     unwinding; ATP hydrolysis accelerates the recruitment of
                     mRNA during 48S preinitiation complex (PIC) assembly;
                     ATPase activity stimulated by either eIF4G1 or by the PIC
                     in an eIF3g and eIFGi subunit-dependent manner,
                     independent of eIF4E and eIF4G; subunit of the mRNA
                     cap-binding protein complex (eIF4F) with eIF4E and eIF4G;
                     protein abundance increases in response to DNA replication
                     stress"
                     /codon_start=1
                     /product="translation initiation factor eIF4A"
                     /protein_id="NP_012985.3"
                     /db_xref="GeneID:853933"
                     /db_xref="SGD:S000001767"
                     /translation="

MSEGITDIEESQIQTNYDKVVYKFDDMELDENLLRGVFGYGFEEPSAIQQRAIMPIIEGHDVLAQAQSGTGKTGTFSIAALQRIDTSVKAPQALMLAPTRELALQIQKVVMALAFHMDIKVHACIGGTSFVEDAEGLRDAQIVVGTPGRVFDNIQRRRFRTDKIKMFILDEADEMLSSGFKEQIYQIFTLLPPTTQVVLLSATMPNDVLEVTTKFMRNPVRILVKKDELTLEGIKQFYVNVEEEEYKYECLTDLYDSISVTQAVIFCNTRRKVEELTTKLRNDKFTVSAIYSDLPQQERDTIMKEFRSGSSRILISTDLLARGIDVQQVSLVINYDLPANKENYIHRIGRGGRFGRKGVAINFVTNEDVGAMRELEKFYSTQIEELPSDIATLLN"

     misc_feature    28..1182
                     /gene="TIF1"
                     /locus_tag="YKR059W"
                     /note="N-terminal helicase domain of the DEAD-box helicase
                     superfamily; Region: DEAD-like_helicase_N; cl28899"
                     /db_xref="CDD:475120"
     misc_feature    order(70..72,124..126,130..132,145..147,202..222)
                     /gene="TIF1"
                     /locus_tag="YKR059W"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:350804"
     misc_feature    order(73..75,103..105,112..114,127..129)
                     /gene="TIF1"
                     /locus_tag="YKR059W"
                     /note="eIF4G interface [polypeptide binding]; other site"
                     /db_xref="CDD:350804"
ORIGIN      

atgtctgaaggtattactgatattgaagaatcccaaattcaaaccaactatgacaaggttgtctacaagttcgatgatatggaattggacgaaaacttgttaagaggtgttttcggttacggtttcgaagaaccatctgccattcaacaacgtgccatcatgcctattattgaaggtcacgatgtcttggctcaagctcaatctggtactggtaagaccggtaccttttccattgctgctttgcaaagaattgacacctctgtcaaggctcctcaagctttgatgttggctccaactagagaattggctttgcaaatccaaaaggttgtcatggctttggctttccacatggacatcaaggtccacgcttgtatcggtggtacttcctttgttgaagacgctgaaggtttgagagatgctcaaatcgtcgttggtactccaggtcgtgtttttgacaacatccaaagacgtagattcagaactgacaagatcaagatgttcatcttagatgaagctgatgaaatgttgtcttctggtttcaaggaacaaatctaccaaattttcaccttacttccaccaaccactcaagttgttctattgtccgccaccatgccaaatgacgtcttggaagttaccaccaaatttatgagaaacccagttagaattttggttaagaaggatgaattgactttggaaggtatcaaacaattctacgttaatgttgaagaagaagaatacaaatacgagtgtttgaccgatttatacgactctatctccgttactcaagctgtcatcttctgtaacaccagaagaaaggtcgaagaattgaccactaagttaagaaacgacaaatttaccgtttctgccatctactctgatttaccacaacaagaaagagacaccatcatgaaggaattcagaagtggttcttccagaattttgatctccactgatttgttggctagaggtatcgatgtccaacaagtttctttggttattaactacgacttaccagctaacaaagaaaactatattcacagaatcggtagaggtggtcgtttcggtagaaagggtgttgccatcaactttgttactaacgaagacgttggcgctatgagagaactagaaaagttctactccactcaaattgaagaattgccatccgacatcgctactttgttgaactaa

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