LOCUS       NM_001179798            1878 bp    mRNA    linear   PLN 17-DEC-2024
DEFINITION  Saccharomyces cerevisiae S288C Rsc4p (RSC4), partial mRNA.
ACCESSION   NM_001179798
VERSION     NM_001179798.4
DBLINK      BioProject: PRJNA128
KEYWORDS    RefSeq.
SOURCE      Saccharomyces cerevisiae S288C
  ORGANISM  Saccharomyces cerevisiae S288C
            Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
            Saccharomycetes; Saccharomycetales; Saccharomycetaceae;
            Saccharomyces.
REFERENCE   1  (bases 1 to 1878)
  AUTHORS   Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M.,
            Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S.,
            Weng,S. and Cherry,J.M.
  TITLE     New data and collaborations at the Saccharomyces Genome Database:
            updated reference genome, alleles, and the Alliance of Genome
            Resources
  JOURNAL   Genetics 220 (4) (2022)
   PUBMED   34897464
REFERENCE   2  (bases 1 to 1878)
  AUTHORS   Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B.,
            Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M.,
            Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and
            Oliver,S.G.
  TITLE     Life with 6000 genes
  JOURNAL   Science 274 (5287), 546 (1996)
   PUBMED   8849441
REFERENCE   3  (bases 1 to 1878)
  AUTHORS   Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V.,
            Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M.,
            Bossier,P. et al.
  TITLE     Complete DNA sequence of yeast chromosome XI
  JOURNAL   Nature 369 (6479), 371-378 (1994)
   PUBMED   8196765
REFERENCE   4  (bases 1 to 1878)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (17-DEC-2024) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   5  (bases 1 to 1878)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (04-MAY-2012) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Protein update by submitter
REFERENCE   6  (bases 1 to 1878)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (31-MAR-2011) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Sequence update by submitter
REFERENCE   7  (bases 1 to 1878)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (14-DEC-2009) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by SGD. This record
            is derived from an annotated genomic sequence (NC_001143).
            
            On Jul 30, 2012 this sequence version replaced NM_001179798.3.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: SGD
            Annotation Status   :: Full Annotation
            Annotation Version  :: R64-4-1
            URL                 :: http://www.yeastgenome.org/
            ##Genome-Annotation-Data-END##
            COMPLETENESS: incomplete on both ends.
FEATURES             Location/Qualifiers
     source          1..1878
                     /organism="Saccharomyces cerevisiae S288C"
                     /mol_type="mRNA"
                     /strain="S288C"
                     /db_xref="taxon:559292"
                     /chromosome="XI"
     gene            <1..>1878
                     /gene="RSC4"
                     /locus_tag="YKR008W"
                     /db_xref="GeneID:853877"
     CDS             1..1878
                     /gene="RSC4"
                     /locus_tag="YKR008W"
                     /experiment="EXISTENCE:direct assay:GO:0006337 nucleosome
                     disassembly [PMID:16492771]"
                     /experiment="EXISTENCE:direct assay:GO:0006338 chromatin
                     remodeling [PMID:12183366]"
                     /experiment="EXISTENCE:direct assay:GO:0006368
                     transcription elongation by RNA polymerase II
                     [PMID:17081996]"
                     /experiment="EXISTENCE:direct assay:GO:0016586 RSC-type
                     complex [PMID:10619019|PMID:12183366]"
                     /experiment="EXISTENCE:direct assay:GO:0070577
                     lysine-acetylated histone binding [PMID:20126658]"
                     /note="Component of the RSC chromatin remodeling complex;
                     found in close proximity to nucleosomal DNA; displaced
                     from the surface of nucleosomal DNA after chromatin
                     remodeling; acetylated (K25) by Gcn5p, altering
                     replication stress tolerance; contains tandem bromodomains
                     that recognize histone H3 acetylated on K14 (H3K14ac) by
                     Gcn5p"
                     /codon_start=1
                     /product="Rsc4p"
                     /protein_id="NP_012933.4"
                     /db_xref="GeneID:853877"
                     /db_xref="SGD:S000001716"
                     /translation="

MVVKKRKLATEAGGSDERPKYLPGKHPKNQEKTPHVDYNAPLNPKSELFLDDWHIPKFNRFISFTLDVLIDKYKDIFKDFIKLPSRKFHPQYYYKIQQPMSINEIKSRDYEYEDGPSNFLLDVELLTKNCQAYNEYDSLIVKNSMQVVMLIEFEVLKAKNLKRNYLINSEVKAKLLHYLNKLVDATEKKINQALLGASSPKNLDDKVKLSEPFMELVDKDELPEYYEIVHSPMALSIVKQNLEIGQYSKIYDFIIDMLLVFQNAHIFNDPSALIYKDATTLTNYFNYLIQKEFFPELQDLNERGEINLEFDKFEFENYLAIGGGGPAAAGALAISALDNDIEPESNREDLIDQADYDFNHFEGLGNGYNRSLLTEDYLLNPNNFKKLIAKPETVQSEVKNERSTTSDIEKTNSLESEHLKIPKYNVIKSMQKEMQSLSEQHTMEYKPYKLIQQIYIFSSKNLYSQATKPLLGSRPSCNQNWVEYIFNGNELSQNENAFSFMLQPMQTFLTLQSHLTSSLKDTETLLTINKEPVKSRTSNVNSNLSQPQQQENDVIGNDTKQDIENLTIGGGNNNDIVGNDNDKRNNITEIFDIRLSEGLNHLMFRCEDKISHETEFMNFWINVLP"

     misc_feature    118..1269
                     /gene="RSC4"
                     /locus_tag="YKR008W"
                     /note="Transcription factor involved in chromatin
                     remodeling, contains bromodomain [Chromatin structure and
                     dynamics / Transcription]; Region: COG5076"
                     /db_xref="CDD:227408"
ORIGIN      

atggtagttaagaagcgtaagttggcaactgaggccggtggcagtgatgaaaggcctaaatacttgccgggaaaacatcctaaaaaccaagagaaaactccgcatgtggattataacgccccattaaaccctaaatctgaactttttctagatgactggcatatacctaaatttaatcgatttattagtttcactttggatgttcttatcgacaaatacaaagatattttcaaagatttcatcaaactaccaagtaggaagtttcatccacagtattattacaagatccagcagccaatgtctattaatgaaatcaagtcaagagattatgaatacgaagatggtccaagtaattttcttttggatgttgagctactgacaaagaattgtcaagcttacaatgaatatgacagtttgattgtaaaaaactccatgcaagtagtaatgttgattgaatttgaagtattgaaggcaaaaaatttgaaaagaaattacttaattaacagcgaggtcaaagccaaattactgcactatcttaataagctagttgacgccacggaaaagaaaatcaaccaggctctgctgggtgcgtcatctcctaaaaacttagacgacaaagtcaagctaagtgaaccgtttatggaattagtcgataaagatgaacttcctgaatattatgaaatagtgcatagccccatggctttatcgatcgtaaagcagaacctcgaaattggtcagtattccaagatatatgatttcatcattgatatgcttttagtttttcagaatgctcatatattcaatgatccaagcgctttgatttacaaagacgcaacaactttaacaaattattttaactacttaatacaaaaggaattcttcccagagttacaggatttaaatgaacgtggcgaaattaatttagaatttgacaaattcgaattcgaaaactacttagctattggtggtggtggtccagccgcagcaggtgcgttagctatatctgctcttgataatgatattgagccagaatctaaccgtgaagatcttattgatcaagcagattatgatttcaatcatttcgaaggtctcggcaatggttataatcgttctctcctaactgaagattatttactgaacccaaacaacttcaaaaagttaatagccaaaccggaaacagtgcaatccgaagtcaaaaatgaaagatcaacgacatctgatattgagaagacaaactccttagagagcgaacatttaaaaatccccaaatacaatgttataaaatccatgcaaaaagaaatgcaatcactctcagagcaacacaccatggagtataagccctataaattaatacaacaaatttacattttttcttctaaaaatttgtattcgcaggcaactaagcctttactgggttcaaggccatcatgcaatcaaaattgggtagagtatattttcaatggtaatgaattgagtcaaaatgaaaacgctttctccttcatgttacaacccatgcaaacttttttaacattacagtctcatttgacctcatcattaaaggatacagagactttattaaccattaataaagagccagtgaagtctagaacttcaaatgtaaacagtaacctttcccaacctcagcaacaagaaaatgatgttattggaaacgatacgaagcaagatatagaaaatttgacaatcggcggcggcaacaataacgatattgttggtaacgataatgataaacgtaataatataaccgaaatctttgatattcgcttatcagaaggtttaaatcatttgatgtttaggtgtgaggacaaaatatctcatgaaacggaattcatgaatttctggataaatgtcttaccatga

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